Lori krim Gavrin

Lori Gavrin

Discovery Partnerships with Academia; Sr. Director Collaboration Strategy; Esprit R&D at GSK

Links

• https://www.linkedin.com/in/lori-gavrin-8a834914

  
   https://twitter.com/GavrinLori
   https://www.researchgate.net/profile/Lori_Gavrin/info

LORI GAVRIN has 15 years’ experience as a Ph.D. organic chemist working in the field of drug discovery and development. As a member of GlaxoSmithKline’s highly selective R&D Esprit Leadership Development Program, she is working in the maternal and neonatal health unit in partnership with Save the Children to reduce the tragically high newborn mortality rate in the developing world by increasing access of lifesaving medicines to mothers and newborns. Previous to her current role, Dr. Gavrin has led R&D efforts in cystic fibrosis, diabetes, arthritis and women’s health.  She has more than a dozen publications and is a named inventor on 11 patents.  A passionate supporter of the research being done in the pharmaceutical and biotech industry, Dr. Gavrin recently chaired the world’s premier medicinal chemistry conference, the Gordon Research Conference, and has delivered numerous talks on the drug discovery and development process around the world to graduate students, professors, fellow industry members, and high school teachers.  Dr. Gavrin earned a B.S. at Colgate University and her Ph.D. in organic chemistry at University of Pennsylvania.  @gsk

Experience

Discovery Partnerships with Academia; Sr. Director Collaboration Strategy; Esprit R&D

GSK

August 2015 – Present (11 months)Upper Providence, PA

This Discovery Partneships with Academia unit at GSK (dpac.gsk.com) aims to build integrated partnerships with academics that can translate innovative research into medicines to benefit patients. I will be responsible for developing an enhanced strategic and business development approach to academic collaborations for the Upper Providence-Philadelphia geography and will assume responsibility for portfolio management across the entire DPAc portfolio. I will also co-lead a 2015 Discovery Fast Track (gsk.com/discoveryfasttrack) winner and guide the project through the development of high through-put and triage assays.

Discovery Partnerships with Academia (DPAc) | GlaxoSmithKline

Esprit Associate - Scientific Director in Maternal & Neonatal Health R&D

GSK

July 2014 – August 2015 (1 year 2 months)Stevenage, United Kingdom

Our R&D unit is developing a portfolio in the maternal and neonatal health therapeutic area and also has accountability for the R&D Workstream of the GSK-Save the Children Partnership. (http://www.gsk.com/about-us/corporate-partnerships/save-the-children-partnership.html?tab=taba-new-way-of-working)

Finding new ways to give mothers and newborns a healthier start

Chair

2015 Medicinal Chemistry Gordon Research Conference

August 2012 – August 2015 (3 years 1 month)Colby Sawyer College, New Hampshire

The 2015 Medicinal Chemistry Gordon Research Conference will feature talks on the cutting edge of the discipline that include new compounds, targets and technologies that advance the science.

Esprit Associate - R&D Strategy

GlaxoSmithKline

May 2013 – July 2014 (1 year 3 months)Upper Merion, PA

R&D Strategy comprises a diverse group of experienced professionals who combine scientific knowledge, strong business acumen and an ability to drive strategy from concept to embedded change. The group maintains a keen awareness of internal and external R&D dynamics in order to effectively shape and continuously challenge the strategic direction of R&D through creative thinking, effective problem solving and strong stakeholder management

Senior Principal Scientist

Pfizer

October 2009 – May 2013 (3 years 8 months)Cambridge, MA

Principal Research Scientist

Wyeth Research

October 2001 – October 2009 (8 years 1 month)

Pfizer Research, Rare Disease Chemistry and Chemical Biology, BioTherapeutics Chemistry, 200 Cambridgepark Drive, Cambridge, USA
E-mail: lori.gavrin@pfizer.com
Tel: +1 617-665-5616

Education

University of Pennsylvania

PhD, Organic Chemistry

1996 – 2001

Colgate University

BS, Organic Chemistry

1992 – 1996

Activities and Societies: Ice Hockey, Rugby

Holliston High School

1988 – 1992

 

 Dr. Lori Gavrin, Senior Director of Discovery Partnerships in Academia, hosted an energizing panel discussion, “Reviving Your Career: Actionable Steps to Achieve a Professional Renaissance”. Panelists included (left to right): Wendy Wallbridge, Leslye Louie, Patrice D’Eramo, and Kerry Hannon. Great job, Lori!

