BAYER HEALTHCARE......Working Together to Combat River Blindness

The risk of the disease transmission is extremely high on fertile river banks of endemic countries – like in the Democratic Republic of Congo. Photo: Matias Boem
READ AThttp://pharma.bayer.com/en/press/focus-on/working-together-to-combat-river-blindness.php

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Dr. Luckhana Lawtrakul

Faculty : School of Bio-Chemical Engineering and Technology (BCET) Name : Dr. Luckhana Lawtrakul (Associate Professor) Position : Head of the School of Bio-Chemical Engineering and Technology and Chairperson of Chemical Engineering Curriculum E - Mail : luckhana@siit.tu.ac.th Phone Rangsit : +66-2-986-9009, +66-2-986-9101, +66-2-564-3226 Phone Bangkadi : Phone Extension : 2301

Education B.Sc. in Chemistry, Kasetsart University, Thailand M.Sc. in Physical Chemistry, Kasetsart University, Thailand Dr.rer.nat. in Theoretical Biochemistry, University of Vienna, Austria Academic Awards 2013 Gold Medal, 41st International Exhibition of Inventions of Geneva 2007 Best Teaching Award, Sirindhorn International Institute of Technology 2001 Research Award, National Research Council of Thailand (NRCT) 1997 Outstanding Thesis Award, Kasetsart University 1987-2000 Development and Promotion of Science and Technology Talents Project (DPST) Scholarship Research Areas Computer-aided molecular modeling and molecular design, Structure-activity relationships, Conformational analysis. Research Interests Molecular modeling is a collective term that refers to theoretical methods and computational techniques to model or mimic the behavior of molecules. The techniques are used in the fields of computational chemistry and computational biology for studying molecular systems ranging from small chemical systems to large biological molecules. Currently, applications in the following areas are of special concern: Molecular dynamics (MD) simulations and quantum chemical calculations on the stability of guest-cyclodextrins inclusion complexes, and Quantitative Structure-Activity Relationship (QSAR) studies of DHFR inhibitors used for tuberculosis treatment. thailand Theses Supervised Doctoral Thesis Supervised 1. Pimonluck Sittikornpaiboon. Computer Aided Molecular Modeling of Anti-Tuberculosis Drugs 2. Krit Inthajak. Structure-Activity Relationships of Anti-Folate Agents Work Experiences 2002-Present: SIIT 2000-2001: Postdoctoral Fellow, Institute of Pharmaceutical Technology, Institute for Theoretical Chemistry and Structural Biology, University of Vienna, Austria 1998-1999: Research and Teacher Assistant, Institute for Theoretical Chemistry and Structural Biology, University of Vienna, Austria 1997-2000: International Research (NRCT-FWF), Cooperation between Kasetsart University (Thailand) and University of Vienna (Austria) List of Publications International Journal Publications Lawtrakul, L., Inthajak, K., Toochinda, P. Molecular calculations on β-cyclodextrin inclusion complexes with five essential oil compounds from Ocimum basilicum (sweet basil) (2014) ScienceAsia, 40 (2), pp. 145-151. Boonyarattanakalin, K., Wolschann, P., Toochinda, P., Lawtrakul, L. Molecular dynamics simulations of UC781-cyclodextrins inclusion complexes in aqueous solution (2012) European Journal of Pharmaceutical Sciences, 47 (4), pp. 752-758. Boonyarattanakalin, K.S., Wolschann, P., Lawtrakul, L. Molecular dynamics of β-CD in water/co-solvent mixtures (2011) Journal of Inclusion Phenomena and Macrocyclic Chemistry, 70 (3-4), pp. 279-290. Yodmalai, D., Sahamitmongkol, R., Tangtermsirikul, S., Lawtrakul, L. Carbonation resistance of concrete with crystalline material coating (2011) Magazine of Concrete Research, 63 (8), pp. 573-582. Prakasvudhisarn, C., Wolschann, P., Lawtrakul, L. Predicting complexation thermodynamic parameters of β-cyclodextrin