Central Drug Research Institute, Lucknow
Ph.D, Medicinal Organic Chemistry
2003 – 2008
Research work focused on design and synthesis of novel scaffolds which act as nuclear receptor modulator and used for the prevention and treatment of various high profile human diseases such as breast cancer, endometrial cancer, osteoporosis, diabetes and in fertility regulation etc. Among the nuclear hormone receptors super gene family we are most interested in estrogen receptor (ER) and also in peroxisome-proliferators-activated receptor for anti-diabetic activity. As estrogen action is also associated with many health problems in women. In order to use estrogen receptor modulator in its full length, we have designed some selective estrogen receptor modulator (SERMs). The aim of the present dissertation is synthesis and identification of some novel scaffolds with selective agonistic as well as antagonistic activity in desired tissue profiles and further the biological evaluation of these scaffolds in vitro cell line model and in vivo animal models for predictive clinical utility.
M.S., Organic Chemistry (2003, 77.3%)
Lucknow University, Lucknow (U. P.), India
B.S., Chemistry, Zollogy and Botany (2000,74.4%)
Lucknow University, Lucknow, (U. P.), India
Publications
· “Amino acid catalyzed thio-Michael addition reactions” Atul Kumar, Akanksha. Tetrahedron, 2007,
63, 11086-11092.
· “Zirconium chloride catalyzed efficient synthesis of 1, 3-diaryl-2-propenones in solvent free conditions
via aldol condensation” Atul Kumar, Akanksha. Journal of Molecular Catalysis A: Chemical, 2007,
274, 212-216.
· “HbA/H2O2: an efficient biomimetic catalytic system for the oxidation of sulfides to sulfoxides” Atul
Kumar, Akanksha. Tetrahedron Letters, 2007, 48, 7857-7860.
· “An efficient one way selective oxidative cleavage of oximes using hypervalent iodine” Atul Kumar,
Pervez Ahmad, Akanksha and Ram Awatar Murya. Combinatorial Chemistry and high throughput
screening, 2005, 8, 445-447.
· “Multicomponent, solvent-free synthesis of β-aryl-β-mercapto ketones using zirconium chloride as a
catalyst” Atul Kumar, Akanksha. Tetrahedron Letters, 2007, 48, 8730.
· “Design and synthesis of 1,3-biarylsulfanyl derivatives as new anti-breast cancer agents” Atul Kumar,
Vishwa Deepak Tripathi, Promod Kumar, Lalit Prakash Gupta, Akanksha, Ritu Trivedi, Hemant Bid,
V.L. Nayak, Jawed A. Siddiqui, Bandana Chakravarti, Ruchi Saxena, Anila Dwivedi, M.I. Siddiquee,
U. Siddiqui, Rituraj Konwar, Naibedya Chattopadhyay. Bioorganic & Medicinal Chemistry, 2011,19
5409.
· Design and Synthesis of novel benzisoxazole motif with basic amino anti-estrogenic side chain
as ER-receptor subtype ligands selective. Bioorganic and Medicinal Chemistry letter.Atul
Kumar, Akanksha Communicated.
Attented/Paper Presented in International
Conferences:
· Attended “Indian Science Congress” from Lucknow University, Lucknow, India, 3-7 January 2002.
· Attended the joint International Conference on “Current Trends in Drug Discovery Research” Central
Drug Research Institute, Lucknow, India, 17-21 Febuary-2004.
· IInd Inter. Symp. on Current Trends in Drug Discovery Research, Central Drug Research Institute,
Lucknow, India, 17-22 Febuary-2007. Presented a poster on in the “Qunoline amide as a antithrombotic
agent.”
· 10th National Symposium in Chemistry, Indian Institute of Science, Bangalore, 1 Febuary-2008.
Presented a poster on “Human hemoglobin an efficient biomimetic catalytic system for the oxidation of
sulfides to sulfoxides.”
Selected Abstracts
· “Qunoline amide as a antithrombotic agent.” Atul Kumar, Akanksha. 2nd Inter. Symp. on Curr.Trends
in Drug Discovery Res. (CTDDR-2006),organized by CDRI (CSIR), Lucknow, India, Feb 2006.
· “Human hemoglobin an efficient biomimetic catalytic system for the oxidation of sulfides to
sulfoxides.” Atul Kumar, Akanksha.10th National Symposium in Chemistry Division of Chemical
Sciences organized by Indian Institute of Science, Bangalore.
Selected Oral presentation
· “Artificial Sweetners” (Jan 2003) in University of Lucknow, Lucknow
· “Design and Synthesis of Novel Nuclear Receptor Modulator” (Jan 2008) at Central Drug Research
Institute, Lucknow-226001, India.
· Diels Alder Reaction” (April 2006) at Central Drug Research Institute, Lucknow-226001, India.
Muirwood Park, Pleasanton
.
