Dr. Sobia Ahsan Halim
Assistant Professor in Department of Biochemistry at Kinnaird College for Women
SOBIA AHSAN HALIM C-126, Block-A, North Nazimabad, Karachi-Pakistan.
Sobiahal@gmail.com, sobia_halim@yahoo.com. Contact: 021-6637644
http://www.pcst.org.pk/wst/cv%5CSobia%20Ahsan%20Halim.pdf
https://pk.linkedin.com/in/dr-sobia-ahsan-halim-7a3a3825
Sobia Ahsan Halim
Summary
I
am trained as a computational medicinal chemist and have command over
structure and ligand based drug design techniques. I am highly motivated
and dynamic person, always ready to take challenging tasks. My research
Interest are:
Molecular simulation of any systems of pharmaceutical and biological interest.Design of new bio-active molecules using computer aided modelling techniques
Modelling of small organic molecules, proteins, and protein-ligand interactions
Ligand based and structure based pharmacophore design and
3D-QSar analysis
These research involves the application and development of all aspects of medicinal chemistry, organic synthesis, molecular modeling, computational chemistry, computer-aided drug design, virtual screening (docking, scoring, 3D-QSAR; CoMFA, COMSIA), virtual combinatorial library design using pharmacophore approaches, protein structure prediction and molecular dynamics simulations.
I have worked on following Molecular Modeling Tools:
Sybyl, Pipeline pilot, Maestro, MOE.
Docking Programs: Glide, LigandFit, FlexX, GOLD, FlexiDock, eHits, MOE, AutoDock, SurflexDock, and FRED.
Pharmacophore based tools: LigandScout, Catalyst, GASP and Galahad
Visualization Programs: VMD, Chimera, Ligplot and Vida.
MD Simulation: AMBER
Specialties: Fragment based library designing
Evaluation and validation of several docking and scoring tools Molecular docking
Pharmacophore Modeling
Homology Modeling
Generation and screening of large virtual combinatorial compound libraries
Virtual Screening
3D-QSAR using CoMFA and CoMSIA
Molecular Dynamics simulations by AMBER
Experience
Assistant Professor in Department of Biochemistry
Kinnaird College for Women
Assistant Professor
National Center of Excellence in Molecular Biology, University of Punjab, Lahore
Bioinformatics Unit at CEMB
Sobia Ahsan Halim
Research Officer
Computational Chemistry Unit, Dr. Panjwani Center for Molecular Medicine and Drug Research, ICCBS
Molecular Modeling
Ph. D Scholar
Dr.Panjwani Center for Molecular Medicine and Drug Research, ICCBS.
Computational Drug Designing
Lecturer
JUW Jinnah University for Women
Visiting Scholar
School of Pharmacy, Southern Illinois University Edwardville
Fragment based Library Designing
Patents
Anti Inflammatory Compounds
United States 8329678B1/13/184551
Issued November 12, 2012
Azadirachta
indica cell suspension culture was used for the biotransformation of
Dianabol to yield a metabolite 17-beta-hydroxy-17-alpha methyl 5-alpha
androstan 3-one which can also be synthesized, as a potent anti
inflammatory agent
Immunosuppressive Compounds
United States US-Patent US-20140378515 A1, Application No, 13/921705
Issued December 25, 2014Courses
Independent Coursework
- Computational Drug Designing
- Biochemistry
- Cell Biology
- Microbiology
- Genetics
- Neurochemistry
- Pharmacology
Publications
Immunosuppressive Activity of Buxidin and E-Buxenone from Buxus hyrcana(Link)
Chemical Biology and Drug Design
2010
Buxidin
(1) and E-Buxenone (2), steroidal alkaloids from Buxus hyrcana, are
found to possess potent immunosuppressive properties. The activity was
tested in vitro on oxidative burst, chemotaxis, T-cell proliferation,
and cytokine production. Both compounds showed a significant
immunomodulatory activity with clear suppressive effect on oxidative
burst and chemotaxis in a dose-dependent manner. They...more