with chiral guests by using swarm intelligence and support vector machines (2009) International Journal of Molecular Sciences, 10 (5), pp. 2107-2121. Prakasvudhisarn, C., Lawtrakul, L. Feature set selection in QSAR of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio) thymine (HEPT) analogues by using swarm intelligence (2008) Monatshefte fur Chemie, 139 (3), pp. 197-211. Lawtrakul, L., Hannongbua, S. Molecular dynamics study on the unbinding of HBY 097 in the K103N mutant RT (2007) Monatshefte fur Chemie, 138 (10), pp. 1029-1034. Beyer, A., Lawtrakul, L., Pungpo, P., Wolschann, P. Structural aspects of non-nucleoside HIV-1 reverse transcriptase inhibition (2007) Current Computer-Aided Drug Design, 3 (2), pp. 87-100. Lawtrakul, L., Prakasvudhisarn, C. Correlation studies of HEPT derivatives using swarm intelligence and support vector machines (2005) Monatshefte fur Chemie, 136 (9), pp. 1681-1691. Lawtrakul, L., Beyer, A., Hannongbua, S., Wolschann, P. Quantitative Structural Rearrangement of HIV-1 reverse transcriptase on binding to non-nucleoside inhibitors (2004) Monatshefte fur Chemie, 135 (8), pp. 1033-1046. Beyer, A., Lawtrakul, L., Hannongbua, S., Wolschann, P. Systematic investigation of non-nucleoside inhibitors of HIV-1 reverse transcriptase (NNRTIs) (2004) Monatshefte fur Chemie, 135 (8), pp. 1047-1059 Lawtrakul, L., Viernstein, H., Wolschann, P. Molecular dynamics simulations of β-cyclodextrin in aqueous solution (2003) International Journal of Pharmaceutics, 256 (1-2), pp. 33-41. Hannongbua, S., Nivesanond, K., Lawtrakul, L., Pungpo, P., Wolschann, P. 3D-Quantitative Structure-Activity Relationships of HEPT Derivatives as HIV-1 Reverse Transcriptase Inhibitors, Based on Ab Initio Calculations (2001) Journal of Chemical Information and Computer Sciences, 41 (3), pp. 848-855. Ecker, G., Kalchhauser, H., Lawtrakul, L., Wolschann, P. Levcromakalim revisited: NMR spectroscopic and theoretical investigations (2001) Monatshefte fur Chemie, 132 (3), pp. 373-386. Klein, C.Th., Lawtrakul, L., Hannongbua, S., Wolschann, P. Accessible charges in structure-activity relationships. A study on HEPT- based HIV-1 RT inhibitors (2000) Scientia Pharmaceutica, 68 (1), pp. 25-40. Lawtrakul, L., Hannongbua, S., Beyer, A., Wolschann, P. Molecular calculations on the conformation of the HIV-1 reverse transcriptase inhibitor 1-((2-Hydroxyethoxy)methyl)-6-(phenylthio)thymine (HEPT) (1999) Monatshefte fur Chemie, 130 (11), pp. 1347-1363. Lawtrakul, L., Hannongbua, S. Quantitative structure-activity relationships of HIV-1 RT inhibitors in the class of 1-[(2-hydroxyethoxy)methyl]-5,6-substituted thymine [HEPT] analogues (1999) Scientia Pharmaceutica, 67 (1), pp. 43-56. Lawtrakul, L., Hannongbua, S., Beyer, A., Wolschann, P. Conformational study of the HIV-1 reverse transcriptase inhibitor 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) (1999) Biological Chemistry, 380 (2), pp. 265-267. Hannongbua, S., Lawtrakul, L., Limtrakul, J. Structure-activity correlation study of HIV-1 inhibitors: Electronic and molecular parameters (1996) Journal of Computer-Aided Molecular Design, 10 (2), pp. 145-152. Hannongbua, S., Lawtrakul, L., Sotriffer, C.A., Rode, B.M. Comparative molecular field analysis of HIV-1 reverse transcriptase inhibitors in the class of 1[2-hyddroxyethoxy)-methyl]-6(phenylthio)thymine (1996) Quantitative Structure-Activity Relationships, 15 (5), pp. 389-394. International Conferences Tuncharoen, S., Boonchokchuay, C., Trakanluechai, P., Lawtrakul, L. “A density functional theory study of the precipition reactions of Hg(II) with sodium sulfide” Pure and Applied Chemistry International Conference 2014 (PACCON2014); January 8-10, 2014; Khon Kaen, Thailand. Atireklap, S., Saejao, C., Weerisrapong, N., Toochinda, P., Lawtrakul, L. “Molecular calculations on inclusion complexes of cyclodextrins