.

Murugan Kaliyappan

Research scientist at Yung Shin pharamaceutical group

 

Dr. K. Murugan, M.Sc., Ph.D  

Research Scientist                                                                                                                                  

Generics R&D, Yung Zip Chemical                                                                                                        

Dajia, Taichung, Taiwan-43767                                                                           

( +886-919575034;  
EMAIL * muruganjk5@gmail.com

Links

 https://tw.linkedin.com/in/murugan-kaliyappan-70605182

 https://www.facebook.com/sai.murugan.5

• Postdoctoral Researcher at National Taiwan University, Taipei

  Past: National Dong Hwa University
• 
  

  Studied at Bharathidasan University

  Past: G H High School
• 
  

  Lives in Taipei, Taiwan

  From Dharmapuri

Founded in 1978, Yung Zip Chemical is located in Youth Industrial Park, Tachia, Taichung. Yung Zip Chemical specializes in the production and sales of API ...

 

 

Experience

Research Scientist

yung shin pharmaceuticals group

October 2014 – Present (1 year 9 months)Taichung City, Taiwan

Postdoctoral fellow

National Taiwan University

August 2011 – July 2014 (3 years)Taiwan

Senior Research Scientist

Sanmar Group

October 2006 – August 2007 (11 months)Chennai Area, India

Process development
medicinal chemistry research

Junior Research Scientist

Malladi Drugs and Pharmaceuticals Limited

July 2004 – September 2006 (2 years 3 months)

Education

National Dong Hwa University

Doctor of Philosophy (Ph.D.), Organic Chemistry

2007 – 2011

 HIS CV CUT PASTED

Dr. K. Murugan, M.Sc., Ph.D  

Research Scientist                                                                                                                                                  

Generics R&D, Yung Zip Chemical                                                                                                        

Dajia, Taichung, Taiwan-43767                                                                           

( +886-0919575034;  * muruganjk5@gmail.com

Current position

Research Scientist at Yung Zip Chemical (Yung Shin Pharma Group), Taiwan. (Oct. 2014 – present):

Academic and Industrial experience

National Taiwan University, Dept. of Chemistry and School of Pharmacy, Taiwan (Aug. 2011 – Jul. 2014)	Postdoc. Research Fellow (Prof. Ya-Ching Shen Lab)
Sanmar Speciality Chemicals Ltd, Chennai (Oct. 2006 – Aug. 2007)	Senior Research Officer
Malladi Drugs & Pharmaceuticals Ltd, Chennai (Jul. 2004 – Sep. 2006)	Junior Scientist
IIT Madras, Chennai (Jan. 2004 – Jul. 2004)	Research Fellow,    Industrial Project (Prof. B.Viswantahn)

Academic Profile

§  Ph.D Organic Chemistry, (Advisor: Prof. Chinpiao Chen), National Dong Hwa University, Taiwan (Sep.2007-Aug-2011)

§  MSc Chemistry (first class), St. Joseph College, Bharathidasan University, Tamilnadu, India (2001− 2003).

§  BSc Chemistry (first class),  Govt. Arts College, Dharmapuri, Madras University, Tamilnadu, India (1996−1999).

Key achievements

Yung Zip Chemical:

§  Activities includes synthetic route selection, process optimization, costing, in-process controls and complete specification generation, lab validation.

§  Non-infringing selection of process, and polymorph identification (innovator).

§  Impurities identification (process-related, KSM carry-over) for the related substances of final API and their synthetic route selection.

§  Cross functional team interactions with analytical R&D, IP, engineering, etc. at different stages of project.

§  Non-infringing routes, impurity synthesis, and process optimization of the following API molecules:

§  Non-infringing routes, impurity synthesis, process optimization and lab validation of the following API molecules:

Sanmar Specialities Chemicals Ltd.:

§  CRO work and custom synthesis for Pfizer, Merck, BMS and Asinex Moscow.

§  Preparation of library molecules and API intermediates and delivery of 1 g to   100 g samples.

Malladi Drugs & Pharmaceuticals Ltd.:

§  Process optimization, impurity synthesis, validation and scale-up to plant level for the following API molecules and Intermediates:

Postdoctoral Research:

§  Development of organocatalytic reactions for synthesis of a key precursor to DMP 777, a leukocyte elastase inhibitor.

§  Organocatalytic-mediated synthesis of model core of Atorvastatin from enamide starting material.

§  Synthesis of carbozolyl-3,4-dihydro-β-carboline analogues as potential antitumor agents.

§  Semisynthesis of Ambrox (terpenoid) from naturally occurring starting material.

