Dr Charlotte Wiles

Dr Charlotte Wiles  

Chief Executive Officer, Chemtrix BV, 
Dr. Charlotte Wiles has been actively researching within the area of micro reactor technology for ten years, starting with a PhD entitled `Micro reactors in organic chemistry`, which she obtained from The University of Hull in 2003.
In the past decade she has authored many scientific papers and review articles, recently co-authoring a book on the subject 'Micro reaction technology in organic synthesis'.
More recently, she has tailored her experience to the development and evaluation of commercially available continuous flow reactors, systems and peripheral equipment.

WITH DR ANTHONY CRASTO, Dr VIJAY KRIPALANI
EXTREME RIGHT .....DR CHARLOTTE WILES. ....AT SELECTBIO FLOW CHEMISTRY CONFERENCE IN MUMBAI, INDIA,  22 JAN 2015
























Starting her research in the area of continuous flow synthesis in 2000, Charlotte obtained her PhD in 2003 entitled “Microreactors in organic synthesis”.

This was followed by 5 years of Post-Doctoral research into the rapidly developing field of continuous flow synthesis, specifically in the area of heterogeneous catalysis for small molecule synthesis.

In 2008 Charlotte joined Chemtrix BV as a Senior Chemist where she worked on the commercialisation of lab-scale micro reactor apparatus.

 In 2010 she was promoted to Chief Technology Officer within Chemtrix BV where she continues to research and develop continuous flow systems and solutions for industrial partners; with more recent developments focusing on industrial flow reactors, suited towards the development of flexible tonne-scale production plants.

Over the course of her research career, Charlotte has published more than 55 peer-reviewed articles, several book chapters and in 2011 published a book “Micro reaction technology in organic synthesis”.


EMAIL
C.Wiles@chem.hull.ac.uk
c.wiles@chemtrix.com

Links
uk.linkedin.com/pub/charlotte-wiles/1b/8a/441
http://www.chemtrix.com/
http://www.chemtrix.com/downloads
http://www.researchgate.net/profile/Charlotte_Wiles
www2.hull.ac.uk/

CPhI India, Dec2015, MUMBAI, INDIA.

With Dr Charlotte Wiles, CEO, CHEMTRIX BV , Cambridge, UK at CPhI India, Dec2015, MUMBAI, INDIA......At Pi-inc (Process Intensification Experts LLP) stall, hall 5 H47,

At Pi-inc (Process Intensification Experts LLP) stall, hall 5 H47, seen is Mr Vijay Kirpalani with Charlotte wiles —

Experience

CEO

Chemtrix BV.

August 2013 – Present

In the 5 years since the start of Chemtrix BV the Team has developed a complete product portfolio of Flow Chemistry Equipment and Services, setting up strategic partnerships with ESK Ceramics (Germany) and DSM Fine Chemicals (Austria) and it is with this strong background that Chemtrix BV will continue to grow under the Management of Dr Charlotte Wiles.

Being part of the Company since its start in 2008, and CTO of Chemtrix BV since 2010, I will continue to use my 13 years experience in the area of Flow Chemistry to grow the Company in the new role of CEO, effective as of the 7th of August 2013.

Chief Technology Officer

Chemtrix BV

April 2008 – August 2013 (5 years 5 months)

As the Chief Technology Officer at Chemtrix BV I am involved in the design and evaluation of equipment developed to enable users to successfully implement continuous flow reactor technology into their synthetic processes from both a research and production perspective

Post Docotoral Research Associate

The University of Hull

September 2003 – March 2008 (4 years 7 months)

Continuous flow organic synthesis using glass based micro reactors
www2.hull.ac.uk/

With Dr (Ms) Charlote wiles, CEO chemtrix , at IISER-PUNE, Pune INDIA on 27 Aug 2016 for Flow Chemistry Symposium + Workshop ...

IGCW | Home

www.industrialgreenchem.com

Dr. Charlotte Wiles Chief Executive Officer,

 

PDRA

Hull University

2003 – 2008 (5 years)

Development of continuous flow reactions in custom fabricated glass micro reactors - in conjunction with Industrial partners.

