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n

Friday 16 January 2015

Dr. Dhananjay Sathe

Dhananjay Sathe

Dhananjay Sathe


Vice President, chemical research department at Unichem Laboratories Limited



Contact

in.linkedin.com/pub/dhananjay-sathe/18/34a/412
https://twitter.com/dgsathe, @dgsathe
https://www.facebook.com/dhananjay.sathe.35
http://www.unichemlabs.com/index.html




Experience

Vice President, Research & Technology Development



Unichem Laboratories Limited





 – Present 
Guide API process research, Analytical Method Development, IPR groups. New project selection, exploring and implementing new technologies....................http://www.unichemlabs.com/index.html
Over the years, Unichem has invested significantly in its Research & Development (R&D) program to create state-of-the-art R&D facilities. Backed by a research team of over 150 highly-trained scientists with excellent credentials, the company’s R&D facilities are equipped with cutting-edge pharmaceutical research technology.

Unichem’s laboratories are equipped with the latest sophisticated analytical instruments like XRD, NMR, GC, LC MSMS, IR/UV, TGA, DSC, Prep HPLC and Flash Chromatography among others.
The company’s expanded R & D facilities have strengthened its Chemical and Formulation capabilities. At the same time, its new Biotechnology R&D facility, which focuses on cost-effective bio-similar products using recombinant micro organisms, is geared to provide a new edge to Unichem’s Research & Development efforts.

Unichem’s R&D activities are focused on the following:

  • Novel cost-efficient Process Developments for Active Pharmaceutical Ingredients (APIs) and intermediates
  • Formulation Developments for generic APIs
  • Non-infringing routes for manufacturing products to be marketed internationally
  • Bio-similar products by recombinant DNA
  • Contract research to develop formulations for New Chemical Entities (NCEs) and Generic APIs
Inspired by an ambition to drive path-breaking innovative research, Unichem aims to enhance people’s health by consistently providing better, more effective and safer products.

The Active Pharmaceutical Ingredient (API) business requires strong infrastructure, technological expertise and the experience and capability to carry out contract manufacturing and custom synthesis.
Unichem provides customers a complete solution for API development starting from samples and trial quantities right up to regulatory assistance that is required for registration and regulatory compliance.
The company’s facilities are designed to meet the highest global standards for API development with a focus on complex APIs, controlled substances and APIs for regulated markets, all of which are key to achieving the Unichem’s strategic goals.







Associate Vice President


 –  (8 years 3 months)

Developed more than 80 APIs, including complex peptides and polymers. Set up preparative chromatography, TFF technologies.

Sr. R&D Manager

RPG LifeSciences Ltd.

 –  (9 years)

Developed about 25 processes for APIs, intermediates, agrochemicals




Education


Institute of Chemical Technology

M. Pharm, Pharmaceutical Chemistry






University of Mumbai

Ph.D, Pharmaceutical Chemistry

Poona College of Pharmacy

B. Pharm., Pharmaceutical Sciences





Courses

Institute of Chemical Technology





Address
  • Plot 9-21 Port Bell Road, Nakawa
  • Matunga, Maharashtra, India 400019
Phone022 2414 5616
Websitehttp://www.ictmumbai.edu.in/
Institute of Chemical Technology , formerly the University Department of Chemical Technology , is a premier chemical engineering research institute located in MumbaiMaharashtra,India. It is focused on training and research in various branches of chemical engineering, chemical technology, and pharmacy
Stereochemistry, Structure elucidation


Patents by Dhananjay Sathe

Process for Preparation of Sevelamer Carbonate

Application number: 20100331516
Abstract: The present invention discloses simple process for preparation of salt of polyallylamine polymer.
Type: ApplicatiFiled: April 6, 2009Issued: December 30, 2010
Inventors: Govind Dhananjay Sathe, Harish Kashinath Mondkar, Tanaji Shamrao Jadhav, Samadhan Daulat Patil

