DR ANTHONY MELVIN CRASTO,WorldDrugTracker, helping millions, A 90 % paralysed man in action for you, I am suffering from transverse mylitis and bound to a wheel chair,With death on the horizon, This will not stop me, Gods call only..........
DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai) , INDIA 29Yrs Exp. in the feld of Organic Chemistry,Working for GLENMARK PHARMA at Navi Mumbai, INDIA. Serving chemists around the world. Helping them with websites on Chemistry.Million hits on google, world acclamation from industry, academia, drug authorities for websites, blogs and educational contribution

Monday, 11 April 2016

Shaughnessy Robinson




Shaughnessy Robinson received a B.S. in Chemistry from Wright State University, OH. He worked at Sterling Winthrop and Pfizer for many years doing synthetic and computational chemistry on a variety of small molecule drug discovery programs. He is currently employed by Schrödinger, Inc. in the Drug Discovery Applications Group.



IRAK INHIBITORS AND USES THEREOF

Publication number: 20160068543
Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
Type: Application
Filed: September 17, 2015
Publication date: March 10, 2016
Inventors: Jeremy Robert Greenwood, Geraldine C. Harriman, Rosana Kapeller-Libermann, Craig E. Masse, Shaughnessy Robinson, Donna L. Romero, Mee Shelley, Ronald T. Wester

IRAK INHIBITORS AND USES THEREOF

Publication number: 20160002256
Abstract: The present invention provides thienopyridine compounds, compositions thereof, and methods of using the same.
Type: Application
Filed: June 17, 2015
Publication date: January 7, 2016
Inventors: Geraldine C. Harriman, Ronald T. Wester, Donna L. Romero, Craig E. Masse, Shaughnessy Robinson, Jeremy R. Greenwood

IRAK INHIBITORS AND USES THEREOF

Publication number: 20160002257
Abstract: The present invention provides arylo-fused thienopyrimidine compounds, compositions thereof, and methods of using the same.
Type: Application
Filed: June 17, 2015
Publication date: January 7, 2016
Inventors: Donna L. Romero, Shaughnessy Robinson, Matthew David Wessel, Jeremy Robert Greenwood

IRAK inhibitors and uses thereof

Patent number: 9212190
Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
Type: Grant
Filed: January 10, 2013
Date of Patent: December 15, 2015
Assignee: Nimbus Iris, Inc.
Inventors: Geraldine C. Harriman, Ronald T. Wester, Donna L. Romero, Shaughnessy Robinson, Mee Shelley, Matthew David Wessel, Jeremy Robert Greenwood, Craig E. Masse, Rosana Kapeller-Libermann

IRAK INHIBITORS AND USES THEREOF

Publication number: 20150329498
Abstract: The present invention provides quinazoline and quinoline compounds, compositions thereof, and methods of using the same. Also disclosed is the activity of such compounds as inhibitors of IRAK enzymes.
Type: Application
Filed: April 21, 2015
Publication date: November 19, 2015
Inventors: Donna L. Romero, Shaughnessy Robinson, Jeremy Robert Greenwood, Mee Shelley, Craig E. Masse, Geraldine C. Harriman

IRAK inhibitors and uses thereof

Patent number: 9175007
Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
Type: Grant
Filed: January 8, 2014
Date of Patent: November 3, 2015
Assignee: Nimbus Iris, Inc.
Inventors: Jeremy Robert Greenwood, Geraldine C. Harriman, Rosana Kapeller-Libermann, Craig E. Masse, Shaughnessy Robinson, Donna L. Romero, Mee Shelley, Ronald T. Wester

IRAK inhibitors and uses thereof

Patent number: 9085586
Abstract: The present invention provides arylo-fused thienopyrimidine compounds, compositions thereof, and methods of using the same.
Type: Grant
Filed: July 11, 2013
Date of Patent: July 21, 2015
Assignee: Nimbus Iris, Inc.
Inventors: Donna L. Romero, Shaughnessy Robinson, Matthew David Wessel, Jeremy Robert Greenwood

IRAK inhibitors and uses thereof

Patent number: 9067948
Abstract: The present invention provides thienopyridine compounds, compositions thereof, and methods of using the same.
Type: Grant
Filed: July 11, 2013
Date of Patent: June 30, 2015
Assignee: Nimbus Iris, Inc.
Inventors: Geraldine C. Harriman, Ronald T. Wester, Donna L. Romero, Craig E. Masse, Shaughnessy Robinson, Jeremy Robert Greenwood

IRAK INHIBITORS AND USES THEREOF

Publication number: 20150094305
Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
Type: Application
Filed: September 25, 2014
Publication date: April 2, 2015
Inventors: Donna ROMERO, Craig E. MASSE, Shaughnessy ROBINSON, Jeremy Robert GREENWOOD, Geraldine C. HARRIMAN

IRAK INHIBITORS AND USES THEREOF

Publication number: 20150025093
Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
Type: Application
Filed: February 25, 2014
Publication date: January 22, 2015
Applicant: Nimbus Iris, Inc.
Inventors: Donna L. Romero, Matthew David Wessel, Shaughnessy Robinson, Jeremy Robert Greenwood, Karl Shawn Watts, Leah Lynn Frye, Geraldine C. Harriman, Alan Franklin Corin, Craig E. Masse, Mee Shelley

IRAK INHIBITORS AND USES THEREOF

Publication number: 20140194417
Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
Type: Application
Filed: January 8, 2014
Publication date: July 10, 2014
Applicant: Nimbus Iris, Inc.
Inventors: Jeremy Robert Greenwood, Geraldine C. Harriman, Rosana Kapeller-Libermann, Craig E. Masse, Shaughnessy Robinson, Donna L. Romero, Mee Shelley, Ronald T. Wester