Academic output

 

Research Papers:

1.      Sankareswaran, Srimurugan, Kaliyappan Murugan, Chinpiao Chen* A facile method for preparation of 2 [ H3]-Sufentanil and its metabolites, Chem. Pharm. Bull. 57(12) 1421-1424 (2009).

2.      Kaliyappan Murugan,Sankareswaran Srimurugan and Chinpiao Chen* A mild, catalytic and efficient Nazarov cyclization mediated by phosphomolybdicacid, Chem. Commun., 2010, 46, 1127–1129.

3.      Kaliyappan Murugan, Sankareswaran Srimurugan, Chinpiao Chen* Silicomolybdicacid supported on silica-gel: An efficient catalyst for Hosomi-Sakurai allylation reactions. Tetrahedron 2011, 67, 5621.

4.      Kaliyappan Murugan,Chinpiao Chen* HClO4-supported on silica gel: a mild and efficient catalyst for Hosomi-Sakurai reaction, Tetrahedron Lett. 2011, 52, 5827-5830.

5.      Sankareswaran Srimurugan, Chi-Ju Su, Hun-Chi Shu, Kaliyappan Murugan, Chinpiao Chen* A facile and improved synthesis of desomorphine and its deuterium labeled analogue, MonatshChem. 2012, 143, 171-174.

6.      Kaliyappan Murugan, Da-wei Huang, Yu-Ting Chien, Shiuh-Tzung Liu* An efficient preparation of Nacetylenamides catalyzed by Ru(II) complexes, Tetrahedron 2013, 69, 268-273.

7.      Kaliyappan Murugan, Shiuh-Tzung Liu* Preparation of substituted pyrroles via Ru(II)-catalyzed coupling of alkynes with enamides, Tetrahedron Lett. 2013, 54, 2608-2611.

8.      Chun-RuYang, Wei-Siang Liaob, Ya-Hui Wu, Kaliyappan Murugan, Chinpiao Chen*, Jui-I Chao* CR108, a novel vitamin K₃ derivative induces apoptosis and breast tumor inhibition by reactive oxygen species and mitochondrial dysfunction, Toxicology and Applied Pharmacology, 2013, 273, 611–622.

9.      Atul Chaskar* Kaliyappan Murugan* Direct Allylation of Alcohols using allyltrimethyl-silane: A Move Towards Economical and Ecological Protocol for C-C Bond Formation, (Review) Catalysis Science & Technology, 2014, 4, 1852-1868.

10.  Hanuman P. Kalmode,  Kamlesh S. Vadagaonkar  Kaliyappan Murugan* and   Atul C. Chaskar* A multicomponent pathway-inspired regioselective synthesis of 2,3,4-trisubstit -uted 1H-pyrroles via [3+2] cycloaddition reaction, New J. Chem, 2015, 39, 4631-4639.

Academic Scholarships/Fellowships Received:

§  NSC post-doctoral fellowship, Taiwan, 2011-2014.

§  Taiwan scholarship for PhD from National Science Council (NSC)  Taiwan, 2007- 2010.

§  TITAN Merit Scholarship for MSc from Titan India Ltd. from 2001-2003.

Personal Information

 

         Name               :           K. Murugan

         Gender             :           Male

         Gender             :           May, 5, 1978

         Marital status   :           Married

         Nationality       :           Indian

         Languages        :           English, Tamil, Chinese (elementary level)

References:

            Professor Chinpiao Chen

            Department of Chemistry

             National Dong Hwa University, Hualien-974, Taiwan

            Email: chinpiao@mail.ndhu.edu.tw Ph: +886-3-8633597      

            Professor Ya-Ching Chen

            School of pharmacy, National Taiwan University Medical college

            No.1, Sec.1, Jen-Ai Road, Taipei, Taiwan.

            Email: ycshen@ntu.edu.tw Ph: +886-2-33668774      

            Professor B.Viswanathan

            Department of Chemistry,

            Indian Institute of Technology Madras, Chennai, India-600036.

            Email: bvnathan@iitm.ac.in Ph: +9144- 22574241.

In 1978, initially Yung Zip Chemical was founded for manufacturing and supplying the active pharmaceutical ingredients (APIs) to Yung Shin Pharma. (one of the leading pharmaceutical industries in Taiwan). Through years' researching and improving, Yung Zip Chemical had laid the groundwork for the technology and quality, also started expanding its business scope, Yung Zip started serving and supplying the APIs to other domestic pharmaceutical industries, and earned a foremost position in bulk pharmaceutical chemical industry in Taiwan. It was an important foundation for Yung Zip to step into international market and become an international company. In 2001, Yung Zip Chemical had been inspected, approved by US FDA and ensured our excellent quality, allowing our products to market in US, Europe and other industrialization countries. In order to offer our qualified products worldwide and serving our international customers, extensive marketing-networks were set up and the Drug Master Files for most Active Pharmaceutical Ingredients are prepared and offered to satisfy our customer's information requirement. With the foundation in Taiwan, Yung Zip Chemical has a brilliant achievement in world market and aims to be the top APIs manufacturer in the world.