Novel process for the preparation of 1-(9h-carbazol-4-yloxy)-3-[[2-(-methoxyphenoxy)-ethyl] amino]-propan-2-ol

Application number: 20070191456
Abstract: The present invention discloses a novel process for preparation of carvedilol by using eco friendly solvents to obtain the said carvedilol in high purity. The said process comprises, reacting 4-hydroxy carbazole of formula (IV) with epichlorhydrin in presence of an organic solvent and a base at temperatures between 10° C.-30° C.; further reacting the resultant 4-(2,3-epoxypropoxy)- carbazole of formula (II) with a salt of 2-(2-methoxyphenoxy)ethylamine of formula (III), preferably hydrochloride salt in presence of a base and a hydroxylic solvent at temperatures between 30° C.-90° C.
Filed: May 3, 2005Issued: August 16, 2007
Inventors: Venkatasubramanian Tarur, Dhananjay Sathe, Swapnil Kulkarni

Donepezil Hydrochloride Form VI

Application number: 20070123565
Abstract: The present invention discloses a novel, stable polymorph of 1-benzyl-4-[(5,6-dimethoxy-1-indanone)-2-yl] methyl piperidine hydrochloride commonly known as Donepezil hydrochloride. Further the present invention discloses a process for producing Donepezil HCl amorphous and its polymorph Form (VI).
Filed: November 8, 2006Issued: May 31, 2007
Inventors: Umesh Aher, Venkatasubramanian Tarur, Dhananjay Sathe, Avinash Naidu, Kamlesh Sawant

Process for preparing 5,6-dihydro-4-(S)-(ethylamino)-6-(S) methyl-4H-thieno[2,3b]thiopyran-2-sulphonamide-7,7-dioxide HCI

Application number: 20060142595..........http://www.google.com/patents/US20060142595
Abstract: The present invention relates to an improved process for the preparation of 5,6-dihydro-4-(S)-(ethylamino)-6-(S)methyl-4H-thieno[2,3b]thiopyran-2-sulphonamide-7,7-dioxide hydrochloride of formula (I) commonly known as Dorzolamide Hydrochloride useful as an agent to reduce intraoccular pressure by inhibiting carbonic anhydrase enzyme
Filed: December 28, 2004Issued: June 29, 2006
Inventors: Mukund Gurjar, Madhusudan Deshmukh, Vincent Paul, Venkatasubramanian Tarur, Dhananjay Sathe, Santosh Pardeshi, Sanjay Naik, Tushar Naik
Figure US20060142595A1-20060629-C00001

Novel process for preparation of clopidogrel bisulfate polymorph - Form I

Application number: 20060047121
Abstract: A process for making Clopidogrel Bisulfate Form I which comprises dissolving Clopidogrel Bisulfate Form II in a solublizing solvent at room temperature to form a solution; adding an anti-solvent to the said solution till turbid; stirring the said turbid solution; collecting the precipitated solid and drying the final solid product, form 
Filed: October 4, 2004Issued: March 2, 2006
Inventors: Kamlesh Sawant, Venkatasubramanian Tarur, Dhananjay Sathe

Polymorph of (1-benzyl-4-[(5,6-dimethoxy-1-indanone)-2-y1] methyl piperidine hydrochloride (Donepezil hydrochloride) and a process for producing thereof

Application number: 20050272775.........http://www.google.com/patents/US20050272775
Abstract: The present invention discloses a novel, stable polymorph of 1-benzyl-4[(5,6-dimethoxy-1-indanone)-2-yl]methyl piperidine hydrochloride commonly known as Donepezil hydrochloride. Further the present invention discloses a process for producing Donepezil HCl amorphous and its polymorph Form (VI).
Filed: June 3, 2005Issued: December 8, 2005
Inventors: Umesh Aher, Venkatasubramanian Tarur, Dhananjay Sathe, Avinash Naidu, Kamlesh Sawant
Figure US20050272775A1-20051208-C00001

Process for the preparation of 4-(2-dipropylaminoethyl)-1,3-dihydro-2H-indol-2-one hydrochloride

