.Murugan Kaliyappan
Research scientist at Yung Shin pharamaceutical group
Dr. K.
Murugan, M.Sc., Ph.D
Research Scientist
Generics R&D,
Yung Zip Chemical
Dajia, Taichung,
Taiwan-43767
Links
- Postdoctoral Researcher at National Taiwan University, Taipei
Founded in
1978, Yung Zip Chemical is located in Youth Industrial Park, Tachia,
Taichung. Yung Zip Chemical specializes in the production and sales of
API ...
Experience
Senior Research Scientist
Sanmar Group
Process development
medicinal chemistry research
medicinal chemistry research
HIS CV CUT PASTED
Dr. K.
Murugan, M.Sc., Ph.D
Research Scientist
Generics R&D,
Yung Zip Chemical
Dajia, Taichung,
Taiwan-43767
Current position
Research
Scientist at Yung
Zip Chemical (Yung Shin Pharma Group), Taiwan. (Oct. 2014 – present):
Academic and Industrial experience
National Taiwan University,
Dept. of Chemistry and School of Pharmacy, Taiwan
(Aug. 2011 – Jul.
2014)
|
Postdoc.
Research Fellow
(Prof. Ya-Ching Shen
Lab)
|
Sanmar Speciality Chemicals Ltd, Chennai
(Oct. 2006 – Aug.
2007)
|
Senior Research
Officer
|
Malladi Drugs & Pharmaceuticals Ltd, Chennai
(Jul. 2004 – Sep.
2006)
|
Junior
Scientist
|
IIT Madras, Chennai
(Jan. 2004 – Jul.
2004)
|
Research
Fellow,
Industrial Project
(Prof. B.Viswantahn)
|
Academic
Profile
§ Ph.D
Organic Chemistry, (Advisor: Prof. Chinpiao Chen), National Dong Hwa
University, Taiwan (Sep.2007-Aug-2011)
§ MSc
Chemistry (first class), St. Joseph College, Bharathidasan University,
Tamilnadu, India (2001− 2003).
§
BSc Chemistry (first class), Govt. Arts College, Dharmapuri, Madras
University, Tamilnadu, India (1996−1999).
Key
achievements
Yung Zip Chemical:
§ Activities includes synthetic route
selection, process optimization, costing, in-process controls and complete
specification generation, lab validation.
§ Non-infringing selection of process, and
polymorph identification (innovator).
§ Impurities identification
(process-related, KSM carry-over) for the related substances of final API and their
synthetic route selection.
§
Cross
functional team interactions with analytical R&D, IP, engineering, etc. at different
stages of project.
§ Non-infringing routes, impurity
synthesis, and process optimization of the following API molecules:
§ Non-infringing routes, impurity
synthesis, process optimization and lab validation of the following API
molecules:
Sanmar Specialities Chemicals Ltd.:
§ CRO work and custom synthesis for
Pfizer, Merck, BMS and Asinex Moscow.
§ Preparation of library molecules and
API intermediates and delivery of 1 g to 100 g samples.
§ Process optimization, impurity
synthesis, validation and scale-up to plant level for the following API
molecules and Intermediates:
Postdoctoral Research:
§ Development of organocatalytic
reactions for synthesis of a key precursor to DMP 777, a leukocyte elastase
inhibitor.
§ Organocatalytic-mediated synthesis of
model core of Atorvastatin from enamide starting material.
§ Synthesis of
carbozolyl-3,4-dihydro-β-carboline analogues as potential antitumor agents.
§ Semisynthesis of Ambrox (terpenoid)
from naturally occurring starting material.
|
Research Papers:
1. Sankareswaran,
Srimurugan, Kaliyappan Murugan, Chinpiao Chen* A facile method for
preparation of 2 [ H3]-Sufentanil and its metabolites, Chem. Pharm. Bull.
57(12) 1421-1424 (2009).
2. Kaliyappan
Murugan,Sankareswaran Srimurugan and Chinpiao Chen* A mild, catalytic and
efficient Nazarov cyclization mediated by phosphomolybdicacid, Chem.
Commun., 2010, 46, 1127–1129.
