.
Thirumala Govender
Department of Pharmaceutical Sciences,University of KwaZulu-Natal, Private Bag X54001, Durban 4000, South Africa.
mail: govenderth@ukzn.ac.za Phone: +27 31 2607358 Fax:+27 31 2607792
University of KwaZulu-Natal, School of Pharmacy: Professor of Pharmaceutics - See more at: https://www.wits.ac.za/waddp/research-team/#sthash.U0pZRNni.dpuf
Professor Thirumala Govender
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Telephone
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+27 (031) 260 7357/8
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Email
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Campus
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Westville
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Research Interests
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Design and Evaluation of novel drug delivery systems, Buccal and Transdermal Delivery of ARV drugs, Nanoantibiotics.
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Designation
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Acting Academic Leader /Professor/Head of Drug Delivery Unit
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https://za.linkedin.com/in/thirumala-govender-887628a8
https://twitter.com/govenderth
https://www.researchgate.net/profile/Thirumala_Govender
Professor
Thirumala Govender, leading researcher in Pharmaceutics and her students
have in the past few weeks received several accolades in recognition of
excellence in research. From UKZN’s School of Pharmacy and
Pharmacology, the team has been recognized both nationally and
internationally for their work in the development of novel drug delivery
systems for the buccal route. Professor Govender was awarded a
Commonwealth Scholarship and completed a Doctor of Philosophy degree in
Pharmacy (Pharmaceutics) at the University of Nottingham (UK), the top
ranked Pharmacy school for research in the UK. Currently she is one of
the University of KwaZulu-Natal’s leading scientists and heads up the
Drug Delivery Research Unit based on the Westville Campus. Her principal area of research is the design and evaluation of novel drug delivery systems,
At the recent 5th
International Conference on Pharmaceutical and Pharmacological
Sciences, Professor Govender was jointly awarded the Adcock Ingram Best
Research Publication Award in Pharmaceutics from the Academy of
Pharmaceutical Sciences of South Africa. The paper was evaluated by both
local and international judges. The paper entitled, “Formulation of monolayered films with drug and polymers of opposing solubilities”,
was published in International Journal of Pharmaceutics . It featured
research findings of her masters student, Ms Velisha Perumal who
graduated cum laude in 2007 . The aim of the study was to prepare
and characterise novel monolayered multipolymeric films comprising of a
hydrophilic drug (Propranolol HCI) (PHCI) and polymers of opposing
solubilities for delivery via the buccal route. The study used a new
method of film preparation and identified optimal polymeric blends to
provide improved improved mucoadhesion on the mucosa and
controlled drug release kinetics. The various physicochemical and
mechanical tests on the delivery system confirmed the potential of this
monolayered multipolymeric film, as a promising candidate for controlled
buccal drug delivery.
Honours
level student Ms Razeena Khan moved to South Africa about eight years
ago from Canada and feels “blessed” to be working with an individual
that is so professional and devoted to the students as Professor
Govender is. Ms Khan said, “Professor Govender doesn’t spoon-feed the
students and at the same time is accessible to provide guidance and
mentorship. She teaches us in a way that we’re able to understand the
concepts and hence the performance of all her students are always par
excellence”.
In addition to the above awards this year, Prof Govender has also been awarded funds from the Goho Life Sciences International Fund in Japan to be a Distinguished Visiting Scientist
at Tohoku University, one of the leading universities in Japan, She
will be embarking on this visit to share and learn new techniques in
nanotechnology for drug delivery systems. The Department of Science and
Technology has also invited her to teach at their first national Nano
Summer School later in the year. She was also specifically invited by
the University of Western Cape a few weeks ago to participate in the
development of the first MSc degree in Nanotechnology in South Africa.
Prof Govender believes that the above achievements in recent weeks have
been due to a collective team effort and therefore sincerely
acknowledges her postgraduate students including task supervisor Mr
Sanjeev Rhambarose, local and international collaborators including Dr
Irene Mackraj from the School of Medical Sciences and the Biomedical
Resources and Electron Microscopy Unit at UKZN, MRC, NRF, Aspen,
CAPRISA/Gilead Sciences/CONRAD and laboratory support staff for their
invaluable contributions.
