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Monday, 1 August 2016

Shanthi Paranawithana

Professor Shanthi Paranawithana

Assistant Professor
Hampton University
Hampton, VA 23668

(757) 727-5837

shanthi.paranawithan@hamptonu.edu

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Contact

Office:
Turner Hall, Rm 325
Phone: 757-727-5837
Email: shanthi.paranawithana
@hamptonu.edu

Dr. Shanthi R. Paranawithana

Position: Assistant Professor, Ph.D.

Areas of Interest:
Biochemistry, protein expression, macromolecular interactions, effects of cancer drugs on tumor cell activities and survival.

Education

Ph.D. (Biochemistry): City University of New York
B.Sc. (Botany): University of Sri Lanka, Peradeniya Campus, Sri Lanka

Dr. Paranawithana at Graduation 2013

Previous Work

2003- Aug. 2005 Johns Hopkins University, Bloomberg School of Public Health, Department of Biochemistry and Molecular Biology, Baltimore, Maryland. Postdoctoral Fellow Conducted research in crystallography of proteins and DNA,
2000-2001 Moffitt Cancer Research Center, University of South Florida, Tampa, Florida. Research Fellow, Conducted research on the effect of cancer drugs on tumor cell activities and survival, apoptosis, signal transduction and cell cycle regulation.
1989-1995 Rutgers University, College of Pharmacy, Piscataway, New Jersey. Research Associate, Postdoctoral Research Associate Conducted research on the role of P-450 enzymes devised methods of expressing the human enzymes in large quantity using different expression used site-directed mutagenesis to study the active site of the enzyme.
1986 - 1988 University of Florida, Health Center, Florida. Postdoctoral Research Associate Conducted research in molecular biology and biochemistry to determine the role of human carbonic anhydrase III using protein over-expression and site-directed mutagenesis.

Publications

X-Ray crystal structure of an antimicrobial compound bound to AT rich DNA decamer at 0.95Å resolution.Shanthi R. Paranawithana, Yuan Lin and Clara L. Kielkopf (In preparation).
Structural basis of poly-pyrimidine tract recognition by U2AF65. E. A. Sickmier, S. Paranawithana, et al.(submitted)
X-ray structure of a Rex-Family repressor/NADH Complex: Insights into the Mechanism of Redox Sensing. E. Allen Sickmier, Dimitris Brekasis, Shanthi R.Paranawithana, Jeffrey B. Bonano, Mark S. B. Paget, Stephen K. Burley and Clara L. Kielkopf, Structure, (13) 43-54, 2005.
Enhancement of catalytic activity of carbonic anhydrase III by phosphates. Paranawithana, S. R., Tu, C. K., Laipis, P. J. and Silverman, D. N., J. Biol. Chem. 265 (36), 22270-2274, 1990.
Epothilone B analogue (BMS-247550)-mediated cytotoxicity through inductionof Bax conformational change in human breast cancer cells.Yamaguchi H, Paranawithana S, Lee M, Huang Z, Bhalla K, Wang H-G. Cancer Res. (62) 466-471, 2002