One Organic Chemist One Day............Honouring Profiles of leading Organic Chemists brought to you by DR ANTHONY MELVIN CRASTO, worlddrugtracker, helping millions, amcrasto@gmail.com, +91 9323115463, India, skype amcrasto64
DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai) , INDIA 29Yrs Exp. in the feld of Organic Chemistry,Working for GLENMARK PHARMA at Navi Mumbai, INDIA. Serving chemists around the world. Helping them with websites on Chemistry.Million hits on google, world acclamation from industry, academia, drug authorities for websites, blogs and educational contribution
Research activity in our group is focused on the use of synthetic organic chemistry to probe and solve biological problems. Current projects include the use of water as a reaction solvent and the use of catalytic and biocatalytic synthetic strategies. Also novel kinase inhibitors, cytosine-based hydrogen-bonding polymers and new lipid design for use in a ternary gene delivery vector.
Scheme 1 Overview of the biocatalytic and non-enzymatic cascades presented in this work, including the ‘triangular’ cascade.
Scheme 2 One-pot chemoenzymatic synthesis of (S)-4 and (S)-5. Reaction conditions: (a) 20 mM 2, 10 mM sodium pyruvate, 500 μg mL−1 NCS and 20% v.v−1 CV2025 lysate, 50 mM HEPES pH 7.5, 37 °C, 3 h. (b) 40 mM formaldehyde, 1 M sodium phosphate, pH 6, 30 min, 37 °C.
More than 20 years of rich experience in process research for API’s, new chemical entities (NCE’s), custom chemical synthesis (CCS) and contract research & manufacturing services (CRAMS) with reputed pharmaceutical organizations. Good understanding and analytical capabilities over various research areas (Medicinal chemistry & process research) and different business segments like APIs, CCS business.
Role and Responsibilities:
-New synthetic route identification.
-Development of non-infringing synthetic routes for Generic API’s and new chemical entities (NCE) with multiple-step chemistry and Scale-up varies therapeutic areas in a cost effective and environment friendly manner.
-Selection of cost effective suitable synthetic route for commercialization (Process research).
-Process optimization and process robustness demonstration from lab scale to commercial supplies (process development)
-Project leadership roles.
-Managing large team, team building, motivation and drive the team to achieve target.
Professional Experience:
-Complete project management includes heading a group of scientists working in various kind of projects (API, CCS)
-Providing sound technical proposals (chemistry selection, estimation of cost and timelines) & project plans for the custom synthesis and contract research for various clients.
-Responsible to meet the timeline for DMF filings as per business plan.
-Responsible for addressing the regulatory and business queries.
-Responsible for successful scale-up of technology at plant.
-Trouble shooting in Kilo lab/PP/Plant
-Identification of cost contributors and reduction of cost for better project margins and competitive advantage during the execution of projects.
C. Prabhakar, N.Vasanth Kumar, M. Ravikanth
Reddy, M.R. Sarma and G. Om Reddy.
Organic Process Research & Development
1999, 3, 155-160
ÃœSynthesis and Biological activity of novel
Anti-bacterial Quinolones
M R Sarma, N Vasanth Kumar, A S R Prasad, S Eswaraiah, C
Prabhakar, G Om Reddy, M Sitaram Kumar, A K Sadhukhan, A Venkateswarlu & K
Anji Reddy. Indian Journal of Chemistry.
Vol. 40B, 2001, 331-335
ÃœSynthesis
of some novel ethyl 6-cyano-7-substituted-5-methyl-2-oxo-2H-pyrano
[2, 3-b] pyridine-3-carboxylate derivatives. N Vasanth Kumar & Uday C Mashelker.
Indian J Chem. 45B, 2006,
1770.
ÃœDiasteroselective
synthesis of some novel Benzopyranopyridine derivatives.
Pradeep K
Mohakhud, Sujeet Kumar, N Vasanth Kumar, V. Ravi Kumar, J. Moses Babu, K. Vyas
and G Om Reddy, Beilstein Journal of Organic Chemistry 2006, 2:25
ÃœSynthesis
of novel 1,2,4-oxadiazole heterocyclic compounds contain
2-H-pyranopyridine-2-one moiety and related compounds. N Vasanth Kumar & Uday C Mashelker. Indian
Journal of Chemistry, 46B, 2007, 216.
ÃœSynthesis
of novel 3-substituted derivatives of 2H-pyrano[2,3-b]pyridine-2-one
moiety
N Vasanth Kumar & Uday C Mashelkar. Journal of Indian Chemical Society, Vol. 84,October 2007, 1048-1051.
ÃœSynthesis
of new heterocyclic compounds containing 2H-pyrano-[2,3-b]pyridine-2-one moiety
N
Vasanth Kumar & Uday C Mashelkar,
Indian Journal of Heterocyclic Chemistry, Vol. 17, July-Sept., 2007, 99-100
ÃœSynthesis
of some novel 1,2,4-triazolo[4,3-a]-2H-pyrano[3,2-e] pyridine derivatives.
N
Vasanth Kumar & Uday C Mashelkar,Heterocyclic
Communications, Vol. 13, No. 4, 2007, 211-214.
Patents & Patent Applications
ÃœA novel method for the preparation of aryl piperazinyl
heterocyclic compounds.
Tyagi Om dutt;
Srivastava Tushar kumar; Chauhan Yogendra Kumar; Nalam Vasanth Kumar
WO
2006/011157 A2.
ÃœPreparation of [2-Methyl-5Phenyl-3-(Piperazin-1-yl
Methyl)] Pyrrole Derivatives
ÃœNovel
Method for the Preparation of Aryl Piperazinyl-Heterocyclic Compounds
Tyagi Om D;
Srivastava Tushar k ; Chauhan Yogendra K ; Nalam Vasanth K US2007238877
ÃœImproved Process for the preparation of
7-amino-3-alkyl-3-cephem-4-carboxylic acid
compounds. Application 961/MUM/2004 published 2007-04-27, filed
2004-09-08
ÃœA process for the preparation of novel crystalline form
of Ziprasidone base.
Application 1118/MUM/2004 published 2007-06-08,
filed 2004-10-19
ÃœA process for the preparation of novel crystalline form
of Ziprasidone Hydrochloride Monohydrate Salt.
Application
1119/MUM/2004 published 2007-06-08, filed 2004-10-19.
ÃœImproved Process for the manufacture of Ziprasidone.
Tyagi Om D;
Srivastava Tushar k ; Chauhan Yogendra K ; Nalam Vasanth K, Patil Sadanand Nilkanth.
Prof Helen Hailes
