Dr. Santosh J. Gharpure
Associate professor,
Department of Chemistry,
Indian Institute of Bombay,
Powai, Mumbai-400076.
Work Tel: (022) 2576 7171
Home Tel: (022) 2576 817
E-mail: sjgharpure@iitb.ac.in
sjgharpure[at]chem.iitb.ac.in
sjgharpure[at]iitb.ac.in
Dr. Santosh J. Gharpure graduated with an M.Sc. degree in 1996, from
Indian Institute of Technology Bombay, Powai. He obtained Ph.D. from
Indian Institute of Science, Bangalore working with Late Prof. A.
Srikrishna in 2001. He held a post-doctoral position with Prof. P.
Andrew Evans at Indiana University, Bloomington, U.S.A. Subsequently; he
joined the Department of Chemistry, IIT Madras, Chennai in the year
2004. In 2012, he moved to Department of Chemistry, IIT Bombay, Powai,
Mumbai as an associate professor. His research focuses on organic
chemistry pertaining to natural and unnatural product synthesis and
developing new synthetic methodologies.
Dr. Gharpure is a recipient of INSA Medal for Young Scientist. He was
awarded IIT Madras Young Faculty Recognition Award (YFRA) for his
contribution in teaching and research in 2010. He received B. M. Birla
science Prize in Chemistry for the year 2011. Recently, he was selected
as one of the Thieme Chemistry Journal Awardees for the year 2013.
Our broad areas of Research Interests include :
- Organic synthesis
- New synthetic methods
- Asymmetric synthesis
- Natural product synthesis
- Catalysis
- Organometallic chemistry
Education :
View
CV in pdf form :
| Degree |
University/Institute |
Year |
| Ph.D |
IISc, Bangalore (Ph.D.
in Synthetic Organic Chemistry with Professor A. Srikrishna,
"Enantiospecific Approaches to Neopupukeananes") |
Aug 1996 - July 2001 |
| | |
| M.Sc. |
IIT Bombay, (M.Sc. in
Organic Chemistry, M.Sc. Project with Professor S. V. Bhat, "Synthesis
and Evaluation of Biological Activity of Polyenes") |
July 1994 - April 1996 |
| | |
| B.Sc. |
V. G. Vaze College, University of Bombay, Mumbai |
July 1989 - June 1994 |
| | |
Professional Experience :
| Employment |
University/Institute |
Year |
| Post-Doctoral Fellow with Professor P. Andrew Evans |
Dept. of Chemistry, Indiana University, Bloomington |
Aug 2001 - April 2004 |
| | |
| Assistant Professor |
IIT Madras |
May 2004 - July 2012 |
| | |
| Associate Professor |
IIT Bombay |
July 2012 - present |
| | |
Honors and Awards :
|
| KET's V. G. Vaze Alumni Achievers Award, January 2013. |
|
| Selection as one of the Thieme Chemistry Journal Awardees 2013, December 2012. |
|
| B.M. Birla Science Prize in Chemistry, November 2012. |
|
| Awarded Young Faculty Recognition Award (YFRA) by IIT Madras, Chennai, September 2010. |
|
| Awarded INSA Medal for Young Scientist by Indian National Science Academy, New Delhi, India, April 2008. |
|
| Junior and Senior Research Fellow of Council for Scientific and Industrial Research, New Delhi, India, Aug. 1996-July 2001. |
|
| Qualified Graduate Aptitude Test in Engineering, All India Rank-1, March 1996. |
|
| Winner of the Gold Medal at the Chemistry Aptitude Test held by the Indian Chemical Society, March 1995. |
|
| 17th Rank in the Merit List of the S.S.C. Board Examination Held by Maharashtra Board, July 1989. |
|
|
|
Memberships :
|
| Chemical Research Society of India (CRSI) |
| American Chemical Society (ACS) |
| Indian Association of Chemistry Teachers (IACT) |
|
|
 |
|
Research :
In the broad area of Organic Chemistry, the main focus of Prof.
Gharpure's research has been the development of new synthentic methods,
which would be applicable for the synthesis of natural and unnatural
products of biological relevance.
