James P. Stambuli

 

 James P. Stambuli

Senior Scientist III at AbbVie
https://www.linkedin.com/in/james-stambuli-80a4958

James Stambuli was born in Paterson, NJ and received his BA in Chemistry with Honors from Rutgers University in Newark, NJ in 1998. He obtained his PhD from Yale University in the laboratory of Prof. John Hartwig in 2003 and was an NIH Postdoctoral Fellow with Prof. Barry Trost at Stanford University from 2003 to 2006. He began an independent research career at the Ohio State University in 2006 and recently joined the PR&D division of AbbVie. Prof. Stambuli’s research is in the fields of organometallic and organic chemistry with particular emphasis on transition metal catalyst design to assist in the invention of new technologies for chemical transformations.

Summary

Academic Experience: Graduated 10 PhD and 5 MS Students; Published 20 papers (33 total), 2 book chapters, and 1 patent as a PI; Taught organic chemistry to >2000 students.

Industrial Experience: Team Leader of 4 PhD chemists and an external team from a CRO; cGMP synthesis; Route scouting; Enable seamless technology transition from MedChem to Process Development.

Experience

Senior Scientist III

AbbVie

June 2015 – Present (7 months)

Senior Scientist II

AbbVie

July 2014 – June 2015 (1 year)North Chicago, IL

Assistant Professor

The Ohio State University

July 2006 – May 2014 (7 years 11 months)

NIH Postdoctoral Fellow

Stanford University

December 2003 – June 2006 (2 years 7 months)

Education

Yale University

Ph.D., Chemistry

1998 – 2003

Rutgers, The State University of New Jersey-Newark

B. A., Chemistry

James Stambuli

Assistant Professor
Department of Chemistry
Ohio State University
100 W. 18th Avenue
Columbus, Ohio 43210

stambuli@chemistry.ohio-state.edu
(614)-688-8082

Education and Research Experience

NIH Postdoctoral Fellow: Stanford University
Research advisor: Professor Barry M. Trost

Ph.D. in Chemistry Yale University
Research Advisor: Professor John F. Hartwig

B.A. in Chemistry, Biology minor; with Honors, Rutgers University
Research Advisors: Professor Susanne Raynor, Ramy Farid

Honors and Awards

2013	Thieme Chemistry Journal Awardee
2012	Organometallics Fellow (ACS)
2004	Wolfgang Prize for Best Thesis (Yale University)
2004	Chemical Abstracts Service Science Spotlight Award-'Most Requested' Article
2003	National Institutes of Health Postdoctoral Fellowship
1998	Rutgers University Honors College
1995	Howard Hughes Medical Institute Internship

Contact Us

James Stambuli

	Ohio State University Deparment of Chemistry 4081 Evans Lab 100 W. 18th Ave. Columbus, OH 43210
	+1 (614) 688 8082
	+1 (614) 292 1685

Stambuli Laboratories

	4083 - 4087 Evans Lab
	+1 (614) 247 2490

Webmaster

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Publications

• 32. A Survey of Sulfide Ligands for Allylic C-H Oxidations of Terminal Olefins
  Chi "Chip" Le, Kamala Kunchithapatham, William H. Henderson, Christopher T. Check, Prof. James P. Stambuli Chem. Eur. J. 2013, 19, 11153.
  
  
  
  
• 31. Palladium-Catalyzed Reactions of Enol Ethers: Access to Enals, Furans, and Dihydrofurans
  Matthew G. Lauer , William H. Henderson , Amneh Awad , and James P. Stambuli Org. Lett. 2012, 14, 6000.
  
  
  
  
• 30. Site-Selective Alkyl Dehydrogenation of a Coordinated Acylphosphine Ligand
  Sean M. Whittemore, Ryan J. Yoder, and James P. Stambuli Organometallics 2012, 31, 6124.
  
  
  
  
• 29. Synthesis of diaryl ketones via a phosphine-free Fukuyama reaction
  Kamala Kunchithapatham, Chad C. Eichman and James P. Stambuli Chem. Commun. 2011, 47, 12679.
  
