Liron Oskar
Research and Development Chemist at Taro Pharmaceutical Industries
links
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- https://il.linkedin.com/in/liron-oskar-8a98917b
https://www.facebook.com/lirono1
- Former Teaching Assistant at הטכניון - מכון טכנולוגי לישראל | TechnionPast: אס"ט - אגודת הסטודנטים בטכניון
- https://il.linkedin.com/in/liron-oskar-8a98917b
Experience
Research and Development Organic Chemist
Taro Pharmaceutical Industries
Education
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| M.Sc Thesis | |
| M.Sc Student | Liron Oskar |
|---|---|
| Subject | Merging Allylic Carbon-Hydrogen and Carbon-Carbon Bond Activations en-route to Sophisticated Molecular Framework |
| Department | Department of Chemistry |
| Supervisor | Full Professors Marek Ilan |
| Full Thesis text |  |
Recently, our group has developed the zirconocene-mediated ring opening of alkylidenecyclopropanes (ACPs) and w-ene cyclopropanes derivatives, via a unique and selective merging of allylic carbon-hydrogen and carbon-carbon bond activations, leading to bismetallated zirconocene complex. The addition of two different electrophiles gives bisfunctionalized acyclic molecules in excellent yields. By diversifying the nature of the two electrophiles, two stereogenic centers were created with high diastereoselectivity.
In this context, we proposed to enlarge the scope of this process by creating three stereogenic centers in an acyclic product via a one-pot sequence, while studying the diastereoselectivity.
Since zirconocene-mediated ring opening was done with stoichiometric amount of zirconocene complex, we tried to develop a catalytic process for the ring cleavage applied on ACPs derivatives, based on the successful catalytic carbozirconation on multiple bonds.
A deeper mechanistic understanding of the combined allylic carbon-hydrogen and carbon-carbon bond activations pathway was also proposed, using labeled experiments.
Finally, we applied our zirconocene-mediated ring opening methodology to the synthesis of the two enantiomers of deuterated neopentane: the smallest enantiomerically enriched hydrocarbons that possess an all-carbon quaternary stereocenter, that is, a carbon center with four different non-hydrogen substituents. Using advanced and sensitive methods, we successfully determined their absolute configuration.
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