.Masoumeh Divar
Research Associate at Pharmaceutical Sciences Research Center, Shiraz university of Medical Sciences
LINKS
Summary
I'm
passionate about pharmaceutical sciences, dendrimer synthesis and
organic chemistry and also I'm perfectionist in modern spectroscopic
techniques, chromatographic techniques, Nuclear Magnetic Resonance
Spectroscopy (NMR), Fourier Transform Infrared Spectroscopy (FT-IR),
UV-Vis Spectroscopy, Matrix-assisted laser desorption/ionization
(MALDI-TOF), Gel permeation chromatography (GPC), High-Performance
Liquid Chromatography (HPLC), and Visible and Ultraviolet Spectroscopy.
I'm looking forward to applying organic synthesis and characterization
technique in post doc position.
Experience
research assistant
Pharmaceutical Science Research center, Shiraz University of Medical Sciences.
I've
desined and done some pharmacutical projects in this center and also I
designed projects for undergraduate pharmacy students and mentored them
during thair projects.
- (Open)4 projects
PhD in organic chemistry ( teaching assistant)
Shiraz university
Leading
undergraduate student in organic chemistry lab I & II. I also
taught general chemistry I & II and organic chemistry I & II.
Visiting Scholar
University of Pennsylvania
I worked on peptide dendrimer synthesis
Education
Publications
Magnetic nanoparticles-supported tungstic acid (MNP-TA): an efficient magnetic recyclable catalyst for the one-pot synthesis of spirooxindoles in water
RSC Advances
May 2015This paper reports the preparation, characterization and catalytic application of a novel, magnetically separable catalyst consisting of tungstic acid supported on silica coated magnetic nanoparticles. To obtain this new catalyst system, first, (3-chloropropyl)triethoxysilane was reacted with silica coated magnetic nanoparticles to generate a 3-chloropropyl magnetic nanoparticle (3-CPMNP)Nucleosides as reagents in multicomponent reactions: one-pot synthesis of heterocyclic nucleoside analogues incorporating pyrimidine-fused rings
Tetrahedron Letters
2013In this study, a general and efficient protocol for the synthesis of new heterocyclic nucleoside analogues (HNAs), using a four-component coupling reaction of nucleosides, aldehydes, barbituric acid/2-thiobarbituric acid, or dimedone is described. The synthesized HNAs contain a pyrimidine-fused heterocycle coupled to the nucleoside via a C–N linkage. The nucleosides served as amine components and...Synthesis of α‑Aminonitriles with Benzimidazolic and Theophyllinic Backbones Using the Strecker Reaction
JOC
August 26, 2013An example of the application of the Strecker reaction in the synthesis of a new class of α-aminonitriles with benzimidazole and theophylline backbones has been developed. For the synthesis of these compounds, first 4-hydroxybenzaldehyde was reacted with 1,3- and 1,5-dibromides/epibromohydrin to produce the corresponding bromo-substituted aldehydes. Then, benzimidazole/theophyl-line was reacted..
Silica sulfuric acid (SSA) as a highly efficient heterogeneous catalyst for persilylation of purine and pyrimidine nucleobases and other N-heterocycles using HMDS
Phosphorus, Sulfur, and Silicon and the Related Elements
2010
Purine and pyrimidine nucleobases and other N-heterocycles have been
silylated with HMDS in excellent yields in the presence of a catalytic
amount of silica sulfuric acid (SSA), as a heterogeneous catalyst. SSA
utilizes shorter reaction time and higher yields of silylated
nucleobases. SSA is reusable for several times without decrease in
reactivity and the yield of silylated
adducts
adducts
Honors & Awards
Iran Nanotechnology Initiative Council Incentive Support
Doctor of Philosophy Admission
Ranke first in the Entrance Exam for Ph.D. in Organic Chemistry in Shiraz University
One of the Highest Ranked Ph.D. Student. G.P.A. (GPA 3.76)
Projects
Synthesis and Evaluation of Some New Quinazoline Derivatives as Antifungal Agents
a
variety of quinazolinone derivatives were successfully synthesized, via
a three-component condensation reaction between anthranilic acid,
anhydrides and primery amines. The synthesized compounds will be
evaluated for their antifungal activity.
Antibacterial and Antifungal Effect of Some new Heterocyclic Nucleoside Analogues Incorporating Quinoline and Pyrimidine-fused Rings
In
summary, this study describes an efficient one-pot access to a new
class of heterocyclic nucleoside analogues having quinoline or
pyrimidine-fused ring in its structural framework. To obtain these
categories of heterocyclic compounds, nucleoside acts as amine component
and remind in the structure of obtained molecule via a C-N linkage.