Application number: 20050159605.........http://www.google.com/patents/US20050159605
Abstract: The present invention discloses a novel process and novel intermediates for the Preparation of 4-[2-(di-n-propyl amino) ethyl]-1,3-dihydro-2H-indol-2-one, commonly known as Ropinirole (I) and pharmaceutical composition comprising the same. Further the present invention also discloses a method of treatment for cardiovascular disorders and Parkinson's disease.
Filed: July 9, 2004Issued: July 21, 2005
Inventors: Venkatasubramanian Tarur, Dhananjay Sathe, Harish Mondkar, Rajesh Bhopalkar, Samadhan Patil
Figure US20050159605A1-20050721-C00001

Novel pharmaceutical salt of (1-benzyl-4-[(5,6-dimethoxy-1-indanone)-2-yl] methyl piperidine (Donepezil)

Application number: 20050107613........http://www.google.com/patents/US20050107613
Abstract: The present invention relates to the oxalate salt of 1-benzyl-4-[(5,6-dimethoxy-1-indanone)-2-yl]methyl piperidine, commonly known as Donepezil, and its method of preparation.
Filed: June 29, 2004Issued: May 19, 2005
Inventors: Venkatasubramanian Tarur, Dhananjay Sathe, Avinash Naidu, Umesh Aher
Example 1
To Donepezil base (obtained after benzylation; benzylation is known in the art, and is taught by, e.g., U.S. Pat. No. 6,649,765) (10 gms.) in ethyl acetate (200 ml) was added oxalic acid (5 gms dissolved in 100 ml acetone) slowly with stirring. After addition the reaction mass was concentrated in vacuum. The solid separated was filtered and washed with acetone and dried at 60° C. afforded the title compound with a yield of 12 gms (90.2%) and melting point 176-770° C.Figure US20050107613A1-20050519-C00001

Patent NumberTitle Of PatentDate Issued
8187634Process for the preparation of sevelamer hydrochloride and formulation thereofMay 29, 2012
Disclosed herein is an improved process for preparation of Sevelamer hydrochloride having phosphate binding capacity of 4.7 to 6.4 mmol/g. Further, the invention discloses Sevelamer hydrochloride compositions and a novel process for preparation of said compositions comprising high sh
7847112Polymorphs of atovaquone and process of preparation thereofDecember 7, 2010
Novel crystalline forms of anti Pneumocystis carinii compound (2-[4-(4-Chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthoquinone) commonly known as Atovaquone and methods for producing the same is disclosed herein. This also provides pharmaceutical compositions comprising the said polymo
7446200Rapid resolution process of clopidogrel base and a process for preparation of clopidogrel bisulfNovember 4, 2008
The present invention discloses a rapid resolution process of racemic clopidogrel base followed by conversion of the resolved (S) isomer to crystalline Clopidogrel bisulfate Form I. The invention also discloses novel racemization process of the unwanted (R) isomer of clopidogrel base
7439365Pharmaceutical salt of (1-benzyl-4-[(5,6-dimethoxy-1-indanone)-2-yl] methyl piperidine (DonepeziOctober 21, 2008
The present invention relates to the oxalate salt of 1-benzyl-4-[(5,6-dimethoxy-1-indanone)-2-yl]methyl piperidine, commonly known as Donepezil, and its method of preparation.
7378439Process for the preparation of 4-(2-dipropylaminoethyl)-1,3-dihydro-2H-indol-2-one hydrochlorideMay 27, 2008
The present invention discloses a novel process and novel intermediates for the Preparation of 4-[2-(di-n-propyl amino) ethyl]-1,3-dihydro-2H-indol-2-one, commonly known as Ropinirole (I) and pharmaceutical composition comprising the same. Further the present invention also discloses
7186842Polymorph of (1-benzyl-4-[(5,6-dimethoxy-1-indanone)-2-y1] methyl piperidine hydrochloride (DoneMarch 6, 2007
The present invention discloses a novel, stable polymorph of 1-benzyl-4-[(5,6-dimethoxy-1-indanone)-2-yl] methyl piperidine hydrochloride commonly known as Donepezil hydrochloride. Further the present invention discloses a process for producing Donepezil HCl amorphous and its polymor


WO 2012025944
SITAGLIPTIN, SALTS AND POLYMORPHS THEREOFThe present invention relates to an improved process for preparation of Sitagliptin or pharmaceutically acceptable salts thereof. The present invention further relates to novel polymorphs of Sitagliptin salts and process for preparation thereof.