Education

John Smeaton Community High School

Click and see

White paper: Continuous Manufacturing - Producing more with less

FDA Supports the use of Continuous Manufacturing

Chemtrix' KiloFlow® featured on cover of Chemical and Engineering news (C&EN)

Hydrodynamic characterization of gas-liquid-liquid slug flow and parallel-slug flow through a ...

Symposium 'Waste not want not, profit from sustainable chemistry' at Chemspec Europe 2014

Visit Chemtrix at Chemspec Europe, booth B33

Silicon Carbide micro reactors remove compatibility issues assiciated with metallic micro reactors

CHILL and Chemtrix provide Flow Chemistry services to the chemical industry

Micro Reactor Technology Education Package

Chemtrix at Informex 2014, January 21-24, Miami (FL), USA

New U.S. Application Lab!

Chemtrix expands international network with distributor in India

Norteastern University Boston (US) Demonstrates Labtrix® S1

DSM and Chemtrix sign collaboration agreement in Continuous Flow Chemistry

 

 

ORGANISATION

 

Organisation
Chemtrix BV is located on 2 sites. In Hull (United Kingdom) Dr Charlotte Wiles (CEO) is running the Chemtrix R&D laboratory within facilities of The University of Hull. All the other activities (Management, Engineering, Product Development, Quality Assurance, Marketing & Sales) are located at the headquarters based on the Chemelot (www.chemelot.com) site in Geleen.

Chemtrix BV, Chemical Department is located at The University of Hull

Address
Cottingham Road
Hull HU6 7RX
United Kingdom
T: +44 (0) 1482 466 459
F: +44 (0) 1482 466 410

Company Profile

HISTORY

2013

DSM and Chemtrix sign collaboration agreement in Continuous Flow Chemistry

2012

Launch of Plantrix Industrial Flow Reactor

2012

ESK Ceramics acquires minorty share in Chemtrix B.V.

2011

Launch of KiloFlow®

2010

Launch of Labtrix® Start

2009

Launch of Labtrix® and Plantrix®

2009

Launch of Chemtrix USA

July 2008

Entrance of new investors

April 2008

Chemtrix BV established in Geleen

2006

Chemtrix LTD established in Hull

2005

Start negotiations between Lionix BV and The University of Hull about co-operation

2003

Change over to high quality chips purchased from Lionix BV (www.lionixbv.nl) in Enschede (the Netherlands)

2000

Dr Paul Watts starts MRT Research at the University of Hull (www.hull.ac.uk) using in-house fabricated reactors

............



 Monograph on Microreaction Technology

CRC Press, Boca Raton, 2011. 453 pp., hardcover, £ 89.00.—ISBN 978-1439824719

Micro Reaction Technology in Organic Synthesis. By Charlotte Wiles and Paul Watts.

http://onlinelibrary.wiley.com/doi/10.1002/anie.201107992/abstract 

 

 

Publications Authored By Charlotte Wiles

2012Sep

Ask the experts: the challenges and benefits of flow chemistry to optimize drug development.

Future Med Chem

Future Med Chem 2012 Sep;4(14):1779-89

Neal Anderson, Krist V Gernaey, Timothy F Jamison, Manfred Kircher, Charlotte Wiles, Nicholas E Leadbeater, Graham Sandford, Paul Richardson

Against a backdrop of a struggling economic and regulatory climate, pharmaceutical companies have recently been forced to develop new ways to provide more efficient technology to meet the demands of a competitive drug industry. This issue, coupled with an increase in patent legislation and a rising generics market, makes these themes common issues in the growth of drug development. As a consequence, the importance of process chemistry and scale-up has never been more under the spotlight.

2012Feb

Solid-supported gallium triflate: an efficient catalyst for the three-component ketonic Strecker reaction.

ChemSusChem

ChemSusChem 2012 Feb 8;5(2):332-8. Epub 2011 Dec 8.

Charlotte Wiles, Paul Watts

Chemtrix BV, Burgemeester Lemmensstraat 358, 6163JT Geleen, The Netherlands. c.wiles@chemtrix.com

In light of the growing interest in the use of rare earth metal triflates as water-tolerant Lewis acid catalysts, we embarked upon the development of a solid-supported gallium triflate (PS-Ga(OTf)(2) ) derivative as a means of increasing the cleanliness and cost effectiveness of using these increasingly expensive catalytic materials in synthetic processes. Having previously highlighted the advantages associated with coupling solid-supported catalysis and the emerging area of micro-reaction technology, we screened PS-Ga(OTf)(2) for activity towards the ketonic Strecker reaction, in which the target α-aminonitriles were obtained in higher yield and purity compared to reactions reported in literature, in which the analogous homogeneous catalyst was used.

