Dr Joelle Prunet

• Senior Lecturer (Chemistry)

telephone: 01413308774
email: Joelle.Prunet@glasgow.ac.uk

A4-13 Organic Section, Chemistry, Joseph Black Building, Glasgow G12 8QQ




links
https://uk.linkedin.com/in/joelle-prunet-36954315

Experience

Senior Lecturer - Head of Organic Chemistry

University of Glasgow

August 2009 – Present (7 years 5 months)

Directrice de Recherche

CNRS

October 2003 – August 2009 (5 years 11 months)

Education

Harvard University

PhD, Organic Chemistry

1987 – 1993

PhD advisor: Professor David A. Evans

Ecole Normale Superieure Paris

BsC

1984 – 1987

Lycee Saint-Genevieve

1981 – 1984

Research Interests

The main research interest of the Prunet group is the synthesis of biologically active natural products, such as taxol, a powerful antitumor agent, or dolabelide C and hexacyclinic acid, molecules with cytotoxic activity. In our approaches towards the target molecules, we uncover problems that cannot be easily solved by known reactions, and to overcome these difficulties we try to develop new methodologies that can also be applied to other syntheses.

‌‌  Publication Highlights

• Gamba-Canchez, D.; Prunet, J. J. Org. Chem. 2010, 75, 3129-3132 Synthesis of Modified Methyl Furanosides by Intramolecular Oxa-Michael Reaction followed by Pummerer Rearrangement.
• Ma, C.; Schiltz, S.; Le Goff, Xavier F.; Prunet, J. Chem. Eur. J. 2008, 7314-7323 Ring-Closing Metathesis in the Synthesis of BC Ring-Systems of Taxol.
• Toueg, J.; Prunet J. Org. Lett. 2008, 10, 45-48 Dramatic Solvent Effect on the Diastereoselectivity of Michael Addition: Study towards the Synthesis of the ABC Ring-System of Hexacyclinic Acid.
• Rotulo-Sims, D.; Prunet J. Org. Lett. 2007, 9, 4147-4150 Tandem Conjugate Addition-Elimination for the Diastereoselective Synthesis of 4E-Alkenyl Syn 1,3-Diols.
• Vincent, A.; Prunet, J. Synlett 2006, 2269-2271 Enantioselective Synthesis of the C1-C15 Fragment of Dolabelide C.

Ma, C., Letort, A., Aouzal, R., Wilkes, A., Maiti, G., Farrugia, L. J., Ricard, L., and Prunet, J. (2016) Cascade metathesis reactions for the synthesis of taxane and isotaxane derivatives. Chemistry: A European Journal, 22(20), pp. 6891-6899. (doi:10.1002/chem.201600592) (PMID:27062670)

Letort, A., Aouzal, R., Ma, C., Long, D.-L., and Prunet, J. (2014) Highly efficient synthesis of the tricyclic core of Taxol by cascade metathesis.Organic Letters, 16(12), pp. 3300-3303. (doi:10.1021/ol501304j)

Chevalley, A., Prunet, J., Mauduit, M., and Ferezou, J.-P. (2013) Model studies for a ring-closing metathesis approach to the Bafilomycin macrolactone core from a 2,2-dimethoxy tetraenic ester precursor.European Journal of Organic Chemistry, 2013(36), pp. 8265-8278.(doi:10.1002/ejoc.201300559)

Redon, S., Wierzbicki,, M., and Prunet, J. (2013) A new oxa-michael reaction and a gold-catalysed cyclisation en route to C-glycosides.Tetrahedron Letters, 54(16), pp. 2089-2092.(doi:10.1016/j.tetlet.2013.02.022)

Prunet, J. (2011) Progress in metathesis through natural product synthesis. European Journal of Organic Chemistry, 2011(20-21), pp. 3634-3647. (doi:10.1002/ejoc.201100442)

Braun, M.G., Vincent, A., Boumediene, M., and Prunet, J. (2011) Highly demanding cross metathesis in the synthesis of the C16-C30 fragment of dolabelide C. Journal of Organic Chemistry, 76(12), pp. 4921-4929.(doi:10.1021/jo200466t)

Gamba-Sanchez, D., and Prunet, J. (2010) Synthesis of modified methyl furanosides by intramolecular oxa-Michael reaction followed by Pummerer rearrangement. Journal of Organic Chemistry, 75(9), pp. 3129-3132. (doi:10.1021/jo100241e)

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