with 2-Acetyl-1-Pyrroline” Pure and Applied Chemistry International Conference 2014 (PACCON2014); January 8-10, 2014; Khon Kaen, Thailand. Atireklap, S., Harrison, J., Eiampanidpong, P., Lawtrakul, L. “Molecular modeling investigations of 1, 3, 5-Dihydrotriazine analogues binding to M.Tuberculosis dihydrofolate reductase” Pure and Applied Chemistry International Conference 2014 (PACCON2014); January 8-10, 2014; Khon Kaen, Thailand. Sittikornpaiboon, P., Inthajak, K., Toochinda, P., Tarnchompoo, B., Leartsakulpanich, U., Thongpanchang, C.,Lawtrakul, L. “Molecular modeling investigations of pyrimethamine analogues binding to M.Tuberculosisdihydrofolate reductase” Pure and Applied Chemistry International Conference 2014 (PACCON2014); January 8-10, 2014; Khon Kaen, Thailand. Inthajak, K., Sittikornpaiboon, P., Toochinda, P., Lawtrakul, L. “Molecular docking studies of trimethoprim and cycloguanil analogues binding to M. Tuberculosis dihydrofolate reductase” 2014 Annual Conference on Engineering & Information Technology (ACEAIT 2014); March 28-30, 2014; Tokyo, Japan. Inthajak, K., Toochinda, P., Lawtrakul, L. “Theoretical study on the molecular encapsulation of Thai sweet basil essential oils by β-cyclodextrin” the 17th International Annual Symposium on Computational Science and Engineering (ANSCSE17); March 27-29, 2013; Khon Kaen, Thailand. Sittikornpaiboon, P., Toochinda, P., Lawtrakul, L. “Molecular Modeling Investigations of Inhibitors Binding to M. Tuberculosis Dihydrofolate Reductase” the 17th International Annual Symposium on Computational Science and Engineering (ANSCSE17); March 27-29, 2013; Khon Kaen, Thailand. Roekmongkol, W., Wisarnmetinee, J., Lawtrakul, L. “Molecular Modeling Investigations of Eugenol-Cyclodestrins Inclusion Complexes” Pure and Applied Chemistry International Conference (PACCON2013); January 23-25, 2013; Chon Buri, Thailand. Theawthua, P., Poocharoen, S., Lawtrakul, L. “Theoretical Study of Santalol with β-Cyclodextrin Inclusion Complexes” Pure and Applied Chemistry International Conference (PACCON2013); January 23-25, 2013; Chon Buri, Thailand. Kamolvarin, R., Pisudchaikul, M., Jariyapaktikorn, S. Lawtrakul, L. “Molecular Modeling Investigation 0f Inhibitors Binding To HIV-1 Reverse Transcriptase” Pure and Applied Chemistry International Conference (PACCON2013); January 23-25, 2013; Chon Buri, Thailand. Toochinda, P., Lawtrakul, L. “Theoretical study on the molecular encapsulation of Thai sweet basil essential oils by β-cyclodextrin” The 16th International Cyclodextrins Symposium (ICS16); May 6-10, 2012; Tianjin, P.R. China. Boonyarattanakalin, K., Wolschann, P., Toochinda, P., Lawtrakul, L. “Molecular dynamics simulations of UC781-cyclodextrins inclusion complexes in ethanol-water solution systems” The 16th International Cyclodextrins Symposium (ICS16); May 6-10, 2012; Tianjin, P.R. China. Chingchit, R., Lawtrakul, L. “Nanoencapsulation of antiviral agent by cyclodextrins: molecular modeling approach” Pure and Applied Chemistry International Conference (PACCON2012); January 11-13, 2012; Chiang Mai, Thailand. Sittikornpaiboon, P., Lawtrakul, L. “Prediction of the interaction of M. Tuberculosis dihydrofolate reductase and its antifolates through molecular modeling approach” Pure and Applied Chemistry International Conference (PACCON2012); January 11-13, 2012; Chiang Mai, Thailand. Baingam, L., Lawtrakul, L., Saengsoy, W., Sirisawat, I., Tangtermsirikul, S. “Study on mechanism of magnesium sulfate attack on hardened cementitious systems by using computation methods” Pure and Applied Chemistry International Conference (PACCON2012); January 11-13, 2012; Chiang Mai, Thailand. Sitthikornkul, L., Purpiriyapan, P., Tantisuk, S., Lawtrakul, L. “Encapsulation of Thai basil essential oil by cyclodextrins: Molecular inclusion complexes investigation” Pure and Applied Chemistry