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M.
Sreenivasa Reddy obtained Ph.D from University of Hyderabad under the
direction Prof Professor Goverdhan Mehta in 1992. From 1992-1994, he was
a post doctoral fellow at University of Wisconsin in Professor Jame
Cook's lab. From 1994 to 2000, worked at Chemical process R&D at
Procter & Gamble Pharmaceuticle (P&G). From 2001 to 2007 worked
at Global Chemical Process R&D at Eli Lilly and Company in
Indianapolis.
In 2007 resigned to his job and found Sreeni Labs based
in Hyderabad and working with various global customers and solving
various challenging synthesis problems. The main strength of Sreeni Labs is in the design, development of a
novel chemical route and its development into a robust process followed
by
production of quality product from 100 grams to 100s of kg scale.
They have helped number of customers by successfully developing highly
economical simple chemistry routes to number of products that were made
by Suzuki coupling. they are able to shorten the route by drastically
reducing number of steps, avoiding use of palladium
& expensive ligands. they always use readily available or easy to
prepare starting materials in their design of synthetic routes.
Sreeni Labs is Looking for any potential opportunities where people need
development of cost effective scalable routes followed by quick scale
up to produce quality products in the pharmaceutical & specialty
chemicals area. They have flexible business model
that will be in sink with customers. One can test their abilities &
capabilities by giving PO based projects
Abstract: The present
invention provides a process for making 2-amino-2-imidazoline,
guanidine, and 2-amino-3,4,5,6-tetrahydroyrimidine derivatives by
preparing the corresponding activated 2-thio-subsituted-2-derivative in a
two-step, one-pot procedure and by further reacting yields this
isolated derivative with the appropriate amine or its salts in the
presence of a proton source. The present process allows for the
preparation of 2-amino-2-imidazolines, quanidines, and
2-amino-3,4,5,6-tetrahydropyrimidines under reaction conditions that
eliminate the need for lengthy, costly, or multiple low yielding steps,
and highly toxic reactants. This process allows for improved yields and
product purity and provides additional synthetic flexibility.
Type:
Grant
Filed:
November 25, 1997
Date of Patent:
May 23, 2000
Assignee:
The Procter & Gamble Company
Inventors:
Michael Selden Godlewski, Sean Rees
Klopfenstein, Sreenivasa Reddy Mundla, William Lee Seibel, Randy Stuart
Muth
Sreenivasa Reddy Mundla
The present invention provides
2-(6-methyl-pyridin-2-yl)-3-[6-amido-quinolin-4-yl)
-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole monohydrate, i.e., Formula I.
EXAMPLE 1
Preparation of 2-(6-methyl-pyridin-2-yl)-3-[6-amido-quinolin-4-yl-5,6-dihydro-4H -pyrrolo[1,2-b]pyrazole monohydrate
.
