1: Bigoniya, P. and A.C. Rana, 2007. Wound healing activity of Euphorbia neriifolia leaf extract. J. Nat. Remedies, 7: 94-101.
2: Bigoniya, P. and A.C. Rana, 2008. A comprehensive Phyto-pharmacological review of Euphorbia neriifolia Linn. J. Pham. Rev., 2: 57-66.
Direct Link |
3: Bigoniya, P. and A.C. Rana, 2005. Psychopharmacological profile of hydro-alcoholic extract of Euphorbia neriifolia leaves in mice and rats. Indian J. Exp. Biol., 43: 859-862.
4: Bigoniya,
P. and A.C. Rana, 2006. Comparative macroscopic microscopic and
Physico-chemical studies and quantitative physical evaluation of Wrightia tinctoria seed fibres with cotton and jute. Planta Indica, 2: 44-50.
5: Bigoniya, P. and A.C. Rana, 2008. Immunomodulatory activity of Euphorbia neriifolia leaf hydro-alcoholic extract in rats. Indian Dru., 45: 90-97.
6: Bigoniya, P., 2008. Ethnopharmacology in herbal drug development. J. Pharm. Rev., 6: 109-116.
7: Bigoniya,
P., 2009. Pharmacovigilance of herbal medicines: Current status and
future strategies. J. Pharm. Rev., 7: 77-88.
8: Bigoniya, P., A. Shukla, G.P. Agrawal and A.C. Rana, 2008. Pharmacological screening of Wrightia tinctoria bark hydro-alcoholic extract. Asian J. Exp. Sci., 22: 235-244.
9: Bigoniya, P., A.C. Rana and G.P. Agrawal, 2006. Evaluation of the antiulcer activity of hydro-alcoholic extract of Wrightia tinctoria bark in experimentally induced acute gastric ulcers on rat. J. Nig. Nat. Prod. Med., 10: 36-40.
10: Bigoniya, P., Rana and A.C. Lariya, 2007. Immunomodulatory activity of Wrightia tinctoria bark alcoholic extract on rats. Current Pharma. Res. J., 1: 1-9.
11: Bigoniya,
P., V. Shrivastava and A.C. Rana, 2005. Effect of coconut milk on
bioavailability of isoniazide. J. Asian Exp. Sci., 19: 93-102.
 
Papiya
Bigoniya and Faraz Siddique are helping to cultivate world''s future
scientists. Under their leadership the research area is surely likely to
excel. In historic victory the celebrity scientists: Papiya Bigoniya
and Faraz Siddique honored with Hugo de Vries Research Award-2015 in
Traditional Medicine. Ahead of several thousands competitors, Papiya
Bigoniya and Faraz Siddique representing India won prestigious Hugo de
Vries Research Award-2015 in Traditional Medicine. Again India has
proved its International leadership via producing brilliant scientists
in the form of Papiya Bigoniya and Faraz Siddique. IASR expressed, 'It
is a privilege to have such international celebrity from Traditional
Medicine among us who will shape the future of this domain.' Papiya
Bigoniya and Faraz Siddique made International news headlines while IASR
announced them among World’s 500 Most Influential Pharmacologists for Year 2015 on Earth.
Mr. Faraz Siddiqui completed his Bechlor in Pharmacy degree from
Laxmi Narain College of Technology Bhopal and Master in Pharmcy
(Pharmacology specialization) from Radharaman College of Pharmacy
Bhopal. He worked for SAVA healthcare Limited as Chemist Quality
Control for 1.5 years. Presently he is working as an Officer Quality
assurance in Sun Pharmaceutical Industries Limited, Halol (Gujarat). His
present research project is focused on phytopharmacological work on
active isolated constituents from Indian folklore medicine directed to
explore their therapeutic potential. He is having 3.5 years of
experience in Pharmaceutical industries in Quality Control and Quality
assurance departments. He is supervising a number of Analytical Method
Validation studies of newly developed Active Pharmaceutical Ingredients
under his active supervision as reviewer.
