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Friday, 13 March 2015

Dr. Arshad Jilani

Arshad Jilani

President & CSO at Progeneca Biotech Inc.

Montreal, Canada Area

Biotechnology

Summary

Experience:
Business Development of a new company. Management skills in managing multiple projects and research personnel. Over twenty years of research experience including Biotech industry experience of more than ten years: Directed GLP and R&D studies,

Expert in protein purification using HPLC and FPLC, Refolding/Purification of proteins (including disulphide bonded protein) from inclusion bodies, PEGylation of protein, Truncation of protein to create more stable/protease resistant protein and determining the minimal size that can retain both the enzymatic activities, Developed fluorescence based enzyme assay which is being used as a release assay for the drug,

Monitored technology transfer to CROs, expert in cloning several genes: cloned the first human polynucleotide kinase phosphatase gene and demonstrated its role in DNA-repair, developed a method to radio-iodinate hyaluronic acid, experience with small molecules and proteins using RP-HPLC.

Experience with hollow fibre system for washing inclusion bodies and diafiltration. Method development to enrich biomarkers and processing for mass spectrometry. Experience with LIMS.

Goal: To lead a group of scientists/technicians to develop new drugs and to help save money to small biotech companies to make drugs at a lower cost.

Specialties: Can handle difficult projects with confidence and emerge successful

Contacts
ajilani@progeneca.com

ca.linkedin.com/pub/arshad-jilani/5/897/88a/en

DR ARSHAD WITH HIS FAMILY

Experience

President & CSO

Progeneca Biotech Inc.

July 2012 – Present (2 yearsPLUS)Montreal, Canada Area

Progeneca is dedicated to providing quality services to small and large biotech companies as well as to the academic sector. Progeneca provides services in the areas of gene cloning, expression, purification, analytical method development, technology transfer to CROs, enrichment of biomarkers, preliminary identification of biomarkers, IND filings, etc. Progeneca also provides consultancy services to Biotech industries and to the academic sector.

Senior Scientist/Group Leader

Caprion Proteomics

March 2009 – January 2012 (2 years 11 months)

HPLC and glycocapture method development for its use in proteomics to discover new Biomarkers for various diseases. Sample preparation for Mass Spectrometry. Analysis of data and writing/communicating reports as Scientific leader. Excellent management skills in managing multiple projects and research personnel.

Part time teacher

Cegep John Abbott College

2006 – 2010 (4 years)

Senior Research Scientist, Process Development

Osprey Pharmaceuticals Ltd.

February 2007 – March 2009 (2 years 2 months)Montreal

Protein expression, purification method development: improved quality and yield. Developed a RP-HPLC method for a therapeutic protein and transferred the method to a CRO. Developed method to improve the washing of inclusion bodies and reduced the washing time by setting up a hollow fibre system procedure.

Senior Research Scientist, Product Development & Protein Engineering

BioAxone Therapeutics Inc., Canada

September 2002 – April 2006 (3 years 8 months)

Optimized the expression and purification procedure for a therapeutic protein and achieved ten-fold increase in the yield. Removed the proteolysis susceptible regions of this therapeutic protein. Identified the amino acids critical for the inherent enzymatic activity of this therapeutic protein. Identified the smallest size active protein. Developed a fluorescence based enzymatic assay which is being used as a release assay for a protein drug. Developed and optimized PEGylation chemistry so as to get either mono- , Di- or multi-PEGylated forms of a therapeutic protein. Developed procedure for purification / renaturation of enzymes which form inclusion bodies. Technology transfer to CRO and solved technical difficulties faced by the CRO. Monitoring CROs for outsourced work – Worked in a team to monitor the stability testing and formulation of a therapeutic protein at CROs and solved technical issues. Worked in a team to write the Pre-IND and IND document

Post-doctoral fellow

McGill University

1996 – 1999 (3 years)

Education

Jawaharlal Nehru University

Ph.D., Biotechnology

1987 – 1994

EDUCATION:
Ph. D. (Biotechnology) 1994 Jawaharlal Nehru University, New Delhi

FELLOWSHIPS AND AWARDS
1) Stood 2nd in All India Test conducted at 24 centres by Jawaharlal Nehru University for admission to the Ph.D. program in Biotechnology, 1987.
2) Qualified the Joint CSIR-UGC (Council for Scientific & Industrial Research-University Grants Commission ) Junior Research Fellowship Examination, 1987.
3) Awarded Junior and Senior Research Fellowships under Dept. of Biotechnology-University Grants Commission Collaborative Fellowship, 1987-1992

Aligarh Muslim University

M.Sc. (Biotechnology) 1987 A.M. University, Aligarh
M.Sc. (Chemistry, 1 year) 1985 A.M. University, Aligarh