Benchmarking docking and scoring protocol for the identification of potential acetylcholinesterase inhibitors(Link)
Journal of Molecular Graphics and Modelling
2010
Acetylcholinesterase
(AChE) plays a crucial role in nerve impulse transmission at
cholinergic synapses by rapid hydrolysis of the neurotransmitter
acetylcholine (ACh). AChE has become an important drug target because
partial inhibition of AChE results in modest increase in ACh levels that
can have therapeutic benefits, thus AChE inhibitors have proved useful
in the symptomatic treatment of...more
Synthesis of Novel Inhibitors of β-glucuronidase Based on Benzothiazole Skeleton and Study of their Binding Affinity by Molecular Docking(Link)
Bioorganic and Medicinal Chemistry
2011
Benzothiazole
derivatives 1-26 have been synthesized and their in vitro
β-glucuronidase potential has been evaluated. Compounds 4 (IC(50)=8.9 ±
0.25 μM), 5 (IC(50)=36.1 ± 1.80 μM), 8 (IC(50)=8.9 ± 0.38 μM), 13
(IC(50)=19.4 ± 1.00 μM), 16 (IC(50)=4.23 ± 0.054 μM), and 18
(IC(50)=2.26 ± 0.06 μM) showed β-glucuronidase activity potent than the
standard (d-saccharic acid 1,4-lactone, IC(50)=48.4 ± 1....more
In Silico and In Vitro Immunomodulatory Studies on Compounds of Lindelofia stylosa(Link)
Chemical Biology and Drug Design
2012
Lindolefia
stylosa (Kar. and Kir.) is an important medicinal plant in Central and
West Asia. Compounds 1 (ethyl lithospermate), 2 (methyl lithospermate), 3
(lithospermate B), 4 (rosmarinic acid), 5 (methyl rosmarinate), 6
(ethyl rosmarinate), 7 (3-O-feruloyl-6'-O-coumaroyl sucrose), 8
(3-O-feruloyl-6'-O-caffeoyl sucrose), 9 (3,6'-O-diferuloyl sucrose), 10
(3,6'-O-diferuloyl-1-kestose), 11 (3-O-...more
Synthesis, biological evaluation, and molecular docking studies of benzyl, alkyl and glycosyl [2-(arylamino)-4,4-dimethyl-6-oxo-cyclohex-1-ene]carbodithioates, as potential immunomodulatory and immunosuppressive agents(Link)
Bioorganic and Medicinal Chemistry
2012
The
immunomodulating properties of functionalized
[2-(arylamino)-4,4-dimethyl-6-oxo-cyclohex-1-ene] carbodithioates and
6,6-dimethyl-4-(2-(propan-2-ylidene)hydrazinyl)-6,7-dihydro-2H-indazole-3(5H)-thione
compounds have been investigated. Four of them, 13, 18, 19 and 20
inhibited PBMC proliferation induced by phytohemagglutinin (PHA) in a
dose dependent manner with an IC(50) of ≤ 20 μM. The Th-1...more
Identification of Novel Interleukin-2 Inhibitors through Computational Approaches
Molecular Diversity
February 2013
Interleukin-2
(IL-2), a 15.5 kDa cytokine that is now emerging as a target in drug
discovery for novel therapeutic approaches in several autoimmune
disorders. In an attempt to identify new inhibitors for IL-2/IL-2R
interaction, virtual screening (VS) was performed. Four different
docking programs (GOLD, FlexX, Glide and LigandFit) in combination with
several scoring functions were used to identify...more
A combined 3D-QSAR and docking studies for the In-silico prediction of HIV-protease inhibitors(Link)
Chemistry Central Journal
May 22, 2013
Background
Tremendous research from last twenty years has been pursued to cure human life against HIV virus. A large number of HIV protease inhibitors are in clinical trials but still it is an interesting target for researchers due to the viral ability to get mutated. Mutated viral strains led the drug ineffective but still used to increase the life span of HIV patients.
Tremendous research from last twenty years has been pursued to cure human life against HIV virus. A large number of HIV protease inhibitors are in clinical trials but still it is an interesting target for researchers due to the viral ability to get mutated. Mutated viral strains led the drug ineffective but still used to increase the life span of HIV patients.