Synthetic Methodology :
We have used vinylogous functional groups, namely vinylogous carbonate
and carbamate, in the stereoselective synthesis of oxa- and aza-cycles.
The reactivity of vinylogous carbonates/carbamates was studied under a
variety of conditions. Thus, our group has used radical cyclisation to
vinylogous carbonates/carbamates for the stereoselective synthesis of
new oxa-cages as well as angular oxa- and aza-triquinanes. An efficient
strategy for the synthesis of tetrahydrofurans (THFs), tetrahydropyrans
(THPs) and oxepane derivatives has been developed employing a tandem
SN2-Michael addition to vinylogous carbonates. On the other hand,
intramolecular cyclopropanation of vinylogous carbonates/carbamates
using carbenes led to the oxygen and nitrogen bearing donor-acceptor
substituted cyclopropanes (DACs). These DACs could be converted into
diversely functionalized THFs, THPs, lactones, pyrrolidine, piperidine
and lactam derivatives, which is again explored for the total synthesis
of bioactive molecules such as butanolide and butenolide based natural
products.Vinylogous carbonates/carbamates were also found to give useful
reactions in the presence of Lewis acids undergoing intramolecular
Pictet-Spengler as well as Prins type cyclizations leading to N-fused
oxazinoindoles, dihydrobenzofurans and dihydroindole derivatives.
Natural Product Synthesis :
Apart from using vinylogous functional groups in the synthesis of oxa-
and aza-cycles, our group has developed efficient strategies for the
synthesis of flavans and isoflavans. Flavans and isoflavans are class of
compounds, which are thought to be responsible for biological activity
of traditional Chinese medicines. The strategy relying on o-quinone
methides has been used for the total synthesis of variety of natural
products of this family like equol, 3'-hydroxyequol, vestitol and
myristinins.
Very recently, we have also developed stereoselective strategies for
construction of morpholines and oxazepenes, which are important
pharmacophores.This method also used for the total synthesis of chelonin
A and Chelonin C.
Research Highlights :
- "Shortest Route to Mucocin", C & E News2003, 81(49), 32.
- "Synthesis of Heterocyclic Triquinanes via Sequential Radical
Cyclizations", Victor Snieckus and Nathan E. Genung (Pfizer),
Synfacts2013, 9, 33.
- "Young Career Focus: Dr. Santosh J. Gharpure (Indian Institute of
Technology Bombay, Mumbai, India)", Synstories, SYNFORM, 2014/03,
Published online: 17.02.2014, DOI: 10.1055/s-0033-1340792.
Publications :
48. Counter Ion Dependent Alkyne Iminium Ion Cyclization for
Divergent Synthesis of N-Fused Indolylidine, Indole and Indoline
Derivatives Promoted by the Lewis/Bronsted Acid.
S. J. Gharpure, Y. G. Shelke and D. P. Kumar, Org. Lett. accepted.
47. Stereoselective Synthesis of cis-2,6-DisubstitutedMorpholines and
1,4-Oxathianes by Intramolecular Reductive Etherification of
1,5-Diketones.
S. J.Gharpure, D. Anuradha, J. V. K Prasad, and P. S. Rao, Eur. J. Org. Chem., 2015, 86-90.
46.Donor-Acceptor Substituted Cyclopropane to Butanolide and
Butenolide Natural Products: Enantiospecific First Total Synthesis of
(+)-Hydroxyancepsenolide.
S. J. Gharpure, Laxmi Narayan Nanda and M. K. Sukla, Org. Lett.2014,16, 6424?6427.
45.On the Photophysics of ButadiyneBridged Pyrene-Phenyl Molecular
Conjugates: Multiple Emissive Pathways Through Locally Excited,
Intramolecular Charge Transfer and ExcimerStates.
A. K.Pati,
S. J. Gharpure and A. K. Mishra,Faraday Discuss.2014.(Invited)
44.Synthesis of IsochromeneDerivatives using an Intramolecular
Benzylic C(sp3)-C(sp2) Bond Forming Heck Reaction on Vinylogous
Carbonates.
S.J. Gharpure ,Yogesh, G. Shelke and S.R.B. Reddy,RSC Adv.,2014, 4, 46962-46965.
