DR ANTHONY MELVIN CRASTO,WorldDrugTracker, helping millions, A 90 % paralysed man in action for you, I am suffering from transverse mylitis and bound to a wheel chair,With death on the horizon, This will not stop me, Gods call only..........
DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai) , INDIA 29Yrs Exp. in the feld of Organic Chemistry,Working for GLENMARK PHARMA at Navi Mumbai, INDIA. Serving chemists around the world. Helping them with websites on Chemistry.Million hits on google, world acclamation from industry, academia, drug authorities for websites, blogs and educational contribution

Monday, 12 October 2015

AMY HAMLIN


 

Amy Hamlin

Senior Scientist at Ash Stevens Inc.



LINKS https://www.facebook.com/amy.hamlin/about
https://www.linkedin.com/pub/amy-hamlin/17/377/627
amy.m.hamlin@gmail.com


Experience

Senior Process Development Scientist

Ash Stevens Inc.
– Present (1 year 5 months)Riverview, MI

Graduate Student Researcher

UC Berkeley
– (4 years 6 months)
Organic Chemistry Graduate Student in Richmond Sarpong's Lab

Graduate Student Instructor

UC Berkeley
– (2 years 10 months)

Laboratory Teaching Assistant

University of Detroit Mercy
– (1 year 8 months)

Undergraduate Researcher

University of Detroit Mercy
– (3 years 4 months)
Undergraduate Researcher in Matthew Mio's Lab.

Undergraduate Research Assistant

University of Illinois at Urbana-Champaign
– (4 months)
Undergraduate in Christina White's Lab.




Publications

Ga(III)-Catalyzed Cycloisomerization Approach to the Diterpenoid Alkaloids: Construction of a Core Structure for the Hetidines and Hetisines(Link)

Angewandte Chemie International Edition
March 2013
Hamlin, A. M.; Cortez, F. de J.; Lapointe, D.; Sarpong, R. "Ga(III)-Catalyzed Cycloisomerization Approach to the Diterpenoid Alkaloids: Construction of a Core Structure for the Hetidines and Hetisines" Angew. Chem. Int. Ed. 2013, 52, 4854-4857.

Synthetic Studies on the Icetexones: Enantioselective Formal Syntheses of Icetexone and epi-Icetexone(Link)

Tetrahedron
April 2013
Cortez, F. de J.; Lapointe, D.; Hamlin, A. M.; Simmons, E. M.; Sarpong, R. "Synthetic Studies on the Icetexones: Enantioselective Formal Syntheses of Icetexone and epi-Icetexone" Tetrahedron 2013, 69, 5665-5676.

Synthetic strategies toward hetidine and hetisine-type diterpenoid alkaloids(Link)

Organic & Biomolecular Chemistry
February 14, 2014
Within the diterpenoid alkaloid family of natural products, the hetidine and hetisine structural types have been the targets of a number of synthetic studies. This review article examines the different disconnections and approaches that have been applied to the synthesis of these natural products to date.

Studies on C20-Diterpenoid Alkaloids: Synthesis of the Hetidine Framework and Its Application to the Synthesis of Dihydronavirine and the Atisine Skeleton(Link)

Journal of Organic Chemistry
July 2014
Hamlin, A, M.; Lapointe, D.; Owens, K.; Sarpong, R. "Studies on C20-Diterpenoid Alkaloids: Synthesis of the Hetidine Framework and Its Application to the Synthesis of Dihydronavirine and the Atisine Skeleton" J. Org. Chem. 2014, ASAP. DOI: 10.1021/jo501214b

Planning Your Path Through Graduate School-How to Start Planning Your Future Career-Now!

inChemistry
April 2014

Undergrad vs. Graduate School: How Do They Compare?

inChemistry
September 2012

Making the Most of Graduate Student Visit Weekends

inChemistry
September 2011

The Teaching Assistant’s Guide to Success

inChemistry
September 2010

Education








College Of Chemistry - UC Berkeley






























 