Professor Mrs. Papiya Bigoniya completed her B. Pharm from Dr.
H.S. Gour University, Sagar and M. Pharm in Pharmacology specialization
from Jadavpur University, Kolkata. She received her Ph.D. degree in
Pharmaceutical Sciences from Dr. H.S. Gour University, Sagar, under
National Doctoral Fellowship awarded by All India Council of Technical
Education. She is GATE’95 qualified and a UGC Junior research fellow for
2 years during post-graduation. She served as a faculty in Department
of Pharmacy, Barkatullah University and Globus College of Pharmacy,
Bhopal. Presently she is working as a Professor and Principal in
Radharaman College of Pharmacy, Bhopal. She is a gold medalist in P.G
Diploma in Pharmaceutical Management from IPER, Pune and done P.G
Diploma in Public Health from Annamalai University, Tamilnadu. Her
present research projects are focused on phytopharmacological work on
active isolated constituents from Indian folklore medicine directed to
explore their therapeutic potential and attempting on formulation of
standardized product by following the modern herbal Ayurvedic monographs
and international guidelines. Her field of research focuses on
pharmacological screening, pharmacokinetic, pharmacodynamic and
bioavailability studies, drug-food interactions, and standardization
method development for herbals. She has 80 National and International
publications in peer reviewed journals, contributed in 8 book series and
has presented more than 76 papers in various conferences, workshops,
seminars, SDPs and training programs. She is having 17 years of
experience in research and teaching viz. Anatomy & physiology,
Pathophysiology, Pharmacology, Clinical pharmacy, Quality assurance and
Drug regulatory affairs in graduate and post graduate departments. She
is supervising a number of students in post graduate and doctoral
studies under her active supervision. She is also serving the
international scientific community by extending expertise as Editorial
Board member, reviewer and referee in number of journal Elsevier, Taylor
& Francis, Academic Journals, Science Alert and BioMed Central. Dr.
P. Bigoniya is life member of IPA, APTI, InPharm and IPS societies. Dr.
Bigoniya has recently participated and presented a scientific research
paper in the 2nd International conference on “Pharma-Nutrition 2013”
organized by Elsevier publications in Max Atria Singapore. This
presentation was supported by DST, New Delhi and MPCST, Bhopal by
providing International Travel Grant.
Papiya Bigoniya and Faraz Siddique from India made a historical
victory over the international competition and won Hugo de Vries
Research Award-2015 in Traditional Medicine. Their research was
highlighted in international media and gathered a large worldwide
attention in scientific circles while it appeared in world's most read
journal 'The Journal of Ethnobiology and Traditional Medicine'. In their
report on Anti-inflammatory and anti-arthritic effect of triterpene
fraction isolated from Euphorbia neriifolia L. leaf they mention that
Euphorbia neriifolia Linn. (Euphorbiaceae) is a abundantly growing
spurge in the dry hilly and rocky areas which has been reported to have
rich presence of triterpenes. The present study aimed at evaluation and
phytopharmacological correlation of E. neriifolia leaf anti-inflammatory
and anti-arthritic activity targeting triterpenoidal fraction (TFEN).