43. Stereoselective Synthesis of C-fused Pyranoindoles,
Pyranobenzofurans and PyranobenzothiopheneScaffolds using
Oxa-Pictet-Spengler Type Teaction of Vinylogous Carbonates.
S. J. Gharpure and V. Prasath,Org. Biomol. Chem., 2014,12, 7397-7409.
42.Substituted DiphenylButadiynes: a Computational Study of Geometries and Electronic Transitions using DFT/TD-DFT.
A. K.Pati,
S. J. Gharpure and A. K. Mishra, Phys. Chem. Chem. Phys.,2014, 16, 14015-14028.
41.Tandem Nucleophilic Addition/Oxa-Michael Reaction for the Synthesis of cis-2,6-DisubstitutedTetrahydropyrans.
S. J. Gharpure, J. V. K. Prasad and KalisankarBera,Eur. J. Org. Chem., 2014,3570-3574.
40. Stereoselective Synthesis of Oxa-Bowls by Nucleophilic Addition
to Oxonium Ions: Observation of Nucleophile-Dependent Hydride Migration.
S. J. Gharpure and S. K. Porwal, Eur. J. Org. Chem., 2013, 7277-7281.
39. Coordination Polymers via Self-assembly of Silver(I) and cis-Bisnitrile-oxa-bowl Derivatives.
P. Niranjana, A. Pati, S. K. Porwal, V. Ramkumar,
S. J. Gharpure and D. K. Chand, CrystEngComm.,2013.15, 9623-9633.
38. Hetero Diels-Alder Reaction of Olefin with o-Quinone Methides
Generated Using (±) Binolphosphoric Acid for the Stereoselective
Synthesis of 2,4-Diarylbenzopyrans: Application to the Formal Synthesis
of Myristinin B/C.
S. J. Gharpure, A. M. Sathiyanarayananand P. K. Vuram, RSC Adv., 2013,3, 18279-18282.
37. Deciphering the Photophysical Role of Conjugated Diyne in
Butadiynyl Fluorophores: Synthesis, Photophysical and Theoretical Study.
A. K. Pati, M. Mohapatra, P. Ghosh,
S. J. Gharpure and A. K. Mishra, Phys. Chem. A.,2013, 117, 6548-6560.
36. Stereoselective synthesis of benzoxepines using tandem alkylation-Michael addition to vinylogous carbonates.
S. J. Gharpure and S. R. B. Reddy, Eur. J. Org. Chem., 2013, 2031-2038.
35. Stereoselective Synthesis of Substituted 1,4-Oxazepanes by Intramolecular Reductive Etherification.
S. J. Gharpure and J. V. K. Prasad, Eur. J. Org. Chem., 2013, 2076-2079.
34. Synthesis of Oxa-, Aza- and Thia-Bowls and Cages.
S. J. Gharpure and S. K. Powal, Org. Prep. Proc. Int., 2013, 45, 81. (Invited review).
33. Stereoselective Synthesis of Oxa- and Aza-Angular Triquinanes
Using Tandem Radical Cyclization to Vinylogous Carbonates and
Carbamates.
S. J. Gharpure, P. Niranjana and S. K. Powal, Org. Lett., 2012, 14, 5476.
(Highlighted in Synfacts, 2013, 9(1), 0033).
32. Stereoselective Synthesis and Applications of Nitrogen
Substituted Donor-Acceptor Cyclopropanes (N-DACs) in the Divergent
Synthesis of Azacycles.
S. J. Gharpure, U. Vijayasree and S. R. B. Reddy, Org. Biomol. Chem., 2012, 10, 1735.
31. Stereoselective Synthesis of C-Substituted Morpholine Derivatives
using Reductive Etherification Reaction: Total Synthesis of Chelonin C.
S. J. Gharpure and J. V. K. Prasad, J. Org. Chem., 2011, 76, 10325 .
30. Enantioselective Total Synthesis of (+)-Hagen's Gland Lactones.
S. J. Gharpure, L. N. Nanda, and M. K. Shukla, Eur. J. Org. Chem., 2011, 6632.
(Among the top 10 most downloaded paper for October 2011).