 
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ROOPA RAI


Roopa Rai

Roopa Rai

Sr. Director, Medicinal Chemistry at Medivation
https://www.linkedin.com/pub/roopa-rai/1/681/578
roopa.rai@medivation.com


Medivation , Inc. 
201 Spear Street 3Rd Floor
San Francisco , California 94105
United States 
Medivation, Inc. is a biopharmaceutical company with small molecule drugs in clinical development to treat three medical needs: Alzheimer’s disease, Huntington’s disease and castration-resistant prostate cancer. The Company has formed separate subsidiaries to hold the product candidates it is developing. The Company’s subsidiary Medivation Neurology, Inc. holds its Dimebon technology, and its subsidiary Medivation Prostate Therapeutics, Inc. holds its MDV300 series technology. 

Experience



Sr. Director, Medicinal Chemistry

Medivation
January 2014 – Present (1 year 10 months)San Francisco Bay Area


Director, Medicinal Chemistry

Medivation
August 2012 – Present (3 years 3 months)San Francisco


Principal Scientist

Celera Genomics
1996 – 2006 (10 years)


Senior Scientist

Axys Pharmaceuticals
1996 – 2002 (6 years)
 




Patents

HETEROCYCLIC COMPOUNDS AND METHODS OF USE

Application number: 20150065519
Abstract: This disclosure provides compounds and methods of using those compounds to treat metabolic disorders and hyperproliferative disorders, including administration of the compounds in conjunction with hormone receptor antagonists.
Type: Application
Filed: August 28, 2014
Issued: March 5, 2015
Inventors: Sarvajit Chakravarty, Roopa Rai, Son Minh Pham, Brahmam Pujala, Ramniwas Jangir, Rambabu Guguloth, Vijay Kumar Sharma

2-(2-HYDROXYBIPHENYL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE DERIVATIVES AS FACTOR VIIA INHIBITORS

Application number: 20140378453
Abstract: The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders, cancer or rheumatoid arthritis. Processes for preparing these inhibitors are also disclosed.
Type: Application
Filed: June 27, 2014
Issued: December 25, 2014
Inventors: Aleksandr KOLESNIKOV, Roopa RAI, William Dvorak SHRADER, Steven M. TORKELSON, Kieron E. WESSON, Wendy B. YOUNG

FACTOR VIIA INHIBITOR

Application number: 20140221667
Abstract: The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders, cancer or rheumatoid arthritis. Processes for preparing these inhibitors are also disclosed.
Type: Application
Filed: April 11, 2014
Issued: August 7, 2014
Assignee: Pharmacyclics, Inc.
Inventors: Daniel A. DICKMAN, Dange Vijay KUMAR, Colin O'BRYAN, Roopa RAI, William Dvorak SHRADER

2-(2-hydroxybiphenyl-3-yl)-1H-Benzoimidazole-5-carboxamidine derivatives as factor VIIA inhibitors

Patent number: 8778625
Abstract: The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders, cancer or rheumatoid arthritis. Processes for preparing these inhibitors are also disclosed.
Type: Grant
Filed: September 7, 2012
Issued: July 15, 2014
Assignee: Pharmacyclics, Inc.
Inventors: Aleksandr Kolesnikov, Roopa Rai, William Dvorak Shrader, Steven M. Torkelson, Kieron E. Wesson, Wendy B. Young

FUSED PYRIMIDINE COMPOUNDS AND USE THEREOF

Application number: 20140179668
Abstract: Fused pyrimidine compounds as kinase inhibitors, such as multi-kinase inhibitors, are provided. Fused pyrimidine compounds as IGF-IR inhibitors are provided. The compounds may be used in a method of treating cancer. Pharmaceutical compositions containing a fused pyrimidine compound and a pharmaceutically acceptable carrier are also provided, as are kits containing a fused pyrimidine compound or salt thereof and instructions for use, e.g., in a method of treating cancer.
Type: Application
Filed: December 26, 2013
Issued: June 26, 2014
Assignee: MEDIVATION TECHNOLOGIES, INC.
Inventors: Sarvajit CHAKRAVARTY, Roopa RAI, Michael John GREEN

