Dr. Pravin C. Patil
Postdoctoral Research Associate at University of Louisville
LINKS
pravinchem@gmail.comhttps://www.researchgate.net/profile/Pravin_Patil18/infohttps://www.linkedin.com/in/dr-pravin-c-patil-80741a5/https://www.facebook.com/pravinchem?lst=100000982203141%3A100002955527551%3A1492682395
- Dr. Pravin C Patil completed his B.Sc. (Chemistry) at ASC College Chopda (Jalgaon, Maharashtra, India) in 2001 and M.Sc. (Organic Chemistry) at SSVPS’S Science College Dhule in North Maharashtra University (Jalgaon, Maharashtra, India) in year 2003.
During his research experience, he has authored 23 international publications in peer reviewed journals and inventor for 4 patents. - After M.Sc. degree he was accepted for summer internship training program at Bhabha Atomic Research Center (BARC, Mumbai) in the laboratory of Prof. Subrata Chattopadhyay in Bio-organic Division.
- In 2003, Dr. Pravin joined to API Pharmaceutical bulk drug company, RPG Life Science (Navi Mumbai, Maharashtra, India) and worked there for two years. In 2005, he enrolled into Ph.D. (Chemistry) program at Institute of Chemical Technology (ICT), Matunga, Mumbai, Maharashtra, under the supervision of Prof. K. G. Akamanchi in the department of Pharmaceutical Sciences and Technology.
- After spending two years at Lupin as a Research Scientist, he got an opportunity in June 2012 to pursue Postdoctoral studies at Hope College, Holland, MI, USA under the supervision of Prof. Moses Lee. During year 2012-13 he worked on total synthesis of achiral anticancer molecules Duocarmycin and its analogs.
- In 2014, he joined to Prof. Frederick Luzzio at the Department for Chemistry, University of Louisville, Louisville, KY, USA to pursue postdoctoral studies on NIH sponsored project “ Structure based design and synthesis of Peptidomimetics targeting P. gingivalis.
- During his research experience, he has authored 23 international publications in peer reviewed journals and inventor for 4 patents.
- Ph.D. Organic chemist with significant experience in the field of academic research, postdoctoral studies and pharmaceutical industries.
Specialties:
1. Good theory and practical knowledge of Organic Chemistry.
2. Expertise in chiral resolution, racemization, purification techniques such as extraction, distillation, recrystallization and column chromatography.
3. Worked on various organic reactions like Vilsmeier-Haack reaction, Knoevenagel condensation, Friedal-Crafts alkylation and acylation, Suzuki Coupling, Aldol condensation, Knorr Pyrrole synthesis, Grignard reaction, Oxidation, Reduction, Diazotization, Reductive alkylation, Hydrogenation etc.
4. Expertise in multi-step organic synthesis of heterocyclic compounds based on quinoxaline, coumarin, benzoxazole, benzothiazole, benzimidazole, pyrroles, thiazole, pyridine, oxazole, thiophene, imidazole etc from milligram to kilogram scale.
5. Experience in route scouting, route selection, process development, optimization, technology transfer to pilot plant and bulk synthesis of active pharmaceutical ingredients (APIs).
6. Expertise in literature survey using Sci-Finder, Cross Fire Beilstein, Chemical Abstracts (CA), Patents.
7. Aware about the knowledge and functions of all spectroscopic techniques and instrumentation which are the essential part of research
• Strong background in organic reaction mechanisms and contemporary synthetic methods.
• Wide range of experience in route scouting, optimization, process development, scale up, technology transfer and commercialization of APIs and intermediates.
• Experience in multi step organic synthesis of NCE molecules for pre-clincal trials following GMP guidelines.
• Expertise in synthesis of heterocyclic compounds based on oxazoles, coumarin, benzoxazole, benzothiazole, benzimidazole, highly sensitive pyrroles, thiazole, thiophene, imidazole.
• Characterization / Identification of API Impurities as a part of DMF filing process.
• Experience in laboratory scale high pressure reactions and catalytic hydrogenation.
• Expertise in techniques routinely used in synthetic organic chemistry laboratories, including analytical, preparative, and spectroscopic techniques like nuclear magnetic resonance, mass, infrared and purification techniques such as flash chromatography, recrystallization.
• Experience in writing scientific manuscripts, mentoring undergraduate students/Junior colleagues.
