.Dr. Hira Choudhury
Lecturer at International Medical University [IMU]
links
https://www.facebook.com/hira.choudhury.1
https://www.researchgate.net/profile/Hira_Choudhury2/info
https://scholar.google.co.in/citations?user=46-X_6UAAAAJ&hl=en
https://www.facebook.com/hira.choudhury.1
https://www.researchgate.net/profile/Hira_Choudhury2/info
https://scholar.google.co.in/citations?user=46-X_6UAAAAJ&hl=en
- Worked at Dr. Reddy's Laboratories Ltd.
Summary
Summary
• PhD in Pharmacy from the Department of Pharmaceutical Technology, Jadavpur University, Kolkata.
• Received DST-Women Scientist (WOS-A) award (Ministry of Science and Technology, Govt. of India) in Department of Pharmaceutical Technology at Jadavpur University, Kolkata during PhD tenure.
• Industrial experience (5 years) as Associate Scientist (DMPK) at Discovery Research (DR), Dr. Reddy’s Laboratories Ltd., Hyderabad, India.
Expertise
• Performed bio-analytical method development and validations in HPLC and LC-MS/MS.
• Analytical method development and validation in HPLC.
• ‘In vivo’ pharmacokinetic studies in different preclinical species.
• Dissolution study for generics drugs for BA/BE studies.
• Bioequivalence studies assignments (industry) for DCGI approval
• Industrial pre-clinical and clinical development activities for regulatory requirement.
• Computer knowledge acquainted with softwares such as Analyst, Millennium, Chromeleon, Class VP, EZChrom Elite, Spinchrom, WinNonlin etc.
• PhD in Pharmacy from the Department of Pharmaceutical Technology, Jadavpur University, Kolkata.
• Received DST-Women Scientist (WOS-A) award (Ministry of Science and Technology, Govt. of India) in Department of Pharmaceutical Technology at Jadavpur University, Kolkata during PhD tenure.
• Industrial experience (5 years) as Associate Scientist (DMPK) at Discovery Research (DR), Dr. Reddy’s Laboratories Ltd., Hyderabad, India.
Expertise
• Performed bio-analytical method development and validations in HPLC and LC-MS/MS.
• Analytical method development and validation in HPLC.
• ‘In vivo’ pharmacokinetic studies in different preclinical species.
• Dissolution study for generics drugs for BA/BE studies.
• Bioequivalence studies assignments (industry) for DCGI approval
• Industrial pre-clinical and clinical development activities for regulatory requirement.
• Computer knowledge acquainted with softwares such as Analyst, Millennium, Chromeleon, Class VP, EZChrom Elite, Spinchrom, WinNonlin etc.
Experience
Research Scholar (DST Women Scientist-Scheme-A)
Jadavpur University
I had completed my research work on “An approach to intravenous to oral switch in cancer chemotherapy based on nanoemulsion formulation”. The research work comprised of the following major areas:
• Development and optimization of paclitaxel nanoemulsion
• Characterization and stability study of nanoemulsion
• Pharmacokinetic study of paclitaxel nanoemulsion and solution by developed and validated LC-MS/MS method
• Pharmacokinetic study of paclitaxel nanoemulsion in presence of P-glycoprotein inhibitors by the developed and validated LC-MS/MS method
• In vitro and in vivo evaluation of anticancer activity
• Sub-chronic toxicity study of paclitaxel nanoemulsion
• Additionally, I was actively engaged in bio-analysis of bioequivalence study samples by using developed and validated HPLC and LC-MS/MS method
• Development and optimization of paclitaxel nanoemulsion
• Characterization and stability study of nanoemulsion
• Pharmacokinetic study of paclitaxel nanoemulsion and solution by developed and validated LC-MS/MS method
• Pharmacokinetic study of paclitaxel nanoemulsion in presence of P-glycoprotein inhibitors by the developed and validated LC-MS/MS method
• In vitro and in vivo evaluation of anticancer activity
• Sub-chronic toxicity study of paclitaxel nanoemulsion
• Additionally, I was actively engaged in bio-analysis of bioequivalence study samples by using developed and validated HPLC and LC-MS/MS method
Associate Scientist
Dr. Reddy's Laboratories
• Pre-clinical pharmacokinetics, metabolism and clinical drug development of metabolic disorder New Chemical Entities (NCE), anti- cancer and anti-infective and CB1 antagonist NCEs under GLP norms.