IRAK inhibitors and uses thereof

Patent number: 8703941
Abstract: The present invention provides thienopyrimidine and thienopyridine compounds, compositions thereof, and methods of using the same for the treatment of diseases mediated by IRAK enzymes. Such diseases include inflammatory and proliferative diseases.
Type: Grant
Filed: January 10, 2012
Date of Patent: April 22, 2014
Assignee: Nimbus Iris, Inc.
Inventors: Donna L. Romero, Matthew David Wessel, Shaughnessy Robinson, Jeremy Robert Greenwood, Karl Shawn Watts, Leah Lynn Frye, Geraldine C. Harriman, Alan Franklin Corin, Craig E. Masse, Mee Shelley

IRAK INHIBITORS AND USES THEREOF

Publication number: 20140018343
Abstract: The present invention provides arylo-fused thienopyrimidine compounds, compositions thereof, and methods of using the same.
Type: Application
Filed: July 11, 2013
Publication date: January 16, 2014
Inventors: Donna L. Romero, Shaughnessy Robinson, Matthew David Wessel, Jeremy Robert Greenwood

IRAK INHIBITORS AND USES THEREOF

Publication number: 20140018357
Abstract: The present invention provides thienopyridine compounds, compositions thereof, and methods of using the same.
Type: Application
Filed: July 11, 2013
Publication date: January 16, 2014
Inventors: Geraldine C. Harriman, Ronald T. Wester, Donna L. Romero, Craig E. Masse, Shaughnessy Robinson, Jeremy Robert Greenwood

IRAK INHIBITORS AND USES THEREOF

Publication number: 20140018361
Abstract: The present invention provides furano- and pyrrolo-pyrimidine and pyridine compounds, compositions thereof, and methods of using the same.
Type: Application
Filed: July 11, 2013
Publication date: January 16, 2014
Inventors: Geraldine C. Harriman, Donna L. Romero, Craig E. Masse, Shaughnessy Robinson, Matthew David Wessel, Jeremy Robert Greenwood

IRAK INHIBITORS AND USES THEREOF

Publication number: 20130231328
Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
Type: Application
Filed: January 10, 2013
Publication date: September 5, 2013
Applicant: NIMBUS IRIS, INC.
Inventors: Geraldine C. Harriman, Ronald T. Wester, Donna L. Romero, Shaughnessy Robinson, Mee Shelley, Matthew David Wessel, Jeremy Robert Greenwood, Craig E. Masse, Rosana Kapeller-Libermann

IRAK INHIBITORS AND USES THEREOF

Publication number: 20120283238
Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
Type: Application
Filed: January 10, 2012
Publication date: November 8, 2012
Applicant: NIMBUS IRIS, INC.
Inventors: Donna L. Romero, Matthew David Wessel, Shaughnessy Robinson, Jeremy Robert Greenwood, Karl Shawn Watts, Leah Lynn Frye, Geraldine C. Harriman, Alan Franklin Corin, Craig E. Masse

SUBSTITUTED HETEROCYCLIC DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS

Publication number: 20120065188
Abstract: Compounds of the general Formula I, wherein X1, X2, X3, X4, X5, X6, X7, R1, R2, R4, R5, R6, R7, R8, R9, R10, Y1, n, m, p and q are defined as above, their preparation and their use as antimicrobial agents.
Type: Application
Filed: November 22, 2011
Publication date: March 15, 2012
Inventors: Steven Joseph Brickner, Jinshan Michael Chen, Zhengong Bryan Li, Anthony Marfat, Mark Joseph Mitton-Fry, Michael A. Plotkin, Usa Datta Reilly, Chakrapani Subramanyam, Zhijun Zhang, Shaughnessy Robinson

Substituted Heterocyclic Derivatives and Their Pharmaceutical Use and Compositions

Publication number: 20110092480
Abstract: Compounds of the general Formula I, wherein X1, X2, X3, X4, X5, X6, X7, R1, R2, R4, R5, R6, R7, R8, R9, R10, Y1, n, m, p and q are defined as above, their preparation and their use as antimicrobial agents.
Type: Application
Filed: December 20, 2010
Publication date: April 21, 2011
Inventors: Steven Joseph Brickner, Jinshan Michael Chen, Zhengong Bryan Li, Anthony Marfat, Mark Joseph Mitton-Fry, Michael A. Plotkin, Usa Datta Reilly, Chakrapani Subramanyam, Zhijun Zhang, Shaughnessy Robinson

SUBSTITUTED HETEROCYCLIC DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS

Publication number: 20080280879
Abstract: Compounds of the general Formula I, wherein X1, X2, X3, X4, X5, X6, X7, R1, R2, R4, R5, R6, R7, R8, R9, R10, Y1, n, m, p and q are defined as above, their preparation and their use as antimicrobial agents.
Type: Application
Filed: May 8, 2008
Publication date: November 13, 2008
Inventors: Steven Jospeh BRICKNER, Jinshan Michael Chen, Zhengong Bryan Li, Anthony Marfat, Mark Joseph Mitton-Fry, Micheal A. Plotkin, Usa Datta Reilly, Chakrapani Subramanyam, Zhijun Zhang, Shaughnessy Robinson 
 
 
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Recent Advances in the Discovery of Small Molecule Inhibitors of Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) as a Therapeutic Target for Inflammation and Oncology Disorders

Miniperspective

† Nimbus Discovery, 25 First Street, Suite 404, Cambridge, Massachusetts 02141, United States
‡ Schrödinger Inc., 120 West Forty-Fifth Street, New York, New York 10036, United States
J. Med. Chem., 2015, 58 (1), pp 96–110
DOI: 10.1021/jm5016044
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