2011Nov

Translation of microwave methodology to continuous flow for the efficient synthesis of diaryl ethers via a base-mediated S(N)Ar reaction.

Beilstein J Org Chem

Beilstein J Org Chem 2011 4;7:1360-71. Epub 2011 Oct 4.

Charlotte Wiles, Paul Watts

Chemtrix BV, Burgemeester Lemmensstraat 358, 6163 JT, Geleen, The Netherlands.

Whilst microwave heating has been widely demonstrated as a synthetically useful tool for rapid reaction screening, a microwave-absorbing solvent is often required in order to achieve efficient reactant heating. In comparison, microreactors can be readily heated and pressurised in order to "super-heat" the reaction mixture, meaning that microwave-transparent solvents can also be employed. To demonstrate the advantages associated with microreaction technology a series of S(N)Ar reactions were performed under continuous flow by following previously developed microwave protocols as a starting point for the investigation.

2011Jun

Recent advances in micro reaction technology.

Chem. Commun. (Camb.)

Chem Commun (Camb) 2011 Jun 29;47(23):6512-35. Epub 2011 Mar 29.

Charlotte Wiles, Paul Watts

Chemtrix BV, Burgemeester Lemmensstraat 358, 6163 JT, Geleen, The Netherlands. c.wiles@chemtrix.com

It is the intention of this review to provide the reader with a survey of the current literature pertaining to the use of micro reactors in synthetic chemistry; recent advances are briefly discussed, with references provided to assist with further reading on this rapidly growing research topic.

2011Mar

Improved method for kinetic studies in microreactors using flow manipulation and noninvasive Raman spectrometry.

J. Am. Chem. Soc.

J Am Chem Soc 2011 Mar 22;133(10):3601-8. Epub 2011 Feb 22.

Sergey Mozharov, Alison Nordon, David Littlejohn, Charlotte Wiles, Paul Watts, Paul Dallin, John M Girkin

WestCHEM, Department of Pure and Applied Chemistry and CPACT, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL, United Kingdom.

A novel method has been devised to derive kinetic information about reactions in microfluidic systems. Advantages have been demonstrated over conventional procedures for a Knoevenagel condensation reaction in terms of the time required to obtain the data (fivefold reduction) and the efficient use of reagents (tenfold reduction). The procedure is based on a step change from a low (e.

2009Dec

Continuous-flow organic synthesis: a tool for the modern medicinal chemist.

Future Med Chem

Future Med Chem 2009 Dec;1(9):1593-612

Charlotte Wiles, Paul Watts

Chemtrix BV, Burgemeester Lemmensstraat 358, 6163JT Geleen, The Netherlands. c.wiles@chemtrix.com

Medicinal chemists are under increasing pressure, not only to identify lead compounds and optimize them into clinical candidates, but also to produce materials in sufficient quantities for subsequent investigation. With this in mind, continuous-flow methodology presents an opportunity to reduce the time taken to, first, identify the compound and, second, scale the process for evaluation and, where necessary, production. It is therefore the aim of this review to provide the reader with an insight into the advantages associated with the use of continuous-flow chemistry through the use of strategically selected literature examples.

2009Jul

The development and evaluation of a continuous flow process for the lipase-mediated oxidation of alkenes.

Beilstein J Org Chem

Beilstein J Org Chem 2009 2;5:27. Epub 2009 Jun 2.

Charlotte Wiles, Marcus J Hammond, Paul Watts

Department of Chemistry, The University of Hull, Cottingham Road, Hull, HU6 7RX, UK. c.wiles@chemtrix.com

We report the use of an immobilised form of Candida antarctica lipase B, Novozym((R)) 435, in a preliminary investigation into the development of a continuous flow reactor capable of performing the chemo-enzymatic oxidation of alkenes in high yield and purity, utilising the commercially available oxidant hydrogen peroxide (100 volumes). Initial investigations focussed on the lipase-mediated oxidation of 1-methylcyclohexene, with the optimised reaction conditions subsequently employed for the epoxidation of an array of aromatic and aliphatic alkenes in 97.6 to 99.

