Divya Chaudhary
Pharmaceutical R&D and Commercial Strategy
links
https://www.linkedin.com/in/divya-chaudhary-7584579
https://twitter.com/divya_divyach
https://www.researchgate.net/profile/Divya_Chaudhary3
Divya Chaudhary has been working in the pharmaceutical and biotechnology industry in drug discovery and development of small molecules and biologics for autoimmune diseases and oncology at Wyeth, Pfizer, and Nimbus Discovery. She received her Ph.D. from University of Alabama at Birmingham at the Comprehensive Cancer Center, working on regulation of oncogene expression, and did postdoctoral fellowships at University of Michigan and Genentech in molecular oncology and signal transduction.
Summary
Created
value in pharmaceutical R&D organizations in small molecule and
biologics drug discovery and development. Strong experience in strategic
thinking and innovation, communication and diligence, and effective
management of projects with diverse functional teams.
Effectivey managed external partners and client relations
Mentored staff as they enter and grow in organizations
Unique combination of a deep scientific and a strategy consulting experience
Disease areas experience in inflammation, autoimmune diseases, respiratory diseases, and immuno-oncology
Specialized in commercialization and operations strategy in life sciences, pharmacology, biochemistry, cell biology, CRO and supply chain, and program and alliance management
Effectivey managed external partners and client relations
Mentored staff as they enter and grow in organizations
Unique combination of a deep scientific and a strategy consulting experience
Disease areas experience in inflammation, autoimmune diseases, respiratory diseases, and immuno-oncology
Specialized in commercialization and operations strategy in life sciences, pharmacology, biochemistry, cell biology, CRO and supply chain, and program and alliance management
Experience
Consultant
IMS Health
Managed Markets Strategy for Commercialization of Bio-Pharmaceutical Products
Conducted subnational market analysis and created Tableau dashboard tools for a newly launched therapeutic to help define local market strategies
Conducted subnational market analysis and created Tableau dashboard tools for a newly launched therapeutic to help define local market strategies
Life Science Consultant
Putnam Associates
Conducted primary research with physicians, academics, and key opinion
leaders for development insights and commercial assessments for multiple
assets
Analyzed physician and patient data to understand segmentation/ positioning and building patient journey and treatment flow models
Refined a revenue model by performing sensitivity analysis, for the purpose of projecting revenue scenarios
Conducted due diligence for private equity client evaluating a medium sized pharmaceutical company’s assets
Developed product positioning strategies for cell immunotherapy product in hematology
Assessed global opportunities in vaccines; conducted research for HEOR analysis data inputs for the purpose of asset prioritization
Analyzed physician and patient data to understand segmentation/ positioning and building patient journey and treatment flow models
Refined a revenue model by performing sensitivity analysis, for the purpose of projecting revenue scenarios
Conducted due diligence for private equity client evaluating a medium sized pharmaceutical company’s assets
Developed product positioning strategies for cell immunotherapy product in hematology
Assessed global opportunities in vaccines; conducted research for HEOR analysis data inputs for the purpose of asset prioritization
Head of Pharmacology
Nimbus Discovery
Led preclinical discovery in a virtual CRO outsourced model, contributing to successful series B and program transaction
Contributed to the selection of IRAK4 inhibitor development candidates resulting in program partnering with Genentech
Communicated lead candidate profiles and timelines for board meetings and external discussions, and for diligence discussions and evaluation
Initiated and fast tracked the oncology project strategy with staff embedded at a CRO
Managed the early efforts to initate the ACC inhibitor evaluation in tumor cell lines
Developed the preclinical markers approach working with a CRO to contribute to the program's oncology strategy
Advanced critical business development objectives in the areas of cancer and autoimmune disease
Evaluated and critiqued multiple target ideas; initiated and implemented two programs
Proposed, planned, and led TYK2 inhibitor lead optimization biology effort
Contributed to the selection of IRAK4 inhibitor development candidates resulting in program partnering with Genentech
Communicated lead candidate profiles and timelines for board meetings and external discussions, and for diligence discussions and evaluation
Initiated and fast tracked the oncology project strategy with staff embedded at a CRO
Managed the early efforts to initate the ACC inhibitor evaluation in tumor cell lines
Developed the preclinical markers approach working with a CRO to contribute to the program's oncology strategy
Advanced critical business development objectives in the areas of cancer and autoimmune disease
Evaluated and critiqued multiple target ideas; initiated and implemented two programs
Proposed, planned, and led TYK2 inhibitor lead optimization biology effort
Consultant
Nimbus Discovery
Project
management for IRAK4 inhibitor and ACC inhibitor programs lead
discovery efforts, with contract research organization, for both fee for
service and full time equivalent resourced projects
Senior Principal Scientist
Pfizer Pharmaceuticals
Managed
the preclinical, biomarker, and pharmacology strategy for four
autoimmune disease programs (small molecule and biologics)
Scientist
Wyeth Research
Managed and led two biologics programs and one small molecule program
Education
Indian Institute of Technology, Roorkee
M.Sc., BioSciences and Biotechnology
Graduated top of the class with a gold medal award
Activities and Societies: RUSA Senator
University of Alabama at Birmingham - School of Medicine
Ph.D., Biochemistry and Molecular Genetics
Recent Advances in the Discovery of Small Molecule Inhibitors of Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) as a Therapeutic Target for Inflammation and Oncology Disorders
Miniperspective
† Nimbus Discovery, 25 First Street, Suite 404, Cambridge, Massachusetts 02141, United States
‡ Schrödinger Inc., 120 West Forty-Fifth Street, New York, New York 10036, United States
J. Med. Chem., 2015, 58 (1), pp 96–110
DOI: 10.1021/jm5016044
MKC-3946 is a potent inhibitor of inositol-requiring enzyme 1α (IRE1α). It inhibits XBP1 mRNA splicing and exhibits cytotoxicity against AML cells. MKC-3946 leads to modest growth inhibition in MM cells but has no effect on normal mononuclear cells in vitro. MKC-3946
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