Lori Krim Gavrin, PhD

R&D Esprit Associate; Manager R&D Strategy and Portfolio
Esprit
Program at Penn: Organic Chemistry
Graduation Year: 2001

Describe your current position and firm/organization and the career path you took to get there
The Esprit R&D programme is all about developing future scientific leaders, with the knowledge, capabilities and behaviours to deliver our strategic R&D challenges. Lasting three years, this global development programme has been created to attract high-potential individuals and put them on a fast track to leadership. Esprit Associate – Manager R&D Strategy and Portfolio, GlaxoSmithKline, 2013–Present The Esprit R&D programme includes a diverse group of experienced professionals who combine scientific knowledge, strong business acumen and an ability to drive strategy from concept to embedded change. The group maintains a keen awareness of internal and external R&D dynamics in order to effectively shape and continuously challenge the strategic direction of R&D through creative thinking, effective problem solving and strong stakeholder management. My roles have included: Portfolio Analytics: Evaluation of Late Stage Assets: Prioritization of the very late stage studies (i.e., Ph 3b/4) with a goal of facilitating a sound cross-portfolio investment strategy which is critical for the delivery of our pipeline. Strategy & Programme Management: Innovation in Clinical Design (ICD) Project: Transforming the clinical development paradigm at GSK by driving more widespread utilization of novel trial designs to deliver meaningful patient-centered clinical results at a lower cost.  A member of the ICD strategy team; currently serving as Programme Manager for implementation of the program. Prior to GSK, I served in Principal Scientist and Research Scientist roles at Wyeth/Pfizer: Senior Principal Scientist, Pfizer, 2009–2013 Design Lead, Rare Disease Discovery Medicinal Chemistry Team leader in collaboration with Cystic Fibrosis Foundation Lab Head, Inflammation and Immunology Discovery Medicinal Chemistry Principal Research Scientist, Wyeth Research, 2001–2009 Senior/Principal/Lead Research Scientist, Multiple TAs, Medicinal Chemistry Initial member of start-up exploratory group	Skills/capabilities/knowledge that have been developed on current assignment Strategic approach to problem solving Transforming strategic programme output into a plan with implementable workstreams Cross-functional portfolio and pipeline decision-making Developed understanding of GSK R&D organizational structure through networking, discussions, interviews and many interactions with teams, scientists and leaders Programme Management Tools and Skills
What skills, strengths, or knowledge did your graduate training provide you that helped you on your career path?
Scientific problem solving Impactful drug design and medicinal chemistry knowledge Collaboration and working with others; teamwork Communication and clearly articulating your work – making a compelling argument (ie defending your thesis)
If other graduate students and postdocs wanted to get a position similar to yours, what 3 specific pieces of advice would you offer them that they can be doing now while still at Penn?
Don't be afraid of new challenges and pushing yourself beyond your "comfort zone" The skills I learned from my chemistry background can be applied to different functional areas and, in fact, help me to provide diverse and valuable viewpoints Communication, transparency and knowledge-sharing are key to your success
How can graduate students/postdocs at Penn find out more about your career field?
Check out the Esprit website: www.gsk.com/uk/careers/postgraduates/postgraduate-esprit-r-and-d-programme.html GSK and other pharmaceutical companies are exploring new programs to develop scientists into leaders.  Explore all options.  Consider enrolling in one of these programs or moving outside your typical role for a secondment or rotation.  New skill sets will develop and distinguish you!
What do you most enjoy about your current position?
Being a scientific leader who can broaden horizons, invigorate scientists, empower decision making and create scientific influencers. Positively impacting the strategic decisions that shape the future of GSK and our industry. Aiding in changing the image of our industry and ultimately helping more patients around the world.
What are you looking forward to doing at work over the next week or two?
Learning something new every day. Meeting new people and collaborating with new groups.

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Paramjit Arora

Paramjit Arora 
Professor of Chemistry, NYU

Principal Investigator
B.S. Chemistry University of California at Berkeley
Ph.D. Chemistry University of California at Irvine
Postdoctoral Fellow California Institute of Technology
Email: arora@nyu.edu

The PI was born in New Delhi and raised in the friendly confines of the San Fernando Valley. When not in the lab, he fights battles of good versus evil with Adais.


