One Organic Chemist One Day............Honouring Profiles of leading Organic Chemists brought to you by DR ANTHONY MELVIN CRASTO, worlddrugtracker, helping millions, amcrasto@gmail.com, +91 9323115463, India, skype amcrasto64
DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai) , INDIA 29Yrs Exp. in the feld of Organic Chemistry,Working for GLENMARK PHARMA at Navi Mumbai, INDIA. Serving chemists around the world. Helping them with websites on Chemistry.Million hits on google, world acclamation from industry, academia, drug authorities for websites, blogs and educational contribution
Trained in laws related to protection of intellectual property (IP), management of IPR, ascertaining patentability of an invention, searches of databases related to patents and allied databases and other aspects of IPR
Patent Search and Preparation of Patent Landscape Report
- Patent Infringement analysis
- Claim drafting and Patent filing Activity
- New Product selection and IP opportunity analysis
- Generic Entry determination
- Patent Opposition / Invalidation
- Knowledge Sharing & IP Group Discussions
Structure Based Drug Design :Platforms _ Experienced user of the ChemAxon toolkit, familiar withKNIME. Comfortable on various OS platforms .Experience in software development in bio and chemoinformatics on CDK, a Java toolkit for cheminformatics,descriptors, pharmacophores.
Publishings.
Dr. Sunil H. Ganatra, and Ms. Shilpa A. Gurjar*Structure-based design of 2-Bezylidine-Benzofuran-3-one class of compounds as an inhibitor to Cyclin Dependent Kinases.
Dr. Sunil H. Ganatra, and Ms. Shilpa A. Gurjar*Structure-based design of potent Pyrimidine-based Cyclin-dependent kinase inhibitor.
Dr. Sunil H. Ganatra, and Ms. Shilpa A. Gurjar*Structure based docking of derivatives of 2-Bezylidine-benzofuran-3-one as novel and Potent cyclin dependent kinase inhibitors. (* Abstact published in ACS –CSIR OCCB 2006 International Conference)
Poster submission at National conference on drug designing and synthesis at Dr.Ambedkar College Nagpur.
Participated in Conference titled BioTalk conducted by Biotechnology department Hislop College Nagpur in January 2005.
Specialties: Cheminformatics analysis and data mining of small molecule HTS applications, in a variety of
biological systems.Computer simulation techniques study and perform molecular modeling and protein docking with software’s like Amber and QSAR TECHNIQUES
Predictive Toxicology.
January 2015 – Present (10 months)Pune Area, India
Toxicological tool study and design of tool for end point using chemistry software interfaces.
Performing prior art searches by using commercial and non-commercial databases
searches related to patentability of inventions, freedom to operate, sell or recommend products or processes, validity of competitor's patents or patent applications, legal status, and general state-of-the-art,generating various reports such as Literature Evaluation Report for the products of interest,providing the Infringement opinion on proposed schemes related with the Active Pharmaceutical Ingredients and chemicals assisting in patent drafting, filing, prosecution, maintenance and management of the patent portfolio for the in-house projects,supporting R&D for selecting non-infringing route Orange book data search for various products and patent documentation.
Structured based molecule design is utilized to identify potent inhibitors of a Kinase family that collectively functions as key regulators of cell cycle. Our approach uses virtual molecular screening methods to identify and refine chemical entities that act as inhibitors and increase the success rate of discovering potent and selective molecules that can be future drugs to incurable diseases like...more
Phenol based natural products are widely used as an anti-cancer drugs. Generally the targets of these drugs are either DNA or Cyclin dependent kinase enzymes (CDKs). The present study is to understand the molecular level interactions of selected phenol based natural products with cell regulator CDKenzyme using in-silico techniques.
Honors & Awards
International Training Program on Leadership and Career development for Women Scientists and Technologists
DST,IUSSTF and COAch
September 2015
International Training Program on Leadership and Career development for Women Scientists and Technologists
Additional Honors & Awards
conferred P.hd in chemistry from Nagpur University for the title"Critical studies of Anti-cancer drug design using Computer Simulation Techniques".
Passed State Eligibility test [SET] conducted by University Grants Commission India for eligibility of Lectureship in Universities.