Factor VIIa inhibitor

Patent number: 8729117
Abstract: The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders, cancer or rheumatoid arthritis. Processes for preparing these inhibitors are also disclosed.
Type: Grant
Filed: September 20, 2012
Issued: May 20, 2014
Assignee: Pharmacyclics, Inc.
Inventors: Daniel A. Dickman, Dange Vijay Kumar, Colin O'Bryan, Roopa Rai, William Dvorak Shrader

Anti-viral compounds, compositions, and methods of use

Patent number: 8729077
Abstract: Disclosed are compounds, stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, their preparation, use, and compositions thereof for treating an infection mediated at least in part by a virus in the Flaviviridae family of viruses.
Type: Grant
Filed: November 19, 2009
Issued: May 20, 2014
Assignee: GlaxoSmithKline LLC
Inventors: Frank Ulrich Schmitz, Roopa Rai, Christopher Don Roberts, Wieslaw Kazmierski, Richard Grimes

FACTOR VIIA INHIBITOR

Application number: 20140080879
Abstract: The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders, cancer or rheumatoid arthritis. Processes for preparing these inhibitors are also disclosed.
Type: Application
Filed: September 20, 2012
Issued: March 20, 2014
Assignee: PHARMACYCLICS, INC.
Inventors: Daniel A. Dickman, Dange Vijay Kumar, Colin O'Bryan, Roopa Rai, William Dvorak Shrader

2-(2-Hydroxybiphenyl-3-yl)-1H-Benzoimidazole-5-Carboxamidine Derivatives as Factor VIIA Inhibitors

Application number: 20130157298
Abstract: The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders, cancer or rheumatoid arthritis. Processes for preparing these inhibitors are also disclosed.
Type: Application
Filed: September 7, 2012
Issued: June 20, 2013
Assignee: Pharmacyclics, Inc.
Inventors: Aleksandr Kolesnikov, Roopa Rai, William Dvorak Shrader, Steven M. Torkelson, Kieron E. Wesson, Wendy B. Young

Factor VIIa inhibitor

Patent number: 8415328
Abstract: The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders, cancer or rheumatoid arthritis. Processes for preparing these inhibitors are also disclosed.
Type: Grant
Filed: May 3, 2011
Issued: April 9, 2013
Assignee: Pharmacyclics, Inc
Inventors: Daniel A. Dickman, Dange Vijay Kumar, Colin O'Bryan, Roopa Rai, William Dvorak Shrader, Kieron Wesson

2-(2-hydroxybiphenyl-3-yl)-1-benzoimidazole-5-carboxamidine derivatives as factor VIIa inhibitors

Patent number: 8299110
Abstract: The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders, cancer or rheumatoid arthritis. Processes for preparing these inhibitors are also disclosed.
Type: Grant
Filed: May 3, 2011
Issued: October 30, 2012
Assignee: Pharmacyclics, Inc.
Inventors: Aleksandr Kolesnikov, Roopa Rai, William Dvorak Shrader, Steven M. Torkelson, Kieron E. Wesson, Wendy B. Young

2-(2-HYDROXYBIPHENYL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE DERIVATIVES AS FACTOR VIIA INHIBITORS

Application number: 20110269806
Abstract: The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders, cancer or rheumatoid arthritis. Processes for preparing these inhibitors are also disclosed.
Type: Application
Filed: May 3, 2011
Issued: November 3, 2011
Assignee: Pharmacyclics, Inc.
Inventors: Aleksandr Kolesnikov, Roopa Rai, William Dvorak Shrader, Steven M. Torkelson, Kieron E. Wesson, Wendy B. Young

Anti-Viral Compounds, Compositions, And Methods Of Use

Application number: 20110224211
Abstract: Disclosed are compounds, stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, their preparation, use, and compositions thereof for treating an infection mediated at least in part by a virus in the Flaviviridae family of viruses.
Type: Application
Filed: November 19, 2009
Issued: September 15, 2011
Inventors: Frank Ulrich Schmitz, Roopa Rai, Christopher Ron Roberts, Wieslaw Kazmierski, Richard Grimes