Current
Experience
Education
A great opportunity to work here as once it was a dream for me, but now it made me a proud to be a part of UD inside as well as outside its campus. Learned the things how to overcome on problems of any type by considering the limit of time and situation. The Ph.D experience helped to gained the knowledge of process chemistry and its important parameters to study with.
Tetrahedron Letters14
Publications
Synthesis of extended oxazoles II: Reaction mniolds of 2-(halomethyl)-4,5 diaryloxazoles.
Tetrahedron LettersJan 10, 2016Authors
AzaHx, a novel fluorescent, DNA minor groove and G·C recognition element: Synthesis and DNA binding properties of a p-anisyl-4-aza-benzimidazole-pyrrole-imidazole (azaHx-PI) polyamideBioorganic Medicinal Chemistry LettersSep 1, 2015Authors
Nuclear Localization and Gene Expression Modulation by a Fluorescent Sequence Selective p-Anisylbenzimidazolecarboxamido Imidazole-Pyrrole PolymideChemistry and BiologyJul 23, 2015Authors
Oxazoles for click chemistry II: synthesis of extended heterocyclic scaffoldsTetrahedron LettersNov 8, 2014Authors
Simple and effective route for synthesis of parvaquone, an antiprotozoal drugRSC AdvancesOct 20, 2014Authors
Inhibition of Human Glutathione Transferases by Dinitronaphthalene DerivativesArchives of Biochemistry and BiophysicsJun 12, 2014Authors
4
Patents
A novel method for the synthesis of 2-alkyl-3-hydroxy -1, 4-naphthoquinones
in 2007/IN1474/MUM2007Issued 2007Contributors
Bisulphite adduct of Donepezil intermediate
in IN1164/KOL/2010Filed 2012Contributors
A novel method for synthesis of Parvaquonin IN 2678/Mum/2009Filed 2009Contributors
2
Honors & Awards
PATENTS
1. Bisulphite adduct of Donepezil intermediate. Patil, Pravin; Lande, Hemraj; Singh, Gurvinder pal; Ray Purna. Lupin Ltd, From Indian (2010), IN 1164/KOL/2010.
2. Process for preparation of methyl –(+)-(S)-Alpha-(2-chlorophenyl)-6,7-dihydrothieno [3,2-C] pyridine-5(4H)-acetic acid methyl esters or salts thereof having higher chiral purity and products thereof. By Srivasatava, Anita Ranjan; Pawar, Prashant Pandurang; Poojari, Krishna Anand; Patil, Pravin Chaitram; Dalvi, Rajiv Ramchandra. RPG Life Sciences: US2010/0004453 A1.
3. A novel method for the synthesis of 2-alkyl-3-hydroxy -1, 4-naphthoquinones. Patil, Pravin C. and Akamanchi, Krishnacharya G. From Indian (2007), IN 1474/ Mum/ 2007.
AWARDS/FELLOWSHIPS
• Outstanding Performance Year Award (2010-2011) by Lupin Ltd.(Research Park) Pune, India.
• Senior Research Fellowship (2008-2009) by World Bank through TEQIP (Technical Education Quality Improve Programe) at Institute of Chemical Technology, Mumbai, India.
• Junior Research Fellowship (2005-2008) by World Bank through TEQIP (Technical Education Quality Improve Programe) by Institute of Chemical Technology, Mumbai, India.
• Nominated for Best Ph.D. Student in Institute of Chemical Technology, Mumbai, Maharashtra, India for the years 2007-08 and 2009-10.
• Ranked in top 5% in Master (M. Sc.) and Bachelor (B. Sc.) examinations at university level.
An honor to be invited at book inauguration " Publish and Flourish" by Prof. Stephen K Taylor at Hope College
AT ICT MATUNGA MUMBAI INDIA
MEMORIES
I was Postdoc at Hope college during June 2012-Dec 2013. Chemistry department of Hope college has tradition to take annual photo of faculty / staff to upload on department website. This one was from year 2012 and the another one from year 2013. I am grateful to all those eminent faculties for considering me as a part of Hope family almost everyday.
Dream come true !!
Photo and 15 min talk with Prof. Peter Agre (Nobel Laureate- 2003) at Department of Chemistry, University of Louisville, Louisville, Kentucky, USA...below
//////////////