The award comprises a citation, a plaque, a cash prize of Rs 5 lakh
The Shanti Swarup Bhatnagar Prize for the year 2015 in chemical sciences has been awarded to Dr. D. Srinivasa Reddy of CSIR-National Chemical Laboratory (CSIR-NCL), Pune for his outstanding contributions to the area of total synthesis of natural products and medicinal chemistry.
This is a most prestigious award given to the scientists under 45 years of age and who have demonstrated exceptional potential in Science and Technology. The award derives its value from its rich legacy of those who won this award before and added enormous value to Indian Science.
Dr. Reddy will be bestowed with the award at a formal function, which shall be presided over by the honourable Prime Minister. The award, named after the founder director general of Council of Scientific & Industrial Research (CSIR), Dr. Shanti Swarup Bhatnagar, comprises a citation, a plaque, a cash prize of Rs 5 lakh.
Dr. Reddy's research group current interests are in the field of total synthesis and drug discovery by applying medicinal chemistry. He has also been involved in the synthesis of the agrochemicals like small molecules for crop protection. The total synthesis of more than twenty natural products has been achieved in his lab including a sex pheromone that attracts the mealy bugs and has potential use in the crop protection. On the medicinal chemistry front significant progress has been made by his group using a new concept called "Silicon-switch approach" towards central nervous system drugs. Identification of New Chemical Entities for the potential treatment of diabetes and infectious diseases is being done in collaboration with industry partners.
His efforts are evidenced by 65 publications and 30 patents. He has recently received the NASI-Reliance industries platinum jubilee award-2015 for application oriented innovations and the CRSI bronze medal. In addition, he is also the recipient of Central Drug Research Institute award for excellence in the drug research in chemical sciences and scientist of the year award by the NCL Research Foundation in the year 2013. Dr. Reddy had worked with pharmaceutical companies for seven years before joining CSIR-NCL in 2010.
AN INTRODUCTION
Ph.D., University of Hyderabad, 2000 (Advisor: Professor Goverdhan Mehta).
Post-doctoral with Profs. Sergey A. Kozmin(University of Chicago, USA) and Prof.
Our group research interests are broadly in total synthesis of biologically active compounds and medicinal chemistry. Current projects include the total synthesis of bioactive natural products such as antiinflammatory agents, antibacterial agents, antimalarial compounds and anti-cancer agents. Targets are chosen for their interesting biological activity and moderate complexity, which drives our creative solutions to their synthesis. Our ability to achieve an efficient synthesis enables us to access sufficient quantities of target molecule for biological profiling and ready access to different analogs that may prove to be more selective and efficacious as a drug-like molecule. We have plans to divert our total synthesis projects into medicinal chemistry projects by simplifying the complex structures. In medicinal chemistry front, our main interest is to use "silicon-switch approach" to discover novel drugs or drug-like molecules with improved pharmacokintetic (PK) and pharmacodynamic (PD) properties.
DEC2014 NCL PUNE INDIA
DR ANTHONY WITH DR REDDY
Some pictures of his group
NCL, PUNE
D. Srinivasa Reddy of CSIR-National Chemical Laboratory Pune devised (J. Org. Chem.2013, 78, 8149. DOI: 10.1021/jo401033j) a cascade protocol of Diels-Alder cycloaddition of 8 to the diene 7 followed by intramolecular aldol condensation, to give the enone 9.
Oxidative manipulation followed by methylenation completed the
synthesis of the commercially important grapefruit flavor Nootkatone (10).
A simple and efficient synthesis of functionalized cis-hydrindanes and cis-decalins
was achieved using a sequential Diels–Alder/aldol approach in a highly
diastereoselective manner. The scope of this method was tested with a
variety of substrates and was successfully applied to the synthesis of
two natural products in racemic form. The highlights of the present work
provide ready access to 13 new cis-hydrindanes/cis-decalins,
a protecting group-free total synthesis of an insect repellent
Nootkatone, and the first synthesis of a Noreremophilane using the
shortest sequence.
A simple and efficient synthesis of functionalized cis-hydrindanes and cis-decalins
was achieved using a sequential Diels–Alder/aldol approach in a highly
diastereoselective manner. The scope of this method was tested with a
variety of substrates and was successfully applied to the synthesis of
two natural products in racemic form. The highlights of the present work
provide ready access to 13 new cis-hydrindanes/cis-decalins,
a protecting group-free total synthesis of an insect repellent
Nootkatone, and the first synthesis of a Noreremophilane using the
shortest sequence.
