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Wednesday, 13 July 2016

Mosad Ghareeb

DrMosad Ghareeb's Profile Photo



 Mosad Ghareeb
Lecturer at Theodor Bilharz Research Institute (TBRI)

Dr. Mosad Ahmed Ghareeb, Ph.D.
Lecturer (Medicinal Chemistry).
Biochemistry& Molecular Biology and Medicinal Chemistry Department.
Theodor Bilharz Research Institute (TBRI).
Warrak El-Hadar-12411, P.O Box 30 Imbaba, Giza, Egypt.
Web Site: http://www.tbri.sci.eg.Tel. 002-0235401019; Fax 002-0235408125.
Home  Tel. 00201122034012.
E. Mails: mosad_tbri@hotmail.com/ m.ghareeb@tbri.gov.eg
                 mosad.tbri@gamilcom/ mosad_tbri@yahoo.com
Home Address: 7 El-Nozha St., Gezert El-Nagdi, Kaluib City, El-Kaluibia, Governorate, Egypt





Summary

I am interested in the field of natural products. My research includes: Medicinal Chemistry, Chemistry of natural product, phytochemistry including isolation, purification and structural elucidation of the different classes of natural products which isolated from medicinal plants. Biological evaluation of the different extracts as well as fractions and the isolated compounds as anti-tumor (Cell Lines), anti-HIV, antimicrobial, antioxidant and hepatoprotective activities. Study of the structure activity relationship (SAR) of the isolated compounds as well as nanoparticles technology. In details, my research interests focus on finding out novel bioactive antioxidant and anticancer chemo-preventive agents from the medicinal plants by subjecting the plants under investigation to comprehensive bioassay-guided investigation to isolate and evaluate the anticancer related activities of the known and novel secondary metabolites that might be present in these plants. Isolation and identification of the potent anti-tumor lead compounds based on various chromatographic methods, and spectroscopic NMR and MS analysis. Study the mechanism of action and evaluating the cytotoxicity, antioxidant and antitumor in vitro activities of the obtained extracts, fractions, sub-fractions, and the isolated secondary metabolites in a close collaboration with the biologists and pharmacologists.

Experience

Lecturer

Theodor Bilharz Research Institute (TBRI)
 – Present (5 years 5 months)Biochemistry& Molecular Biology and Medicinal Chemistry Department

Dr

Self-employed
 – Present (12 years 8 months)

Publications

Antioxidant and Cytotoxic Activities of Gmelina arborea ROXB. Leaves(Link)

British Journal of Pharmaceutical Research
October 5, 2013
Aims: The leaves of Gmelina arborea (ROXB.) (Family Verbenaceae) are widely used in
the folklore to treat various types of diseases. In this study, the antioxidant and cytotoxic
activities of different methanolic extracts and the derived subfractions of 90% methanolic
extract of this plant were evaluated.
Methodology: The antioxidant activity was carried out via three different quantitative

Radical scavenging potential and cytotoxic activity of phenolic compounds from Tectona grandis (Linn.)

Global Journal of Pharmacology
November 10, 2013
Ten compounds including two phenolic acids and eight flavonoids were isolated from n-butanol and
ethyl acetate fractions of Tectona grandis leaves part (Family Verbenaceae). All of the compounds were
isolated and purified via different column chromatography. Their structures were elucidated via UV, IR
and NMR spectral techniques as well as (Co-PC, Co-TLC and Co-m.p.) and acid hydrolysis to be...more

Antioxidant and cytotoxic activities of Tectona grandis Linn leaves

International Journal of Phytopharmacology
January 15, 2014
Cancer prevention and treatment have attracted increasing interest. Leaves of Tectona grandis Linn. (Verbenaceae) are widely used in the folklore to treat various types of diseases. This study characterizes the antioxidant activity, total phenolic content (TPC) and cytotoxic activity of different methanolic extracts as well as the derived subfractions (Pet. ether; CHCl3, EtOAc and n-BuOH) from the...more

Antioxidant and cytotoxic activities of flavonoidal compounds from Gmelina arborea (Roxb.)