3D Structure Prediction of Human β1-Adrenergic Receptor via Threading-Based Homology Modeling for Implicationsin Structure-Based Drug Designing (Submitted)(Link)
PLoS One
April 10, 2015
Dilated
cardiomyopathy is a disease of left ventricular dysfunction accompanied
by impairment of the β1-adrenergic receptor (β1-AR) signal cascade. The
disturbed β1-AR function may be based on an elevated sympathetic tone
observed in patients with heart failure. Prolonged adrenergic
stimulation may induce metabolic and electrophysiological disturbances
in the myocardium, resulting in...more
Structure-based design, synthesis and biological evaluation of β-glucuronidase inhibitors(Link)
Journal of Computer-Aided Molecular Design
April 27, 2014
Using
structure-based virtual screening approach, a coumarin derivative (1)
was identified as β-glucuronidase inhibitor. A focused library of
coumarin derivatives was synthesized by eco-benign version of chemical
reaction, and all synthetic compounds were characterized by using
spectroscopy. These compounds were found to be inhibitor of
β-glucuronidase with IC50 values in a micromolar range. All...more
Structure-Based Design, Synthesis and Biological Evaluation of Selective ß-Glucuronidase Inhibitors(Link)
Journal of Computer Aided Molecular Design
April 27, 2014
Using
structure-based virtual screening approach, a coumarin derivative (1)
was identified as β-glucuronidase inhibitor. A focused library of
coumarin derivatives was synthesized by eco-benign version of chemical
reaction, and all synthetic compounds were characterized by using
spectroscopy. These compounds were found to be inhibitor of
β-glucuronidase with IC50 values in a micromolar range. All...more
Sobia Ahsan Halim (Personal Introduction)
I, Sobia Ahsan Halim was born on 31st August 1983 in Karachi, the largest city of Pakistan. I am second child of my parents, having an elder and a younger brother. My mother is one who provided me early education since I was a child and it was her dream that her children get higher education. She encouraged me throughout my career to accomplish Ph. D. I passed matriculation examination from Aisha Children Paradise School, North Nazimabad-Karachi. After passing intermediate in Pre-Medical discipline in 2001, I got admission in Jinnah University for Women, Karachi and completed M. Sc. in Biochemistry in 2005. I secured 1st class 1st position in the department of Biochemistry, J.U.W. in B. Sc. (H) as well as in M. Sc. Working in laboratories during graduation; I used to think how these scientific procedures help to improve human lives. Since then I got interest in research. I was fortunate enough to get an opportunity to start my research career as a thesis student (M. Sc. thesis) with Dr. Sadaf Naeem (Former Lecturer, Dept. of Biochemistry, J.U.W) in collaboration with Dr. Zaheer-ul-Haq Qasmi (Assistant Professor, PCMD, ICCBS, University of Karachi) under the project entitled “Different Docking Approached to Explore Protein-Ligand Interactions”. This was the beginning of the fascinating time of my life when I started learning what research is and how to pursue it? During M. Sc. Thesis, I learned some docking techniques which developed my interest in a new and very exciting field of Computational Medicinal Chemistry. Soon after M. Sc., I decided to pursue Ph. D. in Computational Medicinal Chemistry under the supervision of my dear teacher and mentor Dr. Qasmi in 2006. I am fortunate in completing my Ph. D. studies on the topic “Modeling Aided Lead Design of Cytokines Inhibitors”. During M.Phil/Ph. D. program, I passed all the M. Phil. and Ph. D. courses and Molecular Medicine Subjective GRE and NTS general and Subjective GAT tests and got command over several structure and ligand based drug designing techniques. In 2009, I was granted six months split Ph. D. scholarship (December 2009-June 2010) under “International Research Support Initiative Program” from Higher Education Commission Pakistan that help me to study at School of Pharmacy, Southern Illinois University Edwardsville, IllinoisUSA. There I carried out my research project entitles “A Structure Guided Fragment Library through Massive Screening of Chemogenomics” under the supervision of Dr. Maria Kontoyianni (Assistant Professor, School of Pharmacy, SIUE). During my research, I was able enough to publish couple of research articles in peer review scientific journals of international repute. In 2012, I received scholarship from Brazilian Agriculture Research Corporation (ESPCA) to attend the course of “Computational Biology-Agrochemical and Drug Design” held in Sao Paulo School of Advanced Sciences (ESPCA), Campinas, Brazil (April 1-6, 2012). There I won the Best poster award titled “The Role of Computer-Aided Drug Design in the identification of Cytokines Inhibitors” among hundred participants of over forty countries. This course helped me to understand the role of Computational Biology in Agriculture. My keen interest is to identify novel therapeutic compounds which can be used to cure diseases and pathological conditions, to understand the drug-receptor interactions at the molecular level through computational tools and to generate large virtual compound libraries which can be used freely throughout the academic/scientific community and serves as recognition of our institute and country.