Prof
Govender is currently the elected Vice Chair of the Academy of
Pharmaceutical Sciences of South Africa and has also been appointed on
the Pharmaceutical and Analytical Committee of the Medicine Control
Council of South Africa. She is also a member of the College of Health
Sciences Women in Leadership and Leverage committee and is devoted to
mentoring young health scientists at UKZN. She is the recipient of
several other national awards for recognition of excellence in both
teaching and research such as the Johnson and Johnson Distinguished
Teacher award and the Roche achievement and Adcock Ingram awards for the
Best Research Publication in Pharmaceutics. Prof Govenders research has
been published in more than 30 internationally accredited journals and
presented at several local and international conferences. Her
dedication and enthusiasm in the field of pharmaceutics is unrivalled
and as a woman she is paving the way for future scientists in the fields
of buccal drug delivery and nanotechnology.
Prof Thirumala Govender is currently
Professor of Pharmaceutics, Head of the Drug Delivery Research
Proto-Unit, Head of the Nano-Health Sector of the UKZN Nanotechnology
Platform, and Acting Academic Leader of Discipline of Pharmaceutical
Sciences at University of KwaZulu-Natal (UKZN), Her Masters degree,
awarded with distinction, focused on microparticulate systems for
sustained drug release. She was subsequently awarded a Commonwealth
Scholarship and completed a PhD at University of Nottingham (UK). Her
PhD research in nanotechnology identified technologies for enhancing
drug incorporation into polymeric nanosystems for targeted delivery.
Prof Govender’s current research on novel delivery systems focuses on
nanotechnology and alternate routes of drug delivery. She has extensive
experience in the formulation and physicochemical/mechanical/mechanistic
evaluation of various delivery systems e.g. pellets, nanoparticles,
nanomicelles, nanofibers, nanobubbles and buccal
patches/films/tablets/microspheres/wafers.
Prof
Govender is a South African National Research Foundation (NRF) C2 rated
scientist. Her current h-index is calculated as 17 (Web of Science), 21
(Google Scholar) and 19 (Scopus) with 1381, 1987 and 1482 citations
respectively. She has 63 publications in ISI international journals, is a
co-author on a patent granted and has 43 international and 57 local
conference contributions. She has won several national awards from the
Academy of Pharmaceutical Sciences of South Africa for excellence in
both research and teaching i.e.: Johnson and Johnson Distinguished
Teacher Award, Roche Achievement Award as well as the Adcock Ingram
Award for Best Research Publications in Pharmaceutics. She has been the
recipient of the UKZN Faculty of Health Sciences Award for Most
Productive Researcher in the Associate Professor category. She has also
received the UKZN nomination for Best Emerging Young Woman Scientist for
the South African Women in Science Awards. Prof Govender has secured
scholarships/research grants from the UK Commonwealth Association, NRF,
Medical Research Council (MRC) and UKZN. She has successfully
supervised/co-supervised students at Honours, Masters, PhD and
Postdoctoral levels. Several have passed with distinction and have won
international, national and UKZN awards for excellence in
publications/presentations/posters. Prof Govender currently has 2
Postdocs, 5 PhD and 4 Masters students.
Prof
Govender was awarded funds from the Japanese Goho Life Sciences
International Fund to be a visiting scientist at Tohoku University
(Japan) and from NRF as a visiting academic to University of Queensland
(Australia). She has been invited to deliver lectures at international
symposiums i.e. 4th International Symposium on Current Trends in Drug
Discovery (India) and International Symposium of Aids and Tuberculosis
(Japan) and also to present her research at international universities
(Tohoku University and Osaka Prefecture University). She was also
invited by an international organization, i.e. Organisation for the
Prohibition of Chemical Weapons at The Hague to deliver a presentation
on Nano drug delivery at the All African Nanoscience and Nanotechnology
Workshop in Cape Town. She has been invited to chair sessions at several
local conferences and an international conference (11th International
Pharmaceutical Technology Symposium-Turkey). She is a regular invited
reviewer for reputable international journals including Colloids and
Surfaces, International Journal of Pharmaceutics, Journal of Controlled
Release, Molecular Pharmaceutics and Journal of Pharmaceutical Sciences.
Prof Govender has conducted invited reviews of research applications
for the NRF and the Department of Science and Technology (DST) in South
Africa (SA). She is an invited undergraduate and postgraduate examiner
for universities in Africa (University of Nairobi, Harare Institute of
Technology) and in SA (University of the Witwatersrand, University of
Western Cape, Stellenbosch University, Nelson Mandela Metropolitan
University, North West University, Tshwane University of Technology).