• Also involved in dose proportionality, quantitative tissue distribution and oral bioavailability studies in different lab animals (mouse, rat, dog and rabbit).
• Identification and characterization of metabolites in plasma, urine, feces and bile using LC-MS/MS and HPLC method. Correlating the metabolites from in-vivo and in-vitro studies.
• Gender variation in pharmacokinetics studies and effect of food on pharmacokinetics in rodents.
• Bio-analytical method validation of different NCEs using HPLC-FL, UV detector and LC-MS/MS in different biological matrices.
• In-vitro metabolic stability of NCEs of various therapeutic areas in mouse, rat, dog and human liver microsomes.
• In-vitro protein binding study.
• Knowledge about in-vitro CYP Phenotyping and CYP Liability study of different NCEs.
• Also involved in dose proportionality, quantitative tissue distribution and oral bioavailability studies in different lab animals (mouse, rat, dog and rabbit).
• Identification and characterization of metabolites in plasma, urine, feces and bile using LC-MS/MS and HPLC method. Correlating the metabolites from in-vivo and in-vitro studies.
• Gender variation in pharmacokinetics studies and effect of food on pharmacokinetics in rodents.
• Bio-analytical method validation of different NCEs using HPLC-FL, UV detector and LC-MS/MS in different biological matrices.
• In-vitro metabolic stability of NCEs of various therapeutic areas in mouse, rat, dog and human liver microsomes.
• In-vitro protein binding study.
• Knowledge about in-vitro CYP Phenotyping and CYP Liability study of different NCEs.
Junior Scientist
Dr. Reddy's Laboratories
• Pre-clinical pharmacokinetics, metabolism and clinical drug development of metabolic disorder New Chemical Entities (NCE), anti- cancer and anti-infective and CB1 antagonist NCEs under GLP norms.
• Also involved in dose proportionality, quantitative tissue distribution and oral bioavailability studies in different lab animals (mouse, rat, dog and rabbit).
• Identification and characterization of metabolites in plasma, urine, feces and bile using LC-MS/MS and HPLC method. Correlating the metabolites from in-vivo and in-vitro studies.
• Gender variation in pharmacokinetics studies and effect of food on pharmacokinetics in rodents.
• Bio-analytical method validation of different NCEs using HPLC-FL, UV detector and LC-MS/MS in different biological matrices.
• In-vitro metabolic stability of NCEs of various therapeutic areas in mouse, rat, dog and human liver microsomes.
• In-vitro protein binding study.
• Knowledge about in-vitro CYP Phenotyping and CYP Liability study of different NCEs.
• Also involved in dose proportionality, quantitative tissue distribution and oral bioavailability studies in different lab animals (mouse, rat, dog and rabbit).
• Identification and characterization of metabolites in plasma, urine, feces and bile using LC-MS/MS and HPLC method. Correlating the metabolites from in-vivo and in-vitro studies.
• Gender variation in pharmacokinetics studies and effect of food on pharmacokinetics in rodents.
• Bio-analytical method validation of different NCEs using HPLC-FL, UV detector and LC-MS/MS in different biological matrices.
• In-vitro metabolic stability of NCEs of various therapeutic areas in mouse, rat, dog and human liver microsomes.
• In-vitro protein binding study.
• Knowledge about in-vitro CYP Phenotyping and CYP Liability study of different NCEs.
Publications
A novel approach for nanoemulsion components screening and nanoemulsion assay of olmesartan medoxomil through a developed and validated HPLC method
RSC Advances
April 18, 2013
A novel sensitive, specific, reproducible and innovative reverse-phase high-performance liquid chromatographic method was developed for the detection of olmesartan medoxomil.This
method was successfully applied to quantitatively assess the solubility of olmesartan medoxomil in various oils, surfactants and mixtures of both. The innovative application of this method was the assay of olmesartan...more
method was successfully applied to quantitatively assess the solubility of olmesartan medoxomil in various oils, surfactants and mixtures of both. The innovative application of this method was the assay of olmesartan...more
Education
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