Randa Latif

Associate professor

 

Cairo University, Cairo · Department of Pharmaceutics

• 
  Cairo University

  Department of Pharmaceutics

  Cairo, Giza, Egypt
  
  

https://www.researchgate.net/profile/Randa_Latif
https://eg.linkedin.com/in/randa-latif-788b6118

https://www.facebook.com/randa.latif.9

 

 

 

RESEARCH EXPERIENCE

 

• Jun 1987–Jan 2014
   

  associate professor

  Cairo University · Faculty of Pharmacy
  Egypt · Cairo

OTHER

• Languages
   
  English, French

2013

R., L., A. H. S.A, and A. K. O.M, "FUROSEMIDE LOADED SUPERPOROUS HYDROGEL COMPOSITE AS A CONTROLLED RELEASE DEVICE: DIFFERENT STRATEGIES FOR DRUG LOADING",Journal of Pharmaceutical Research and Opinion, vol. 3, issue 6, pp. 28 - 35., 2013. AbstractGastroretentive.pdf

Latif, R., C. M. Zaki, and I. I. Soliman, "Microencapsulation of hydroxyzine HCl by thermal phase separation: in vitro release enhancement and in vivo pharmacodynamic evaluation",Pharmaceutical Development and Technolgy, vol. 12, issue 3, pp. 989-1002, 2013. AbstractThermal encapsulation.pdf

, "Optimization for glimepiride dissolution enhancement utilizing different carriers and techniques", Journal of Pharmaceutical Investigation, vol. 43, issue 2, pp. 115-131, 2013. AbstractSD.pdf

Latif, R., "Zero-order release profile of metoclopramide hydrochloride sublingual tablet formulation", Pharmaceutical Development and Technology, vol. 18, issue 6, pp. 1372–1378, 2013.Abstractfinal_sublingual_paper.pdf

2011

, "In Vitro and In Vivo Evaluation of Hydroxyzine Hydrochloride Microsponges for Topical Delivery", AAPS PharmSciTech, 2011.microsponges.pdf

Latif, R., H. Refai, and S. Tawakkol, "Photostabilization of sunscreen oil through preparation of a free-flowing powder", Journal of Microencapsulation, vol. 28, issue 3, pp. 159–165, 2011.Abstractsun_screen_paper_final.pdf

 

 

 

 

 

 

 

 

 

 

Cairo University

Department of Pharmaceutics

Cairo, Giza, Egypt

 

 

Cairo, Giza, Egypt

 

 

 

 

//////Cairo, Giza, Egypt, Randa Latif

Tamer S Saleh

Associate Prof.

Professor (Associate)

King Abdulaziz University, Jeddah · Department of Chemistry

 https://www.researchgate.net/profile/Tamer_Saleh2

 https://sa.linkedin.com/pub/tamer-saleh/62/564/4b3

 http://loop.frontiersin.org/people/252186/overview

 http://loop.frontiersin.org/people/252186/publications

• 
  King Abdulaziz University

  Department of Chemistry

  Jeddah, Makkah Province, Saudi Arabia

 

Associate Professor

(Associate Professor)

National Research Centre

Egypt

Doctorate

Giza, Egypt

 Giza, Egypt

 

 

 

 

 





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DR SOBHI M GOMHA

Abstract: The title compound, ethyl 3-{2-[(3-methyl-1H-indol-2-yl)carbonyl]hydrazinylidene} butanoate (3), was prepared via reaction of 3-methyl-1H-indole-2-carbohydrazide (1) and ethyl 3-oxo­butanoate (2) under reflux. The structure of the synthesized compound was assigned on the basis of elemental analysis, IR, 1H-NMR, mass spectral and X-ray data.




http://www.mdpi.com/1422-8599/2012/1/M749

Molbank 2012, 2012(1), M749; doi:10.3390/M749

Short Note

Ethyl 3-{2-[(3-Methyl-1H-indol-2-yl)carbonyl]­hydrazinylidene}­butanoate

Thoraya A. Farghaly and Sobhi M. Gomha * 

 E-Mail: s.m.gomha@hotmail.com.

Department of Chemistry, Faculty of Science, University of Cairo, Giza 12613, Egypt

* Author to whom correspondence should be addressed.

DR SOBHI M GOMHA - UNIVERSITY OF CAIRO

http://cu.edu.eg/ar/Home

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Synthesis of Ethyl 3-{2-[(3-Methyl-1H-indol-2-yl)carbonyl]hydrazinylidene}butanoate (3)

A mixture of the hydrazide 1 (1.89 g, 10 mmol) and ethyl 3-oxobutanoate 2 (10 mmol) in absolute

ethanol (20 mL) was heated at reflux temperature for 2 h. The reaction mixture was then cooled and

the formed precipitate was filtered off, washed with ethanol to afford the title compound 3. Yield:

84%; yellow microcrystals (from ethanol); mp: 238–240 °C.

 IR (KBr): v 1706, 1668 (2 C=O), 3409,3234 (2 NH) cm−1

1H NMR (DMSO-d6): δ 1.24 (t, J = 7.0 Hz, 3H, CH3), 2.03 (s, 3H, CH3), 2.53 (s,

3H, CH3), 3.43 (s, 2H, CH2), 4.23 (q, J = 7.0 Hz, 2H, CH2), 6.87–7.98 (m, 4H, ArH ), 10.38 (s, 1H,

D2O exchangeable, NH), 11.21 (s, 1H, D2O exchangeable, NH). 

MS m/z (%): 301 (M+, 42), 189 (100),155 (318), 117 (46), 77 (21).

Anal. Calcd for C16H19N3O3 (301.34): C, 63.77; H, 6.36; N, 13.94. Found C, 63.39; H, 6.46; N, 13.65.

References and Notes

1. Ismail, M.F.; Shmeiss, N.A.M.M.; El-Diwani, H.I.; Arbid, M.S. Synthesis and pharmacological

activity of some 2,3-diphenylindole derivative. Indian J. Chem. Sect. B 1997, 36B, 288–292.

2. von Angerer, E.; Knebel, N.; Kager, M.; Ganss, B.J. 1-(Aminoalkyl)-2-phenylindoles as novel

pure Estrogen Antagonists. J. Med. Chem. 1900, 33, 2635–2640. 

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