Sobia Ahsan Halim 2012 2 | P a g e
SOBIA AHSAN HALIM C-126, Block-A, North Nazimabad, Karachi-Pakistan. Sobiahal@gmail.com, sobia_halim@yahoo.com. Contact: 021-6637644
OBJECTIVE Biochemistry graduate with extensively willing to work in top educational and research organizations with an opportunity to learn and explore the new horizons of scientific aspects. I would like a challenging and fulfilling post to get prosperity in education, academics, research and development.
HIGHLIGHTS OF QUALIFICATIONS Six years of research experience in Computational Medicinal Chemistry, strong communication and presentation skills, self-motivated, research oriented knowledge of Molecular Modeling, Fluent in spoken English and proficient use of Internet. Worked in United States for six months and learned important structure and fragment based drug designing techniques.
ACADEMIC CAREER 2010 Visiting Scholar School of Pharmacy Southern Illinois University Edwardsville 220 University Park Drive, Edwardsville, IL 62026-2000, United States of America December 2009- June 2010 2006 Ph. D Scholar (current position too) Dr. Panjwani Center Molecular Medicine & Drug Research Center International Center for Chemical & Biological Sciences, University of Karachi-75270 April2006-Up to date Expected date of completion: Oct-Nov 2012 2005 M. Sc, Biochemistry with 1st Division and 1st Class 1st Position Jinnah University for Women, Karachi-Pakistan January 2005-December 2005 2004 B.Sc (Honors), Biochemistry with 1st Division and 1st Class 1st Position Subsidiary: Microbiology and Chemistry Jinnah University for Women, Karachi-Pakistan January 2002-December 2004 2001 Higher School Certificate, Board of Intermediate Education, Karachi-Pakistan Major: Biology, Chemistry, Physics (2nd division) August 1999- July 2001 1999 Secondary School Certificate (Science with 1st Division) Board of Secondary Education, Karachi-Pakistan (March 1999).
RESEARCH EXPERTIES Fragment based library designing for entire druggable genome using virtual chemogenomics approach. Benchmarking and validation of widely used docking and scoring tools for several medicinally Sobia Ahsan Halim 2012 3 | P a g e important proteins. Molecular modeling of small organic molecules and several potential drug targets by molecular docking. Design of new immune-modulators and bio-active molecules for a range of pharmaceutically important targets using computer aided modeling techniques Ligand based and structure based pharmacophore design Generation and screening of large virtual combinatorial compound libraries Determination of molecular activity using 3D-QSAR calculations. Molecular Dynamics simulations studies of protein-ligand complex.
