Mourad Daoubi Khamlichi
Medicinal Chemistry, Synthetic Chemistry, Heterocyclic Chemistry, Drug Discovery
LINKS
https://www.facebook.com/Moudakmo
https://es.linkedin.com/in/mouraddaoubikhamlichi
https://www.youtube.com/channel/UCjIAg1cE1ui2A9XJCAoCO9w
Went to AL ADARISSA
Mourad Daoubi KhamlichiCartagena Murcia 30204 Spain
Education
University of Cádiz
Doctor of Philosophy (Ph.D.), Organic Chemistry
Ph.D.Activities and Societies: PhD. In Organic Chemistry: Anti-fungal Products Reasearch
University of Cadi Ayyad - Marrakech
Doctor of Philosophy (Ph.D.), Organic Chemistry
PhD. in Applied Industrial Organic ChemistryActivities and Societies: PhD.Experience
Senior Scientist - Team Leader
Villapharma Research
* Total Synthesis of organic products with pharmaceutical interests
* Multi-Steps Synthesis of Organic Products as specified by the client Requests.
* High Throughput Synthesis of molecules destinated to different type of medical screening.
* Biotransformations with microorganisms (Specially with Fungus)
* Coordination and Planification of different projects at the same time
* High capacity to communicate and discuss the results to clients (in English, French and/or Spanish).
* Management and accompagnement of technical staff on a daily basis.
Researcher
Algry companies
Research of new and low cost synthetic routes for three existing drugs in the market.
Researcher
Newbiotechnologic
I have been the responsible of the preparation of small molecules to be forwarded afterwards to antifungal high throughput screening.Volunteer Experience & Causes
Causes Mourad cares about:
- Education
- Health
- Science and Technology
Patents
Preparation of piperidinopyrimidine derivatives for use as antiviral agents
Europe
Issued August 15, 2013
MACROCYCLIC TGF-BR2 KINASE INHIBITORS
Europe WO2015136073
Issued September 17, 2015
The present invention relates to macrocyclic compounds and compositions containing said compounds acting as kinase inhibitors, in particular as inhibitors of Transforming Growth Factor beta Receptor 2 (TGF-β R2) and/or mutants thereof, for use in the diagnosis, prevention and/or treatment of TGF-β R2 -kinase associated diseases. Moreover, the present invention provides methods of using said...morePublicationsHemisynthesis and absolute configuration of novel 6-pentyl-2H-pyran-2-one derivatives from Trichoderma spp.
Tetrahedron
June 20, 2009
A comparative study of the secondary metabolism of two Trichoderma spp. with that of the Thctf1 transcription factor gene null mutant of Trichoderma harzianum 34 was carried out in order to deepen our knowledge of the biosynthetic pathway and mode of action of 6-pentyl-2H-pyran-2-one (1) and its derivatives as biocontrol agents. New isolated metabolites have shed light on the detoxification...more
Lipase-catalyzed resolution of 5-acetoxy-1,2-dihydroxy-1,2,3,4-tetrahydronaphthalene. Application to the synthesis of (+)-(3R,4S)-cis-4-hydroxy-6-deoxyscytalone, a metabolite isolated from Colletotrichum acutatum
Tetrahedron
April 25, 2009
(+)-cis-4-Hydroxy-6-deoxyscytalone, a natural product bio-synthesized by Colletotrichum sp., has been prepared and its absolute configuration confirmed as 3R,4S, the key step being a kinetic racemic resolution of a cis-diol easily obtained from commercial 1,2,3,4-tetrahydronaphthalen-1,5-diol. Four lipases and different reaction conditions were tested in order to obtain the best yield and...more
Selective Synthesis of β‐Hydroxy Nitroethanol Ethers by Alcoholysis of Oxiranes
Synthetic Communications
October 5, 2007
β‐Hydroxy nitroethanol ethers are prepared by selective alcoholysis of oxiranes. The best results are obtained using a clay (monmorillonite K10) or a π‐acid (TCNE) as the catalyst.
Isolation of new phenylacetylingol derivatives that reactivate HIV-1 latency and a novel spirotriterpenoid from Euphorbia officinarum latex
Bioorganic & Medicinal Chemistry
July 1, 2007
Three new, highly functionalized ingol diterpenes, ingol 7,8,12-triacetate 3-phenylacetate (1), ingol 7,8,12-triacetate 3-(4-methoxyphenyl)acetate (2) and 8-methoxyingol 7,12-diacetate 3-phenylacetate (3), together with the novel spirotriterpene, 3S,4S,5R,7S,9R,14R-3,7-dihydroxy-4,14-dimethyl-7[8 → 9]-Abeo-cholestan-8-one (4), have been isolated from Euphorbia officinarum latex. Structures were...more
The role of botrydienediol in the biodegradation of the sesquiterpenoid phytotoxin botrydial by Botrytis cinerea
Tetrahedron
August 28, 2006
The biotransformation of botrydienediol (6) labelled with deuterium on carbons C-10 and C-15 has been studied. This has led to modification of some previous assumptions about the biodegradative route of botrydial. The [10-2H,15-2H]-botry-1(9)-4-diendiol (12) was transformed into dehydrobotrydienediol derivatives 13–15 but it was not incorporated into secobotryane skeleton (7). In addition, three...more
Biosynthetic Studies on the Botcinolide Skeleton: New Hydroxylated Lactones from Botrytis cinerea
Journal of Organic Chemistry
2006
The biosynthetic origin of the botcinolide skeleton was investigated by means of feeding 13C- and 2H-labeled precursors to Botrytis cinerea. Three new compounds, two homobotcinolide derivatives, 3-O-acetylhomobotcinolide (5) and 8-methylhomobotcinolide (6), and a new 11-membered lactone (7), were isolated. Their structures were elucidated on the basis of spectroscopic data, including one-bond and...more
Screening Study of Lead Compounds for Natural Product-Based Fungicides: Antifungal Activity and Biotransformation of 6α,7α-Dihydroxy-β-himachalene by Botrytis cinerea
Journal of Agriculture and Food Chemistry
2005
Eleven β-himachalene derivatives were tested, using the poisoning food technique, for their potential antifungal activity against the phytopathogen Botrytis cinerea. Compounds 1−11 displayed moderate activity, whereas the 6,7-diol derivative (12) produced an inhibition of 91% after 6 days. The microbial transformation of 12 was investigated and yielded four new compounds hydroxylated at positions...more
Antifungal Activity and Biotransformation of Diisophorone by Botrytis cinerea
Journal of Agriculture and Food Chemistry
2005
Diisophorone (1) was tested against two strains of the necrotrophic plant pathogen Botrytis cinerea. Fungal sensitivity varied according to the strain. B. cinera 2100 was more sensitive than B. cinerea UCA992: its mycelial growth was significantly inhibited at concentrations of 50 ppm and above. Although diisophorone (1) showed an effective control of B. cinerea, a detoxification mechanism was...more
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Síntesis 7 and Síntesis 10. Villapharma Research. — with Agueda Trabalón Bonillo, Mourad Daoubi Khamlichi, Rebeca Gallardo Garcia, Jesús Francisco Meroño Nicolás and Pascual Ribelles.
Villapharma Research.
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University of Cádiz
Cartagena, Murcia, SPAIN
Cadi Ayyad University
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