  
  
  
• 28. Oxidant-Controlled Stereoselectivity in the Pd-Catalyzed Allylic Oxidation of cis-Vinylsilanes
  Christopher T. Check, William H. Henderson, Brenda C. Wray, Matthew J. Vanden Eynden, and James P. Stambuli J. Am. Chem. Soc. 2011, 133, 18503.
  
  
  
  
• 27. Synthesis and Reactivity of the Anionic Iridium(III) Complex [Cp*Ir(OTf)3][Ag{tBu2P(heptanoyl)}]
  Sean M. Whittemore, Judith Gallucci, and James P. Stambuli Organometallics 2011, 30, 5273.
  
  
  
  
• 26. Characterization, Reactivity, and Potential Catalytic Intermediacy of a Cyclometalated Tri-tert-butylphosphine Palladium Acetate Complex
  William H. Henderson, Jimmy M. Alvarez, Chad C. Eichman, and James P. Stambuli Organometallics 2011, 30, 5038.
  
  
  
  
• 25. Mechanistic Insight into the Halogen Dance Rearrangement of Iodooxazoles
  Proust, N.; Chellat, M. F.; Stambuli, J. P. Synthesis 2011.
  
  
• 24. Synthesis of Key Fragments of Leiodelide A
  Chellat, M. F.; Proust, N.; Lauer, M. G.; Stambuli, J. P. Org. Lett. 2011, 13, 3246.
  
  
  
  
• 23. Exploiting Guanidine as a Ligand in Cobalt-Catalyzed Alkyne Cyclotrimerizations
  Eichman, C. C.; Bragdon, J. P.; Stambuli, J. P. Synlett 2011, 1109.
  
  
  
  
• 22. Transition Metal Catalyzed Synthesis of Aryl Sulfides
  Eichman, C. C.; Stambuli, J. P. Molecules 2011, 16, 590.
  
  
• 21. Synthesis of 2,4- and 2,5-Disubstituted Oxazoles via Metal- Catalyzed Cross-Coupling Reactions
  Counceller, C. M.; Eichman, C. C.; Proust, N.; Stambuli, J. P. Adv. Synth. Catal. 2011, 353, 79.
  
  
  
  
• 20. The Preparation of Indazoles via Metal Free Intramolecular Electrophilic Amination of 2-Aminophenyl Ketoximes
  Counceller, C. M.; Eichman, C. C.; Wray, B. C.; Welin, E. R.; Stambuli, J. P. Org. Synth. 2011, 88, 33.
  
  
  
  
• 19. Calcium-Promoted Pictet-Spengler Reactions of Ketones and Aldehydes
  Vanden Eynden, M. J.; Kunchithapatham, K.; Stambuli, J. P. J. Org. Chem. 2010, 75, 8542.
  
  
  
  
• 18. Synthesis of N-Arylindazoles and Benzimidazoles from a Common Intermediate
  Wray, B. C.; Stambuli, J. P. Org. Lett. 2010, 12, 4576.
  
  
  
  
• 17. Allylic Oxidations of Terminal Olefins Using a Palladium Thioether Catalyst
  Henderson, W. H.; Check, C. T.; Proust, N.; Stambuli, J. P. Org. Lett. 2010, 12, 824.
  
  
  
  
• 16. Zinc-Mediated Palladium-Catalyzed Formation of Carbon−Sulfur Bonds
  Eichman, C. C.; Stambuli, J. P. J. Org. Chem. 2009, 74, 4005.
  
  
  
  
• 15. Nickel-Catalyzed Synthesis of Oxazoles via C-S Activation
  Lee, K; Counceller, C. M.; Stambuli, J. P. Org. Lett. 2009, 11, 1457.
  
  
  
  
• 14. Calcium-Catalyzed Pictet-Spengler Reactions
  Vanden Eynden, M. J.; Stambuli, J. P. Org. Lett. 2008, 10, 5289.
  
