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Friday, 30 October 2015

Mohan Thiruvazhi



Mohan Thiruvazhi

Independent Business Development and Scientific Professional
Dr. Thiruvazhi has several years of scientific and management experience gained during his tenure at Therachem, HepatoChem,  Incedis Therapeutics, Abbott Labs, ChemBridge Research Labs (CRL), and GVK BIO. He has a proven track record of success in managing collaborations in medicinal chemistry, custom synthesis, and library synthesis. t Abbott Labs, his chemistry R&D efforts led to commercialization of assays for diagnosis of certain nutritional disorders, and diseases such as CAD, stroke, deep vein thrombosis, dementia, and Alzheimer. At CRL, he championed a chemistry research department dedicated to support clientsÂ' medicinal chemistry programs. He also managed and co-chaired a multi-year $100 million ChemBridge-Pfizer file enrichment collaboration. Starting from HTS results, Dr. Thiruvazhi has delivered high quality leads in internal and external medicinal chemistry collaborations. Prior to founding Incedis, he was an Associate Director at GVK Biosciences (an Indian Contract Research Organization) where his responsibilities spanned from collaboration management to business development. Dr. Thiruvazhi received his Ph.D. in synthetic chemistry from SUNY-Albany and was a Postdoctoral fellow at University of Pittsburgh and Research Triangle Institute

links

 

Experience






VP (Chemistry & Business Development)

Therachem Research Medilab Pvt Ltd
– Present (5 months)Greater Boston Area, MA
Therachem is an innovative, chemistry-driven global service provider for pharmaceutical and biopharmaceutical companies. Therachem believes in quality work and timely deliverance of services.

With high-end standard processes and guidance of technical experts, we provide comprehensive solutions to support medicinal chemistry research and chemical process research and development.

Therachem,a world-class research & development facility is located at Jaipur, Rajasthan, India.





VP Business Development

HepatoChem
– Present (6 months)Beverly, MA
Hepatochem is a C-H Activation chemistry technology company helping cleints with
(a) rapid analoging of hits/leads in a single chemical transformation in order to develop SAR or fix potential DMPK liabilities
(b) synthesize metabolites in single step in single digit mg to 100 mg quantities and deliver these in 2-4 weeks.
(c) supplying BMO (Biomimetic Oxidation Kits) for synthesis of metabolites and Glucuronidation kits that allows to identify reaction condition that produces glucuronide adduct of a drug compound. The reaction conditions are derivative of the Koenigs–Knorr reaction

visit our website at www.hepatochem.com

My responsibilities include but is not limited to

- acquisition of new clients, expansion of services to existing clients, helping clients best leverage Hepatochem technology.

- Strategy to expand technology to new service lines and secure funding for the same.








Independent Business Development and Chemistry Consultant

Independent Business Development and Chemistry Consultant
– Present (6 months)Greater Boston Area, MA
I help Life Science vendors and service providers

- develop and implement a well-defined sales strategy for increased revenue generation
- acquire new customer and expand services within existing customers
- out reach into North America or specific North American territory(ies)
- market on one or more products or services w/o committing to a full time business development professional
- define and implement marketing strategy
- retain and expand CRO-Client relationships via synthetic chemistry consulting





Head, Global Discovery Services (Sales & Marketing)

GVK Biosciences
(3 years 8 months)Greater Boston Area
I was responsible for a global team of business development professionals in US, Europe, APAC, and India. Delivered revenues in excess of budget and beat market growth by delivering 20% growth in drug discovery services. Built high performing teams in each territory and trained, motivated, and empowered them to deliver their targets.
Interacted very strongly with Operational Heads and next level leaders to ensure projects were delivered on time and under budget. Matrix interactions with Finance & Legal teams, and reporting responsibilities into the CEO and the executive leadership team.





President (Operations) and Co-founder

Incedis Therapeutics
(3 years)
Incedis is a San Diego drug discovery services company specializing in medicinal chemistry. We provide expertise in medicinal chemistry, synthetic chemistry, and project management to support our clients’ preclinical discovery chemistry efforts. We have seamlessly integrated U.S. based medicinal chemistry expertise with synthetic chemistry operations in India and manage these to U.S. standards. This integration has enabled us to provide unique, cost-effective, high-quality medicinal chemistry outsourcing solutions to our clients.

