-
Department of Pharmacology
Jamshoro, Pakistan
https://www.researchgate.net/profile/Nasreen_Qazi
Short communication-Evaluation of antianxiety and antidepressant properties of Carthamus tinctorius L. (Safflower) petal extract
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES 28(3):991-5 · MAY 2015
ABSTRACT
Nowadays anxiety and depression are most commonly encountered diseases. They are not only difficult to diagnose but even difficult to treat since both are sometimes seen together or one predisposes the other. Apart from this side effect profile of these drugs is also high; hence there is immense scope for the herbal drugs to treat these disorders. Present study was therefore performed to evaluate the antianxiety and antidepressant effect of Carthamus tinctorius petal extract. 28 white albino rats bred in the animal house of Department of Pharmacology, University of Karachi weighing 180-220gm were randomly divided into four groups (n=7/group) to assess behavioral effects. The anxiolytic and antidepressant effects of Carthamus tinctorius petal extract were evaluated using elevated plus maize and forced swim test respectively at100 and 200mg/kg. These effects were compared with standard drugs Diazepam (anxiolytic) 2mg/kg and Nortriptyline (antidepressant) 12.5mg/kg. Results show that CT produced highly significant anxiolytic and anti-depressant effects at both doses as compared to control, similar to standard anxiolytic and antidepressant drugs diazepam and nortriptyline. It increased the latency of first entry to closed arms and the time spent in open arms very significantly at both doses while entries to open arm were increased significantly at 100mg/kg and very significantly at 200mg/kg in EPM test and increased the immobility time very significantly in FST. Hence it can be concluded that CT may be used as an alternative therapeutic agent while treating patients with anxiety and depressive disorders
Liaquat University of Medical and Health Sciences
Department of Pharmacology
Jamshoro, Pakistan
Postal Address
Liaquat University of Medical and Health Sciences (LUMHS)
Administration Block
Deh Soun Valhar
City: Jamshoro
District: Jamshoro
Province: Sindh
Country: Pakistan
Postal Code: 76090
Phone: +92 22 9213305, +92 22 9213307
Fax: +92 22 9213306
//////////
