.
Dr. Chun-Yu Ho received his Ph.D. in 2005, for his development in the
area of organocatalytic asymmetric epoxidation, under the supervision of
Prof. Dan Yang in The University of Hong Kong (HKU). After pursing
post-doctoral research for transition metal catalysis with Prof. Timothy
F. Jamison during 2005-07 in Massachusetts Institute of Technology
(MIT), he started his independent career at The Chinese University of
Hong Kong (CUHK) as a Research Assistant Professor in 2007. Now he is an
Associate Professor in South University of Science and Technology of
China (SUSTC) and Adjunct AP of CUHK.
Poster Award at the Junior Workshop on Cutting-Edge Organic Chemistry in Asia, organized by National Tsing Hua University and National Science Council, ...
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Ph.D
South University of Science an..., Shenzhen · Chemistry
Research Experience
- Center of Novel Functional Molecules, Department of Chemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR (China)
Email: Dr. Chun-Yu Ho (jasonhcy@cuhk.edu.hk)
*Center
of Novel Functional Molecules, Department of Chemistry, The Chinese
University of Hong Kong, Shatin, NT, Hong Kong SAR (China)
Dr. Ho shared his recent breakthrough in the area
of alkene chemistry during the 5th International Conference on
Cutting-Edge Organic Chemistry in Asia (ICCEOCA-5), 7-11 November 2010.
He has been selected by the coordinator of Japan to receive an ACP
Lectureship Award and invited to deliver a series of lectures in 2011.
The presented work complements the P-Ni-H catalyzed alkene dimerization (for monoenes) and olefin cross-metathesis technology (for internal olefins), provides the first highly selective catalytic route to synthesize unsymmetric geminal disubstituted alkenes directly from two different types of monosubstituted olefins (http://en.wikipedia.org/wiki/Alkene). US Patent filed on 16 Feb 2010 via TLO, CUHK.
For further details about that work, please visit:
Angew. Chem. Int. Ed. 2010, 49, 9182.
http://onlinelibrary.wiley.com/doi/10.1002/anie.201001849/abstract
For the story behind the scene & the potential in regard to synthetic organic chemistry, please see:
SYNFACTS 2011, SYNFORM A15.
https://www.thieme-connect.com/ejournals/pdf/synfacts/doi/10.1055/s-0030-1259399.pdf
The presented work complements the P-Ni-H catalyzed alkene dimerization (for monoenes) and olefin cross-metathesis technology (for internal olefins), provides the first highly selective catalytic route to synthesize unsymmetric geminal disubstituted alkenes directly from two different types of monosubstituted olefins (http://en.wikipedia.org/wiki/Alkene). US Patent filed on 16 Feb 2010 via TLO, CUHK.
For further details about that work, please visit:
Angew. Chem. Int. Ed. 2010, 49, 9182.
http://onlinelibrary.wiley.com/doi/10.1002/anie.201001849/abstract
For the story behind the scene & the potential in regard to synthetic organic chemistry, please see:
SYNFACTS 2011, SYNFORM A15.
https://www.thieme-connect.com/ejournals/pdf/synfacts/doi/10.1055/s-0030-1259399.pdf
Research Interests：
**Organometallic Chemistry
N-Heterocyclic Carbene and its applications in OMCOS
Develop novel, practical, green and energy efficient methodology for:
◆ Organic chemical library synthesis and polymerization;
◆ Sustainable organic/hybrid materials preparations and applications;
◆ Phosphonylation and cyanation to access important biological cpds & their subsequent SAR studies.