3. Kaliyappan
Murugan, Sankareswaran Srimurugan, Chinpiao Chen* Silicomolybdicacid supported
on silica-gel: An efficient catalyst for Hosomi-Sakurai allylation reactions. Tetrahedron
2011, 67, 5621.
4. Kaliyappan
Murugan,Chinpiao Chen* HClO4-supported on silica gel: a mild and efficient
catalyst for Hosomi-Sakurai reaction, Tetrahedron Lett. 2011, 52,
5827-5830.
5. Sankareswaran
Srimurugan, Chi-Ju Su, Hun-Chi Shu, Kaliyappan Murugan, Chinpiao
Chen* A facile and improved synthesis of desomorphine and its deuterium labeled
analogue, MonatshChem. 2012, 143, 171-174.
6. Kaliyappan
Murugan, Da-wei Huang, Yu-Ting Chien, Shiuh-Tzung Liu* An efficient preparation
of Nacetylenamides catalyzed by Ru(II) complexes, Tetrahedron 2013,
69, 268-273.
7. Kaliyappan
Murugan, Shiuh-Tzung Liu* Preparation of substituted
pyrroles via Ru(II)-catalyzed coupling of alkynes with enamides, Tetrahedron
Lett. 2013, 54, 2608-2611.
8. Chun-RuYang,
Wei-Siang Liaob, Ya-Hui Wu, Kaliyappan Murugan, Chinpiao Chen*, Jui-I
Chao* CR108, a novel vitamin K3 derivative
induces apoptosis and breast tumor inhibition by reactive oxygen species and
mitochondrial dysfunction, Toxicology and Applied
Pharmacology, 2013, 273, 611–622.
9. Atul
Chaskar* Kaliyappan Murugan* Direct Allylation of
Alcohols using allyltrimethyl-silane: A Move Towards Economical and Ecological
Protocol for C-C Bond Formation, (Review) Catalysis Science &
Technology, 2014, 4, 1852-1868.
10. Hanuman P. KalmodeKamlesh S. VadagaonkarKaliyappan
Murugan Atul C. ChaskarA multicomponent pathway-inspired regioselective synthesis of 2,3,4-trisubstit
-uted 1H-pyrroles via [3+2] cycloaddition reaction, New
J. Chem, 2015, 39, 4631-4639.
Academic Scholarships/Fellowships Received:
§ NSC post-doctoral fellowship, Taiwan,
2011-2014.
§ Taiwan scholarship for PhD from
National Science Council (NSC) Taiwan,
2007- 2010.
§ TITAN Merit Scholarship for MSc from
Titan India Ltd. from 2001-2003.
|
Name : K.
Murugan
Gender : Male
Gender : May,
5, 1978
Marital status : Married
Nationality : Indian
Languages : English,
Tamil, Chinese (elementary level)
References:
Professor
Chinpiao Chen
Department
of Chemistry
National Dong Hwa University, Hualien-974,
Taiwan
Professor Ya-Ching Chen
School of pharmacy, National Taiwan
University Medical college
No.1, Sec.1, Jen-Ai Road, Taipei, Taiwan.
Email: ycshen@ntu.edu.tw Ph:
+886-2-33668774
Professor B.Viswanathan
Department of Chemistry,
Indian Institute of Technology Madras, Chennai,
India-600036.
Email:
bvnathan@iitm.ac.in Ph: +9144- 22574241.
| R&D Department Sung, Che-Ming Manager TEL:+886-4-26811344 FAX:+886-4-26820920 E-mail:yzcrd@yungshingroup.com |
| Yung Zip Chemical manufactures and markets
qualify quality Active Pharmaceutical
Ingredients products, such as anti-viral,
anti-inflammatory, analgesic, anti-fungal,
anti-cancer and etc. We always R&D
new APIs without end to satisfy our
customer's requirement and more choice.
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Science and technology is changing with each passing day, cease making progress is equal to
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| do
less well than before,
due to the R&D news
products influences the
life and death ofa company,
we are enthusiastic to
enhance our R&D and
employ many professional
persons to enter our R&D
teams. The increasing of new facilities and upgrading equipments of pilot plant is the foundation for Yung Zip to expand its business scope in photoelectron domain, also combines with modernized management, Yung Zip has a strong background forward to its brightness future. |
Dajia, Taichung
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