For the past few years, the opto-electrical industries are rising and flourishing in Taiwan, the material supplying is unable to meet the demand. Base on our technology in fine chemicals, Yung Zip started researching and developing the special chemicals for opto-electrical industries in order to satisfy the market demand and solve the situation. We are successful in R&D the OPC drums materials and become the main supplier in Taiwan, products also market in Korea, China and etc. Yung Zip chemical is enthusiastic in this domain, also R&D the liquid crystal materials, we not only want to satisfy Taiwan market, but also the world market. It is our ambition to become the world-class manufacturer of APIs and opto-electrical chemical materials.

Technical Collaboration

R&D Department Sung, Che-Ming Manager TEL:+886-4-26811344 FAX:+886-4-26820920 E-mail:yzcrd@yungshingroup.com

	Yung Zip Chemical manufactures and markets qualify quality Active Pharmaceutical Ingredients products, such as anti-viral, anti-inflammatory, analgesic, anti-fungal, anti-cancer and etc. We always R&D new APIs without end to satisfy our customer's requirement and more choice.
	Product DOH Taiwan US FDA Other Countries Acyclovir                           *FDA 036596 19948 95111 Canada 20050831-33-A-74-02 Korea 217MF10872 Japan Cefaclor 044799 　 　 　 Cephalexin 034027 　 　 　 Clonidine Hydrochloride 22873 　 　 　 Clopidogrel Bisulfate 　 22280 　 　 Curcumin 　 　 　 　 Deferasirox 　 　 　 　 Diclofenac Acid 　 　 　 　 Diclofenac Diethylamine 　 　 　 　 Diclofenac Epolamine 　 　 　 　 Diclofenac Potassium         *FDA 38298 10831 　 　 Diclofenac Sodium             *FDA 22090 6981 97/31308 Australia 225 Belgium 94131 Canada 95-012 France 770 Greece IS-74 Iceland 11140002 Ireland 819812741 Italy 0035 Netherlands 95/03204-001 Norway 015:166 Singapore DS/195/98 Spain 5154401 Switzerland 11263-A4745 UK 20071228-80-D-16-03 Korea 218MF10677 Japan Docetaxel 　 　 　 　 Econazole Nitrate 23124 11140 　 　 Famotidine 047598 　 　 　 Felodipine 　 　 　 　 Lovastatin                          *FDA 042724 14049 　 　 Meclofenamate Sodium 038157 　 　 　 Meclofenamic Acid 　 　 　 　 Mefenamic Acid 22087 5677 9154 Canada 98-041 France 246 Greece 11140001 Ireland 11263-A0854 UK 2003-DMF-43 Cyprus TT60-664-18-1 New Zealand 217-MF10873 Japan Meloxicam 049938 　 　 　 Metaxalone 047595 　 　 　 Metoprolol Succinate 　 　 　 　 Miconazole Base 　 　 　 　 Miconazole Nitrate             *FDA 22089 6982 9363 Canada 217-MF10874 Japan Modafinil 048090 　 　 　 Olanzapine 　 　 　 　 Paclitaxel (Extraction) 044779 15319 　 　 Paclitaxel  42226 　 　 　 Quetiapine Fumarate 　 　 　 　 Sodium Starch Glycolate 　 7247 　 　 Valacyclovir Hydrochloride 　 　 　 　 *FDA Accepted

 

 ung Zip Chemical would like to further strengthen their R&D abilities, integrate the laboratory's achievement with actually mass-produce in produce line and hope our new products could successful enter the market as soon as possible, so Yung Zip invests such amount to make replacements of facilities and upgrade the equipments, enable us to appear our R&D's achievements, that's the reasons why we strengthen our pilot plant.

Science and technology is changing with each passing day, cease making progress is equal to

do less well than before, due to the R&D news products influences the life and death ofa company, we are enthusiastic to enhance our R&D and employ many professional persons to enter our R&D teams. The increasing of new facilities and upgrading equipments of pilot plant is the foundation for Yung Zip to expand its business scope in photoelectron domain, also combines with modernized management, Yung Zip has a strong background forward to its brightness future.

 



 Dajia, Taichung


 

 

 



 


 

 
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