Global Journal of Pharmacology
January 10, 2014
A bioassay-guided fractionation and chemical investigation of the Gmelina arborea leaves
(Verbenaceae) resulted in the isolation and characterization of six known flavonoids (1, 3-7) along with new
flavone glycoside (2), identified as; luteolin (1), luteolin-4'-O- -D-4C -galactoside (2), kaempferol (3), quercetin -
1
3 - O - - D - 4C -glucopyranoside (isoquercitrin) (4), quercetin - 3 - O - -...more

Antioxidant Activity of Heterocyclic Compounds Derived from 4-(4-Acetamidophenyl)-4-oxobut-2-enoic Acid

International Journal of Science and Research
May 10, 2014
4-(4-Acetamidophenyl)-4-oxobut-2-enoic acid 1 and / or its aza Michael adduct 2 were efficiently utilized to construct novel
various heterocycles including derivatives of furanones (3a-c & 14), pyridazinones (4-6), diazepine (7), piperazine (8), oxazine (9),
oxazole (10a), thiazole (10b), benzo-, [-diazin, -oxazin, -thiaz-]-ones (11a-c). Conduct (11c) with NH2-NH2..H2O in boiling ethanol and...more

TOTAL PHENOLIC CONTENTS AND ANTIOXDANT ACTIVITIES OF FICUS SYCOMORUS AND AZADIRACHTA INDICA

Pharmacologyonline 3: 590-602 (2009)
February 10, 2009
In this study, the total phenolic content of the methanol, methanol-water mixtures and
water extracts of the leaves of two plants growing in Egypt; Ficus sycomorus and
Azadirachta indica were determined by using Folin-Ciocalteu reagent. Also, the
antioxidant activity of these extracts was evaluated by using two methods including
DPPH radical scavenging activity assay and total antioxidant...more

BIO-GUIDED ISOLATION AND STRUCTURE ELUCIDATION OF ANTIOXIDANT COMPOUNDS FROM THE LEAVES OF FICUS SYCOMORUS

Pharmacologyonline 3: 317-332 (2010)
March 15, 2010
This study was performed to investigate the antioxidant activity of the defatted
70% methanol extract of Ficus sycomorus leaves using DPPH radical scavenging
assay-guided isolation. This extract was fractionated using CHCl3, EtOAc and n-
BuOH. The results revealed that EtOAc and n-BuOH have strong DPPH radical
scavenging (SC50 =13.48 and 8.47 μg/ml). Therefore, each EtOAc and n-BuOH was
...more

EFFECT OF FICUS SYCOMORUS AND AZADIRACHTA INDICA EXTRACTS ON LIVER STATE OF MICE INFECTED WITH SCHISTOSOMA MANSONI

J. Egypt. Soc. Parasitol., 41 (1), 2011: 77 - 88
March 20, 2011
The potential role of hepatoprotective and antipathological effect of Ficus
sycomorus and Azadirachta indica extracts was evaluated for scavenging the
reactive oxygen species (ROS) and reduced the oxidative damage and pathological
changes in the liver of S. mansoni infected mice. The levels of alanine
aminotransferase (ALT), asparate aminotransferase (AST) and gamma glutamyl
transferase (GGT)...more

Chemical constituents, antischistosomal and antioxidant activity of methanol extract of Azadirachta indica

Egyptian Journal of Chemistry 54, 105-119, 2011
June 15, 2011

In vitro Antimicrobial Activity of Five Egyptian Plant Species

Journal of Applied Pharmaceutical Science
September 4, 2015
In this study, five Egyptian species were tested for their In vitro antimicrobial activities. The antimicrobial
screening was carried out via disc diffusion method toward four strains of the clinical antibiotic resistant
pathogens including Escherichia coli, Staphylococcus aureus, Candida albicans and Aspergillus niger. Among
the methanolic extracts screened, Azadirachta indica, Tectona grandis...more

CYTOTOXIC SCREENING OF THREE EGYPTIAN PLANTS USING BRINE SHRIMP LETHALITY TEST

International Journal of Pharmacy and Pharmaceutical Sciences
August 25, 2015
Objective: Brine shrimp (Artemia salina L.) bioassay is considered as a preliminary screening for the presence of antitumor compounds and used to determine the toxicity of plant extracts. Different extracts of three Egyptian plants, philodendron selloum (Araceae), Bougainvillea alba (Nyctaginaceae) and Ulmus parvifolia (Ulmaceae) 

Additional Info

  • Advice for Contacting Mosad

    E-mail addresses: mosad_tbri@hotmail.com.
    mosad_tbri@yahoo.com.





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