TEACHING EXPERIENCE Served as Lecturer in Department of Biochemistry, Jinnah University for Women, Karachi (June 2011-February 2012). Taught courses to B.S: Introductory Biochemistry -I, Introduction to Neurochemistry, Nutrition and Dietetics, Metabolism-I and Nutrition and Biochemical Techniques-II Taught Courses to M.S: Communication of Sciences, Research Methodology
REVIEW EXPERIENCE Reviewer of Arabian Journal of Chemistry
ACHIEVEMENTS Won the Best poster award titled “The role of Computer-Aided Drug Design in the identification of Cytokines Inhibitors” in the course “Advance topics in Computational Biology-Agrochemical and Drug Design” held in Sao Paulo School of Advanced Sciences (ESPCA) hosted by EMBRAPA (Brazilian Agricultural Research Corporation) in Campinas, Brazil, April 1-6, 2012. Award of scholarship under “International Research Support Initiative Program” from Higher Education Commission, Government of Pakistan. December 2009–June 2010. International Center for Chemical and Biological Sciences Fellowship. May 2006–August 2011 Gold Medal for securing 1 st position in M. Sc, Department of Biochemistry, Jinnah University for Women, Karachi. April 3, 2006. Khushal Khan Khattak Memorial Award for securing 1 st position in M. Sc, Department of Biochemistry, Jinnah University for Women, Karachi. April 3, 2006. Cash Price from Governor of Sindh Dr. Ishrat-ul-Ibad Khan, Government of Pakistan. April 3, 2006. Molvi Reaz-Uddin Hashmi Memorial Award for securing 1 st position in B. Sc Honors from Department of Biochemistry, Jinnah University for Women, Karachi. April 4, 2005. Cash Price from Governor of Sindh Dr. Ishrat-ul-Ibad Khan, Government of Pakistan. April 4, 2005.
INTERNATIONAL PUBLICATION 1. Immunosuppressive Activity of Buxidin and E-Buxenone from Buxus hyrcana M. A. Mesaik, Sobia A. Halim, Zaheer Ul-Haq, M. Iqbal Choudhary, Salma Shahnaz, S. A. M Ayatollahi, Shahnaz Murad and Aqeel Ahmad, Chemical Biology and Drug Design (2010) 75:310–317. (IF: 2.473) 2. Benchmarking Docking and Scoring Protocol for the Identification of Potential Acetylcholinesterase Inhibitors Zaheer-ul-Haq, Sobia Ahsan Halim, Reaz Uddin and J. D. Madura, Journal of Molecular Graphics and Modelling (2010) 28:870-882. (IF: 2.169) 3. Synthesis of Novel Inhibitors of β-glucuronidase Based on Benzothiazole Skeleton and Study of their Binding Affinity by Molecular Docking Khalid M. Khan, Fazal Rahim, Sobia Ahsan Halim, Muhammad Taha, Momin Khan, Shahnaz Perveen, Zaheer-ul-Haq, Muhammad Ahmed Mesaik, M. Iqbal Choudhary, Bioorganic and Medicinal Chemistry (2011) 19: 4286-4294 (IF: 2.822) Sobia Ahsan Halim 2012 4 | P a g e 4. In Silico and In Vitro Immunomodulatory Studies on Compounds of Lindelofia stylosa M. Ahmed Mesaik, Almas Jabeen, Sobia Ahsan Halim, Afshan Begum, Ahmed Shukralla Khalid, Muhammad Asif, Beenish Fatima, Zaheer-ul-Haq and M. Iqbal Choudhary, Chemical Biology and Drug Design (2012)79: 290–299 (IF: 2.978) 5. Synthesis, biological evaluation, and molecular docking studies of benzyl, alkyl and glycosyl [2-(arylamino)- 4,4-dimethyl-6-oxo-cyclohex-1-ene]carbodithioates, as potential immunomodulatory and immunosuppressive agents El Sayed H. El Ashry, Mohammad R. Amer, Omer M. Abdalla, Aly A. Aly, Samreen Soomro, Almas Jabeen, Sobia Ahsan Halim, M. Ahmed Mesaik, Zaheer Ul-Haq, Bioorganic and Medicinal Chemistry (2012) 20: 3000-3008 (IF: 2.978) 6. Biotransformation of Dianabol by cell suspension culture of Azadiachta indica and immunomodulatory activity and Molecular docking study of its transformed product (submitted) Saifullah, Saifullah khan, Sobia Ahsan Halim, M. Ahmed Mesaik, Zaheer-ul-Haq, Azizuddin, M. Iqbal Chaudhary and Atta-ur-Rahman 7. Structure-Based Design, Synthesis and Biological Evaluation of Selective ß-Glucuronidase Inhibitors (Submitted) Khalid M. Khan, Nida Ambreen, Sobia Ahsan Halim, Zaheer-ul-Haq, Abdul Wadood, Ajmal Khan, Shagufta Naureen, Saima Rasheed, Mohammad Iqbal Choudhry and Atta-ur-Rahman. 