Professor of Chemistry, NYU

 https://www.linkedin.com/in/paramjit-arora-aab4903

Experience

Professor of Chemistry

New York University

2002 – Present (14 years)

Education

University of California, Berkeley

B.S., Chemistry

1988 – 1992

University of California, Irvine

Ph.D., Chemistry

1993 – 1999

California Institute of Technology

Postdoc, Bioorganic Chemistry

1999 – 2002

Experience

Professor of Chemistry

New York University

2002 – Present (14 years)

Education

University of California, Berkeley

B.S., Chemistry

1988 – 1992

University of California, Irvine

Ph.D., Chemistry

1993 – 1999

California Institute of Technology

Postdoc, Bioorganic Chemistry

1999 – 2002

 

 24th American Peptide Symposium 2015

 Starting session IX, METABOLISM & SYNTHESIS of BIOACTIVE PEPTIDES, Professor Paramjit Arora with New York University, was introduced as this year's winner of the Makineni Lectureship Award. This award is significant as it recognizes recent achievements in peptide research. Professor Arora proceeded with his lecture, titled "Protein Domain Mimetics as Modulators of Protein-Protein Interactions."

 Starting session IX, METABOLISM & SYNTHESIS of BIOACTIVE PEPTIDES, Professor Paramjit Arora with New York University, was introduced as this year's winner of the Makineni Lectureship Award. This award is significant as it recognizes recent achievements in peptide research. Professor Arora proceeded with his lecture, titled "Protein Domain Mimetics as Modulators of Protein-Protein Interactions."

Paramjit Arora

Professor of Chemistry
Email: arora@nyu.edu
Phone: 212-998-8470
Office: Brown Building, 29 Washington Place, Room 360
Lab Homepage

Areas of Research/Interest
Bioorganic Chemistry and Chemical Biology
Research Description
Proteins often utilize small folded domains for recognition of other proteins, DNA and RNA. The hypothesis guiding our research is that by mimicking these folded domains we can modulate the function of a particular protein with metabolically stable synthetic molecules. The manifestation of this hypothesis into specific and potent compounds that interfere with chosen targets in cellular and animal systems requires new computational and synthetic approaches. We seek to devise a systematic framework to evaluate and target protein-protein interactions with structured peptidic and nonpeptidic scaffolds designed to reproduce the critical interfacial features of proteins.

Publications
Lao, B. B.; Drew, K.; Guarracino, D.; Brewer, T.; Heindel, D.; Bonneau, R.; Arora, P. S. “Rational Design of Topographical Helix Mimics as Potent Inhibitors of Protein-Protein Interactions.” J. Am. Chem. Soc. 2014, 136, 7877–7888.

Lao, B. B.; Grishagin, I.; Mesallati, H.; Brewer, T. F.; Olenyuk, B. Z.; Arora, P. S. “In vivo modulation of hypoxia-inducible signaling by topographical helix mimetics.” Proc. Natl. Acad. Sci. U.S.A. 2014, 111, 7531–7536.

Miller, S. E.; Watkins, A. M.; Kallenbach, N. R.; Arora, P. S. “Effects of side chains in helix nucleation differ from helix propagation.” Proc. Natl. Acad. Sci. U.S.A. 2014, 111, 6636-6641.

Kushal, S.; Lao, B. B.; Henchey, L. K.; Dubey, R. Mesallati, H.; Traaseth, N. J.; Olenyuk, B. Z.; Arora, P. S. “Protein Domain Mimetics as In Vivo Modulators of Hypoxia-Inducible Factor Signaling.” Proc. Natl. Acad. Sci. U.S.A. 2013, 110, 15602-15607.

Patgiri, A.; Joy, S. T.; Arora, P. S. “Nucleation Effects in Peptide Foldamers.” J. Am. Chem. Soc. 2012, 134, 11495-11502.

Bullock, B. N.; Jochim, A. L.; Arora, P. S. “Assessing Helical Protein Interfaces for Inhibitor Design.” J. Am. Chem. Soc. 2011, 133, 14220-14223.

