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DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai) , INDIA 29Yrs Exp. in the feld of Organic Chemistry,Working for GLENMARK PHARMA at Navi Mumbai, INDIA. Serving chemists around the world. Helping them with websites on Chemistry.Million hits on google, world acclamation from industry, academia, drug authorities for websites, blogs and educational contribution

Monday, 18 April 2016

Eugene Piatnitski Chekler

Eugene Chekler

Eugene Piatnitski Chekler

Group Leader at EMD Serono / Merck Serono

Summary

Accomplished pharmaceutical R&D specialist with valuable program oversight experience that facilitates drug discovery from proof-of-concept to development. Oversee internal R&D activities and external vendors. Offer external collaborations management experience and serve on development teams. Documented success in performing independent R&D work via a track record of publications. Bilingual with fluency in Russian.

 Project Leadership
 Intellectual Property Strategy
 Biology/Pharmacology/Drug Discovery
 Interdepartmental Partnerships
 Clinical Candidate Selection
 Medicinal Chemistry
 Chemical Biology
 Synthetic Chemistry
 Personnel Development
 Academic Collaborations
 Structure Based Drug Design
 Fragment Based Drug Design
 Pharmacokinetics/Pharmacodynamics
 Hit-to-Lead and Lead Optimization
SELECTED HIGHLIGHTS
 Delivered two candidates into development in Muscular-skeletal and Cardiovascular therapeutic areas.
 Identified clinical candidates through data analysis to conduct clinical trials in orphan and genetic disease space
 Offer experience with Nuclear Receptor modulators, Endocrinology, Oncology, Kinase Inhibitors design, Epigenetics, Protein Misfolding, Antiarrhythmic agents, and unknown mechanism of action.
 Pharmaceutical discovery management experience includes utilizing CRO chemists in India, China and Eastern Europe; consistently improve scientific diligence while mentoring chemistry colleagues.
 Extensive experience in building more than 100,000 compound libraries using commercial vendors (HTS compound libraries selection).
 Successfully built and led several effective cross site therapeutic area teams.
 Record of innovation and scientific contributions: publications (27), abstracts (9), patent publications (5).

LINKS

https://www.linkedin.com/in/eugene-piatnitski-chekler-92386316

https://www.researchgate.net/profile/Eugene_Chekler

http://www.pubfacts.com/author/Eugene+L+Piatnitski+Chekler

Experience

Group Leader

EMD Serono / Merck Serono

June 2015 – Present (11 months)Greater Boston Area

Immuno-Oncology Medicinal Chemistry

Sr. Principal Scientist

Pfizer

October 2009 – June 2015 (5 years 9 months)Groton, CT and Cambridge, MA

Lead neuro-muscular medicinal chemistry

Design and coordinate studies. Conduct data analysis and communicate results internally and externally. Participate as a leader and member of project teams. Build effective partnerships with partner lines (safety, primary pharmacology, drug metabolism) and research unit biologists. Run external industrial and academic collaborations.
 Serve as a primary chemistry point of contact for projects; lead medicinal chemistry design.
 Develop partnerships with computational chemistry team members to ensure embedding of computational techniques to deliver optimal results.
Nuclear Receptor Modulators, Team Leader - Successfully advanced a Rare Disease associated program to the development stage by discovering a clinical candidate.
 Designed chemistry project strategy and implementation.
 Managed a team of chemists at a foreign contract research organization (CRO).

Senior Research Scientist

Wyeth Research

December 2005 – October 2009 (3 years 11 months)

Nuclear Receptor Modulators, Team Leader - Collaborated with Biology Team to design project strategy and screening paradigm to discover efficacious and selective Nuclear Receptor agonists and antagonists. Designed and synthesized multiple active compound classes to achieve in vivo efficacy.
 Managed a team of internal chemists.

GAP Junction Modulators - Ensured chemistry follow up for a clinical candidate. Discovered pre-development candidates for antiarrhythmic applications. Designed and synthesized compounds to improve in-vivo profile. Developed orally bioavailable dipeptide motif.
 Served as sole medicinal chemistry contributor to US 2007/0149460 patent that covers a clinical candidate scaffold.