She has also been invited by University of Limpopo and DST to deliver a
presentation for the Public Engagement in Nanotechnology programme.
Further, she was invited by the DST to participate in a national
workshop to formulate a Nanotechnology Plan for SA as well as by the
National Nanoscience Centre at University of Western Cape to participate
in the curriculum development of the first MSc in Nanotechnology in SA.
PUBLICATIONS IN THE LAST 3 YEARS
Patents
Inventors: LC du Toit, V PIllay, YE Choonara, T Govender, TR Carmichael
Type: Drug Delivery Device
(US0140023692 A1) APPLIC NUMBER: US 13/989,401) (PCT NUMBER: PCT/IB2011/055328), (Filing date, 28 November 2011, Publication date 23 January 2014)
Type: Drug Delivery Device
(US0140023692 A1) APPLIC NUMBER: US 13/989,401) (PCT NUMBER: PCT/IB2011/055328), (Filing date, 28 November 2011, Publication date 23 January 2014)
The
invention provides an inflammation-responsive implantable device for
the in situ delivery of one or more pharmaceutically active agents to a
human or animal. The device comprises two differential release
bioresponsive polymeric matrices (BPMs): an outer polymeric matrix and
an inner polymeric matrix, both of which contain at least one
pharmaceutically active agent or drug, typically an antibiotic and an
anti-inflammatory agent, respectively. The therapeutically effective
agent may be embedded in nanoparticles or nanobubbles. In response to
inflammation, the pharmaceutically active agents are released, but at
different rates: the rate of drug release from the inner polymeric
matrix is lower than the rate of drug release from the outer polymeric
matrix. Suitable polymers for forming the outer and inner polymeric
matrices are hyaluronic acid and chitosan, respectively. A method of
making the device and a method of treatment are also described.
(HTTP:/WWW.GOOGLE.COM/PATENTS/US20140023692)
Peer Reviewed Publications in ISI Journals
- Suleman, N, Kalhapure RS, Mocktar, C, Rambharose, S, Singh, M, Govender, T, Silver salts of carboxylic acid terminated generation 1 poly (propyl ether imine) (PETIM) dendron and dendrimers as antimicrobial agents against S.aureus and MRSA, RSC Advances, 2015, 5, 34967 – 34978 (Senior Author/Postgraduate Supervisor) (IF = 3.708)
- Kalhapure R, Suleman, N, Seedat, N, Mocktar C, Govender, T, Nanoengineered drug delivery systems for enhancing antibiotic drug therapy, Journal of Pharmaceutical Sciences, 2014, DOI 10.1002/jps.24298 (Senior Author/Postdoctoral Supervisor) (Invited Review).
- Kalhapure, R, Mocktar, C, Muthu, K, Skelton, A, Sonowane, S, Sikwal, D, Govender, T, Ion pairing with linoleic acid simultaneously enhances encapsulation efficiency and antibacterial activity of vancomycin in solid lipid nanoparticles Colloids and Surfaces B: Biointerfaces, 2014, 117, 303-311 (Senior Author/Postdoctoral Supervisor) (IF=4.3)
- Du Toit, L; Pillay, V; Govender, T; Carmichael, T, Kumar, P; Choonara, YE,In Vitro, In Vivo, and In Silico Evaluation of the Bioresponsive Behavior of an Intelligent Intraocular Implant, Pharmaceutical Research, 2014, 31(607-634) (Co-Senior Author/Postgraduate Co-Supervisor). (IF=3.9)
- Jones, E, Ojewole, E, Kalhapure, R, Govender, T, In vitro comparative evaluation of monolayered multipolymeric films embedded with didanosine-loaded solid lipid nanoparticles: A potential buccal drug delivery system for ARV therapy, Drug Development and Industrial Pharmacy, 2014, 40(5), 669-679. (Senior Author/Postgraduate Supervisor) (IF=2.01)
- Rhambarose, S, Ojewole, E, Mackraj, I, Govender, T, Comparative buccal permeability enhancement of didanosine and tenofovir by potential multifunctional polymeric excipients and their effects on porcine buccal histology, Pharmaceutical Development and Technology, 2014, 19(1), 82-90. (Senior Author/Postgraduate Supervisor) (IF=1.34)
