Additional Honors & Awards
•National Association of Professional Women (NAPW) Woman of the Year, 2013-2014
•Who’s Who in Science and Engineering, 1998-1999
•Reilly Fellowship, University of Notre Dame, 1997 - 1998
•J. Peter Grace Fellowship, University of Notre Dame, 1996 - 1997
•NASA Undergraduate Fellowship, University of Alabama in Huntsville, 1991 - 1992
•Highest Undergraduate Achievement in the Department of Chemistry, 1992
•Who's Who on National Dean's List, 1988 - 1992
•Honor Scholar, 1988 - 1992
•Granted Scholarship Renewal, 1989 - 1992
•American Institute of Chemist Award, 1991
•Who's Who in American Colleges and Universities, 1990 - 1991
•National Collegiate Natural Sciences Award, 1990 - 1991
•Academic All-American, 1990 - 1991
•Outstanding High School Senior Scholarship, 1988 - 1989
• Member, Omicron Delta Kappa - Leadership Honor Society, 1990 - present
Vice-President, 1991 - 1992
• Member, Alpha Lambda Delta - Freshman Honor Society, 1988 - 1992
Secretary, 1989 - 1990
Patents
· 6-Methoxy-2-Naphthylacetic
Acid Prodrugs, Ekwuribe, N. N.; Riggs-Sauthier, J. A.
o
US
Patent 6,436,990 (Aug. 20, 2002);
o
US
Patent 6,552, 078 (Apr. 22, 2003);
o
US
Patent 6,610,739 (Aug. 26, 2003);
o
US
Patent 6,653,348 (Nov. 25, 2003);
o
US
Patent 6,713,510 (Mar. 30, 2004);
o
US
Patent 6,730,701 (May 4, 2004)
· 5-ASA Derivatives
Having Anti-Inflammatory and Antibiotic Activity and Methods of
Treating Diseases Therewith, Ekwuribe, N.
N.; Riggs-Sauthier, J.A.
US Patent
6,458,776 (Oct. 1, 2002)
·
Immunoregulatory
compounds and Derivatives and Methods of Treating Diseases Therewith,
Ekwuribe, N. N.; Riggs-Sauthier, J.A.
US Patent 6,583,128 (Jun. 24, 2003)
US Patent 7,119,119 (Oct. 10, 2006)
US Patent 7,151,095 (Dec. 19, 2006)
· Methods of
Treating Inflammatory Conditions of the Gastrointestinal Tract Using 4-APAA and
Compositions Thereof, Ekwuribe, N.N.; Riggs-Sauthier,
J. A.
US Patent
6,903,082 (Jun. 7, 2005)
Membrane Process
for Separating Carbohydrates. Smith, B. D.; Riggs, J. A.
US Patent 5,800,624 (Sep. 1, 1998)
PUBS
1. A Role for Novel, Orally Available Mu-Opioid
Agonists with Both Centrally and Peripherally Mediated Analgesia in the
Treatment of Neuropathic Pain. Webster, L.; Gursahani, H.; Ali, C.; Choi, I.;
Riggs, J.; Gogas, K.; Iverson, M.; Medve, R.; Odinecs, A.; Eldon, M.; Evans,
J.; Quach, P.; Trinchero, P.; Hennessey, M.; Harrison, S. 4th
International Congress on Neuropathic Pain. June 2013.
- Absorption
of Polyethylene Glycol (PEG) Polymers: The Effect of PEG Size on
Permeability. Gursahani, H.; Riggs-Sauthier, J.; Pfeiffer, J.;
Lechuga-Ballesteros, D.; Fishburn, S. J.
Pharm. Sci. 2008.
- The
Benefits and Challenges of PEGylating Small Molecules. Riley, T.;
Riggs-Sauthier, J. Pharmaceutical
Technology 2008.
- Combinatorial
Synthesis of PEG Oligomer Libraries. Wang, H.-J.; Dolan, J.; Chen, Z.;
Gregg, B.; Riggs-Sauthier, J. Org. Process Res. Dev, Manuscript
submitted.
- Synthesis
and Efficacy of Novel 5-Aminosalicylic Acid (5-ASA) – Containing Pro-drugs
For the Treatment of Inflammatory Bowel Disease. Bioorg. Med.
Lett., in preparation.