Professional Experience：
◆ 2013 Associate Professor, South University of Science and Technology of China (SUSTC)
◆ 2013 Adjunct AP, The Chinese University of Hong Kong (CUHK)
◆ 2007 Research Assistant Professor, The Chinese University of Hong Kong (CUHK)
Educational Background：
◆ 2005 Postdoctoral Affiliate, Massachusetts Institute of Technology (MIT)
◆ 2000 Postgraduate Student, The University of Hong Kong (HKU)
Honors & Awards：
◆ 2013 American Chemical Society (ACS) Excellence in Science Symposium:
The Journal of Organic Chemistry and Organic Letters Best Poster Award
◆ 2013 Invited presentation in International Symposium of Organic Reaction Mechanism,
a Celebration in Honor of Grubbs, Houk, Schleyer & Truhlar
◆ 2013 Recognized as Overseas High-Caliber Personnel
(Peacock Program Awardee from Shenzhen Government)
◆ 2013 Adjunct AP at The Chinese University of Hong Kong
◆ 2012 Editorial Member of Natural Products Chemistry & Research Journal
◆ 2012 Invited as one of the three oversea lecturers in
3rd Symposium of Molecular Activation Directed toward Straightforward Synthesis,
at Hanamaki, Iwate (MEXT, Japan)
◆ 2012 Thousand Young Talents Program Awardee (1,1-Disubstituted Olefin Synthesis)
◆ 2012 Faculty of Science Postgraduate Student Research Output Award (Ms Lisi He)
◆ 2012 Publication honored in RSC ChemComm. Emerging Investigator Issue 2012
◆ 2011 Asian Core Program Lectureship Award (from Singapore)
◆ 2010 Asian Core Program Lectureship Award (from Japan)
◆ 2005 The Croucher Foundation Fellowship
Selected publications： * Denoted as the Corresponding Author
Representative Seminal Publications:
◆ “Shuffle off the Classic Beta-Si Elimination by Ni-NHC Cooperation: Implication for C-C Forming Reactions Involving Ni-Alkyl-Beta-Silanes.”
Ho, C.-Y.*; He, L. Chem. Commun. 2012, 48, 1481.
Honored in RSC ChemComm Emerging Investigator Issue 2012
◆ “Catalytic Intermolecular Tail-to-Tail Hydroalkenylation of Styrenes with alpha Olefins: Regioselective Migratory Insertion Controlled by a Nickel/N-Heterocyclic Carbene.”
Ho, C.-Y.*; He, L. Angew. Chem. Int. Ed. 2010, 49, 9182.
Highlighted thrice in:
SynForm 2011, issue 2, A15-16 (by Prof. Matteo Zanda);
SynFacts 2011, issue 3, 310 (by Prof. Paul Knochel & Andreas K. Steib).
Organic Chemistry Highlights, 2011, Functionalization and Homologation of Alkenes (by Prof. D. F. Taber).
◆ “Cyanative Alkene-Aldehyde Coupling: Ni(0)-NHC-Et2AlCN Mediated Chromanols Synthesis with High cis-Selectivity at room temperature”
Ho, C.-Y.* Chem. Commun. 2010, 46, 466.
◆ “Alpha-Olefins as Alkenylmetal Equivalents in Catalytic Conjugate Addition Reactions.”
Ho, C.-Y.; Ohmiya, H.; Jamison, T. F.* Angew. Chem. Int. Ed. 2008, 47, 1893.
◆ “Highly Selective Coupling of Alkenes and Aldehydes Catalyzed by NHC–Ni–P(OPh)3: Synergy Between a Strong σ-Donor and a Strong π-Acceptor.”
Selected as Hot Paper by Editors of Angewandte Chemie and published in advance of the Communication for their importance in a rapidly evolving field of high current interest:
Ho, C.-Y.; Jamison, T. F.* Angew. Chem. Int. Ed. 2006, 45, DOI: 10.1002/anie.200603907.
Angew. Chem. Int. Ed. 2007, 46, 782. Angew. Chem. 2007, 46, 796.
◆ “Nickel-Catalyzed Coupling of Alkenes, Aldehydes, and Silyl Triflates.”
Ng, S.-S.; Ho, C.-Y.; Jamison T. F.* J. Am. Chem. Soc. 2006, 128, 11513.
◆ “Nickel-Catalyzed, Carbonyl-Ene-Type Reactions: Selective for Alpha Olefins and More Efficient with Electron-Rich Aldehydes.”
Ho, C.-Y.; Ng, S.-S.; Jamison, T. F.* J. Am. Chem. Soc. 2006, 128, 5326.
Invited Reviews as Corresponding Author:
◆ “NHC-NiH Reactions with Simple Olefins: Advances in Hydroalkenylation, Polymerization, and Ionic Liquid Synthesis.”
Ho, C.-Y.*; He, L.; Chan, C.-W. Synlett 2011, SynPacts issue, 1649.
◆ “Catalytic Addition of Simple Alkenes to Carbonyl Cpds Using Group 10 Metals”
Ho, C.-Y. *; Schleicher, K. D.; Chan, C.-W.; Jamison, T. F.* Synlett 2009, 2565.
