One Organic Chemist One Day............Honouring Profiles of leading Organic Chemists brought to you by DR ANTHONY MELVIN CRASTO, worlddrugtracker, helping millions, amcrasto@gmail.com, +91 9323115463, India, skype amcrasto64
DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai) , INDIA 29Yrs Exp. in the feld of Organic Chemistry,Working for GLENMARK PHARMA at Navi Mumbai, INDIA. Serving chemists around the world. Helping them with websites on Chemistry.Million hits on google, world acclamation from industry, academia, drug authorities for websites, blogs and educational contribution
To assure the RA- MENA of delivering planned KPIs plus continuous improvement in RA- MENA deliverables (results of project management- KPIs and effectiveness).
This role is responsible for the overall success of KPI compliance and improvement for the RA- MENA. And also responsible for the RA- MENA data analysis reports in addition to the successful RA- MENA KPIs External/Internal audits.
Bachelor of Science (BSc), Applied Chemistry, Very good with first grade
Tabuk Pharmaceutical Manufacturing Company has announced plans to increase its female employee intake in the next 5 years; by hiring 200-300 additional ...
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Associate Professor at Shri Venkateshwara College of Pharmacy
Hema Nair, PhD in Pharmaceutics from Mumbai University, Diploma in Patent Law, Nalsar University, Hyderabad, is currently Associate Professor of Pharmaceutics at Sri Venkateshwara College of Pharmacy, Hyderabad, India. She has 15 years of teaching experience at Bombay College of Pharmacy, Mumbai. Her key research areas include drug delivery systems-conventional & novel, synthesis and evaluation of novel polymeric excipient materials. She has around 10 research projects both Government & Industry sponsored. She has published 14 research articles in both national & international journals and participated in more than 33 conferences. She is currently a reviewer for several national and international journals.
Hema Nair, PhD in Pharmaceutics from Mumbai University, Diploma in Patent Law, Nalsar University, Hyderabad, is currently Associate Professor of Pharmaceutics at Sri Venkateshwara College of Pharmacy, Hyderabad, India. She has 15 years of teaching experience at Bombay College of Pharmacy, Mumbai. Her key research areas include drug delivery systems-conventional & novel, synthesis and evaluation of novel polymeric excipient materials. She has around 10 research projects both Government & Industry sponsored. She has published 14 research articles in both national & international journals and participated in more than 33 conferences. She is currently a reviewer for several national and international journals.
Abstract
Cancer therapy has seen enormous growth in the last few decades in terms of new molecules and novel targeted formulations making a successful entry into the treatment paradigm. The semisynthetic taxane derivative, docetaxel holds great promise in treating solid tumours. However, owing to poor solubility of docetaxel in aqueous milieu, it is formulated as a solution in polysorbate 80, TaxotereÃ’. The solubilizer (polysorbate 80) used, is associated with side effects like hypersensitivity reactions which demand co-administration of dexamethasone. This in turn, compromises immunity of cancer patients, often resulting in discontinuation of docetaxel treatment. The inability to target tumour tissues is another limitation of TaxotereÃ’. In the light of the drawbacks associated with existing docetaxel therapy, the current study presents development of alternative formulations based on polymeric micelles fabricated using biodegradable polymers. Initially, polyethylene glycol-polycaprolactone amphiphilic copolymers of different molecular weights were synthesized by ring opening bulk polymerization and the products characterized (through IR, H1-NMR, XRD, DSC and measurement of critical micelle concentrations). These, in turn, were employed in the preparation of micellar systems containing solubilized docetaxel. The resultant micellar dispersions were characterized for particle size and zeta potential, drug content and efficiency of entrapment of docetaxel, morphology by TEM and for in vitro release studies. The biodegradable copolymers used to fabricate these systems were found to possess low CMC values, thereby conferring resistance to breakdown on dilution encountered in bloodstream in vivo. Also, in vitro cytotoxicity as evaluated in non-small cell lung cancer cell line A549 demonstrated that simple and mixed micelles were as effective as docetaxel solution and bore potential to be used as substituents for polysorbate 80 based formulations.
During
my postdoctoral fellowship at the group of Prof. Dr. Ilan Marek I was
in charge of projects invited by the industry, managing to upgrade them
to the desired level, in limited time schedule.
During
my doctoral studies I was developing new methodologies in Organic
Synthesis, under the title - "Stereoselective synthesis of enolate
intermediate toward the construction of quaternary stereocenters". I
gained experience in frontal teaching in advanced Organic Chemistry
course.
During
my Msc studies I was responsible for method development in Organic
Chemistry under the subject of "Synthesis of Polyhydroxylated Fragments
toward natural products" and teaching undergraduate students.
While
experiencing the Organic Chemistry laboratory as a research assistant I
was handling various techniques and systems in Organic Chemistry and
performing wide range of reactions.
Our
approach leading to the formation of several new stereogenic centers
through a combined metalation–addition of a carbonyl–carbamoyl transfer
to reveal in situ stereodefined α,α-disubstituted enolates of ketone as a
single stereoisomer. This approach could produce a series of aldol and
Mannich products from enol carbamate with excellent diastereomeric
ratios.