2009Apr

A microreactor for the study of biotransformations by a cross-linked gamma-lactamase enzyme.

Biotechnol J

Biotechnol J 2009 Apr;4(4):510-6

Anne Marie Hickey, Bongkot Ngamsom, Charlotte Wiles, Gillian M Greenway, Paul Watts, Jennifer A Littlechild

University of Exeter, UK.

A (+)-gamma-lactamase was precipitated, cross-linked and the resulting solid crushed prior to immobilisation within a capillary column microreactor. The microreactor was subsequently used to study enzyme stability, activity, kinetics and substrate specificity. The thermophilic (+)-gamma-lactamase retained 100% of its initial activity at the assay temperature, 80 degrees C, for 6 h and retained 52% activity after 10 h, indicating the advantage of immobilisation.

2008Jan

An optical sensor for reactive oxygen species: encapsulation of functionalised silica nanoparticles into silicate nanoprobes to reduce fluorophore leaching.

Analyst

Analyst 2008 Jan 2;133(1):71-5. Epub 2007 Oct 2.

Victoria J Hammond, Jonathan W Aylott, Gillian M Greenway, Paul Watts, Abigail Webster, Charlotte Wiles

Department of Chemistry, The University of Hull, Cottingham Road, Hull, UK HU6 7RX.

Sol-gel nanoprobes, also known as Photonic Explorer for Bioanalysis with Biologically Localised Embedding (PEBBLE), capable of performing in-vitro intracellular monitoring of reactive oxygen species have been developed using a modified form of 5(6)-carboxyfluorescein diacetate. A sol-gel matrix was selected for the design of the probes as it is photostable, optically transparent and chemically inert, and to minimise leaching of the dye from the porous matrix it was covalently immobilised to silica nanoparticles (15 nm). Using this approach,

2007Dec

Parallel synthesis in an EOF-based micro reactor.

Chem. Commun. (Camb.)

Chem Commun (Camb) 2007 Dec(46):4928-30

Charlotte Wiles, Paul Watts

The University of Hull, Hull, UK. c.wiles@chem.hull.ac.uk

We present herein a micro reactor set-up that enables parallel syntheses to be performed under electroosmotic flow conditions.

2007Nov

Improving chemical synthesis using flow reactors.

Expert Opin Drug Discov

Expert Opin Drug Discov 2007 Nov;2(11):1487-503

Charlotte Wiles, Paul Watts

University of Hull, Department of Chemistry, Cottingham Road, Hull, HU6 7RX, UK +44 (0)1482 466410 ; P.Watts@hull.ac.uk.

Owing to the competitive nature of the pharmaceutical industry, researchers involved in lead compound generation are under continued pressure to identify and develop promising programmes of research in order to secure intellectual property. The potential of a compound for therapeutic development depends not only on structural complexity, but also on the identification of synthetic strategies that will enable the compound to be prepared on the desired scale. One approach that is of present interest to the pharmaceutical industry is the use of continuous flow reactors, with the flexible nature of the technology being particularly attractive as it bridges the changes in scale required between the initial identification of a target compound and its subsequent production.

2007Mar

The use of electroosmotic flow as a pumping mechanism for semi-preparative scale continuous flow synthesis.

Chem. Commun. (Camb.)

Chem Commun (Camb) 2007 Mar 11(9):966-8. Epub 2006 Dec 11.

Charlotte Wiles, Paul Watts, Stephen J Haswell

Department of Chemistry, Faculty of Science and the Environment, The University of Hull, Cottingham Road, Hull HU6 7RX, UK.

By employing a series of reactions we demonstrate the use of electroosmotic flow as a continuous pumping mechanism suitable for semi-preparative scale synthesis, affording an array of small organic compounds, of analytical purity, with yields ranging from 0.57-1.71 g h(-1)

2007Mar

Micro reactors: a new tool for the synthetic chemist.

Org. Biomol. Chem.

Org Biomol Chem 2007 Mar 30;5(5):727-32. Epub 2007 Jan 30.

Paul Watts, Charlotte Wiles

Department of Chemistry, The University of Hull, Cottingham Road, Hull, UK. P.Watts@hull.ac.uk

This review focuses on the use of micro reactors as tools in synthetic organic chemistry, aiming to highlight the many advantages associated with their use, in particular their ability to synthesise products in high yield, purity and, where relevant, selectivity.

