Renee Bouley
'
LINKS
Summary
I
am an interdisciplinary PhD candidate that headed an antibiotic
discovery project resulting in a patent application and 1 first-author
publication in Journal of the American Chemical Society. I have been
trained in organic chemistry, microbiology, biochemistry, pharmacology,
and x-ray crystallography and co-authored 4 publications including 1
publication in Nature Chemical Biology. Additionally, I have been
awarded 2 individual fellowships during my graduate career from the
American Chemical Society and National Institutes of Health.
Conference Poster 2014
Resume 2015
Nature Chemical Biology cover November 2015
Education
University of Notre Dame
PhD, Organic Chemistry
1 first-author publication, 3 contributing author publications, 1 contributing author on patent application
Activities and Societies: Chemistry-Biology-Biochemistry Interface Steering Committee Student Representative, American Association for the Advancement of Science (AAAS) Member, American Chemical Society (ACS) Member
- (Open)5 honors and awards
Grand Valley State University
Bachelors of Science, Chemistry
1 first author publication
- (Open)1 honor or award
Experience
Graduate Student
University of Notre Dame
Synthesized 40 analogs and determined a structure-activity relationship.
Determined metabolic stability and plasma stability of synthetic compounds
Evaluated synthetic compounds in mouse models of infection
Identified the biological target and mechanism of action of synthetic compounds by protein activity assays, protein-ligand crystal complexes, and macromolecular synthesis assays
Determined metabolic stability and plasma stability of synthetic compounds
Evaluated synthetic compounds in mouse models of infection
Identified the biological target and mechanism of action of synthetic compounds by protein activity assays, protein-ligand crystal complexes, and macromolecular synthesis assays
- (Open)1 honor or award
Research Internship
Consejo Superior de Investigaciones Científicas
Grew crystals of membrane protein and performed co-crystallization studies with ligands
Measured protein crystals at the Swiss Light Source in Zurich, Switzerland
Analyzed the diffraction data by molecular replacement
Measured protein crystals at the Swiss Light Source in Zurich, Switzerland
Analyzed the diffraction data by molecular replacement
Teaching Assistant
University of Notre Dame
Fall 2010:
Supervised and instructed students majoring in chemistry in organic chemistry techniques
Graded weekly lab reports and course exams
Spring 2011 & Fall 2011:
Led weekly discussion sections in which students worked on problem sets
Gave short lectures on the background information needed to complete each problem set
Graded weekly problem sets and course exams
Supervised and instructed students majoring in chemistry in organic chemistry techniques
Graded weekly lab reports and course exams
Spring 2011 & Fall 2011:
Led weekly discussion sections in which students worked on problem sets
Gave short lectures on the background information needed to complete each problem set
Graded weekly problem sets and course exams
Student Learning Assistance Facilitator
Grand Valley State University
Led weekly discussions in which students worked on problems sets I prepared
Gave lectures that reviewed relevant course material
Gave lectures that reviewed relevant course material
Chemistry Tutor
Grand Valley State University
Met
with individual students and small groups (up to 4) of students on a
weekly basis to provide help with homework or material they found
difficult to understand.
Research Assistant
Grand Valley State University
Synthesized a polyaniline matrix and incorporated onto electrodes
Measured polyaniline matrices by electrochemical impedance spectroscopy (EIS)
Measured resistance and capacitance of a redox protein, cytochrome c, by EIS
Measured polyaniline matrices by electrochemical impedance spectroscopy (EIS)
Measured resistance and capacitance of a redox protein, cytochrome c, by EIS
Analytical Chemistry Intern
Alticor
Evaluated anti-inflammatory activity of botanical extracts using a MMP-9 protein activity assay
Evaluated botanical extracts for effects on melanonin production using a mouse tryosinase protein activity assay
Quantified solubility of active ingredients in botanical extracts using HPLC
Evaluated botanical extracts for effects on melanonin production using a mouse tryosinase protein activity assay
Quantified solubility of active ingredients in botanical extracts using HPLC
Honors & Awards
Baxter Young Investigator Award
Baxter Healthcare
Second Tier Awardee for Baxter Young Investigator Award
http://www.baxter.com/inside-baxter/science/programs/young-investigator-award.page
http://www.baxter.com/inside-baxter/science/programs/young-investigator-award.page
Ruth L. Kirschstein NRSA Individual Predoctoral Fellowship (F31)
National Institute of Allergy and Infectious Disease
http://science.nd.edu/news/55138-renee-bouley-earns-kirschstein-national-research-service-award-from-nih/
http://grants.nih.gov/grants/guide/pa-files/PA-14-147.html
http://grants.nih.gov/grants/guide/pa-files/PA-14-147.html
American Chemical Society Division of Medicinal Chemistry Predoctoral Fellowship
American Chemical Society Division of Medicinal Chemistry
http://science.nd.edu/news/40973-renee-bouley-selected-to-receive-prestigious-acs-predoctoral-fellowship/
Chemistry-Biochemistry-Biology Interface Fellowship
University of Notre Dame
Program
at Notre Dame funded by the NIH to provide training to students at the
interface of chemistry and the biological sciences.