Collaborative Research Publications:
◆ "In Vitro Anti-acetylcholinesterase Activities and Permeabilities of Novel Potential Anti-Alzheimer's Agents".
Qian, S.; Mak, M.; He, L.; Ho, C.-Y.*; Han, Y.* and Zuo, Z.* Paper presented in the 9th International ISSX Meeting, organized by International Society for the Study of Xenobiotics. Istanbul, Turkey.
◆ “Nitrile assisted, Brosted acid catalyzed regio and stereoselective diarylphosphonylation of allyl silyl ethers”
Ho, C-Y.*; Chan, C.-W.; Wo, S-K.; Zuo, Z.*; Chan, L.-Y. Org. Biomol. Chem. 2010, 8, 3480.
◆ "Structure-activity and structure-permeability relationships of novel anti-Alzheimer’s agents tacrine dimers".
Qian, S.; He, L.; Mak, M.; Ho, C.-Y.*; Han, Y.* and Zuo, Z.* Paper presented in the 2011 AAPS Annual Meeting and Exposition, organized by The American Association of Pharmaceutical Scientists. Washington, DC, USA.
◆ "Development of LC/MS/MS method for determination of a novel tacrine dimer HLS-3 in rat plasma and its application to pharmacokinetic study".
◆ Qian, S.; He, L.; Wo, S-K.; Mak, M.; Han, Y.*; Ho, C-Y.*; Zuo, Z.* Paper presented in the 2012 AAPS Annual Meeting and Exposition, organized by The American Association of Pharmaceutical Scientists, USA.
Book Chapter:
◆ “NHC-Ni Hydride Catalyzed Terminal Disubstituted Alkene Synthesis”
Ho, C.-Y.*; He, L. ISBN 978-3-8465-0051-4, 88pgs
US Regular Patents:
◆ “Terminal 1,1-Disubstituted Olefin, Methods of Making and Using Thereof”
Solo Inventor: Ho, C.-Y.* US8383873B2 (Granted)
◆ “Process for Preparing Organometalloids”
Solo Inventor: Ho, C.-Y.* US8354554B2 (Granted)
Research Grants:
◆ HK GRF and UGC
◆ Young Thousand Talents Program (Chinese Central Government)
◆ NSFC (Young Program)
Other Info：
Professional Services:
◆ Serve as a reviewer of the following journals:
Angewandte Chemie
Chemistry An Asian Journal
Chemistry An European Journal
Journal of the American Chemical Society (JACS)
Journal of Organometallic Chemistry
Organic Letters
Synthesis
Synlett
◆ Serve as an Editorial member of the Journal below:
Natural Products Chemistry & Research Journal
http://www.esciencecentral.org/journals/editorialboardNPCR.php
Awards received by the students:
◆ Asian Core Program (ACP), Junior Workshop on Cutting-Edge Organic Chemistry in Asia Poster Award (2010 in Taiwan).
◆ Hong Kong Graduate Symposium Poster Award (Organic Chemistry Section).
Awarded by Hong Kong Graduate Symposium Committee (2011)
◆ Hong Kong PhD Fellowship. Awarded by UGC (2011)
◆ Faculty of Science Postgraduate Student Research Output Award (2011, one per year).
◆ Madam Wong Siew Khoon Scholarship, nominated by the Science Faculty Scholarship Committee as CUHK representative (2012, one per year).
In the Campus News:
◆ http://www.sustc.edu.cn/cn/press/campusnews/campusnews-20130326165601/
◆ http://www.sustc.edu.cn/en/press/campusnews/20131024153010/
Contacts：
◆ Email邮箱：jasonhcy@sustc.edu.cn
◆ College 书院: 致仁书院
**Organometallic Chemistry
N-Heterocyclic Carbene and its applications in OMCOS
Develop novel, practical, green and energy efficient methodology for:
◆ Organic chemical library synthesis and polymerization;
◆ Sustainable organic/hybrid materials preparations and applications;
◆ Phosphonylation and cyanation to access important biological cpds & their subsequent SAR studies.