Dr. D. Srinivasa Reddy Senior Scientist Office: R.No-282, Main building Organic Chemistry Division National Chemical Laboratory Dr. Homi Bhabha Road Pune 411008, India Phone +91 20 2590 2445 Fax +91 20 2590 2624
New route for Expensive drug Ivacaftor synthesis from CSIR-NCL, Pune, India
IVACAFTOR
Breaking and Making of
Rings: A Method for the Preparation of 4-Quinolone-3-carboxylic Acid
Amides and the Expensive Drug Ivacaftor N. Vasudevan†, Gorakhnath R. Jachak† and D. Srinivasa Reddy*
A simple and convenient method to access 4-quinolone-3-carboxylic
acid amides from indole-3-acetic acid amides through one-pot oxidative
cleavage of the indole ring followed by condensation (Witkop–Winterfeldt
type oxidation) was explored. The scope of the method was confirmed
with more than 20 examples and was successfully applied to the synthesis
of the drug Ivacaftor, the most expensive drug on the market.
REFERENCES
N. Vasudevan, Gorakhnath R. Jachak And D. Srinivasa Reddy,
Breaking and Making of Rings: A Method for the Preparation of
4-Quinolone-3-carboxylic Acid Amides and the Expensive Drug Ivacaftor,
Eur. J. Org. Chem., , 0000 (2015), DOI:10.1002/ejoc.201501048. http://academic.ncl.res.in/publications/index/select-faculty/2015/ocd
6 days ago – European Journal of Organic Chemistry … 20 examples and was successfully applied to the synthesis of the drug Ivacaftor, the most expensive …
onlinelibrary.wiley.com › … › European Journal of Organic Chemistry
European Journal of Organic Chemistry ….. examples and is successfully applied to the synthesis of the drug Ivacaftor, the most expensive drug on the market.
onlinelibrary.wiley.com › … › Early View › Abstract
6 days ago – … for the Preparation of 4-Quinolone-3-carboxylic Acid Amides and the Expensive Drug Ivacaftor … European Journal of Organic Chemistry.
Update dec2015
DR SRINIVASA REDDY gets NASI – Reliance
Industries Platinum Jubilee Award (2015) for Application Oriented
Innovations in Physical Sciences.
DR
SRINIVASA REDDY recieving NASI - Reliance Industries Platinum Jubilee
Award (2015) for Application Oriented Innovations in Physical Sciences. Dr. D. Srinivasa Reddy, Senior Scientist, Division of Organic Chemistry, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune – 411 008
PUNE:
Senior scientist of National Chemical Laboratory (NCL), D Srinivasa
Reddy has been selected for this year's NASI-Reliance Industries
Platinum Jubilee award for the application oriented innovations in the
area of physical sciences instituted by the National Academy of
Sciences, India (NASI). Two awards each in physical sciences and two in
biological sciences are given every year, a statement issued by NCL
said.
Manindra Agrawal from Department of Computer Science and
Engineering, Indian Institute of Kanpur is the other recipient of this
award in physical sciences. Each award carries a plaque and Rs 2 lakh
cash.
The award will be presented in the 85th annual session of
National Academy of Sciences, India. Reddy's research group interests
are in the field of total synthesis and drug discovery by applying
medicinal chemistry. He has also been involved in the synthesis of the
agrochemicals like small molecules for crop protection, said the
statement. The total synthesis of more than 20 natural products has been
achieved in his lab including a sex pheromone that attracts the mealy
bugs and has potential use in the crop protection.
On the
medicinal chemistry front significant progress has been made by his
group using a new concept called silicon-switch approach towards central
nervous system drugs. Identification of new chemical entities for the
potential treatment of diabetes and infectious diseases is being done in
collaboration with industry partners.