- Synthesis
and Anti-Inflammatory Efficacy of a Series of Novel 6-Naphthylacetic Acid
(6-MNA) Prodrugs. J. Med. Chem, in preparation.
- Convenient
Synthesis of a Water-Soluble,
Discrete PEG Paclitaxel Prodrugs. Karg, M.; Riggs-Sauthier, J.; Dugdell,
R.; Odenbaugh, A. Bioconjugate Chem. Manuscript submitted.
- Inhibition
of Clostridium difficile Toxin
A-Induced Colitis in Rats by APAZAÔ. McVey, D.; Liddle, R.; Riggs-Sauthier,
J.; Ekwuribe, N.; Vigna, S. Dig.
Dis. Sci. 2005, 50, 565-573.
- "Automated chemistry workstation operations guide and
help manual. Version 2," Dixon, J. M.; Wagner, R. W.; Du, H.; Li, F.;
Riggs-Sauthier, J. A.; Lindsey, J. S. North Carolina State
University, Department of
Chemistry, 2004, Technical
Report TR04-1.
- Investigation
of Acid Cocatalysis in Syntheses of Tetraphenylporphyrin. Geier, G. R.,
III; Riggs, J. A.; Lindsey, J. S. J. Porphyrins Phthalocyanines 2001,
5, 681-690.
- Design
and Synthesis of
Porphyrin-Based Optoelectronic Gates.
Ambroise, A.; Wagner, R.; Rao, P.; Riggs, J.A.; Hascoat, P.; Diers, J.; Seth, J.; Lammi, R.; Bocian, D.; Holten, D.; Lindsey, J.S. Chem. Mater. 2001, 13(3),
1023-1034.
- Excited-State
Energy Transfer and Ground-State Hole/Electron Hopping in p-Phenylene-Linked Porphyrin
Dimers. Yang, S.; Seth, J.; Riggs, J.A.; Arai, T.; Kim, D.;
Bocian, D.; Holten, D.; Lindsey, J.S. J.
Phys. Chem. B 1998, 102, 9426-9436.
- Facilitated
Transport of Carbohydrates, Catecholamines, and Amino Acids Through Liquid
and Plasticized Organic Membranes.
Smith, B.D.; Gardiner,
S.J.; Munro, T.A.; Paugam, M.-F.; Riggs, J.A. J. Mol. Rec. Incl. Phenom. 1998, 32, 121-131.
- Facilitated
Transport of Small Carbohydrates through Highly Stable Plasticized
Cellulose Triacetate Membranes.
Evidence for Fixed-Site Jumping Transport Mechanism. Riggs, J.A.; Smith, B.D. J. Am. Chem. Soc. 1997,
119, 2765-2766.
MORE.............
- Munro,
T.A.; Riggs, J.A.; Smith, B.D. Macrocyclic Host Molecules. In Macmillan Encyclopedia of Chemistry; Lagowski, J.J., Ed.; Volume 2; Macmillan Reference USA, Simon &
Schuster Macmillan: New York, 1997; pp 427-431.
- High
Fructose Syrup Production using Fructose-Selective Liquid Membranes. Paugam, M.-F.; Riggs, J.A.; Smith, B.D., Chem. Commun. 1996,
22, 2539-2540.
- Nucleotide
Carrier Mixture with Transport Selectivity for
Ribonucleoside-5'-phosphates. Riggs, J.A.;
Hossler, K. A.; Smith,
B.D.; Karpa, M.J.; Griffen, G.; Duggan, P.J., Tetrahedron Lett. 1996,
37, 6303-6306.
- Molecular
Recognition and Membrane Transport with Mixed-Ligand Borates. Riggs, J.A.; Litchfield, R.K.; Smith, B.D., J. Org. Chem. 1996,
61, 1148-1150.
- Protein-Rejecting
Ability of Surface-Bound Dextran in End-On and Side-On Configurations –
Comparison to PEG. Österberg,
E.; Bergström, K.; Holmberg, K.; Schuman, T.; Riggs, J.A.; Burns, N.; Van Alstine, J.M.; Harris, J.M. J. Biomed. Mater. Res. 1995, 29, 741-747.