WO 2012042542
PROCESS FOR PREPARATION OF CROSSLINKED POLYMER
The present invention relates to desalination/desalting of polymer, in polyallylamine/crosslinked polymers by membrane separation techniques.IPC: C08F8/00 Applicants: SATHE DHANANJAY GOVIND,   PATIL ATUL SURESH,   PATIL SAMADHAN DAULAT,   USV LTD,   MONDKAR HARISH KASHINATH,   JADHAV TANAJI SHAMRAO,   



WO 2010041271
PROCESS FOR PREPARATION OF (S)-N-[2-(1,6,7,8-TETRAHYDRO-2H-INDENO[5,4-B]FURAN-8-YL)ETHYL] PROPIONAMIDE AND NOVEL INTERMEDIATES THEREOFDisclosed herein process for preparation of (S)-Ramelteon and intermediates thereof.IPC: C07D307/79 C07D307/77 Applicants: SATHE DHANANJAY GOVIND,   BHISE NANDU BABAN,   USV LTD,   MAHAJAN ANIL DINKAR,   PATNEKAR SUBODH SHASHIKANT,   GATNE PARAG SUKUMAR,   DEORE RAVIRAJ BHATU,   

Ramelteon (1) and process for preparation thereof.
Figure imgf000002_0001



WO 2011017244
POLYMORPHS OF 5-(4-(2-(5-ETHYLPYRIDIN-2-YL)-2-OXOETHOXY)BENZYL)-1,3-THIAZOLIDINE-2,4-DIONE (MITOGLITAZONE)The present invention relates to novel polymorphs of 5-(4-(2-(5-ethylpyridin-2-yl)-2-oxoethoxy) benzyl)-l,3-thiazolidine-2,4-dione of formula (I) and processes for the preparation thereof and pharmaceutical compositions comprising the novel crystalline polymorphs. Formula (I)IPC: A61K31/44 A01N43/40 Applicants: SATHE DHANANJAY GOVIND,   MANTRIPRAGADA NARAYANA RAO,   METABOLIC SOLUTIONS DEV COMPAN,   NAIK TUSHAR ANIL,   SAWANT KAMLESH DIGAMBAR,   BHOPALKAR RAJESH GANPAT,   



WO 2010092591
CRYSTALLINE POLYMORPHS OF 5-[[(2R,3S)-2-[(1R)-1-[3,5- BIS(TRIFLUOROMETHYL) PHENYL] ETHOXY]-3-(4-FLUOROPHENYL)-4-MORPHOLINYL]METHYL]-1,2- DIHYDRO-3H-1,2,4-TRIAZOL-3-ONE AND PROCESS FOR PREPARATION THEREOF
Disclosed herein is novel polymorph of 5-[[(2R,3S)-2-[(1R)-1-[3,5- bis(trifluoromethyl) phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2- dihydro-3H-1,2,4- triazol-3-one, commonly known as Aprepitant or pharmaceutically acceptable salts thereof and process for preparation thereof. The present invention further relates to highly pure polymorph, Form II of Aprepitant. The present invention further relates to improved process for preparation of Aprepitant.
IPC: C07D413/06 Applicants: SATHE DHANANJAY GOVIND,   PATIL SACHIN SHIVAJI,   BHISE NANDU BABAN,   USV LTD,   SHINDIKAR ANAND VINOD,   NAIK TUSHAR ANIL,   SAWANT KAMLESH DIGAMBAR, Authors: BHISE NANDU BABAN,  NAIK TUSHAR ANIL,  SAWANT KAMLESH DIGAMBAR,  SATHE DHANANJAY GOVIND,  SHINDIKAR ANAND VINOD,  PATIL SACHIN SHIVAJI, ............http://www.google.im/patents/WO2010092591A2?cl=enAprepitant is chemically known as 5-[[(2R,3S)-2-[(lR)-l-[3,5- bis(trifluoromethyl) phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-l,2- dihydro-3H-l ,2,4- triazol-3-one and represented by Formula IX.

