Rajalakshmi Subramaniyam
Postdoctoral Researcher at Konan University
Rajalakshmi Subramaniyam, links
https://www.facebook.com/rajalakshmi.subramaniyam
https://jp.linkedin.com/in/rajalakshmi-subramaniyam-4922763b
rajimaniyam@gmail.com
https://scholar.google.co.in/citations?user=QlgpzQEAAAAJ&hl=en
https://clri.academia.edu/Rajalakshmi
http://www.slideshare.net/rajalakshmisubramaniyam
A CLIPPING
Experience
Postdoctoral Researcher
Konan University
Interaction of organic compounds and metal complexes with non-canonical structures of DNA (G-quadruplex and G-triplexes) under molecular crowding conditions
Graduate student
Central Leather Research Institute
Interaction of copper(II) complexes of bi- and tridentate ligands with DNA and their anti-proliferative effects on osteosarcoma cancer cell
Publications
DNA condensation by copper(II) complexes and their anti-proliferative effect on cancerous and normal fibroblast cells
European Journal of Medicinal Chemistry
May 2, 2014
In our search towards copper(II) based anticancer compounds, copper(II) complexes [Cu(bitpy)2](ClO4)21, [Cu(bitpy)(phen)](NO3)22 and [Cu(bitpy)(NO3)](NO3) 3 were synthesized and characterized. All the three complexes contain the tridentate ligand bitpy, which bears biologically relevant benzimidazolyl head group, as one of the ligands. Because of the presence of the planar benzimidazolyl group in...more
DNA cleavage activity by a mononuclear iron(II)Schiff base complex: Synthesis and structural characterization
J. Chem. Sci., 125 (2013) 1161-1168
March 2013Antibacterial activity of copper(II) complexes against staphylococcus aureus
RSC Advances
July 2014
Biofilm formation on medical implants is very difficult to overcome, since the bacteria in this form resist the host defense mechanism and antibiotic therapy. What is needed is the development of an anti-biofouling agent which will prevent the formation of a biofilm especially on periprosthetic implants. In this study, the antibiofilm forming potential of two copper(II) complexes namely, [Cu(bitpy...more
Anomalous behavior of pentacoordinate copper complexes of dimethylphenanthroline and derivatives of terpyridine ligands: Studies on DNA binding, cleavage and apoptotic activity
European Journal of Medicinal Chemistry 46 (2011) 608-617
Copper(II) complexes with substituted terpyridine ligands, namely [Cu(itpy)(dmp)](NO3)2 (1) and [Cu(ptpy)(dmp)](NO3)2 (2) have been synthesized and characterized. The interaction of the complexes with CT-DNA has been explored using spectroscopic techniques and viscosity. Complexes 1 and 2 bind in the grooves of DNA, interestingly 1 in the minor and 2 in the major groove. Both the complexes have...more
Copper(II) complexes of terpyridine derivatives: A footstep towards development of antiproliferative agent for breast cancer
Journal of Inorganic Biochemistry 117 (2012) 48-59
Two copper(II) complexeswith terpyridyl conjugates, [Cu(meotpy)(dmp)](NO3)2 (1) and[Cu(bitpy)(dmp)](NO3)2 (2) where meotpy, bitpy and dmp stand for methoxybenzyl terpyridine, benzimidazolyl terpyridine and dimethyl phenanthroline respectively have been synthesized and characterized. Complex 1 has also been characterized crystallographically. Both the complexes have been found to bind CT-DNA...mor
DNA binding and cleavage activity by a mononuclear iron(II)Schiff base complex: Synthesis and structural characterization
Journal of Chemical Sciences, Indian Academy of Science 125 (2013) 1161-1168
Cyclic Naphthalene Diimide Binds G-quadruplex DNA independent of Topology and Regulates Transcription
Communicated
2015
Honors & Awards
Member of Chemical Society of Japan
Konan University
Nucleic Acids Chemistry beyond the Watson‐Crick Double Helix: DNA Gtriplexes control production of RNA transcript
S. Rajalakshmi,T. Hisae, N. Sugimoto
Oral Presentation in the 95th international conference "Chemical Society of Japan" 2015
Council of Scientific and Industrial Research Award - Junior and Senior Research Fellowship
CSIR - India
Ph.D dissertation was nominated for "Best thesis Award" by University of Madras
Interaction of copper(II) complexes of bi- and tridentate ligands with DNA and their Anti-Proliferative effects on Osteosarcoma Cancer Cell
Presented one of my research topics in Gordon Research Seminar (GRS) - Bioinorganic Chemistry, Ventura, CA 2012
Awarded travel grant by DST- India (Department of Science and Technology)
Education
Volunteer Experience & Causes
Causes Rajalakshmi cares about:
- Children
- Education
- Human Rights
- Science and Technology
.
- Former Researcher at Konan University
Nanganallur
Nanganallur
has been one of the southern suburbs of Chennai till September 2011,
but it is now a part of Chennai Corporation in Tamil Nadu. It is a
residential area close to the Chennai International Airport. Wikipedia
32 Feet Bhaktha Anjaneya temple at Nanganallur — in Nanganallur, India.
"Sri Arthanareeswarar Temple "
4th Main Road, Nanganallur,
Chennai,Tamil Nadu,
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