8. Receptor-Based Virtual Screening for the Identification of Novel Interleukin-II Inhibitors (Submitted) Sobia Ahsan Halim, Zaheer-ul-Haq, Abdul Wadood, Omer Mohamed Abdalla, M. A. Mesaik and Maria Kontoyianni 9. Structure-based 3D-QSAR Studies of Interleukin-II inhibitors (in preparation) Zaheer-ul-Haq and Sobia Ahsan Halim 10. Assessment of structure based virtual screening protocol for the data mining of large scale databases: An application to human Interleukin-II (in preparation) Zaheer-ul-Haq and Sobia Ahsan Halim 11. In-silico design of Interleukin-II directed fragments library using ZINC database. Structure guided virtual library design of fragments for Interleukin-II (in Preparation) Zaheer-ul-Haq and Sobia Ahsan Halim 12. Design of Fragment based Library using Chemogenomics Approach (in Preparation) Sobia Ahsan Halim and Maria Kontoyianni
RESEARCH BASED PROGRAMS Molecular Modeling Tools SYBYL, DISCOVERY STUDIO, SCHRODINGER, MOE Docking Programs GLIDE, LIGANDFIT, FLEXX, GOLD, FLEXIDOCK, EHITS, MOE, AUTODOCK, SURFLEXDOCK, FLEXIDOCK AND FRED Pharmacophore based tools LIGANDSCOUT, CATALYST, GASP AND GALAHAD MD Simulation AMBER QSAR modeling COMPARATIVE MOLECULAR FIELD ANALYSIS (COMFA), COMPARATIVE MOLECULAR SIMILARITY INDICES ANALYSIS (COMSIA), CATALYST Chemical Database Management MOE, UNITY, PDBSUM, NCI DATABASE, ZINC, THE BINDING DATABASE Drug and Lead like filtering OPENEYES FILTER, OPENEYES OMEGA Conformational Samplings OPENEYES ROCS Visualization Programs VMD, CHIMERA, LIGPLOT AND VIDA
Sobia Ahsan Halim 2012 5 | P a g e COMPUTATIONAL SKILLS MS. Office (MS. Word, PowerPoint, Excel) Net Browsing, Internet & E-mail Linux Operating System and Computational Chemistry research tools. MAJOR SEMESTER PROJECT (M. Sc THESIS) Different Docking Approaches to Explore Protein-Ligand Interaction under the supervision of Dr. Zaheer-ul-Haq Qasmi, Asst. Prof., ICCBS, University of Karachi,
CONFERENCES AND SYMPOSIUM INTERNATIONAL CONFERENCES Attended course of “Computational Biology-Agrochemical and Drug Design” held in Sao Paulo School of Advanced Sciences (ESPCA) hosted by EMBRAPA (Brazilian Agricultural Research Corporation) in Campinas, Brazil, April 1-6, 2012. International workshop on “Modern techniques in Structural Biology”, ICCBS, University of Karachi. 3 rd International Symposium and Workshop-Cum-Training Course on Molecular Medicine and Drug Research, ICCBS, University of Karachi. 12thInternational Symposium on Natural Product Chemistry, ICCBS, University of Karachi. 2 nd International Symposium and Workshop-Cum-Training Course on Molecular Medicine and Drug Research, ICCBS, University of Karachi. 11thInternational Symposium on Natural Product Chemistry, ICCBS, University of Karachi. 1 st International Symposium and Workshop-Cum-Training Course on Molecular Medicine and Drug Research, ICCBS, University Of Karachi. 10th International Symposium on Natural Product, ICCBS, University of Karachi.
