Sabitha Gowravaram
Senior Principal Scientist at Indian Institute of Chemical Technology
| Dr. Gowravaram Sabitha |
| Address | Scientist, Organic Division I, Indian Institute of Chemical Technology, Hyderabad-500 007, India |
| Phone number | +91-40-27160512 |
| Fax number | +91-40-27160512 |
| Country | India |
| Keywords |
- Custom synthesis
- New chemical entities
- New methodologies
- Synthetic organic chemistry
- Total synthesis of natutral products
|
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Total Stereoselective Synthesis and Structural Revision of a γ-Lactone Polyketide of Fungal Origin
Gowravaram Sabitha reports the stereoselective synthesis and structural revision of a γ-lactone polyketide of fungal origin.
A recently described γ-lactone polyketide originally isolated from the fungal strain Diaporthe sp. SXZ-19 of Camptotheca acuminata and its C-8 epimer were synthesized in stereoselective manner and their structure revised by Professor Gowravaram Sabitha and her colleagues from the CSIR-Indian Institute of Chemical Technology (Hyderabad, India).
Professor Reddy – one of the article’s co-authors – said: “Synthesis of a γ-lactone polyketide has been achieved by utilizing Carreira, Ohira–Bestmann and alkyne–aldehyde coupling reactions.”
LIST OF PUBLICATIONS
1. Synthesis of the C1-C25 Southern Domain of Spirastrellolides B and F.
Gowravaram Sabitha,* Allu Senkara Rao and J. S. Yadav. Org & Biomol.
Chem. 2013, 11, 7218-7231.
2. Stereoselective formal synthesis of aspergillide A. Gowravaram Sabitha,*
D. Vasudeva Reddy, Allu Senkara Rao and J. S. Yadav. Tetrahedron Lett.
2010, 51, 4195–4198.
3. The First Stereoselective Total Synthesis of (−)-Synrotolide. Gowravaram
Sabitha,* Allu Senkara Rao, AnkiReddy Sandeep and Jhillu S. Yadav. Eur.
J. Org. Chem. 2013, accepted.
4. Stereoselective synthesis of (−)-synparvolide B. Gowravaram Sabitha,* Allu
Senkara Rao and J. S. Yadav. Tetrahedron: Asymmetry 2011, 22, 866-871.
5. The First Total Synthesis of (−)-Synparvolide C. Gowravaram Sabitha,*
AnkiReddy Sandeep, Allu Senkara Rao and J. S. Yadav. Eur. J. Org. Chem.
2013, accepted.
6. Synthesis of the C1-C13 Subunit of Spirastrellolide A and B by Prins
Cyclization. Gowravaram Sabitha,* Allu Senkara Rao and J. S. Yadav.
Synthesis, 2010, 505-509.
7. International Application published Under The Patent Cooperation Treaty
(PCT). Process For The Preparation Of ASENAPINE Intermediate.
Inventors: SHARMA, Ramnic; H. No. 1012, 2nd Floor, Sector 17B, Gurgaon,
Haryana 122015 (IN). ALLU, Senkara, Rao; s/o Bheemu Naidu, Narasimha
Puram, Gedda Kancharam, Metta Palli, Srikakulam, Andhra Pradesh 535125
(IN). ARYAN, Ram, Chander; 1066, Sector-A, Pocket-A, Vasant Kunj, New
Delhi 110070 (IN). International Publication Number: WO 2013/080069 A1
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Prof. Gowravaram Sabitha (CSIR-Indian Institute of Chemical Technology, Hyderabad, India)
Revised structures of polyketide γ-lactone and its C-8 epimer