Patgiri, A.; Yadav, K.; Arora, P. S.; Bar-Sagi, D. “An Orthosteric Inhibitor of the Ras–Sos Interface.” Nature Chem. Biol. 2011, 7, 585-587.

Jochim, A. L.; Arora P. S. “Systematic Analysis of Helical Protein Interfaces Reveals Targets for Synthetic Inhibitors.” ACS Chem. Biol. 2010, 5, 919-923.

Wang, D.; Liu, J.; Zheng, Q.; Lu, M.; Arora, P. S. “Atomic Structure of a Short Alpha-Helix Stabilized by a Main Chain Hydrogen Bond Surrogate”. J. Am. Chem. Soc. 2008, 130, 4334-4337.

Wang, D.; Lu, M.; Arora, P.S. “Inhibition of HIV-1 Fusion by Hydrogen-Bond Surrogate Based Alpha-Helices.” Angew. Chem. Int. Ed. 2008, 47, 1879-1882.

Fellowships/Honors
American Cancer Society Postdoctoral Fellowship (1999-2002), James D. Watson Investigator Award (2002), Cottrell Scholar Award (2005), Whitehead Fellowship in Biomedical and Biological Sciences (2005-2006), Golden Dozen Teaching Award (2007)

 

NYU, USC study finds potential cancer treatment

A collaborative research project between NYU and the University of Southern California may have made a breakthrough in cancer treatment. According to a university press release, the research groups led by NYU chemistry professor Paramjit Arora and USC School of Pharmacy professor Bogdan Olenyuk have developed a new synthetic molecule that blocks the expression of genes that lead to tumor progression.

Their research showed that the synthetic molecule, called a protein domain mimetic, successfully blocked cell signaling and quic- kly stemmed cancer growth. The molecule exhibits high potential for the development of human cancer treatments, after showing low toxicity to the host body and general compatibility for the host.

Arora said the approach of this project differs from the approaches of other research in drug discovery.

“Typical drugs target enzymes but fail against protein-protein interactions, which are generally considered to be ‘undruggable,’” Arora said. “The significance of this work is that our designed compounds inhibit these recalcitrant interactions.”

The next step in the research process is to improve the synthetic molecule’s compatibility to human subjects.

 

Arora and Olenyuk first met when they studied together at the California Institute of Technology. Olenyuk is an expert in the biology and pharmacology of signaling pathways.

Since it began in 2007, this cancer research project has included three NYU graduate students and four USC students.

Brooke Lao, co-lead author on the paper and a doctoral candidate at NYU, is enthusiastic about the results of the project so far.

“It is exciting and validating to see the compounds you synthesized make it all the way to an animal study,” Lao said.

Currently, more extensive animal studies are needed before a timeframe can be determined for clinical trials. However, Lao states that the ultimate goal of the project would be for the compounds to become readily available drugs for patients who need them.

For some students studying medicine at NYU, research of this caliber is a goalpost to work toward in their time at NYU. Pre-med CAS sophomore Rijul Asri stated that this research indicates NYU’s instrumental role in research in general.

“One of the main reasons I decided to major in chemistry here at NYU was the incredible research going on with regards to biology and medicine,” Asri said. “The work of professors Arora and Olenyuk is truly inspirational and proves the importance of chemical research in contemporary medicine. I am really excited to learn more about the mechanism they devised and to see how it will be applied to ongoing cancer research.”

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.

Ettore Milano

Medicinal plant purchasing manager, intermediates and outsourcing

links

• https://it.linkedin.com/in/ettore-milano-90a47a22/en

 https://www.facebook.com/ettore.milano.96

• Works at Milan, Italy

  Past: INDENA SPA
• 

  Studied at University of Pavia

  Past: Liceo Scientifico Galilei
• 

  Lives in Salice Terme, Liguria, Italy

  From Voghera
• 

  Married to Elisa Volpi

Experience

Medicinal plant purchasing manager, intermediates and outsourcing

Indena

March 2016 – Present (4 months)Milan Area, Italy

Area Manager JP + Strategic Outsourcing Manager

Indena

May 2014 – Present (2 years 2 months)

Sales Area Manager Germany, East Europe+ Japan

INDENA S.p.A.

