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Thursday, 29 October 2015

Wolfgang Reinhard Ludwig Notz

Wolfgang Notz

Wolfgang Reinhard Ludwig Notz

Principal Scientist Process Chemistry/CMC at Takeda Pharmaceuticals
Takeda Pharmaceutical Company Limited 
One Takeda Parkway
Deerfield , Illinois 60015
United States
USA

Germany


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Experience

Principal Scientist

Takeda Pharmaceuticals
February 2008 – Present (7 years 9 months)
Process Chemistry
Located in Osaka, Japan, Takeda (TSE: 4502) is a research-based global company with its main focus on pharmaceuticals. As the largest pharmaceutical company in Japan and one of the global leaders of the industry, Takeda is committed to strive towards better health for people worldwide through leading innovation in medicine.

Senior Scientist

BioVerdant Inc
June 2006 – January 2008 (1 year 8 months)
Process Research & Development; New Route development; biocatalysis; enzymes in chemical synthesis; design of cost-effective API synthesis using enzyme technolgy as key tool

Principal Scientist

Pfizer Inc
November 2001 – May 2006 (4 years 7 months)
process research and development
 

Education

The Scripps Research Institute

Post-Doc, Direct asymmetric organocatalysis
1999 – 2001
Proline/amine catalyzed direct asymmetric aldol and Mannich reactions

Universität Konstanz

PhD, Synthetic organic chemistry
1996 – 1999
Development of a general strategy toward C-ketosides of sialic acids;
De novo synthesis of the Neu5Ac-alpha-2,3-galactose C-disaccharide
Map of university of konstanz

Patents by Wolfgang Reinhard Ludwig Notz

http://www.google.com/patents/US8835420
Figure US08835420-20140916-C00010

Azaindole derivatives

Patent number: 8835420
Abstract: Disclosed are compounds of Formula 1, and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, to pharmaceutical compositions which contain them, and to their use for treating immunological disorders, cardiovascular disease, cancer, and other diseases, disorders or conditions associated with PI3K?.
Type: Grant
Filed: July 8, 2013
Issued: September 16, 2014
Assignee: Takeda Pharmaceutical Company Limited
Inventors: Edcon Chang, Wolfgang Reinhard Ludwig Notz, Michael B. Wallace

AZAINDOLE DERIVATIVES

Application number: 20140018344
Abstract: Disclosed are compounds of Formula 1, and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, to pharmaceutical compositions which contain them, and to their use for treating immunological disorders, cardiovascular disease, cancer, and other diseases, disorders or conditions associated with PI3K?.
Type: Application
Filed: July 8, 2013
Issued: January 16, 2014
Inventors: Edcon Chang, Wolfgang Reinhard Ludwig Notz, Michael B. Wallace

HSP90 INHIBITORS

Application number: 20120172321
Abstract: The invention relates to HSP90 inhibiting compounds consisting of the formula: wherein the variables are as defined herein. The invention also relates to pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
Type: Application
Filed: March 1, 2012
Issued: July 5, 2012
Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventors: Young K. Chen, Erick Co, Prasuna Guntupalli, John D. Lawson, Wolfgang Reinhard Ludwig Notz, Jeffrey A. Stafford, Huong-Thu Ton-Nu

HSP90 inhibitors

Patent number: 8071766
Abstract: The invention relates to HSP90 inhibiting compounds consisting of the formula: wherein the variables are as defined herein. The invention also relates to pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
Type: Grant
Filed: January 30, 2009
Issued: December 6, 2011
Assignee: Takeda Pharmaceutical Company Limited
Inventors: Young K. Chen, Erick Co, Prasuna Guntupalli, John D. Lawson, Wolfgang Reinhard Ludwig Notz, Jeffrey A. Stafford, Huong-Thu Ton-Nu

HSP90 INHIBITORS

Application number: 20110053873
Abstract: The invention relates to HSP90 inhibiting compounds consisting of the formula: (I) wherein the variables are as defined herein. The invention also relates to pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
Type: Application
Filed: January 30, 2009
Issued: March 3, 2011
Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventors: Young K. Chen, Eric Wang Co, Prasuna Guntupalli, John David Lawson, Wolfgang Reinhard Ludwig Notz, Jeffrey A. Stafford, Huong-Thu Ton-Nu

HSP90 INHIBITORS

Application number: 20090305998
Abstract: The invention relates to HSP90 inhibiting compounds consisting of the formula: wherein the variables are as defined herein. The invention also relates to pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
Type: Application
Filed: January 30, 2009
Issued: December 10, 2009
Assignee: Takeda Pharmaceutical Company Limited
Inventors: Young K. Chen, Erick Co, Prasuna Guntupalli, John D. Lawson, Wolfgang Reinhard Ludwig Notz, Jeffrey A. Stafford, Huong-Thu Ton-Nu

Convergent processes for the synthesis of a GARFT inhibitor containing a methyl substituted thiophene core and intermediates therefor

Application number: 20040266796
Abstract: The invention relates to processes for the preparation of a GARFT inhibitor containing a methyl substituted thiophene core having the following structure: 1
Type: Application
Filed: June 23, 2004
Issued: December 30, 2004
Assignee: AGOURON PHARMACEUTICALS, INC.
Inventors: Elena Dovalsantos, Erik Jon Flahive, Brian John Halden, Mark Bryan Mitchell, Wolfgang Reinhard Ludwig Notz, Stacy Ann O'Neill-Slawecki, Qingping Tian

Convergent asymmetric route to produce a key intermediate towards the synthesis of a garft inhibitor

Application number: 20040266827
Abstract: The invention relates to processes for the preparation of a key intermediate in the synthesis of a GARFT inhibitor of formula (Ia) containing a 4-methyl-substituted thiophene core: 1
Type: Application
Filed: June 16, 2004
Issued: December 30, 2004
Assignee: AGOURON PHARMACEUTICALS, INC.
Inventors: Wolfgang Reinhard Ludwig Notz, Carlos Alberto Martinez

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///Wolfgang Notz
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