2007Mar

The use of solid-supported reagents for the multi-step synthesis of analytically pure alpha,beta-unsaturated compounds in miniaturized flow reactors.

Lab Chip

Lab Chip 2007 Mar 8;7(3):322-30. Epub 2007 Jan 8.

Charlotte Wiles, Paul Watts, Stephen J Haswell

Department of Chemistry, University of Hull, Hull, HU6 7RX, UK.

Micro reaction technology offers a safe, controllable and information rich technique suitable for the long-term production of pharmaceutical agents and fine chemicals. To date however, few of the syntheses performed using this technology have addressed the problems associated with product purification. With this in mind, we report herein the incorporation of multiple supported reagents into EOF-based miniaturized flow reactors for the two-step synthesis of analytically pure compounds.

2007Feb

Recent advances in synthetic micro reaction technology.

Chem. Commun. (Camb.)

Chem Commun (Camb) 2007 Feb 12(5):443-67. Epub 2006 Oct 12.

Paul Watts, Charlotte Wiles

The University of Hull, Cottingham Road, Hull, UKHU6 7RX. P.Watts@hull.ac.uk

Although in its infancy, the field of micro reaction technology is growing rapidly, with many research groups investigating the practical advantages associated with reaction miniaturisation. With this in mind, the following Feature Article aims to provide an overview of the progress made in the past decade, paying particular attention to the field of synthetic organic chemistry.

2004Jun

Stereoselective alkylation of an Evans auxiliary derivative within a pressure-driven micro reactor.

Lab Chip

Lab Chip 2004 Jun 17;4(3):171-3. Epub 2004 Mar 17.

Charlotte Wiles, Paul Watts, Stephen J Haswell, Esteban Pombo-Villar

Department of Chemistry, The University of Hull, Cottingham Road, Hull, UK HU6 7RX.

A simple technique for the diastereoselective alkylation of a metal stabilised enolate is demonstrated within a pressure-driven micro reactor whereby enhanced diastereoselectivities were obtained compared to batch. 

2002Aug

Investigation of racemisation in peptide synthesis within a micro reactor.

Lab Chip

Lab Chip 2002 Aug 17;2(3):141-4. Epub 2002 Jun 17.

Paul Watts, Charlotte Wiles, Stephen J Haswell, Esteban Pombo-Villar

Department of Chemistry, University of Hull, Cottingham Road, Hull, UKHU6 7RX.

We demonstrate that peptides derived from alpha-amino acids may be prepared in a micro reactor. The peptides were prepared in 20 min with quantitative conversion, compared to batch reactions which require prolonged reaction times. We illustrate that by using dilute reagent concentrations and short reaction times, less racemisation is observed in micro reactions than in bulk reactions.

2002May

The regioselective preparation of 1,3-diketones within a micro reactor.

Chem. Commun. (Camb.)

Chem Commun (Camb) 2002 May(10):1034-5

Charlotte Wiles, Paul Watts, Stephen J Haswell, Esteban Pombo-Villar

Department of Chemistry, Faculty of Science and the Environment, University of Hull, Cottingham Road, Hull, UK HU6 7RX.

We demonstrate a simple method for the regioselective preparation of 1,3-diketones within a micro reactor from silyl enol ethers where the products are free from both competing O-acylation and diacylation products.

2002May

1,4-addition of enolates to alpha,beta-unsaturated ketones within a micro reactor.

Lab Chip

Lab Chip 2002 May 19;2(2):62-4. Epub 2002 Apr 19.

Charlotte Wiles, Paul Watts, Stephen J Haswell, Esteban Pombo-Villar

Department of Chemistry, Faculty of Science and the Environment, University of Hull, Cottingham Road, Hull, UKHU6 7RX.

We demonstrate the formation of a series of diketone enolates and their subsequent reaction with alpha,beta-unsaturated carbonyl compounds in order to prepare a variety of Michael adducts. In all cases, the conversions observed within a micro reactor were greater than those obtained in batch.Read More...http://www.pubfacts.com/author/Charlotte+Wileshttp://www.pubfacts.com/author/Charlotte+Wiles

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