June 2012 – Present (4 years 1 month)

Sales Area Manager Asia Pacific

Indena

October 2008 – May 2012 (3 years 8 months)

Countries: Indonesia, Japan, South Korea, Australia and Taiwan

Research Scientist

Indena

December 1998 – November 2008 (10 years)

Main job activity was to support the production scale up activity of the processes studied in the lab, to study new phytochemical process to extract active ingredients from new plant material, to synthesize impurities generated in some of our processes to meet regulatory requirements for our pharmaceutical products

Education

Università degli Studi di Pavia

Laurea-PhD, Chimica Farmaceutica

1989 – 1998

Università di Pavia

 
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Masumeh Noruzi

• Biography(Active Tab)
• Research Interests
• Publications
• Scientific Activities

Masumeh Noruzi 

Researcher


Address:Iran

I am Masumeh Noruzi, a nanotechnology researcher of Iran. I am graduated in MS of Analytical Chemistry form Shahid Beheshti University of Tehran in 2005. I have been working in nanotechnology department of Agricultural Biotechnology Research Institute of Iran since 2007. I work on green synthesis and biosynthesis of metallic nanoparticles and have several papers in this field. My research interests are as follows:
 1.Green synthesis and biosynthesis of metallic nanoparticles, and their applications.
 2.Production of biopolymer nanofibers using electrospinning.
 3.Characterization methods of nanoparticles.
 4.Production of nanofertilizers and nanopesticides.

Dr. Jyotirmayee Dash

Dr. Jyotirmayee Dash
 Associate Professor

    Research Interests:

•   Catalysts and catalytic reactions
•   Supramolecular chemistry of nucleobases
•   Recognition of nucleic acid sequences

http://www.iacs.res.in/ochem/ocjd/

Contact:                                                                           Dash Group Homepage Department of Organic Chemistry Indian Association for the Cultivation of Science Phone:+91 33 2473 4971 (Ext 1405) Fax: +91 33 2473 2805 E-mail : ocjd [ AT ] iacs.res.in Short Bio-data: Jyotirmayee Dash received her MSc from Ravenshaw University and PhD in organic chemistry from the Indian Institute of Technology (IIT) Kanpur. Subsequently she was awarded Alexander von Humboldt fellowship (2004-2006) and worked at the Freie University Berlin. Then she worked as a postdoctoral fellow at the ESPCI Paris for one year. Following which she was awarded Marie Curie International incoming fellowship and joined the University of Cambridge, UK (2007-2009). She joined as an Assistant Professor at the Indian Institute of Science Education and Research-Kolkata in 2009 and then moved to the Indian Association for the Cultivation of Science-Kolkata in 2012. Positions: Candidates having MSc degree either in chemistry or biochemistry, closely related areas with inspire/CSIR fellowships can directly apply to Dr Dash (ocjd[AT]iacs.res.in) for PhD positions.

Mrs. A.Meenakshi

Mrs. A.Meenakshi
Assistant Professor in
Chemical Engineering

Education Qualification :	M.Tech(IITM)
Present position :	Assistant Professor in Chemical engineering
Areas of Interest :	Chemical Reaction Engineering, Thermodynamics, Environmental Engineering, Unit operations, Characterization of Nano Material
Teaching Experience :	4 years
No. of Publications :	International Journals: 03
Conferences/ Seminars :	International-01 & National-10
Membership :	LMIIChE
Email :	meenaalg7@gmail.com

Dr. A. Jayashree

Dr. A. Jayashree 
Professor of Chemistry

Education Qualification :	M.Sc, Ph.D.
Present position :	Head of the Department, CCST, IST, JNTUH and Professor of Chemistry
Areas of Interest :	Synthetic Organic Chemistry, Natural Products, Molecular Modeling, Drug Design, Green Chemistry, Chemical Biology
Teaching Experience :	22 years
Research Experience :	25 years
No.of Projects :	one project sanctioned by DST completed
No. of Publications :	90
Conferences/ Seminars :	40
Number of Research Students Guided:	9 CSIR/UGC/JNTUH JRF Holders(on going)
Refresher Courses Conducted:	3
Countries Visited:	USA, China, Dubai, Srilanka
Email :	jayashree_avc@yahoo.co.in jayashreeanireddy@gmail.com