- Electrokinetic
Characterization of Hydrophilic Polymer Coatings of Biotechnical Significance. Van Alstine, James M.; Burns, Norman L.; Riggs, Jennifer A.; Holmberg, Krister; Harris, J. Milton, Colloids and Surfaces 1993,
77, 149-158.
- Comparison
of Polysaccharide and Poly(ethylene glycol) Coatings for Reduction of Protein
Adsorption on Polystyrene Surfaces.
Österberg, Eva; Bergström,
Karin; Holmberg, Krister; Riggs, Jennifer A.; Van Alstine, James M.; Schuman, Thomas P.; Burns, Norman L.; Harris, J. Milton, Colloids and Surfaces 1993,
77, 159-169.
PRESENTATIONS
1.
The
Discovery of a Multi-Arm Polymer Conjugated Taxane with Improved Efficacy in a
Tumor Xenograft Model (poster). Ren, Z.; Zhang, W.; Kozlowski, A.; Fry, D.;
Hoch, U.; Brew, C.; Lee, S.; Dahhani, F.; Riley, T.; Harrison, S.; Riggs, J.
246th American Chemical Society National Meeting, Indianapolis, IN,
September 8-12, 2013.
2.
Development
of A Novel Intravenous Calcimimetic for
End Stage Renal Disease (ESRD) Patients on Dialysis (poster). Dixit, V.; Cheng,
L.; Zhang, J.; Jaladi, R.; Tonkin, L.; Obalapur, P.; Dodda, S.; Shrivastava,
W.; Dama, S.; Kesana, S.; Rubas, W.; Fry, D.; Martin, D.; Riggs, J.; Kantak,
S.; Harrison, S.; Doberstein, S. 50th ERA-EDTA Kidney Congress,
Istanbul, Turkey, May 18-21, 2013.
3.
Polymer-Conjugated
Taxane Shows Improved Efficacy in Tumor Xenograft Models (poster). Fry, D.;
Brew, C.; Hoch, U.; Zhang, W.; Lee, S.; Harrison, S.; Riggs, J. AACR Annual
Meeting, Washington DC, April 6-10, 2013.
4.
Novel
Thymidylate Synthase Inhibitor NKT-TSI-4a Shows Improved PK Profile and
Superior Efficacy Compared to Pemetrexed (poster). Brew, C.; Lee, S.; Jaladi,
R.; Cheng, L.; Dama, S.; Riggs-Sauthier, J.; Fry, D.; Harrison, S. EORTC-NCI-AACR Symposium on “Molecular
Targets and Cancer Therapeutics”, Dublin, Ireland, November 6-9, 2012.
5.
NKTR-171: A Novel Sodium Channel Blocker for
Neuropathic Pain with Reduced CNS Side Effects (poster). Gursahani, H.; Choi.
I.; Deng, B-L.; Dodda, S.; Evans, J.; Grace, K.; Guillon, M.; Harrison, S.;
Mangadu, B.; Pfeiffer, J.; Riggs-Sauthier, J.; Riley. T. 42nd Annual Meeting,
Society of Neuroscience, New Orleans, LA, October 13-17, 2012.
MORE...............
1.
Preclinical
Pharmacology of Mu Opioids-A Comparison of Morphine, Oxycodone, Hydrocodone,
and Fentanyl in Rodent Pain Models (poster). Choi, I.; Ali, C.; Evans, J.;
Gogas, K.; Guillon, M.; Gursahani, H.; Harrison, S.; Kim, G.; McWeeney, D.;
Pfeiffer, J.; Quach, P.; Riggs-Sauthier, J.; Trinchero, P. Riley, T. 42nd
Annual Meeting, Society of Neuroscience, New Orleans, LA, October 13-17, 2012.
2.
NKTR-181:
A Novel, Orally Available Mu Opioid Agonist with Reduced Rate and Extent of CNS
Exposure Exhibits Comparable Analgesic Efficacy but Reduced Abuse Liability and
CNS Side Effects Compared to Oxycodone (poster) Gursahani, H; Gogas, K. Pfeiffer, J.; Choi,
I.; Evans, J.; McWeeney, D.; Pfeiffer, J.; Ali, C.; Choi, I.; Quach, P.;
Trinchero, P.; Gauvin, D.; Fishburn, S.; Harrison, S.; Doberstein, S.; Riley, T;
Riggs-Sauthier, J. International
Conference on Opioids, Boston, MA, June 10-12, 2012.