Professional Experience：
◆ 2013 Associate Professor, South University of Science and Technology of China (SUSTC)
◆ 2013 Adjunct AP, The Chinese University of Hong Kong (CUHK)
◆ 2007 Research Assistant Professor, The Chinese University of Hong Kong (CUHK)
Educational Background：
◆ 2005 Postdoctoral Affiliate, Massachusetts Institute of Technology (MIT)
◆ 2000 Postgraduate Student, The University of Hong Kong (HKU)
Honors & Awards：
◆ 2013 American Chemical Society (ACS) Excellence in Science Symposium:
The Journal of Organic Chemistry and Organic Letters Best Poster Award
◆ 2013 Invited presentation in International Symposium of Organic Reaction Mechanism,
a Celebration in Honor of Grubbs, Houk, Schleyer & Truhlar
◆ 2013 Recognized as Overseas High-Caliber Personnel
(Peacock Program Awardee from Shenzhen Government)
◆ 2013 Adjunct AP at The Chinese University of Hong Kong
◆ 2012 Editorial Member of Natural Products Chemistry & Research Journal
◆ 2012 Invited as one of the three oversea lecturers in
3rd Symposium of Molecular Activation Directed toward Straightforward Synthesis,
at Hanamaki, Iwate (MEXT, Japan)
◆ 2012 Thousand Young Talents Program Awardee (1,1-Disubstituted Olefin Synthesis)
◆ 2012 Faculty of Science Postgraduate Student Research Output Award (Ms Lisi He)
◆ 2012 Publication honored in RSC ChemComm. Emerging Investigator Issue 2012
◆ 2011 Asian Core Program Lectureship Award (from Singapore)
◆ 2010 Asian Core Program Lectureship Award (from Japan)
◆ 2005 The Croucher Foundation Fellowship
Selected publications： * Denoted as the Corresponding Author
Representative Seminal Publications:
◆ “Shuffle off the Classic Beta-Si Elimination by Ni-NHC Cooperation: Implication for C-C Forming Reactions Involving Ni-Alkyl-Beta-Silanes.”
Ho, C.-Y.*; He, L. Chem. Commun. 2012, 48, 1481.
Honored in RSC ChemComm Emerging Investigator Issue 2012
◆ “Catalytic Intermolecular Tail-to-Tail Hydroalkenylation of Styrenes with alpha Olefins: Regioselective Migratory Insertion Controlled by a Nickel/N-Heterocyclic Carbene.”
Ho, C.-Y.*; He, L. Angew. Chem. Int. Ed. 2010, 49, 9182.
Highlighted thrice in:
SynForm 2011, issue 2, A15-16 (by Prof. Matteo Zanda);
SynFacts 2011, issue 3, 310 (by Prof. Paul Knochel & Andreas K. Steib).
Organic Chemistry Highlights, 2011, Functionalization and Homologation of Alkenes (by Prof. D. F. Taber).
◆ “Cyanative Alkene-Aldehyde Coupling: Ni(0)-NHC-Et2AlCN Mediated Chromanols Synthesis with High cis-Selectivity at room temperature”
Ho, C.-Y.* Chem. Commun. 2010, 46, 466.
◆ “Alpha-Olefins as Alkenylmetal Equivalents in Catalytic Conjugate Addition Reactions.”
Ho, C.-Y.; Ohmiya, H.; Jamison, T. F.* Angew. Chem. Int. Ed. 2008, 47, 1893.
◆ “Highly Selective Coupling of Alkenes and Aldehydes Catalyzed by NHC–Ni–P(OPh)3: Synergy Between a Strong σ-Donor and a Strong π-Acceptor.”
Selected as Hot Paper by Editors of Angewandte Chemie and published in advance of the Communication for their importance in a rapidly evolving field of high current interest:
Ho, C.-Y.; Jamison, T. F.* Angew. Chem. Int. Ed. 2006, 45, DOI: 10.1002/anie.200603907.
Angew. Chem. Int. Ed. 2007, 46, 782. Angew. Chem. 2007, 46, 796.
◆ “Nickel-Catalyzed Coupling of Alkenes, Aldehydes, and Silyl Triflates.”
Ng, S.-S.; Ho, C.-Y.; Jamison T. F.* J. Am. Chem. Soc. 2006, 128, 11513.
◆ “Nickel-Catalyzed, Carbonyl-Ene-Type Reactions: Selective for Alpha Olefins and More Efficient with Electron-Rich Aldehydes.”
Ho, C.-Y.; Ng, S.-S.; Jamison, T. F.* J. Am. Chem. Soc. 2006, 128, 5326.