At Incedis, we

― strive to understand the needs, requirements, and objectives of our clients’ projects
― focus our efforts to help our clients achieve their project objectives
― take pride in providing value-added services to our clients





Associate Director (Business Development)

GVK Biosciences, Inc.
(9 months)
Responsible for US medicinal chemistry business development and management of collaborations





Associate Director

ChemBridge Research Laboratories
(6 years 1 month)
Championed new Chemistry Research Department, managed daily chemistry operations. Co-chaired Chemical Working Group of multi-year, multinational Global Pfizer/ChemBridge Collaboration in support of Pfizer's Discovery Efforts.

Executed external discovery collaborations and internal discovery efforts in kinase inhibitors.





Senior Scientist

Abbott Laboratories
(3 years 3 months)



Education





University of Pittsburgh

Post Doctoral Scientist, SYnthetic Organic Chemistry


Mohan Thiruvazhi, Ph.D. 1993, mthiruvazhi@gmail.com

Mohan Thiruvazhi











Since my graduation in 1993 from Professor Block’s group, I have traversed a diverse professional path starting with postdoc stints at the University of Pittsburgh and Research Triangle Institute (RTI), to chemistry in diagnostics, to heading a chemistry research department and managing global chemistry collaborations, to heading business development for a CRO in India.

 In Professor Block’s group, I was exposed to very exciting and rewarding chemistry research leading to more discoveries than I could handle. I thoroughly enjoyed sharing much of my Ph.D. days with all the other group members, and to date cherish those moments. The famous ‘What’s New?’ or its variant ‘Anything New?’ asked by Dr. Block daily or even multiple times in a day still rings in my ears.

Since January 2001, I have lived in beautiful San Diego with my wife Sujitha and kids Meghna (15 years) and Naveen (14 years)[as of January 2013]. Interestingly, my stay in San Diego has been the longest in a city thus far! As part of my business development responsibilities,
 Sujitha

Meghna

 Naveen


 I travel to the East Coast quite, often visiting Boston, NY and NJ cities, Philadelphia, and the Research Triangle Park area of NC.

I enjoy reading non-fiction books, am deeply interested in philosophy, love playing volleyball, and ardently follow cricket. I would love to be reconnected with Prof. Block’s past and present students. I can be reached at mthiruvazhi@gmail.com