FACTOR VIIA INHIBITOR

Application number: 20110207939
Abstract: The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders, cancer or rheumatoid arthritis. Processes for preparing these inhibitors are also disclosed.
Type: Application
Filed: May 3, 2011
Issued: August 25, 2011
Assignee: Pharmacyclics, Inc.
Inventors: Daniel A. Dickman, Dange Vijay Kumar, Colin O'Bryan, Roopa Rai, William Dvorak Shrader, Kieron Wesson

Anti-Viral Compounds, Compositions, And Methods Of Use

Application number: 20110044943
Abstract: Disclosed are compounds of Formula (I), pharmaceutically acceptable salts and solvates thereof, compositions thereof, and methods for their preparation and uses for treating viral infections mediated at least in part by a virus in the Flaviviridae family of viruses.
Type: Application
Filed: July 11, 2008
Issued: February 24, 2011
Inventors: Martin Robert Leivers, Jesse Daniel Keicher, Franz Ulrich Schmitz, Roopa Rai, Ryan Lauchli, Sebastian Reinhard Johannes Liehr, Stephanie Anna Chan, Tony Loc Ton

2-5A ANALOGS AND THEIR METHODS OF USE

Application number: 20100331397
Abstract: Disclosed herein are compounds that activate RNaseL, methods of synthesizing compounds that activate RNaseL and the use of compounds that activate RNaseL for treating and/or ameliorating a disease or a condition, such as a viral infection, a bacterial infection, cancer and/or parasitic disease.
Type: Application
Filed: June 23, 2010
Issued: December 30, 2010
Assignee: ALIOS BIOPHARMA, INC.
Inventors: Leonid Beigelman, Lawrence Blatt, Harri Lönnberg, Roopa Rai, Guangyi Wang, Thomas Horn, Julian Symons, Antitsa Simitrova Stoycheva, Dean Ng, Jerome Deval

Certain Nitrogen Containing Bicyclic Chemical Entities for Treating Viral Infections

Application number: 20100204265
Abstract: Provided are certain chemical entities, pharmaceutical compositions, and methods of treatment of a member of the flaviviradae family of viruses such as hepacivirus (Hepatitis C or HCV).
Type: Application
Filed: February 9, 2009
Issued: August 12, 2010
Inventors: Subramanian Baskaran, Jack Maung, Martin Leon Neitzel, Roopa Rai, Irina Slododov, Vincent W-F Tai

Amido Anti-Viral Compounds, Compositions, And Methods Of Use

Application number: 20100061960
Abstract: Disclosed are compounds, stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, their preparation, use, and compositions thereof for treating an infection mediated at least in part by a virus in the Flaviviridae family of viruses.
Type: Application
Filed: July 16, 2009
Issued: March 11, 2010
Inventors: Franz Ulrich Schmitz, Roopa Rai, Ronald Griffith, Christopher Don Roberts

N-(5-Membered Aromatic Ring)-Amido Anti-Viral Compounds

Application number: 20100004441
Abstract: Disclosed are compounds having Formula (I) and the compositions and methods thereof for treating or preventing a viral infection mediated at least in part by a virus in the Flaviviridae family of viruses, wherein A, R2, m, R, V, W, T, Z, R1, Y, and p are disclosed herein.
Type: Application
Filed: August 20, 2009
Issued: January 7, 2010
Inventors: Franz Ulrich Schmitz, Christopher Don Roberts, Ali Dehghani Mohammad Abadi, Ronald Conrad Griffith, Martin Robert Leivers, Irina Slobodov, Roopa Rai