29. Stereoselective Synthesis of 2,3-Disubstituted Dihydrobenzofuran using Alkyne Prins Type Cyclization to Vinylogous Carbonates.
S. J. Gharpure, V. Prasath, J. Chem. Sci., 2011, 123, 943.
(invited article - International Year of Chemistry) .
28. Stereoselective synthesis of oxazino[4,3-a]indoles employing
oxa-Pictet-Spengler reaction of indoles bearing N-tethered vinylogous
carbonate.
S. J. Gharpure, A. M. Sathiyanarayanan, Chem. Commun., 2011, 47, 3625.
27. Alkyl radical cyclization to vinylogous carbonates for the
stereoselective synthesis of unsymmetrical dioxa-cage compounds: Effect
of conformation on the rate of cyclization v/s reduction.
S. J. Gharpure, S. K. Porwal, Tetrahedron, 2011, 67, 1216 .
26. Tandem SN2-Michael Addition to Vinylogous Carbonates for the
Stereoselective Construction of 2,3,3,5-Tetrasubstituted
Tetrahydrofurans.
S. J. Gharpure, S. R. B. Reddy, Tetrahedron Lett., 2010, 51, 6093.
25. Tandem Radical Cyclization Based Strategy for the Synthesis of Oxa- and Aza-Cages: A Case of Fragmentation v/s Cyclization.
S. J. Gharpure, S. K. Porwal, Tetrahedron Lett., 2010, 51, 3324 .
24. Stereoselective Synthesis of Donor-Acceptor Substituted
Cyclopropafuranones by Intramolecular Cyclopropanation of Vinylogous
Carbonates: Divergent Synthesis of Tetrahydrofuran-3-one,
Tetrahydropyran-3-one and Lactones.
S. J. Gharpure, M. K. Shukla, U. Vijayasree Org. Lett., 2009, 11, 5466.
23. Topologically Driven Tandem Radical Cyclization Based Strategy for the Synthesis of Oxa and Aza-Cages.
S. J. Gharpure, S. K. Porwal, Tetrahedron Lett., 2009, 50, 7162 .
22. Tandem Alkylation-Michael Addition to Vinylogous Carbonates for
the Stereoselective Construction of 2,3,3,6-Tetrasubstituted
Tetrahydropyrans.
S. J. Gharpure, S. R. B. Reddy, Org. Lett., 2009, 11, 2519.
21. o-Quinone Methide Based Approach to Isoflavans: Application to the Total Syntheses of Equol, 3'-Hydroxyequol and Vestitol.
S. J. Gharpure, A. M. Sathiyanarayanan, P. Jonnalagadda, Tetrahedron Lett., 2008, 49, 2974.
20. Stereoselective Synthesis of New Oxa-Cages via Alkyl Radical Cyclization to Vinylogous Carbonates.
S. J. Gharpure, S. K. Porwal, Synlett, 2008, 242 .
19. Stereoselective Synthesis of 1,2,2-Trisubstituted Indane Derivatives Using Tandem SN2-Michael Addition Sequence.
S. J. Gharpure, S. R. B. Reddy, U. Sanyal, Synlett, 2007, 1889 .
18. An Enantiospecific Strategy to All Four Diastereomers of A-Ring Enyne Synthon of 1 ,25- Dihydroxyvitamin D3.
A. Srikrishna,
S. J. Gharpure, P. P. Kumar, Ind. J. Chem. B 2006, 45B, 2736.
17 An Enantiospecific Synthesis of 2-Pupukeanone.
A. Srikrishna, P. R. Kumar,
S. J. Gharpure, Ind. J. Chem. B 2006, 45B, 1909.
16. A Central Strategy for Converting Natural Products into Fluorescent Probes.
M. D. Alexander, M. D. Burkart, M. S. Leonard, P. Portonovo, B. Liang,
X. Ding, M. M. Joulli, B. M. Gulledge, J. B. Aggen, A. R. Chamberlin, J.
Sandler, W. Fenical, J. Cui,
S. J. Gharpure, A. Polosukhin,
H.-R. Zhang, P. A. Evans, A. D. Richardson, M. K. Harper, C. M. Ireland,
B. G. Vong, T. P. Brady, E. A. Theodorakis, J. J. La Clair, Chem. Bio.
Chem. 2006, 7, 409.