This protocol is general for a wide range of nucleosides,...more
Antibacterial and Antifungal Effect of Some new Isatin derivatives including Semicarbazone & Thiosemicarbazone
Anticonvalsunt Effect of Some new Isatin derivatives including Semicarbazone & Thiosemicarbazone
Phosphorus, Sulfur, and Silicon and the Related ElementsVolume 185, Issue 9, 2010 |
 |
||
Original Articles
Silica Sulfuric Acid (SSA) as a Highly Efficient Heterogeneous Catalyst for Persilylation of Purine and Pyrimidine Nucleobases and Other N-Heterocycles Using Hmds
- DOI:
- 10.1080/10426500903383952
pages 1943-1954
- a Department of Chemistry , Faculty of Basic Sciences, Shiraz University of Technology , Shiraz, Iran
- b Department of Chemistry , College of Sciences, Shiraz University , Shiraz, Iran
Synthesis of α-Aminonitriles with Benzimidazolic and Theophyllinic Backbones Using the Strecker Reaction
Department of Chemistry,
College of Sciences, Shiraz University, Shiraz 71454, Iran
J. Org. Chem., 2013, 78 (21), pp 10902–10908
DOI: 10.1021/jo401890g
Publication Date (Web): October 3, 2013
Copyright © 2013 American Chemical Society
*E-mail: khalafi@chem.susc.ac.ir (A.K.-N.)., *E-mail: panahi@shirazu.ac.ir (F.P.). Fax: +98(711)2280926.
Abstract
An
example of the application of the Strecker reaction in the synthesis of
a new class of α-aminonitriles with benzimidazole and theophylline
backbones has been developed. For the synthesis of these compounds,
first 4-hydroxybenzaldehyde was reacted with 1,3- and
1,5-dibromides/epibromohydrin to produce the corresponding
bromo-substituted aldehydes. Then, benzimidazole/theophylline was
reacted with the latter to generate the related
benzimidazolic/theophyllinic aldehydes. Finally, the Strecker reactions
of the synthetic benzimidazolic and theophyllinic aldehydes with
different amines afforded the target products.
Paper
Magnetic nanoparticles-supported tungstic acid (MNP-TA): an efficient magnetic recyclable catalyst for the one-pot synthesis of spirooxindoles in water
*
Corresponding authors
a
Department of
Chemistry, College of Sciences, Shiraz University, Shiraz 71454, Iran
E-mail: khalafi@chem.susc.ac.ir, panahi@shirazu.ac.ir
Fax: +98 711 2280926
Tel: +98-7116137163
E-mail: khalafi@chem.susc.ac.ir, panahi@shirazu.ac.ir
Fax: +98 711 2280926
Tel: +98-7116137163
RSC Adv., 2015,5, 2223-2230
DOI: 10.1039/C4RA12976H
http://pubs.rsc.org/en/Content/ArticleLanding/2015/RA/C4RA12976H#!divAbstract
Received 23 Oct 2014, Accepted 19 Nov 2014
First published online 19 Nov 2014
This
paper reports the preparation, characterization and catalytic
application of a novel, magnetically separable catalyst consisting of
tungstic acid supported on silica coated magnetic nanoparticles. To
obtain this new catalyst system, first, (3-chloropropyl)triethoxysilane
was reacted with silica coated magnetic nanoparticles to generate a
3-chloropropyl magnetic nanoparticle (3-CPMNP) substrate. Subsequently,
the addition of sodium tungstate to 3-CPMNP resulted in the
stabilization of tungstic acid species on the surface of the magnetic
nanoparticles (MNP-TA). The synthesized catalyst was characterized using
some different microscopic and spectroscopic techniques such as X-ray
powder diffraction (XRD), transmission electron microscopy (TEM),
scanning electron microscopy (SEM), and FT-IR spectroscopy. The catalyst
nanoparticles were obtained with near spherical morphology and an
average size of ∼45 nm. The W content of the catalyst was determined by
ICP analysis to be 82.5 ppm (82.5 mg L−1), which was equal to 8.25% w/w (0.45 mmol g−1). The catalyst was successfully used for the one-pot synthesis of spirooxindoles via
the multicomponent reaction of isatins and dicarbonyl compounds in
water, which was used as a green solvent. The results revealed that this
new catalyst showed high catalytic activity in this protocol and that
it can be reused at least 5 times without any change in its catalytic
activity.Received 23 Oct 2014, Accepted 19 Nov 2014
First published online 19 Nov 2014
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