ANTI-VIRAL INHIBITORS AND METHODS OF USE

Application number: 20090317360
Abstract: Disclosed are compounds and compositions of Formula (I), pharmaceutically acceptable salts and solvates thereof, and their uses for treating viral infections mediated at least in part by a virus in the Flaviviridae family of viruses.
Type: Application
Filed: June 11, 2008
Issued: December 24, 2009
Inventors: Roopa Rai, Franz Ulrich Schmitz, Christopher Don Roberts, Irina Slobodov, Martin Robert Leivers

N-(5-membered aromatic ring)-amido anti-viral compounds

Patent number: 7595398
Abstract: Disclosed are compounds having Formula (I) and the compositions and methods thereof for treating or preventing a viral infection mediated at least in part by a virus in the Flaviviridae family of viruses, wherein A, R2, m, R, V, W, T, Z, R1, Y, and p are disclosed herein.
Type: Grant
Filed: December 12, 2006
Issued: September 29, 2009
Assignee: SmithKline Beecham Corporation
Inventors: Franz Ulrich Schmitz, Christopher Don Roberts, Ali Dehghani Mohammad Abadi, Ronald Conrad Griffith, Martin Robert Leivers, Irina Slobodov, Roopa Rai

ANTI-VIRAL COMPOUNDS, COMPOSITIONS, AND METHODS OF USE

Application number: 20090226398
Abstract: Disclosed are compounds and compositions of Formula (I), pharmaceutically acceptable salts and solvates thereof, and their preparation and uses for treating viral infections mediated at least in part by a virus in the Flaviviridae family of viruses.
Type: Application
Filed: March 3, 2009
Issued: September 10, 2009
Inventors: Martin Robert Leivers, Christopher Don Roberts, Sebastian Johannes Reinhard Liehr, Stephanie Anna Chan, Roopa Rai, Ryan Lauchli, Son Minh Pham, Vivek Kumar Rajwanshi, Tony Loc Ton, Adam Christopher Villa

ANTI-VIRAL COMPOUNDS, COMPOSITIONS, AND METHODS OF USE

Application number: 20090197880
Abstract: Disclosed are compounds of Formula (I), pharmaceutically acceptable salts and solvates thereof, compositions thereof, and methods for their preparation and uses for treating viral infections mediated at least in part by a virus in the Flaviviridae family of viruses.
Type: Application
Filed: January 12, 2009
Issued: August 6, 2009
Inventors: Martin Robert Leivers, Jesse Daniel Keicher, Franz Ulrich Schmitz, Roopa Rai, Ryan Lauchli, Sebastian Reinhard Johannes Liehr, Stephanie Anna Chan, Tony Loc Ton, Son Minh Pham, Adam Christopher Villa

Certain nitrogen containing bicyclic chemical entities for treating viral infections

Application number: 20090176778
Abstract: Provided are certain chemical entities, pharmaceutical compositions, and methods of treatment of a member of the flaviviradae family of viruses such as hepacivirus (Hepatitis C or HCV).
Type: Application
Filed: August 8, 2008
Issued: July 9, 2009
Inventors: Franz Ulrich Schmitz, Vincent W-F Tai, Roopa Rai, Christopher Don Roberts, Ali Dehghani Mohammad Abadi, Subramanian Baskaran, Irina Slobodov, Jack Maung, Martin Leon Neitzel

Anti-viral compounds, compositions, and methods of use

Application number: 20090074717
Abstract: Disclosed are compounds of Formula (I), pharmaceutically acceptable salts and solvates thereof, compositions thereof, and methods for their preparation and uses for treating viral infections mediated at least in part by a virus in the Flaviviridae family of viruses.
Type: Application
Filed: July 11, 2008
Issued: March 19, 2009
Inventors: Martin Robert Leivers, Jesse Daniel Keicher, Franz Ulrich Schmitz, Roopa Rai, Ryan Lauchli, Sebastian Reinhard Johannes Liehr, Stephanie Anna Chan, Tony Loc Ton

2-(2-Hydroxybiphenyl-3-yl)-1H-Benzoimidazole-5-Carboxamidine Derivatives as Factor VIIA Inhibitors