Some details
The
National Academy of Sciences, India (NASI) 5, Lajpatrai Road, Allahabad
– 211002 NASI-RELIANCE INDUSTRIES PLATINUM JUBILEE AWARDS FOR THE YEAR
2015 FOR APPLICATION ORIENTED INNOVATIONS COVERING BOTH PHYSICAL AND
BIOLOGICAL SCIENCES NASI invites nominations for the NASI-Reliance
Industries Platinum Jubilee Awards for APPLICATION ORIENTED INNOVATIONS
for the year 2015. The nominee should be an Indian citizen / Overseas
Citizen of India working in India and below the age of 50 years as on
April 15, 2015. Areas for the Awards – Physical Sciences, including –
Chemistry, Engineering, Mathematics, Physics, Electronics,
Nanotechnology, Information & Computer Sciences, Earth and
Atmospheric Sciences; Biological Sciences, including – Agriculture,
Animal and Plant Sciences, Environment, Biotechnology, Biochemistry,
Bioprocess Engineering, Bioinformatics, all branches of medical sciences
and Nanotechnology. Number and Value of Awards – two in Physical
Sciences and two in Biological Sciences each year. Each award carries a
Plaque and Rs. 2 lakhs in cash. Nominators and Last Date – All Science
Secretaries, Secretary HRD, Director Generals – CSIR, ICMR & ICAR;
Directors of IITs, IIITs, National Laboratories, Industries with well
recognized R&D units including private research institutions;
Vice-Chancellors of all Universities – Central & State; Directors of
Indian Institute of Science, Bangalore, AIIMS, New Delhi, PGI’s of
Medical Research, Chairman, UGC; Presidents of all Science and
Engineering Academies (Engineering, Medical, Agriculture); All Fellows
of the NASI. The nomination shall be made in the prescribed format.
Twenty (20) copies of the nomination form along with only one soft copy
(in CD), complete in all respect with the supporting documents, must
reach the Academy latest by April 15, 2015. A candidate may only be
nominated once. However, a nomination will remain valid for
consideration for 3 years or the age eligibility which ever expires
earlier. Selection of the Awardees – As per Regulations of NASI
Presentation of the Awards – The presentation of the Awards will be made
at the time of 85 th Annual Session of NASI. Details and Nomination
form for the award are also available on NASI’s website
http://www.nasi.org.in and http://www.nasi.nic.in ................http://www.nasi.org.in/NASI-Reliance%20Industries%20Platinum%20Jubilee%20Awards%202015.pdf
SEE http://www.nasi.org.in/NASI-Reliance%20Industries%20Platinum%20Jubilee%20Awardees%20(2015).htm PUNE:
Senior scientist at National Chemical Laboratory (NCL) D Srinivasa
Reddy has bagged yet another award, the NASI-Reliance Industries
Platinum Jubilee award for the year 2015.
This is the second award
Reddy has won in a span of less than a fortnight. Earlier, he was
selected for the bronze medal presented by the Chemical Research Society
of India (CRSI). He has also been a recipient of excellence award from
the National Drug Research Institute.
The platinum jubilee award is being conferred for his work in application-oriented innovations in physical sciences category.
Every year, this award recognises two scientists, each working in the fields of physical and biological sciences.
The other scientist who has been awarded in this category is Manindra Agarwal from IIT, Kanpur.
Reddy
along with his team has been involved in several high-end research in
drug discovery, mainly by applying medicinal chemistry. Other major
works he undertook also involve synthesising of agrochemicals meant to
be used for crop protection.
He also has vast experience working with various pharmaceutical companies prior to joining NCL in 2010.
The award consists of cash of Rs 2 lakh.
NASI
National
Academy of Sciences, India (www.nasi.org.in) was founded in 1930 with
the objective to provide a national forum for the scientists to help
them publish their research work and discuss the issues for the
solutions. NASI-Reliance together give two awards each in the areas of
physical and biological sciences for the application oriented
innovations started from the year 2006. Areas for the Awards – Physical
Sciences, including Chemistry, Engineering, Mathematics, Physics,
Electronics, Nanotechnology, Information & Computer Sciences, Earth
and Atmospheric Sciences; Biological Sciences, including Agriculture,
Animal and Plant Sciences, Environment, Biotechnology, Biochemistry,
Bioprocess Engineering, Bioinformatics, all branches of medical sciences
and Nanotechnology.
Exciting lecture by Dr Srinivasa Reddy of NCL pune India, on his
achievements in Drug discovery at Glenmark research centre, mahape, Navi
mumbai, India, 1 Feb 2016, He is Prestigious recipient of Shanti
swaroop Bhatnagar award 2015