Enrichment, isolation and characterization of TFEN was carried out by
TLC, column and HPLC analysis. Paw volume, arthritic index and TNFα
level in serum was determined along with histopathology of tibiotarsal
joint after carrageenan and adjuvant arthritis induced inflammation on
rat. Enriched E. neriifolia leaf triterpene fraction showed presence of
eupha-7,24-dienol and cycloartenol in HPLC. Pre-treatment with TFEN
significantly reduced paw oedema (P<0.001), arthritis index
(P<0.05) and cytokine TNFα (P<0.001) level in CFA induced
arthritic animals upon 28 days of treatment. Positive results of this
study indicate that E. neriifolia triterpene has potent
anti-inflammatory and anti-arthritic effect. Maintenance of synovial
functional ability and decrease in inflammatory process may be through
inhibiting cytokines and leukotrienes infiltration as evidenced by
decrease in TNFα and arthritic index. Positive results of this study
indicate potent anti-arthritic effect of E. neriifolia though detailed
future studies are required to assess the effect on inflammatory
mediators like leukotrienes, phospholipase A2, prostaglandins and
antioxidant enzymes in joint tissue. Under their leadership the research
area is surely likely to expand beyond the horizons. It will be worthy
to explore the further potential under their legacy. Papiya Bigoniya and
Faraz Siddique as valuable intellectuals for the India offer exclusive
opportunities for scholars around the world. One of the most attractive
weightage for India is to have the awardees for promotion of the
concerned scientific discipline for the benefit of its civilians. Thus
India which has excellent track record to produce brain storming
intellectuals, has offered a new extension in terms of Papiya Bigoniya
and Faraz Siddique to world.
Depending on the results obtained in this study we conclude that
E. neriifolia triterpene has potent anti-inflammatory and
anti-arthritic effect. The effect like maintenance of synovial viability
and functional ability and decrease in inflammatory process may be due
to inhibition cytokines and leukotrienes infiltration as evidenced by
decrease in paw edema and arthritic index. Decrease in cartilage
destruction and anti-inflammatory response proposes inhibition of
phospholipase A2 and prostaglandins which can be substantiated by its
antioxidant profile. Positive results of this study indicate potent
anti-arthritic effect of E. neriifolia also its ability to overcome the
complications of AIA by improvement of clinical signs in joint space.
HPLC finger printing chromatogram E. neriifolia leaf triterpene
fraction revealed presence of eupha-7,24-dienol and cycloartenol. E.
neriifolia leaf triterpene fraction has anti-inflammatory and
anti-arthritic activity E. neriifolia leaf triterpene fraction decreases
joint and bone destruction, pannus formation, and cartilage erosion.
The results of this study validate the traditional and reported
analgesic and anti-inflammatory uses of E. neriifolia.
Though level of inflammatory mediator TNFα has been determined
in blood of arthritic animals, the study has not involved determination
of other mediators like leukotrienes, phospholipase A2 or prostaglandins
in blood or inflammatory tissue. Anti-arthritic activity screening
against cotton pallet induced granuloma has not been attempted which can
access effect of E. neriifolia leaf triterpene tissue turnover rate.
Estimation of level of lipid peroxide, superoxide dismutase,
glutathione peroxidase and catalase like anti-antioxidative parameters
in inflammatory tissue has not been done to directly correlate
anti-inflammatory and anti-arthritic activity with antioxidant property.
Determination of inflammatory mediators like leukotrienes,
phospholipase A2 or prostaglandins in blood or inflammatory tissue.
Anti-arthritic activity screening against cotton pallet induced
granuloma. Estimation of level of lipid peroxide, superoxide dismutase,
glutathione peroxidase and catalase like anti-antioxidative parameters
in blood inflammatory tissue.
In the present time due to globalization and fast paced economic
growth standardization is a prerequisite in each and every step to
export the herbal products. These concerns substantiate the need of
isolation and standardization of bioactive marker to proceed for further
preclinical and clinical studies. Large extent of research efforts
along with funding from government and private sector are required to
substantiate isolation and standardization of bioactive
phytoconstituents. All the data qualitative, quantitative, efficacy and
safety will enhance the scientific value and authenticity that will help
in granting patent and peer review publication.
Author Papiya Bigoniya makes substantial contributions towards
conception and design of the study, acquisition and interpretation of
data, formatted and edited the manuscript. Author Faraz Siddique
performed experiments, collected and analysed data, participate in
drafting the article. Both the authors give final approval of the
version of the article revising it critically for important intellectual
content.
Radharaman Institute of Technology & Science Engineering CollegeAddress: Bhadbhada Road, Ratibad, Bhopal, Madhya Pradesh 462046 Phone:0755 289 6660
| 