Figure imgf000002_0001



WO 2010041268
CROSSLINKED POLYMERS
Disclosed herein are pharmaceutical compositions comprising wet granulated bile acid sequestrants and their process of preparation. The present invention also discloses process for preparation of Colesevelam hydrochloride, an antilipemic agent.IPC: A61K31/785 A61K9/20 Applicants: SATHE DHANANJAY GOVIND,   PATIL SAMADHAN DAULAT,   USV LTD,   OMRAY ASHOK,  RAO MANTRIPRAGADA NARAYAN,   MONDKAR HARISH KASHINATH,   BHIDE YOGESH SHARAD,  CHOUDHARY VARSHA SHASHANK,   JADHAV TANAJI SHAMRAO,   Authors: SATHE DHANANJAY GOVIND,  PATIL SAMADHAN DAULAT,  OMRAY ASHOK,  RAO MANTRIPRAGADA NARAYAN,  MONDKAR HARISH KASHINATH,  BHIDE YOGESH SHARAD, CHOUDHARY VARSHA SHASHANK,  JADHAV TANAJI SHAMRAO, ............http://www.google.com/patents/WO2010041268A2?cl=en




WO 2009118753
PROCESS FOR PREPARATION OF NARATRIPTAN HYDROCHLORIDE
The present invention relates to an improved process for the preparation of N-methyl-3- (l-methyl-4-piperidinyl)-lH-indole-5-ethanesulfonamide hydrochloride of formula (I) having less than 0.15% area by HPLC of 3-(l-methyl-4-piperidinyl)-lH-indole-5- ethanesulfonamide (IA) and intermediates thereof.IPC: C07D209/10 A61P25/06 A61P25/04 A61P43/00 A61P9/00 A61K31/404 Applicants: SATHE DHANANJAY GOVIND,   BHISE NANDU BABAN,   USV LTD,   PATNEKAR SUBODH SHASHIKANT,   DEORE RAVIRAJ BHATU,   Authors: SATHE DHANANJAY GOVIND,  BHISE NANDU BABAN,  PATNEKAR SUBODH SHASHIKANT, DEORE RAVIRAJ BHATU, 


WO 2009125433
PROCESS FOR PREPARATION OF AMINE POLYMER SALT


WO 2009063504
NOVEL CRYSTAL MODIFICATION OF EPINASTINE OR SALTS THEREOF AND PROCESS FOR PREPARATION THEREOF
The present invention provides novel crystalline forms of 3-amino-9,13b-dihydro-lH- dibenzo[c,fjimidazo[l,5-a] azepine or salts thereof and process for preparation thereof. Formula (I).IPC: C07D487/04 Applicants: SATHE DHANANJAY GOVIND,   MANTRIPRAGADA NARAYANA RAO,   USV LTD,   SAPLE HRISHIKESH GURUNATH,   NAIK TUSHAR ANIL,   SAWANT KAMLESH DIGAMBAR,   BHOPALKAR RAJESH GANPAT,   ..........http://www.google.im/patents/WO2009063504A2?cl=en