Mohan Santhanam Thiruvazhi

Patent number: 8815906
Abstract: Provided are compounds of the formula (I): or a stereoisomer, tautomer, salt, hydrate or prodrug thereof that modulate tyrosine kinase activity, compositions comprising the compounds and methods of their use.
Type: Grant
Filed: March 18, 2009
Issued: August 26, 2014
Assignee: Chembridge Corporation
Inventors: Yahua Liu, Alexey Vyacheslavovich Anikin, Charles Chamchoumis Mikel, Douglas Eric McGrath, Goverdhan Reddy Vavilala, Jason Conrad Pickens, Aleksander Kadushkin, Luyong Jiang, Mohan Santhanam Thiruvazhi, Sergey Zozulya, Rajendran Vairagoundar, Tong Zhu, Alexander Chucholowski, Zheng Yan, Alisher Khasanov, Christina Gregor
Application number: 20130131062
Abstract: The present invention is directed to pyridazinone compounds of formula (I) and furan compounds of formula (II), pharmaceutical compositions of compounds of formula (I) and (II), kits containing these compounds, methods of syntheses, and a method of treatment of a proliferative disease in a subject by administration of a therapeutically effective amount of a compound of formulae (I) or (II). Both classes of compounds were identified through screening of a collection of small molecule libraries.
Type: Application
Filed: December 21, 2007
Issued: May 23, 2013
Inventors: Hakim Djaballah, Harold E. Varmus, David Shum, Romel Somwar, Alexander Chucholowski, Mohan Santhanam Thiruvazhi
Application number: 20130053376
Abstract: Provided are compounds of the formula (I): or a stereoisomer, tautomer, salt, hydrate or prodrug thereof that modulate tyrosine kinase activity, compositions comprising the compounds and methods of their use.
Type: Application
Filed: March 18, 2009
Issued: February 28, 2013
Inventors: Yahua Liu, Alexey Vyacheslavovich Anikin, Charles Chamchoumis Mikel, Douglas Eric McGrath, Goverdhan Reddy Vavilala, Jason Conrad Pickens, Aleksander Kadushkin, Luyong Jiang, Mohan Santhanam Thiruvazhi, Sergey Zozulya, Rajendran Vairagoundar, Tong Zhu, Alexander Chucholowski, Zheng Yan, Alisher Khasanov, Christina Gregor
Patent number: 8063225
Abstract: Provided are compounds of the formula (I): or a stereoisomer, tautomer, salt, hydrate or prodrug thereof that modulate tyrosine kinase activity, compositions comprising the compounds and methods of their use.
Type: Grant
Filed: August 10, 2007
Issued: November 22, 2011
Assignee: Chembridge Corporation
Inventors: Vlad E. Gregor, Yahua Liu, Alexey Anikin, Danny Peter Claude McGee, Charles Mikel, Douglas Eric McGrath, Goverdhan Reddy Vavilala, Jason C. Pickens, Alexander Kadushkin, Luyong Jiang, Mohan Santhanam Thiruvazhi, Sergey Zozulya, Rajendran Vairagoundar, Tong Zhu, Alexander Chucholowski, Thomas Webb, Vidyasagar Reddy Gantla, Zheng Yan
Application number: 20100210649
Abstract: The present invention is directed to pyridazinone compounds of formula (I) and furan compounds of formula (II), pharmaceutical compositions of compounds of formula (I) and (II), kits containing these compounds, methods of syntheses, and a method of treatment of a proliferative disease in a subject by administration of a therapeutically effective amount of a compound of formulae (I) or (II). Both classes of compounds were identified through screening of a collection of small molecule libraries.
Type: Application
Filed: December 21, 2007
Issued: August 19, 2010
Assignee: Sloan-Kettering Institute for Cancer Research
Inventors: Hakim Djaballah, Harold E. Varmus, David Shum, Romel Somwar, Alexander Chucholowski, Mohan Santhanam Thiruvazhi
Application number: 20080171769
Abstract: Provided are compounds of the formula (I): or a stereoisomer, tautomer, salt, hydrate or prodrug thereof that modulate tyrosine kinase activity, compositions comprising the compounds and methods of their use.
Type: Application
Filed: August 10, 2007
Issued: July 17, 2008
Inventors: Vlad E. Gregor, Yahua Liu, Alexey Anikin, Danny Peter Claude McGee, Charles Mikel, Douglas Eric McGrath, Goverdhan Reddy Vavilala, Jason C. Pickens, Alexander Kadushkin, Luyong Jiang, Mohan Santhanam Thiruvazhi, Sergey Zozulya, Rajendran Vairagoundar, Tong Zhu, Alexander Chucholowski, Thomas Webb, Vidyasagar Reddy Gantla, Zheng Yan


 

  • Spectroscopic, Theoretical, and Electrochemical Studies of 1,2-Dithiins, Richard S. Glass, John R. Pollard, T. Benjamin Schroeder, Dennis L. Lichtenberger, Eric Block, Russell Deorazio, Chuangxing Guo, Mohan Thiruvazhi. Phosphorus, Sulfur Silicon Relat. Elem., 1997, 120 (1), pp 439–440. DOI: 10.1080/10426509708545587
  • Significant Intramolecular Sulfur-Sulfur Interactions in cis- and trans-2,3-Dimethyl-5,6-dithiabicyclo[2.1.1]hexane, Eric Block, Richard. Glass, Russell DeOrazio, Dennis L. Lichtenberger, John R. Pollard, Erin E. Russell, T. Benjamin Schroeder, Mohan Thiruvazhi, Paul J. Toscano. Synlett, 1997, (SI), pp 525-528. DOI: 10.1055/s-1997-6136



 HIS SCHOOL..............

Don Bosco Matriculation School - Egmore,Chennai

www.dbegmore.com/
Don Bosco Matriculation School- Egmore,Chennai,School was founded in 1959 as ... of Madras,On 1st July 1978 it was upgraded as a Higher Secondary School.

13, Casa Major Road, Egmore, Chennai, Tamil Nadu 600008
044 2819 1274
 
 Map of Don Bosco Matriculation Higher Secondary School


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