B.Sc. (Chemistry Hons.) 1984 A.M. University, Aligarh

B.Sc. (Honors), M.Sc. 1 year, Chemistry

SS Masjid beside Strachey Hall, AMU Aligarh

ABOUT HIS COMPANY

Progeneca Biotech Inc., a company dedicated to providing quality biotechnology services. Our expertise in protein drug R&D from cloning to purified product could save you a tremendous amount of time and money. We offer Proteomics and Mass Spectrometry services as well. It would be a great pleasure to present Progeneca's platform at your convenience. Please visit our website at www.progeneca.com for detailed outline of services that Progeneca has to offer. Please do not hesitate to contact us for any questions you may have. - See more at: http://www.shopinmontreal.com/Progeneca-Biotech-Inc-/666306.htm#sthash.hC4bQiUo.dpuf

Health & Medical
Products and Services:

Biotechnology Service Provider

Gene Cloning

Expression

Purification of Proteins

Protein Modification

Protein Characterization

Consultancy

Proteomics

Mass Spectrometry analyses

Biomarkers enrichment

Address:152 Viking Montreal , Quebec H9R 1K7

Phone: 514-825-4634

- See more at: http://www.shopinmontreal.com/Progeneca-Biotech-Inc-/666306.htm#sthash.hC4bQiUo.dpuf

http://www.progeneca.com/

Health & Medical
Products and Services:

Biotechnology Service Provider

Gene Cloning

Expression

Purification of Proteins

Protein Modification

Protein Characterization

Consultancy

Proteomics

Mass Spectrometry analyses

Biomarkers enrichment

Address:152 Viking Montreal , Quebec H9R 1K7

Phone: 514-825-4634

- See more at: http://www.shopinmontreal.com/Progeneca-Biotech-Inc-/666306.htm#sthash.hC4bQiUo.dpuf

Health & Medical
Products and Services:

Biotechnology Service Provider

Gene Cloning

Expression

Purification of Proteins

Protein Modification

Protein Characterization

Consultancy

Proteomics

Mass Spectrometry analyses

Biomarkers enrichment

Address:152 Viking Montreal , Quebec H9R 1K7

Phone: 514-825-4634

- See more at: http://www.shopinmontreal.com/Progeneca-Biotech-Inc-/666306.htm#sthash.hC4bQiUo.dpuf

http://blog.neomed.ca/en/audio-en-progeneca-a-new-rd-services-provider/

Montreal (QUEBEC) – After a long time working in drug discovery, Dr. Arshad Jilani, CEO, has decided in 2012 to take on a new mission: providing R&D services at a reasonable cost for small and large biotech companies, and build its own start-up, Progeneca. After only 2 years, Progeneca, a NÉOMED resident company, has already entered into collaboration with academic research centers in Canada and an American biotech company. Listen to this interview to know more about the services Progeneca offers and what its ambition is in the long term.

Progeneca is dedicated to providing quality services to small and large biotech companies as well as to the academic sector. The vast experience of Dr. Jilani can shorten R&D time and can facilitate faster drug development processes. We believe that shortening the R&D time along with saved money would eventually help companies to go to clinical trials at a much faster rate.

Protein Expression, Purification, Modification & Sequencing

Progeneca provides quality services in the following areas:

Gene cloning
Choice of expression vector
Expression system selection
Selection of best expressing clones
Creation of research cell bank
Master cell bank generation
Protein purification method development
Establishing protein purity criteria
Transfer of method to CRO for pilot scale production
Translating the Pilot scale process into manufacturing
Pilot and Manufacturing stage monitoring to make sure that quality is not compromised
Protein stability testing.
Filing of Pre-IND and IND
Site-specific PEGylation of protein drugs. PEGylation helps the protein drug to escape immune system of the patient and thereby prolongs the life span of the protein drug in the body.
Protein sequencing by LC-MS/MS
Site-specific mutagenesis and other techniques to stabilize the protein

Analytical Method Developement & Biomarkers

Progeneca provides the following services:

Protein Analytics, Analytical methods development as required by FDA and its Canadian and Europian counterparts
In-vitro assays using spectrophotometer
Fluorescence based assays
HPLC based assays
Chromatography based assays
Enriching of biomarkers from body fluids and cell culture secreted fluids
Preliminary identification of putative biomarkers by LC-MS
Consultancy services for all of the above

Consultancy

Progeneca provides quality consultancy services in the areas listed below:

Gene cloning
Choice of expression vector
Expression system selection
Selection of best expressing clones
Creation of research cell bank
Master cell bank generation
Protein purification method development
Establishing protein purity criteria
Transfer of method to CRO for pilot scale production and translating into Manufacturing
Monitor manufacturing at the CRO
Protein stability testing
Filing of pre-IND and IND
Biomarker discoveries