Application number: 20090054432
Abstract: The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders, cancer or rheumatoid arthritis. Processes for preparing these inhibitors are also disclosed.
Type: Application
Filed: October 21, 2008
Issued: February 26, 2009
Assignee: Pharmacylics, Inc. A Delaware Corporation
Inventors: Aleksandr KOLESNIKOV, Roopa Rai, William Dvorak Shrader, Steven M. Torkelson, Kieron E. Wesson, Wendy B. Young

2-(2-hydroxybiphenyl-3-yl)-1H-benzoimidazole-5-carboxamidine derivatives as factor VIIA inhibitors

Patent number: 7479502
Abstract: The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders, cancer or rheumatoid arthritis. Processes for preparing these inhibitors are also disclosed.
Type: Grant
Filed: December 3, 2003
Issued: January 20, 2009
Assignee: Pharmacyclics, Inc.
Inventors: Aleksandr Kolesnikov, Roopa Rai, William Dvorak Shrader, Steven M. Torkelson, Kieron E. Wesson, Wendy B. Young

Factor Viia Inhibitor

Application number: 20080275250
Abstract: The present invention relates to novel inhibitors or Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders, cancer or rheumatoid arthritis. Processes for preparing these inhibitors are also disclosed.
Type: Application
Filed: June 2, 2005
Issued: November 6, 2008
Assignee: PHARMACYCLICS, INC.
Inventors: Daniel A. Dickman, Dange Vijay Kumar, Colin O'Bryan, Roopa Rai, William Dvorak Shrader, Kieron Wesson

Amido Anti-viral Compounds

Application number: 20080181866
Abstract: Disclosed are compounds, stereoisomers, tautomers, pharmaceutically acceptable salts, or prodrugs thereof of having Formula (I), their preparation, use, and compositions thereof for treating an infection mediated at least in part by a virus in the Flaviviridae family of viruses, wherein A, R3, X, V, W, T, Z, R, Y1, and p are as defined herein.
Type: Application
Filed: November 20, 2007
Issued: July 31, 2008
Inventors: Martin Robert Leivers, Franz Ulrich Schmitz, Ronald Conrad Griffith, Christopher Don Roberts, Ali Dehghani Mohammad Abadi, Stephanie Anna Chan, Roopa Rai, Irina Slobodov, Tony Loc Ton

ANTIVIRAL AGENTS

Application number: 20070287699
Abstract: Compounds are provided having utility for the treatment of viral infections, particularly HCV.
Type: Application
Filed: April 30, 2007
Issued: December 13, 2007
Assignee: ViroBay, Inc.
Inventors: Dange Kumar, Roopa Rai, Wendy Young, Huiyong Hu, Jennifer Riggs, Tony Ton, Michael Green, Barry Hart, Kenneth Brameld, Jeffrey Dener

N-(5-MEMBERED AROMATIC RING)-AMIDO ANTI-VIRAL COMPOUNDS

Application number: 20070265265
Abstract: Disclosed are compounds having Formula (I) and the compositions and methods thereof for treating or preventing a viral infection mediated at least in part by a virus in the Flaviviridae family of viruses, wherein A, R2, m, R, V, W, T, Z, R1, Y, and p are disclosed herein.
Type: Application
Filed: December 12, 2006
Issued: November 15, 2007
Inventors: Franz Schmitz, Christopher Roberts, Ali Dehghani Abadi, Ronald Griffith, Martin Leivers, Irina Slobodov, Roopa Rai

Antiviral agents

Application number: 20070032522
Abstract: The present invention is directed to compounds that are antiviral agents. Specifically the compounds of the present invention inhibit replication of HCV and are therefore useful in treating hepatitis C infections. The present invention is also directed to pharmaceutical compositions comprising these compounds and processes for preparing them.
Type: Application
Filed: June 28, 2006
Issued: February 8, 2007
Inventors: Dange Kumar, Roopa Rai