Invited Reviews as Corresponding Author:
◆ “NHC-NiH Reactions with Simple Olefins: Advances in Hydroalkenylation, Polymerization, and Ionic Liquid Synthesis.”
Ho, C.-Y.*; He, L.; Chan, C.-W. Synlett 2011, SynPacts issue, 1649.
◆ “Catalytic Addition of Simple Alkenes to Carbonyl Cpds Using Group 10 Metals”
Ho, C.-Y. *; Schleicher, K. D.; Chan, C.-W.; Jamison, T. F.* Synlett 2009, 2565.
Collaborative Research Publications:
◆ "In Vitro Anti-acetylcholinesterase Activities and Permeabilities of Novel Potential Anti-Alzheimer's Agents".
Qian, S.; Mak, M.; He, L.; Ho, C.-Y.*; Han, Y.* and Zuo, Z.* Paper presented in the 9th International ISSX Meeting, organized by International Society for the Study of Xenobiotics. Istanbul, Turkey.
◆ “Nitrile assisted, Brosted acid catalyzed regio and stereoselective diarylphosphonylation of allyl silyl ethers”
Ho, C-Y.*; Chan, C.-W.; Wo, S-K.; Zuo, Z.*; Chan, L.-Y. Org. Biomol. Chem. 2010, 8, 3480.
◆ "Structure-activity and structure-permeability relationships of novel anti-Alzheimer’s agents tacrine dimers".
Qian, S.; He, L.; Mak, M.; Ho, C.-Y.*; Han, Y.* and Zuo, Z.* Paper presented in the 2011 AAPS Annual Meeting and Exposition, organized by The American Association of Pharmaceutical Scientists. Washington, DC, USA.
◆ "Development of LC/MS/MS method for determination of a novel tacrine dimer HLS-3 in rat plasma and its application to pharmacokinetic study".
◆ Qian, S.; He, L.; Wo, S-K.; Mak, M.; Han, Y.*; Ho, C-Y.*; Zuo, Z.* Paper presented in the 2012 AAPS Annual Meeting and Exposition, organized by The American Association of Pharmaceutical Scientists, USA.
Book Chapter:
◆ “NHC-Ni Hydride Catalyzed Terminal Disubstituted Alkene Synthesis”
Ho, C.-Y.*; He, L. ISBN 978-3-8465-0051-4, 88pgs
US Regular Patents:
◆ “Terminal 1,1-Disubstituted Olefin, Methods of Making and Using Thereof”
Solo Inventor: Ho, C.-Y.* US8383873B2 (Granted)
◆ “Process for Preparing Organometalloids”
Solo Inventor: Ho, C.-Y.* US8354554B2 (Granted)
Research Grants:
◆ HK GRF and UGC
◆ Young Thousand Talents Program (Chinese Central Government)
◆ NSFC (Young Program)
Other Info：
Professional Services:
◆ Serve as a reviewer of the following journals:
Angewandte Chemie
Chemistry An Asian Journal
Chemistry An European Journal
Journal of the American Chemical Society (JACS)
Journal of Organometallic Chemistry
Organic Letters
Synthesis
Synlett
◆ Serve as an Editorial member of the Journal below:
Natural Products Chemistry & Research Journal
http://www.esciencecentral.org/journals/editorialboardNPCR.php
Awards received by the students:
◆ Asian Core Program (ACP), Junior Workshop on Cutting-Edge Organic Chemistry in Asia Poster Award (2010 in Taiwan).
◆ Hong Kong Graduate Symposium Poster Award (Organic Chemistry Section).
Awarded by Hong Kong Graduate Symposium Committee (2011)
◆ Hong Kong PhD Fellowship. Awarded by UGC (2011)
◆ Faculty of Science Postgraduate Student Research Output Award (2011, one per year).
◆ Madam Wong Siew Khoon Scholarship, nominated by the Science Faculty Scholarship Committee as CUHK representative (2012, one per year).
In the Campus News:
◆ http://www.sustc.edu.cn/cn/press/campusnews/campusnews-20130326165601/
◆ http://www.sustc.edu.cn/en/press/campusnews/20131024153010/
Contacts：
◆ Email邮箱：jasonhcy@sustc.edu.cn
◆ College 书院: 致仁书院
Poster Award at the Junior Workshop on Cutting-Edge Organic Chemistry in Asia, organized by National Tsing Hua University and National Science Council, ...
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