3.
Invited Speaker: Strategies for Improving the
Performance of Small Molecule Therapeutics from Discovery to the Clinic:
A Case Study of NKTR-102, a Novel Topoisomerase I Inhibitor-Polymer Conjugate.
Riggs-Sauthier, J. 9th International Symposium on Polymer Therapeutics (ISPT), Valencia,
Spain, May 28-30, 2012.
4.
Invited Speaker: The Design of Novel and Improved
Therapeutics Utilizing Nektar’s Advanced Polymer Conjugation Technology.
Riggs-Sauthier, J. World Molecular
Engineering Network, Los Cabos, Mexico May 6-9, 2012.
5.
Invited Speaker: Improving the Performance of Small
Molecule Therapeutics Using Nektar’s Advanced Polymer Conjugation Technology.
Riggs-Sauthier, J. University of
Mississippi Department of Chemistry & Biochemistry Colloquium Series,
Oxford, Missisippi April 19, 2012.
6.
Pharmacological
characterization of an orally active opioid analgesic with rapid onset of
activity and low abuse liability. (poster) Ali, C.; Choi, I.; Evans, J.; Fishburn, S.; Gogas, K.; Guillon, M.; Gursahani,
H.; Harrison, S.; Kim, G.; Lee, M.; Mangadu,
B.; McWeeney, D.; Pfeiffer, J.; Quach, P.;
Riggs, J.; Phillips, G.; Trinchero, P.; Wong,
S.; Riley, T. 41st
Annual Meeting, Society of Neuroscience, Washington DC, 2011.
7.
Invited Speaker: Strategies for Improving the
Performance of Small Molecule Therapeutics from Discovery to the Clinic:
A Case Study of NKTR-102, a Novel Topoisomerase I Inhibitor-Polymer Conjugate.
Riggs-Sauthier, J. Madison Marshall
Symposium, North Alabama Section of the American Chemical Society Meeting,
Huntsville, Alabama May 17, 2011.
8.
Invited Speaker: Improving the Bioavailability of
Small Molecule Drugs Through the Use of Nektar’s Advanced Polymer Conjugation
Technology. Riggs-Sauthier, J. 10th edition of the Medicinal
Bioorganic Chemistry Foundation meeting, Steamboat, Colorado, 2011.
9.
Controlling
the Rate of Entry to the CNS by Polymer Conjugation. (poster) Gursahani, H.; Wong, S.; Riggs-Sauthier, J.;
Pfeiffer, J.; Allums, S.; Zhang, W.; Deng, B-L.; Trinchero, P.; Quach, P.;
Brew, C.; Evans, J-A.; Harrison, S.; Doberstein, S.; Riley, T.A.; Fishburn, C.S.
40th Annual
Meeting, Society of Neuroscience, San Diego, CA, 2010.
10.
NKTR-181:
A Novel Opioid Analgesic with Slowed CNS Entry Shows Reduced Abuse Liability
and CNS Side Effects. (poster) Fishburn,
C.S.; Riggs-Sauthier, J.; Wong, S.; Pfeiffer, J.; Gursahani, H.; Muthukrishnan,
E.; Ali, C.; Choi, I.; McWeeney, D.; Montague, L.; Harrison, S.; Doberstein, S.;
Riley, T. 40th
Annual Meeting, Society of Neuroscience, San Diego, CA, 2010.
11.
NKTR-105,
a Novel PEGylated-Docetaxel, Demonstrates Superior Anti-tumor Activity Compared
to Docetaxel in Human Non-Small Cell Lung and Colon Cancer Mouse Xenograft
Models. (poster) Wolff, R.; Routt, S.; Hartsook, R.; Riggs, J.; Zhang, W.;
Persson, H. Johnson, R. 20th
EORTC-NCI-AACR Symposium on “Molecular Targets and Cancer Therapeutics”,
Geneva, Switzerland, 2008.
12.
Nektar
R&D Day, Riggs-Sauthier, J. Intercontinental Hotel, New York City, New
York, 2008.
MORE..............
1.
Invited Speaker: Strategies for Improving the
Performance of Small Molecule Therapeutics from Discovery to the Clinic: A Case Study of NKTR-118, an Oral PEGylated
Derivative of Naloxone. (poster) Riggs-Sauthier, J. 7th International Symposium on Polymer Therapeutics (ISPT), Valencia,
Spain, 2008.