2-(2-Hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors

Application number: 20060205942
Abstract: The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders, cancer or rheumatoid arthritis. Processes for preparing these inhibitors are also disclosed.
Type: Application
Filed: December 3, 2003
Issued: September 14, 2006
Inventors: Aleksandr Kolesnikov, Roopa Rai, William Shrader, Steven Torkelson, Kieron Wesson, Wendy Young

2-[5-(5-carbamimidoyl-1h-heteroaryl)]-6-hydroxybiphenyl-3-yl derivatives as factor viia inhibitors

Application number: 20050203094
Abstract: The present invention provides 2-[5-(5-carbamimidoyl-1H-heteroaryl)]-6-hydroxy-biphenyl-3-yl derivatives of formula (I): I That are Factor VIIa and Xa inhibitors
Type: Application
Filed: February 12, 2003
Issued: September 15, 2005
Inventors: Aleksandr Kolesnikov, Roopa Rai, Dvorak Shrader, Wendy Young

2-[5-(5-Carbamimidoyl-1H-heteroaryl)-6-hydroxybiphenyl-3-YL]-succinic acid derivatives as factor viia inhibitors

Application number: 20050176797
Abstract: The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders. Processes for preparing these inhibitors are also disclosed.
Type: Application
Filed: September 13, 2004
Issued: August 11, 2005
Assignee: AXYS PHARMACEUTICALS, INC.
Inventors: Huiyong Hu, John Hendrix, Aleksandr Kolesnikov, Roopa Rai, William Shrader, David Sperandio, Wendy Young, Steven Torkelson

(Hetero)aryl-bicyclic heteroaryl derivatives, their preparation and their use as protease inhibitors

Patent number: 6867200
Abstract: The present invention provides novel compounds of the Formula (I): A-B, its prodrug forms, or pharmaceutically acceptable salts thereof, wherein A represents a saturated, unsaturated, or a partially unsaturated bicyclic heterocyclic ring structure, and B represents an aryl or a heteroaryl group. Preferred compounds of the present invention comprise a benzimidazole or indole nucleus. The compounds of this invention are inhibitors of serine proteases, Urokinase (uPA), Factor Xa (FXa), and/or Factor VIIa (FVIIa), and have utility as anti cancer agents and/or as anticoagulants for the treatment or prevention of thromboembolic disorders in mammals.
Type: Grant
Filed: December 17, 1999
Issued: March 15, 2005
Assignee: Axys Pharmaceuticals, Inc.
Inventors: Darin A. Allen, Jason M. Hataye, Witold N. Hruzewicz, Aleksandr Kolesnikov, Richard L. Mackman, Roopa Rai, Spencer R. Jeffrey, Erik J. Verner, Wendy B. Young, William Dvorak Shrader

Non-amidine containing protease inhibitors

Application number: 20030225036
Abstract: The present invention provides novel compounds of the Formula (I) its prodrug forms, or pharmaceutically acceptable salts thereof. Preferred (I) compounds of the present invention comprise a pyrrolo pyridinyl, pyrrolo pyrimidinyl or indole nucleus. The compounds of this invention are inhibitors of Factor Xa (FXa), Factor VIIa (FVIIa) and/or serine proteases, Urokinase (uPA), and have utility as anti-coagulants for the treatment or prevention of thromboembolic disorders in mammals and as anticancer agents.
Type: Application
Filed: March 24, 2003
Issued: December 4, 2003
Inventors: Aleksandr Kolesnikov, Roopa Rai

2- [5- (5-carbamimidoyl-1H-heteroaryl)-6-hydroxybiphenyl-3-yl]-succinic acid derivatives as factor viia inhibitors

Application number: 20030114457
Abstract: The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders. Processes for preparing these inhibitors are also disclosed.
Type: Application
Filed: July 3, 2002
Issued: June 19, 2003
Assignee: Axys Pharmaceuticals, Inc.
Inventors: Huiyong Hu, John Hendrix, Aleksandr Kolesnikov, Roopa Rai, William Dvorak Shrader, David Sperandio, Wendy Young, Steve Torkelson
 
/////////////Roopa Rai, Sr. Director, Medicinal Chemistry,  Medivation
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