NATIONAL CONFERNECES Workshop on “Developing skills for the Interpretation of 1D and 2D NMR Spectral Data for Structure Determination of Organic Molecules”, L.E.J. National Science Information Center, ICCBS, April 25-26, 2012. Served as a resource person in Workshop on “Bioinformatics Tools in Proteomics”, National center for Proteomics, University of Karachi, December 28-29, 2011. Workshop on “Modern Techniques in Combinatorial Chemistry” L.E.J. National Science Information Center, ICCBS and COMSTECH-Islamabad, June 14-16, 2011 Workshop on “How to write Manuscripts for High Impact Factor Journals”, L.E.J. National Science Information Center, July 23, 2011. Seminar on “Aware and Promote Adolescent and Youth Sexual and Reproductive Health” Organized by Sports and Youth Affairs Department, Government of Sindh in Collaboration with United Nations Population Fund (UNFP), Jinnah University for Women Karachi, July, 2011. Attended Higher Education Commission-British Council-International Center for Chemical and Biological Sciences Workshop on Development of Sustainable and Collaborative Research Networks, Karachi, January, 7-8, 2011. 10th Biennial National Conference of Pakistan Society for Biochemistry & Molecular Biology, December 2010, KIBJE, University of Karachi. Workshop on Computational Chemistry and Its Applications, June 26-28, 2006, ICCBS, University of Karachi. 8 th Biennial National Conference of Pakistan Society for Biochemistry & Molecular Biology, March 7-9, 2005, University of Karachi. Symposium on "Vision of Biochemistry in 21st Century", Biochemical Society, Department of Biochemistry JUW, Karachi, April 20, 2002. Symposium on "Microbiology and Biotechnology: Opportunities and Challenges in Pakistan", PSM JUW Chapter, Karachi.
POSTER DISPLAY AND PRESENTATION Sobia Ahsan Halim 2012 6 | P a g e Lecture on AutoDock Tools - An Application of Molecular Docking in Workshop on Bioinformatics Tools in Proteomics, National Center of Proteomics, University of Karachi, December 28-29, 2011 Lecture on The Role and Applications of Molecular Dynamic Simulation in Drug Designing in Workshop on Bioinformatics Tools in Proteomics, National Center of Proteomics, University of Karachi, December 28-29, 2011. Presentation on General Introduction, Applications & Challenges of Protein-Ligand Docking and Practical Implementation through AutoDock Tools, Workshop On Computational Chemistry And Its Applications, ICCBS, University of Karachi. Poster on A Comparative Molecular Docking Studies for Potential Acetylcholinesterase Inhibitors in 11th International Symposium on Natural Product Chemistry, ICCBS, University of Karachi. Poster and Model Competition on 50 years of DNA discovery, Jinnah University for Women, Karachi, August 16, 2003. Poster on Comparative Molecular docking studies of Cholinesterase Inhibitors in 10th International Symposium on Natural Product Chemistry, ICCBS, University of Karachi. Poster on Modeling Aided Lead Design of Cytokines Inhibitors, 1st International Symposium and WorkshopCum-Training Course on Molecular Medicine and Drug Research, ICCBS, University of Karachi. CORE COURSES IN Ph. D Covalent Modification of DNA as a Target for Small Molecules (on line course) Introduction to Cell Biology Nuclear Magnetic Resonance Spectroscopy Cellular Signaling Mass Spectroscopy CORE COURSES IN M. Phil Biochemistry, Cell and Molecular Biology Molecular Biology and Enzymology Microbiology and Immunology Basic Pharmacology Molecular Genetics and Biotechnology Techniques in Molecular Medicine I & II Bio-Statistics, Mathematics, English and Computer learning course CORE COURSES IN B. Sc HONOURS AND M. Sc Combination in B. Sc (H): Biochemistry (Major), Microbiology & Chemistry (Subsidiary) General Biochemistry Biophysics Bioenergetics Medicinal Biochemistry Enzymology Endocrinology Metabolism Bio-Statistics Molecular Biology Biochemical Genetics Cell Biology Immunology Nutrition & Dietics Pharmacology Techniques in Biochemistry
EXTRACURRICULAR ACTIVITIES Vice President (2003-2005), Biochemical Society, Jinnah University for Women, Karachi. President (2004-2005), Student Advisory Committee, Jinnah University for Women, Karachi. Volunteer (2003-2005), Student Advisory Committee, Jinnah University for Women, Karachi. Active participant of Symposias, Cultural shows and Drama competition in Jinnah University for Women, Karachi (1999-2005).
INTEREST AND ACTIVITIES Book Reading, Computers and Scientific Journals, Conferences & Meetings.
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