2.
Nektar
R&D Day, Riggs-Sauthier, J. Palace Hotel, New York City, New York, 2007.
3.
Invited Speaker: Advanced PEGylation: Taking
Biopharmaceuticals into the Future. Riggs-Sauthier, J. 33rd Annual Meeting and
Exposition of the Controlled Release Society (CRS), Vienna, Austria, 2006.
4.
Invited Speaker: The Art of PEGylation: Advancing
Peptide Drugs into the Future. Riggs-Sauthier, J. Natural Peptides to Drugs
(NP2D) Conference, Zermatt, Switzerland, 2006.
5.
Invited Speaker:
Advanced PEGylation: Taking
Biopharmaceuticals into the Future.
Riggs-Sauthier, J. BIO 2005 Annual International Convention,
Philadelphia, Pennsylvania, 2005.
6.
Strategies
for Reversible Peptide PEGylation. The
TIDES Conference, Boston, Massachusetts, 2005.
7.
Invited Speaker: Strategies Toward the Oral Delivery
of Insulin: Using Molecular Modifications
to Solve Drug Delivery Challenges.
Riggs-Sauthier, J. ACS National
Meeting, Anaheim, California, 2004.
8.
The
Key to Oral Delivery of Proteins and Peptides:
Using Molecular Modifications to Solve Drug Delivery Problems.
Riggs-Sauthier, J. Drug Delivery
Conference, Cherry Hill, New Jersey, 2003.
9.
Oral
Delivery: Design of Carbamate Prodrugs and Structure- Activity Relationships. (poster) Dyakonov, T.;
Riggs-Sauthier, J.; Harris, M.; Surguladze, D.; Bednarcik, M.; Ekwuribe, N.
AAPS National Meeting, Toronto, Canada, 2002.
10.
Synthesis
and Efficacy of Novel 5-Aminosalicylic Acid (5-ASA) – Containing Pro-drugs for the
Treatment of Inflammatory Bowel Disease. (poster) Riggs-Sauthier, J.A.; Malson, E.; Harris, M.; Myung, S.; Liddle, R.;
Ekwuribe, N. ACS National
Meeting, Boston, Massachusetts, 2002.
11.
Synthesis
and Anti-Inflammatory Efficacy of a Series of Novel 6-Naphthylacetic Acid
(6-MNA) Pro-drugs. (poster) Riggs, J.A.;
Dyakonov, T.; Harris, M.; Surguladze, Anderson, W.; Myung, S.;
Jones, M.; Smalley, M.; Ekwuribe,
N. ACS National Meeting, San Diego,
California, 2001.
12.
Investigation
of Conditions in Porphyrin-Forming Reactions Using an Automated Chemistry
Workstation. (poster) Riggs, J.A.;
Wagner, R.W.; Li, F.; Du, H.; Lindsey, J.S.,
ACS National Meeting, Anaheim, California, 1999.
13.
One-Flask
Synthesis of 1,4-Phenylene-Linked
Porhyrin Dimers and Their Rates of Energy Transfer. (poster) Riggs, J.A.;
Arai, T.; Lindsey, J.S.; Holten, D.;
Bocian, D.F., ACS Southeastern
Regional Meeting, Research Triangle Park, North Carolina, 1998.
14.
Innovative
Liquid Membranes Launch High Fructose Syrup Production into the Next
Generation. (poster) Riggs, J.A.; Smith, B.D.,
University of Notre Dame Poster Day, Notre Dame, IN, 1996.
15.
Molecular
Recognition and Membrane Transport of Nucleoside Phosphates. Riggs, J.A.; Hossler, K. A.; Smith,
B.D.; Karpa, M.J.; Griffen, G.;
Duggan, P.J., ACS National
Meeting, Orlando, Florida, 1996.
16.
Electrokinetic
Detection of Biomedical Surface Phenomena.
(poster) Riggs, J. A.; Burns, N. L.;
Schuman, T.; Harris, J.M.; Van
Alstine, J.M., Alabama Materials Research Conference , Birmingham, Alabama,
1991 and ACS Southeastern Regional Meeting, Richmond, Virginia, 1991.
San Francisco, California
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