International Conference (PACCON2011); January 5-7, 2011; Bangkok, Thailand. Pornthanakasem, W., Leartsakulpanich, U., Kongkasuriyachai, D., Ittarat, W., Boonyarattanakalin, K. S., Lawtrakul, L. “Molecular modeling investigations of inhibitors binding to M. tuberculosis dihydrofolate reductase” Pure and Applied Chemistry International Conference (PACCON2011); January 5-7, 2011; Bangkok, Thailand. Boonyarattanakalin, K. S., Wolschann, P., Lawtrakul, L. “Structural characterization of beta-cyclodextrin in aqueous alcoholic solutions by molecular dynamics simulations” The 15th International Cyclodextrins Symposium (CD 2010); May 9-12, 2010; Vienna, Austria. Boonyarattanakalin, K. S., Wolschann, P., Lawtrakul, L. “Molecular dynamics simulations of beta-cyclodextrin in aqueous solution and in the presence of alcohol” Pure and Applied Chemistry International Conference (PACCON2010); Ubonratchathani, January 21-23, 2010; Ubonratchathani University, Thailand. Boonyarattanakalin, K. S., Klomjitr, A., Phatravinij, D., Krutkhuntode, K., Pimantape, P., Lawtrakul, L. “Molecular modeling of inclusion complexes of non-nucleoside reverse transcriptase inhibitors with beta-cyclodextrin” Pure and Applied Chemistry International Conference (PACCON2010); Ubonratchathani, January 21-23, 2010; Ubonratchathani University, Thailand. Boonyarattanakalin, K. S., Lawtrakul, L. “Theoretical calculations of vibrational spectrum and conformational analysis of bis(2-hydroxyphenyl)methane” Pure and Applied Chemistry International Conference (PACCON2010); Ubonratchathani, January 21-23, 2010; Ubonratchathani University, Thailand. Lawtrakul, L., Wolschann, P., Prakasvudhisarn, C., “Quantitative structure-thermodynamics parameters relationship of beta-cyclodextrin inclusion complexes” Pure and Applied Chemistry International Conference (PACCON2009) pp. 476-479; Phitsanulok, January 14-16, 2009; Naresuan University, Thailand. Lawtrakul, L., Wolschann, P., Prakasvudhisarn, C., “Predicting complexation thermodynamics of β-cyclodextrin with enantiomeric pairs of chiral guests by using swarm intelligence and support vector machines” The 14th International Cyclodextrins Symposium (CD 2008); May 8-11, 2008; pp.421-424, Kyoto, Japan. Opaprakasit, P., Lawtrakul, L. “Intra-molecular hydrogen bonding in calixarene-like structures of phenolic resins: phenolic analogue models” Pure and Applied Chemistry International Conference (PACCON 2008); January 30 - February 1, 2008; pp.675-680, Bangkok, Thailand. Prakasvudhisarn, C., Lawtrakul, L. “Particle swarm optimization in quantitative structure-activity relationship of anti-HIV HEPT analogues” Pure and Applied Chemistry International Conference (PACCON 2008); January 30 - February 1, 2008; pp.98-103, Bangkok, Thailand. Lawtrakul, L. “Molecular dynamics simulations of K103N mutant reverse transcriptase” International Conference on Engineering, Applied Sciences, and Technology (ICEAST 2007), Bangkok, Thailand, November 21- 23, 2007  Sirindhorn International Institute of Technology, Thammasat University, Rangsit Campus : Thammasat-Rangsit Post Office P.O. Box 22, Pathum Thani 12121, Thailand Tel. +66 (0) 2986 9009, 2986 9101, 2564 3221-9 Fax: +66 (0) 2986 9112-3    SIIT at Bangkadi : 131 Moo 5, Tiwanont Road, Bangkadi Muang Pathum Thani 12000, Thailand Tel. +66 (0) 2501 3505-20 Fax: +66 (0) 2501 3524 Website : http://www.siit.tu.ac.th Phone numbers & E - Mail : Click Here The university's 70th anniversary was honoured with a commemorative 10-baht coin. The obverse depicts King Bhumibol Adulyadej as a young man in student ... A photo of Thammasat University - Rangsit Campus Bangkadi Campus thailand DRUG APPROVALS BY DR ANTHONY MELVIN CRASTO .....FOR BLOG HOME CLICK HERE Join me on Linkedin Join me on Facebook FACEBOOK Join me on twitter      Join me on google plus Googleplus  amcrasto@gmail.com