  
  
  
• 13. A Practical, Metal-Free Synthesis of 1H-Indazoles
  Counceller, C. M.; Eichman, C. C.; Wray, B. C.; Stambuli, J. P. Org. Lett. 2008, 10, 1021.
  
  
  
  

Postdoctoral and Graduate Work

• 12. Trost, B. M.; Silverman, S. M.; Stambuli, J. P. Palladium-Catalyzed Asymmetric [3+2] Cycloaddition of Trimethylenemethane with Imines. J. Am. Chem. Soc. 2007, 129, 12398-12399.
• 11. Stambuli, J. P.; Weng, Z.; Incarvito, C. D.; Hartwig, J. F. Reductive Elimination of Ether from T-Shaped, Monomeric Arylpalladium Alkoxides. Angew. Chem. Int. Ed. 2007, 46, 7674-7677.
• 10. Trost, B. M.; Stambuli, J. P.; Silverman, S. M.; Schworer, U. Palladium-Catalyzed Asymmetric [3+2] Trimethylenemethane Cycloaddition Reactions. J. Am. Chem. Soc. 2006, 128, 13328-13329.
• 9. Shen, Q.; Shekhar, S.; Stambuli, J. P.; Hartwig, J. F. Highly-Reactive, Long-Lived, and General Catalysts for the Palladium-Catalyzed Reactions of Heteroaryl and Aryl Chlorides with Primary Nitrogen Nucleophiles. Angew. Chem., Int. Ed. 2005, 44, 1371-1375.
• 8. Stambuli, J. P.; Incarvito, C. D.; Buhl, M.; Hartwig, J. F. Synthesis, Structure, Theoretical Studies, and Ligand Exchange Reactions of Monomeric, T-Shaped Arylpalladium(II) Halide Complexes with an Additional, Weak Agostic Interaction. J. Am. Chem. Soc. 2004, 126, 1184-1194.
• 7. Stambuli, J. P.; Hartwig, J. F. Recent advances in the discovery of organometallic catalysts using high-throughput screening assays. Curr. Opin. Chem. Biol. 2003, 7, 420-426.
• 6. Stambuli, J. P.; Kuwano, R; Hartwig, J. F. Unparalleled Rates for the Activation of Aryl Chlorides and Bromides: Coupling with Amines and Boronic Acids in Minutes at Room Temperature. Angew. Chem., Int. Ed. 2002, 41, 4746-4748.
• 5. Stambuli, J. P.; Buhl, M.; Hartwig, J. F. Synthesis, Characterization, and Reactivity of Monomeric, Arylpalladium Halide Complexes with a Hindered Phosphine as the only Dative Ligand. J. Am. Chem. Soc. 2002, 124, 9346-9347.
• 4. Kataoka, N.; Shelby, Q. D.; Stambuli, J. P.; Hartwig, J. F. Air-Stable, Sterically Hindered Ferrocenyl Dialkylphosphines for Palladium-Catalyzed C-C, C-N and C-O Bond-Forming Cross-Couplings. J. Org. Chem. 2002, 67, 5553-5566.
• 3. Stauffer, S. R.; Beare N. A.; Stambuli, J. P.; Hartwig, J. F. Palladium-Catalyzed Arylation of Ethyl Cyanoacetate. Fluorescence Resonance Energy Transfer as a Tool for Reaction Discovery. J. Am. Chem. Soc. 2001, 125, 4641-4642.
• 2. Stambuli, J. P.; Stauffer, S. R.; Shaughnessy, K. H.; Hartwig, J. F. Screening of Homogeneous Catalysts by Fluorescence Resonance Energy Transfer. Identification of Catalysts for Room-Temperature Heck Reactions. J. Am. Chem. Soc. 2001, 123, 2677-2678.
• 1. Stauffer, S. R.; Lee, S.; Stambuli, J. P.; Hauck, S. I.; Hartwig, J. F. High Turnover Number and Rapid, Room-Temperature Amination of Chloroarenes Using Saturated Carbene Ligands. Org. Lett. 2000, 2, 1423-1426.

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