.Michal Shavit
Research Scientist at On Target Chemistry Israel
LINJKS\
Experience
Research Scientist
On Target Chemistry from the Recipharm group
Postdoctoral Researcher
Technion - Israel Institute of Technology
Research Assistant
Columbia University
Education
Technion - Israel Institute of Technology
Doctor of Philosophy (PhD), Chemistry
The Hebrew University
Master of Science (MSc), Chmistry
The Hebrew University of Jerusalem
Bachelor’s Degree, Chmistry
Publications
Active cytotoxic reagents based on non-metallocene non-diketonato well-defined C2-symmetrical titanium complexes of tetradentate bis(phenolato) ligands
J. Am. Chem. Soc.
September 18, 2007
A new family of non-Cp-based non-diketonato-based C2-symmetrical octahedral Ti(IV) complexes of dianionic diamine bis(phenolato) ligands, which are conveniently obtained as single isomers in quantitative yields, leads to appreciable cytotoxicity against colon and ovarian cells with a non-transferrin-dependent cell penetration mechanism. The ligand structural features including steric demands,...more
Structural characterization of dinuclear Ti(IV) complexes of rigid tetradentate dianionic diamine bis(phenolato) ligands; effect of steric bulk on coordination features
Journal of Organometallic Chemistry
October 4, 2008
A small difference in diamine bis(phenolato) ligands, namely an additional single methylene unit, directs formation of dinuclear Ti(IV) complexes rather than mononuclear ones as characterized by X-ray crystallography. Varying steric bulk of the ligand affects the coordination number in the dinuclear complexes and the ligand to metal ratio. A ligand with reduced steric bulk leads to a L2Ti2(OiPr)4...more
Antitumor Reactivity of Non-Metallocene Titanium Complexes of Oxygen-Based Ligands: is Ligand Lability Essential?
J. Biol. Inorg. Chem.
July 2007
In our attempt to define the parameters affecting anticancer activity of titanium complexes and to assess the role of hydrolytic stability, titanium compounds of oxygen-based ligands were studied. A homoleptic complex of hydroxyamino-1,3,5-triazine ligands was prepared and its hydrolysis was investigated by UV–vis spectroscopy at biologically relevant pH and temperature conditions based on its...more
Preparation and X-Ray Structures of Ti(IV) Complexes of Bis(carboxylato) Ligands; Formation of Mono-, Di-, Tetra- and Hexanuclear Complexes With or Without OR and μ-O Ligands
Eur. J. Inorg. Chem.
2008Synthesis, Characterization, Cytotoxicity, and Hydrolytic Behavior of C2 and C1-Symmetrical Ti(IV) Complexes of Tetradentate Diamine Bis(Phenolato) Ligands: A New Class of Antitumor Agents
Chem. Eur. J
2009TiIV Complexes of Branched Diamine Bis(phenolato) Ligands: Hydrolysis and Cytotoxicity
Eur. J. Inorg. Chem.
2011Increased Selectivity toward Cytoplasmic versus Mitochondrial Ribosome Confers Improved Efficiency of Synthetic Aminoglycosides in Fixing Damaged Genes: A Strategy for Treatment of Genetic Diseases Caused by Nonsense Mutations
Journal of Medicinal Chemistry
2012A hybrid drug limits resistance by evading the action of the multiple antibiotic resistance pathway.
Molecular Biology and Evolution
November 3, 2015Design of Novel Aminoglycoside Derivatives with Enhanced Suppression of Diseases-Causing Nonsense Mutations
ACS Medicinal Chemistry Letters
February 8, 2016///////
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