15. Enantiospecific Synthesis of (+)-2-Thiocyanatoneopupukeanane.
A. Srikrishna,
S. J. Gharpure, Proc. of AP Akademi of Sciences 2005, 9, 115.
14. Enantioselective Total Synthesis of the Potent Antitumor Agent
(-)-Mucocin using a Temporary Silicon-Tethered (TST) Ring-Closing
Metathesis (RCM) Cross-Coupling Reaction.
P. A. Evans, J. Cui,
S. J. Gharpure, A. Polosukhin, H. -R. Zhang, J. Am. Chem. Soc. 2003, 125, 14702.
13. Stereoselective Construction of cis-2,6-Disubstituted
Tetrahydropyrans via the Reductive Etherification of ?-Trialkylsilyloxy
Substituted Ketones: Total Synthesis of (-)-Centrolobine.
P. A. Evans, J. Cui,
S. J. Gharpure, Org. Lett. 2003, 5, 3883.
12. Stereoselective Construction of Cyclic Ethers using a Tandem
Two-Component Etherification: Elucidation of the Role of Bismuth
Tribromide.
P. A. Evans, J. Cui,
S. J. Gharpure, R. J. Hinkle, J. Am. Chem. Soc. 2003, 125, 11456.
11. Stereochemistry of the Marine Sesquiterpene 2-Thiocyanatoneopupukeanane: Crystal Structure of Neopupukean-2-yl 4-nitrobenzoate.
A. Srikrishna,
S. J. Gharpure, P. Venugopalan, Ind. J. Chem. B 2003, 42B, 129.
10. Chiral Synthons from Carvone. Part 56. Enantiospecific Synthesis of (-)-4-Thiocyanatoneopupukeanane.
A. Srikrishna,
S. J. Gharpure, ARKIVOC 2002, 7, 52.
9. A Ring Closing Metathesis Based Approach for the Spiroannulation
of Cyclopentanes and Cyclohexanes. Formal Synthesis of (±)-Acorones.
A. Srikrishna, M. S. Rao,
S. J. Gharpure, N. C. Babu, Synlett 2001, 1986.
8. Enantiospecific Synthesis of B-seco-C-Aromatic Taxanes.
A. Srikrishna, T. J. Reddy, P. P. Kumar,
S. J. Gharpure, Ind. J. Chem. B 2001, 40B, 905.
7. Enantiospecific Total Synthesis of (-)-4-Thiocyanatoneopupukeanane.
A. Srikrishna,
S. J. Gharpure, J. Org. Chem. 2001, 66, 4379.
6. An Enantiospecific Synthesis of (-)-2-Pupukeanone via a Rhodium Carbenoid C-H Insertion Reaction.
A. Srikrishna, P. R. Kumar,
S. J. Gharpure, Tetrahedron Lett. 2001, 42, 3929.
5. Novel Formation of Chloromethanesulfinates in the Methanesulfonylation Reaction of Hindered Alcohols.
A. Srikrishna,
S. J. Gharpure, Synlett 2000, 1354.
4. Enantiospecific Total Synthesis of both Enantiomers of 2-Thiocyanatoneopupukeanane from (R)-Carvone.
A. Srikrishna,
S. J. Gharpure, J. Chem. Soc. Perkin Trans. 1 2000, 3191.
3. A Simple, Enantiospecific Approach to both Enantiomers of 1?,25-Dihydroxyvitamin D-3 A-Ring Precursors from (R)-Carvone.
A. Srikrishna,
S. J. Gharpure, P. P. Kumar, Tetrahedron Lett. 2000, 41, 3177.
2. Enantiospecific First Total Synthesis of (-)-4-Thiocyanatoneopupukeanane.
A. Srikrishna,
S. J. Gharpure, Tetrahedron Lett. 1999, 40, 1035.
1. An Intramolecular Rhodium Carbenoid C-H Insertion Approach to
Chiral Isotwistanes. Synthesis of (-)-Neopupukean-4,10-dione and
(-)-Neopupukean-10-one.
A. Srikrishna,
S. J. Gharpure, Chem. Commun. 1998, 1589.
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