.
Dr.MOHAMMAD H.EL-DAKDOUKI
Assistant Professor at Beirut Arab University
Beirut Arab University
Department of Chemistry
Debbieh, Lebanon
Email:m.eldakdouki@bau.edu.lb
Phone:(+961) 71 831 432
https://lb.linkedin.com/pub/mohammad-el-dakdouki/33/153/136
http://www.bau.edu.lb/Library/Files/uploads/sc_cv_dakdouki.pdf
https://www.researchgate.net/profile/Mohammad_El-Dakdouki
Experience
Assistant Professor
Beirut Arab University
Assistant Professor of Bioorganic Chemistry
Visiting Scholar
Michigan State University
- Development of novel biomarkers for detection and treatment of Alzheimer's disease
Research Assistant Professor
Michigan State University
- Molecular imaging (MRI, bioluminescence, confocal microscopy..)
- Nanoparticle development and optimization
- In vitro and in vivo evaluation of therapeutics
- Organic synthesis
- Nanoparticle development and optimization
- In vitro and in vivo evaluation of therapeutics
- Organic synthesis
Research Associate
Michigan State University
Organic synthesis, nanoparticle formulation, molecular imaging
Education
Publications
El-Dakdouki, M.H.;* Xia, J.; Zhu, D.C.; Kavunja, H.; Grieshaber, J.; O’Reilly, S.; McCormick, J.J.; Huang, H.* Assessing the Efficacy of Colloidally Stable Nanoparticles Loaded with Doxorubicin In Vivo. ACS Appl. Mat. Inter. 2013, Just Accepted.
2013El-Dakdouki, M.H.; Puré, E.; Huang, X. Development of drug loaded nanoparticles for tumor targeting. Part 1: synthesis, characterization, and biological evaluation in 2D cell cultures. Nanoscale. 2013, 5, 3895-3903.
El-Dakdouki, M.H.; Puré, E.; Huang, X. Development of drug loaded nanoparticles for tumor targeting. Part 2: enhancement of tumor penetration through receptor mediated transcytosis in 3D tumor models. Nanoscale. 2013, 5, 3904-3911.
El-Dakdouki, M.H.; El-boubbou, K.; Kamat, M.; Huang, R.; Abela, G.S.; Kiupel, M.; Zhu, D.C.; Huang, X. CD44 targeted magnetic glyconanoparticles for atherosclerotic plaque imaging. Pharm. Res. 2013, DOI 10.1007/s11095-013-1021-8.
Kouyoumdjian, H.; Zhu, D.; El-Dakdouki, M.H.; Lorenz, K.; Chen, J.; Li, W.; Huang, X. Glyconanoparticle aided detection of β-amyloid by magnetic resonance imaging and attenuation of β-amyloid induced cytotoxicity. ACS Chem. Neurosci. 2013, 4, 575-584.
El-Dakdouki, M.H. et al. Methods for magnetic nanoparticles synthesis and functionalization. Chemistry of Bioconjugates: Synthesis, Characterization and Biomedical Applications, Editor: Ravin Narain, Wiley & Sons, 2013, In Press.
El-Dakdouki, M.H.; Zhu, D.C.; El-Boubbou, K.; Kamat, M.; Chen, J.; Li, W.; Huang, X. Development of multifunctional hyaluronan-coated nanoparticles for imaging and drug delivery to cancer cells. Biomacromolecules, 2012, 13, 1144-1151.
El-Dakdouki, M.H.; Erhardt, P.W. Analogue-based drug discovery: More than just a practical approach toward obtaining new drugs. Microtubule stabilizers as a case in point. Pure Appl. Chem. 2012, 84, 1479-1542.
Yang, B.; Yoshida, K.; Yin, Z.; Dai, H.; Kavunja, H.; El-Dakdouki, M.H.; Sungsuwan, S.; Dulaney, S.B.; Huang, X. Chemical synthesis of a heparan hulfate glycopeptide: Syndecan-1. Angwe. Chem. Int. Ed. 2012. 51, 10185-10189.
Avila, B.; El-Dakdouki, M.H.; Nazer, M.Z.; Harrison, J.G.; Tantillo, D.J.; Haddadin; M.J.; Kurth, M.J. Acid and base catalyzed Davis-Beirut reaction: Experimental and theoretical mechanistic studies... Tetrahedron Lett. 2012, 53, 6475-6478.
Li, H.*; El-Dakdouki, M.H.*; Zhu, D.C.; Abela, G.S.; Huang, X. Synthesis of -CD conjugated superparamagnetic iron oxide nanoparticles for selective binding and detection of cholesterol crystals. Chem .Comm.2012, 48, 3385-3387.
El-Dakdouki, M.H.; Adamski, N.; Foster, L.; Hacker, M.; Erhardt, P.W. Synthesis of 9- aza-anthrapyrazole N-oxide analogues as potential anticancer prodrugs targeting hypoxic cancer cells, J. Med. Chem. 2011, 54, 8224-8227.
Luniwal A.; Khupse, R.; Reese, M.; Liu, J.; El-Dakdouki, M.H.; Malik, N.; Fang, L.; Erhardt, P.W. Multigram synthesis of glyceollin I. Org. Proc. Res. Devel., 2011, 15, 1149–1162.
El-Dakdouki, M.H.; El-Boubbou, K.; Zhu, D.C.; Huang, X. A simple method for the synthesis of hyaluronic acid coated magnetic nanoparticles for highly efficient cell labelling and in vivo imaging, RSC Advances, 2011, 1, 1449-1452.
Tiruchinapally, G.; Yin, Z.; El-Dakdouki, M.H.; Wang, Z.; Huang, X. Divergent heparin oligosaccharide synthesis with pre-installed sulfate esters. Chem. Eur. J. 2011, 17, 10106-10112.
El-Dakdouki, M.H.; Huang, X. Biological applications of hyaluronic acid functionalized nanomaterials. In Petite and Sweet: Glyco-nanotechnology as a bridge to new medicines, Editors: Huang, X.; Barchi, J. American Chemical Society, 2011, 181-213.
Xie, Z.H.; Tan, W-M.; Qin, A-H.; Dai, H.; Hou, X-T. El-Dakdouki, M.H. Clinical study of JueMing Hainan Holly Tea. Chinese J. Exper. Trad. Med. Formulae. 2011, 17, 230- 235.
El-Dakdouki, M.H.; Erhardt, P.W. Paclitaxel Analogs. In Analogue-based Drug Discovery II, Editors: Fischer, J.; Ganellin, C.R., Wiley-VCH Verlag GmbH & Co. KGaA, 2010, 243-267.
Dr. Mohammad El-Dakdouki from the Chemistry Department at Beirut Arab University attended the celebration of the naming of the Davis-Beirut Reaction at the ...
Beirut Arab University. Department of Chemistry
///////// Dr.MOHAMMAD H.EL-DAKDOUKI, Beirut Arab University. Department of Chemistry