Chemistry-Biology-Biochemistry Interface Symposium Oral Presentation Competition Winner
University of Notre Dame
Chemistry-Biology-Biochemistry Interface Symposium Poster Competition Winner
University of Notre Dame
Undergraduate Award in Inorganic Chemistry
Grand Valley State University
Publications
Discovery of Antibiotic (E)-3-(3-Carboxyphenyl)-2-(4-cyanostyryl)quinazolin-4(3H)-one(Link)
Journal of the American Chemical Society
January 28, 2015
Highlighted in ACS Chem. Biol. 2015, 10, 639
Recommended by Faculty of 1000
Recommended by Faculty of 1000
Synergistic, collaterally-sensitive β-lactam combinations suppress resistance in MRSA.(Link)
Nature Chemical Biology
September 14, 2015
Methicillin-resistant
Staphylococcus aureus (MRSA) is one of the most prevalent
multidrug-resistant pathogens worldwide, exhibiting increasing
resistance to the latest antibiotic therapies. Here we show that the
triple β-lactam combination meropenem-piperacillin-tazobactam (ME/PI/TZ)
acts synergistically and is bactericidal against MRSA subspecies N315
and 72 other clinical MRSA isolates in vitro...more
Synthesis and Evaluation of 1,2,4-Triazolo[1,5-a]pyrimidines as Antibacterial Agents Against Enterococcus faecium(Link)
Journal of Medicinal Chemistry
April 29, 2015Exploration of Mild Copper-Mediated Coupling of Organotrifluoroborates in the Synthesis of Thiirane-Based Inhibitors of Matrixmetalloproteinases(Link)
Bioorganic and Medicinal Chemistry Letters
December 12, 2010Electrochemical Protein Redox Activity under Extreme Martian Conditions(Link)
Electrochemistry Society Transactions
May 29, 2009Renee Bouley selected to receive prestigious ACS Predoctoral Fellowship
This award supports doctoral candidates working in the area of medicinal chemistry who have demonstrated superior achievements as graduate students and who show potential for future work as independent investigators. These fellowships have been awarded annually since 1991 and include one year stipend support and an invitation to present the fellow’s research results at a special awards session at the ACS National Meeting.
Bouley’s work, conducted under the advisement of Shahriar Mobashery, Navari Family Professor in Life Sciences, and Mayland Chang, Research Professor and Director of the Chemistry-Biochemistry-Biology Interface (CBBI) Program, centers around the discovery of a new class of antibiotics that are selective against staphylococcal species of bacteria, including hard-to-treat methicillin-resistant Staphylococcus aureus (MRSA). She has already identified a class of compounds that has in vitro activity against bacteria and demonstrated efficacy in mice. Bouley spent three months in 2012 in the laboratory of Prof. Juan Hermoso at Consejo Superior de Investigaciones Cientificas in Madrid, Spain, where she solved the crystal structure of the lead compound in complex with its target protein. Her studies have shown an unprecedented mechanism of action that opens opportunities for clinical resurrection of β-lactam antibiotics in combination with the new antibiotics. Bouley’s work during her fellowship tenure will explore structural analogs of these compounds with the goal of optimizing their potency in vivo and improving their drug-like properties.
Bouley is already the recipient of a National Institutes of Health Ruth L. Kirschstein National Research Service Award – CBBI (Chemistry-Biochemistry-Biology Interface) Program, a CBBI Research Internship Award, and an American Heart Association Predoctoral Fellowship (declined)………..https://www.linkedin.com/in/renee-bouley-43243215
.Research experience
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