Dr. Rina Chokshi

Rina Chokshi

Americas Application Manager, Health at FMC Corporation

- Expertise in design and development of solid dosage forms of BCS 2/4 compounds and challenging molecules; knowledgeable about biopharmaceutical challenges and regulatory requirements for BA/BE studies
- Experienced in development of conventional as well as novel dosage forms, including solid dispersions such as Hot-melt Extrusion/ Spray-drying/Co-precipitation as well as controlled release formulations
- Leadership roles in cross-functional global product development team with successful execution of formulation and process development strategies, scale-up, and manufacture of clinical, registration/validation batches 
- Extensive experience on formulation and process optimization at small scale using Quality by Design (QbD) approach and successful technology/ knowledge transfer to commercial facilities.

Specialties:Formulation/Process development, formulation/process optimization with Quality by Design, Process scale- up, formulation development of poorly water soluble drugs (solid dispersion and solid solution)

Dr. Rina Chokshi has over several years of experience in formulation and process development. Rina has worked on the development of conventional as well as novel dosage forms, including solid dispersions such as hot-melt extrusion, spray-drying and co-precipitation as well as controlled release formulations. 

She earned her Ph.D. from the University of Rhode Island in collaboration with Hoffman-La Roche, and went on to work for Wyeth (now Pfizer) on formulation and process optimization using Quality by Design (QbD) approaches

https://www.linkedin.com/in/rinachokshi

Education

University of Rhode Island

Ph.D., Applied Pharmaceutical Science

2001 – 2004

University of Rhode Island

M.S., Applied Pharmaceutical Science

1998 – 2001

University of Mumbai

Bachelor, Pharmacy

1993 – 1997

Experience

Americas Application Manager, Health

FMC Corporation

March 2014 – Present Ewing, NJ

Project leader, Controlled release technology

FMC BioPolymer

August 2010 – Present (4 years 10 months)

Principal Research Scientist

Pfizer

October 2009 – August 2010 (11 months)

Principal Research Scientist

Wyeth Pharmaceuticals

November 2007 – October 2009 (2 years)

- Lead the team for formulation and process development and optimization using Quality by Design (QbD) approach
- Designed and executed formulation and process optimization studies at small scale and successful scale up to commercial manufacturing sites
- Developed formulation and process for bilayer tablets containing immediate release and controlled release granulations
- Successfully coordinated clinical manufacture supplies for phase 2 and phase 3
- Hands on experience in direct compression, roller compaction, fluid bed granulation, fluid bed coating, wet granulation, and hot melt extrusion technology platform

Senior Research Scientist I and II

Wyeth Research

May 2004 – November 2007 (3 years 7 months)

- Lead formulator for developing poorly water soluble drug formulations using various novel technologies
- Lead coordinator for technology transfer, manufacture of clinical batches and manufacture of registration batches and validation batches at commercial facilities
- Responsible for preparing Pharmaceutical development reports for regulatory submission and functioned as lead formulator responsible for drafting response for various agencies such as FDA and EMEA

Research Assitant

Hoffman-La Roche

1999 – 2004 (5 years)

- Conducted M.S. and Ph.D. thesis research in an industrial setting
- Developed and evaluated solid dispersions and solid solutions of poorly water soluble compounds using various techniques such as Hot-melt extrusion, Spray drying, Co-precipitation and Co-evaporation
- Assisted in various Roche projects and contributed to the development of tablet and capsule dosage forms of poorly water soluble drugs

"Evaluation of hot -melt extrusion technology to improve dissolution ... Evaluation of hot -melt extrusion technology to improve dissolution rates of poorly water soluble drugs. Rina Chokshi, University of Rhode Island ... digitalcommons.uri.edu/dissertations/AAI3145415/

Applied Pharmaceutical Sciences Chokshi, Rina and Hossein Zia. "Hit Melt Extrusion Technique: A Review." Journal .... May 2004. Zia, Hossein. SEE also: Chokshi, RIna. Zia, H. " Enhancement of ... www.uri.edu/library/faculty_publications/2004/aps04.html

LISTSERV 16.0 - GRADSCHL Archives ... THE ROAD MARKING LUMINANCE CONTRAST AND VARIABLE MESSAGE SIGNSRina Chokshi - PhD Applied Pharmaceutical Sciences - Thursday, May 6  ... listserv.uri.edu/cgi-bin/wa?A2=ind0405&L...F=&S...

Biomedical & Pharmaceutical Sciences - University of Rhode Island Chokshi, Rina J., Harpareet Sandhu, Raman M. Iyer, Navnit H. Shaw, A. Waseem Malick and Hossein Zia. "Characterization of Physico-Mechanical Properties of ... www.uri.edu/library/faculty_publications/2005/bms05.html

University Libraries > URI Faculty Publications > 2007> Biomedical ... Chokshi, Rina J., Hossein Zia, Harpreet K. Sandhu, Navnit H. Shah and Waseem A. Malick. "Improving the Dissolution Ration of Poorly Water Soluble Drug by ... www.uri.edu/library/faculty_publications/2007/bms07.html

Nasser H. Zawia, Ph.D. File Format: PDF/Adobe Acrobat Rina Chokshi, 2001. MEMBER OF PhD COMMITTEE FOR. Sherrie Singleton (98 -99'). Eileen Brantley (99'). Crystal Saunders (00'). Karmardi Mills (98'). www.uri.edu/facsen/CV_N_Zawia.pdf

Biomedical & Pharmaceutical Sciences - University of Rhode Island Chokshi, Rina J., Hossein Zia, Harpreet K. Sandhu, Navnit H. Shah and Waseem A. Malick. "Improving the Dissolution Ration of Poorly Water Soluble Drug by ... www.uri.edu/library/faculty_publications/2007/bps07.html

Browse by Author | DigitalCommons@URI | University of Rhode ... Chokshi, Rina (Docs: 1). Choma, Joshua R (Docs: 1). Chong, Wong (Docs: 1). Chopy, Katelyn (Docs: 2). Chou, Dienfang (Docs: 1). Choudhury, Arpita (Docs: 1). digitalcommons.uri.edu/authors.html

Dissertations and Master's Theses (Campus Access) | University of ... Shaw, Reena L (2005) Enforcement and compliance in the Northeast groundfish ... Chokshi,Rina (2004) Evaluation of hot -melt extrusion technology to improve ... digitalcommons.uri.edu/dissertations/

Biomedical & Pharmaceutical Sciences Chockshi, Rina J., Navnit A. Shah, Harpreet K. Sandhu, Ahmad W. Malick ... Dong, Zedong, Ashish Chatterji, Harpreet Sandhu, Duk Soon Choi, HiteshChokshi ... www.uri.edu/library/faculty_publications/2008/bps.08.html

University of Rhode Island , usa

1. The University of Rhode Island is the principal public research as well as the land grant and sea grant university for the state of Rhode Island. Its main campus is located in the village of Kingston in southern Rhode Island. Wikipedia
3. Address: 45 Upper College Rd, Kingston, RI 02881, United States

University of Rhode Island. Bay Campus. North Kingstown, Rhode Island.