- Rhambarose, M, Branham, S, Ojewole, Govender, T, High?energy ball milling of Saquinavir increases permeability across the buccal mucosa, Drug Development and Industrial Pharmacy, 2014, 40(5), 639-648. (Senior Author/Postgraduate Supervisor) (IF=2.01)
- Ahmed, SM, Kruger HG, Maguire GEM, Govender, T, The impact of active site mutations of South African HIV PR on drug resistance: insight from molecular dynamics simulations, binding free energy and per-residue footprints, Chemical Biology & Drug Design, 2014, 83 (472-481) (Senior Author/Postgraduate Supervisor) (IF=2.5)
- Ojewole, E, Kalhapure, E, Akamanchi, K, Govender, T, Novel Oleic AcidDerivatives Enhance Buccal Permeation of Didanosine, Drug Development and Industrial Pharmacy, 2014, 40(5), 657-668. (Senior Author/Postgraduate Supervisor) (IF=2.01)
- Kalhapure, RS, Govender, T, Akamanchi, KG, Phosphine free tetradentate salicylaldimine ligand complexedwith palladium: First Application in Heck Reactions, Synthetic Communications, 2014, 44 (3337-3345) (Postdoc Supervisor) (IF=0.98)
- Kalhapure, R, Krishnacharya, Ga, Mocktar, C, Govender, T, Synthesis and antibacterial activity of silver nanoparticles capped with a carbozylic acid terminated generation 1 oleodendrimer, Chemistry Letters, 2014, 43, 1110-1112. (Senior Author/Postdoctoral Supervisor) (IF=1.6)
- Kalhapure, R, Kathiravan, M, Akamanchi, K, Govender, T, Dendrimers - From organic synthesis to pharmaceutical applications: An update, Pharmaceutical Development and Technology, In Press, 2014, DOI:10.3109/10837450.2013.862264 (Senior author/Postdoc Supervisor) (IF=1.34)
- E, Jones, E, Ojewole, V. Pillay, P Kumar, S Rambharose, T Govender, Monolayered multipolymeric buccal films with drug and polymers of opposing solubilities for ARV therapy: Physico-mechanical evaluation and molecular mechanics modeling, International Journal of Pharmaceutics, 455 (2013), 197-212. (Senior Author/Postgraduate Supervisor). (IF=3.8)
- Du Toit, L; Pillay, V; Govender, T; Carmichael, T, Kumar, P; Choonara, YE, Design of an anti-inflammatory composite nanosystem and evaluation of its potential for ocular delivery, Journal of Pharmaceutical Sciences, 2013, 102(8): 2780-2805. (Co-Senior Author/Postgraduate Co-Supervisor). (IF=3.00)
- Ahmed, SM, Kruger HG, Govender, T, Maguire GEM, Sayed, Y, Ibrahim, MAA, Naicker, P, Soliman, ME, Comparison of the Molecular dynamics and calculated binding free energies for nine FDA approved HIV-PR drugs against subtype B and C-SA HIV PR, Chemical Biology and Drug Design, 2013, 81, 208-218. (Co-Senior Author/Postgraduate Co-Supervisor). (IF=2.5)
- Branham, M, Moyo, T, Govender, T, Preparation and Solid-State Characterization of Ball Milled Saquinavir Mesylate for Solubility Enhancement, European Journal of Pharmaceutics and Biopharmaceutics, 2012, 80, 194-202. (Senior Author/Postdoctoral Supervisor) (IF=4.2)
- Ojewole, E, Mackraj, I, Akhundov, K, Hamman, J, Viljoen, A, Olivier, E, Smith, JW, Govender, T, Investigating the effect of Aloe vera gel on the buccal permeability of didanosine, Planta Medica, 2012, 78: 354-361. (Senior Author/Postgraduate Supervisor) (IF=2.3)
- Branham, M, Buth, SM, Ross, EA, Govender, T, Effect of ultrasound facilitated fixation on oral mucosal density and Morphology, Biotechnic and Histochemistry, 2012, 87 (5), 331-339. (Senior Author/Postdoctoral Supervisor) (IF=1.0)
- Branham, ML, Ross, EA, Govender, T, Predictive models for Maximum Recommended Therapeutic Dose of antiretroviral drugs. Computational and Mathematical Methods in Medicine, 2012, 469769, 9 pages (doi: 10.1155/2012/469769) (Senior Author/Postdoctoral Supervisor) (IF=1.01)
with Prof Thirumala Govender — at Lagoon Beach Hotel.
Professor Thirumala Govender (right), with her PhD student Ms Elizabeth Ojewole.
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