One Organic Chemist One Day............Honouring Profiles of leading Organic Chemists brought to you by DR ANTHONY MELVIN CRASTO, worlddrugtracker, helping millions, amcrasto@gmail.com, +91 9323115463, India, skype amcrasto64
DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai) , INDIA 29Yrs Exp. in the feld of Organic Chemistry,Working for GLENMARK PHARMA at Navi Mumbai, INDIA. Serving chemists around the world. Helping them with websites on Chemistry.Million hits on google, world acclamation from industry, academia, drug authorities for websites, blogs and educational contribution
With Dr Vilas Dahanukar, Chief scientist, process R &D, Dr Reddys Laboratories, At Chiral India 2016, New horizons in Drug development, Harnessing the power of Chirality .Organised by chemical weekly at Holiday inn international, Mumbai, India, Nov 8 2016
To oversee a team of 130 process chemists and 60 analytical chemists at two different sites; Technical evaluation and formulation of research and business proposals; Participate in customer interactions and presentations; Budget forecasting; Setting specifications for intermediates and final API (salt selection, impurities and polymorphs) and Cost analysis; Project collaborations across various international sites; Promote use of newer technologies and implement them in various projects; Propose new platform technologies and identify suitable projects of commercial importance
Organizational Initiatives Towards Developing Greener Processes for Generic Active Pharmaceutical Ingredients
- Dr. Vilas H. Dahanukar, Chief Scientist-Process R&D, Integerated Product Development Organization, Dr. Reddy's Laboratories Ltd., India
presented at
4th Industrial Green Chemistry World Convention & Ecosystem (IGCW-2015) on 4th - 5th December 2015
Chemical Engineer, ASQ Certified Quality Engineer and ASQ Certified Pharmaceutical GMP Professional.
Significant experience in Pharmaceutical manufacturing sites - Drug Substance Scale-up and Technology Transfer, Manufacturing, Quality Management Systems, Lifecycle Implementation of Quality. Designing Quality into Product Development of Complex Generic Drug Substances & Drug Products currently.
Experience in Continuous Coated Paper and Semi-batch Dye & Pigment Manufacturing.
ASQ Country Counsellor - Switzerland
Key Skills: QbD implementation, Chemical Engineering, cGMP, QMS, Robust Process & Product Design, CMC, Six Sigma, Design of Experiments, Statistical Process Control, Continuous Process Verification, Risk Management, Technical Training.
Improving the Quality of life for customers and in turn businesses, one day at a time.
She has recently started writing in a wonderful Pharmaceutical Magazine called the Medicine Maker. Also I would suggest you to subscribe to and also read the magazine (it is free), it is a very informative, very well articulated magazine.
Developing diverse complex generic products- right first time. Use of Six Sigma and other Quality Management principles to optimize product development. Ensure life cycle assurance of product quality.
February 2014 – Present (1 year 11 months)Hyderabad Area, India
Lead
the Quality by Design facilitation team for Oral Solid Dosage
Development team including Pharmaceutical, Analytical, Packaging, Bio
scientists.
• Create best practices of QbD/ DFSS based development
and champion the use of QbD tools like Design of Experiments (DoE),
Monte Carlo Simulations (MCS), Artificial Neural networks (ANN),
Multivariate Analysis (MVA) and other statistical tools, systematic Risk
Assessment tools including FMECA.
• Develop a QbD based Process Validation strategy for Drug Formulations.
• A part of the organization- wide QbD initiative to facilitate QbD
across the product lifecycle in Drug Substance and Drug Product
Development & Manufacturing.
July 2007 – January 2014 (6 years 7 months)Gurgaon
Process Engineering, Scale-Up, Cost Reduction, Process Intensification:
Responsible for managing the scale-up of chemical processes for generic
Active Pharmaceutical Ingredients from the R&D's Laboratory scale
to the Manufacturing Plant scale through Kilogram Laboratories and Pilot
Plants to deliver robust and safe chemical processes for scale-up,
technology transfer and commercial manufacturing.
Quality by Design Implementation:
Bridging the gap leading to a QbD way of working for Ranbaxy. Well
versed in Chemometrics including Statistical Quality Control tools and
Design of Experiments (DoE) and Multivariate Analysis (MVA) with
hands-on PAT experience with tools like FBRM, PVM, IR etc.Risk
Management Principles and tools like FMECA, HAZOP,etc. for Process and
Safety Risk Assessment. Designing the New Process Validation Guideline
including Lifecycle Implementation of Quality.
Internal Trainer in QbD, PAT and SPC. Participated in QbD seminars and conferences as a Speaker.
Implementation of Statistical Process Control:
Spearhead the Design and Implementation process of Statistical Process Control for various sites across Ranbaxy.
July 2006 – July 2007 (1 year 1 month)Bhigwan, Maharashtra
Employed
in Ballarpur Industries Limited (BILT)Unit Bhigwan, Maharashtra: a
state of the art Coated Paper Manufacturing Plant in two profiles:
PRODUCTION: Managed the Off-Machine Coater and responsible for
production, maintenance and quality. I managed up to twenty people in my
shift directly apart from organizing and coordinating with allied
departments. The 1500m/min speed Jagenberg coater capable of
manufacturing Art and Chromo papers ranging from 70 to 350 gsm offered
me the experience of working with Industrial Control Systems like SCADA,
DCS and PLCs. Also involved in Process Intensification, TPM, TQM, 5S
and 6 sigma projects.
• PROJECT ENGINEERING:
A part of the
Project Team for a brown field project including an online coating
machine from Voith Paper, Germany. The $200 million project taught me
immensely about Project Engineering and Management. Working on the
project with international organizations like Voith, Metso, Jagenberg
etc. gave me global exposure to the Paper Industry.
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