WO 2009063505
PROCESS FOR PREPARATION OF (S) (N-[[3-[3-FLUORO-4-(4-MORPHOLINYL) HEN L -2-OXO-5-OXAZOLIDIN L METHYL]ACETAMIDE
The present invention provides novel process for preparation of (S)-N-[[3-[3-Fluoro-4-(4- morpholinyl)phenyl]-2-oxo-5-oxazolidinyl] methyl] -acetamide which comprises combining (R)-N-[3-[3-fluoro-4-morpholinyl phenyl]-2-oxo-5-oxazolidinyl]methylazide in suitable solvent, acetylating agent and acid in presence of a catalyst.IPC: C07D263/20 Applicants: SATHE DHANANJAY GOVIND,   BHISE NANDU BABAN,   USV LTD,   BHATTACHARYYA ANINDYA SIBNATH,   NAIDU AVINASH VANKATRAMAN,   NAIK TUSHAR ANIL,   SAWANT KAMLESH DIGAMBAR,  ........http://www.google.im/patents/WO2009063505A2?cl=en

Linezolid 
Figure imgf000003_0001




WO 2009113092
PROCESS FOR PREPARATION OF PROGUANIL HYDROCHLORIDE
Disclosed herein is the process for the preparation of 1-(4-chlorophenyl)-5- isopropyl-biguanide hydrochloride (Proguanil hydrochloride), Formula (I), an antimalarial agent.



WO 2008062437
PROCESS FOR THE PREPARATION OF SEVELAMER HYDROCHLORIDE AND FORMULATION THEREOF
Disclosed herein is an improved process for preparation of Sevelamer hydrochloride having phosphate binding capacity of 4.7 to 6.4mmol/g. Further, the invention discloses Sevelamer hydrochloride compositions and a novel process for preparation of said compositions comprising high shear non-aqueous granulation.IPC: A61K47/00 C08F8/44 A61K31/785 A61K9/20 A61P13/12 C08F8/00 C08F26/02 A61K9/28 Applicants: THOOVARA SASIKUMAR MOHAN,   SATHE DHANANJAY GOVIND,   TARUR RADHAKRISHNAN VENKATASUB,   PATIL SAMADHAN DAULAT,   USV LTD,   HEDGE DEEPAK ANANT,  MONDKAR HARISH KASHINATH,   BHIDE YOGESH SHARAD,   CHOUDHARY VARSHA SHASHANK,  .........http://www.google.com/patents/WO2008062437A2?cl=en



WO 2009063486
PROCESS FOR PREPARATION OF DEXTROROTATORY ISOMER OF 6-(5-CHLORO-PYRID-2-YI)-5-[(4-METHYL -1-PIPERAZINYL) CARBONYLOXY]-7-OXO-6,7-DIHYDRO-5H-PYRROLO [3,4-B] PYRAZINE (ESZOPICLONE)Disclosed herein is the process for preparation of 6-(5-chloro-pyrid-2-yl)-5-[(4-methyl-1-piperazinyl) carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo [3,4-b] pyrazine (Zopiclone), its resolution to get the dextrorotatory isomer of formula (I) substantially free of R (-) enantiomer and recovery of key raw material i.e. 6-(5-chloro pyrid-2-yl)-5-hydroxy-7-oxo-5,6-dihydropyrrolo [3,4-b] pyrazine from the R-isomer of Zopiclone followed by conversion of the recovered compound to get pure Eszopiclone (I) in high yield and high purity.IPC: C07D487/04 Applicants: SATHE DHANANJAY GOVIND,   BHISE NANDU BABAN,   USV LTD,   DESHPANDE MANOJ MADHUKARRAOV,   SHINDIKAR ANAND VINOD,   MONDKAR HARISH KASHINATH,   ..........http://www.google.com/patents/WO2009063486A2?cl=en


WO 2008035364
PROCESS FOR THE PREPARATION OF MICRONIZED VALSARTANThe present invention relates to process for preparing micronized Valsartan with particle size distribution of d10 less than 5µ, d50 less than 10 µ and d90less than 20 µ preferably d90< 10 µ.IPC: A61K9/14 A61K31/41 Applicants: SATHE DHANANJAY GOVIND,   MANTRIPRAGADA NARAYANA RAO,   TARUR VENKATASUBRAMANIAN RADHAKRISHNAN,   USV LTD,   RANE BHUPENDRA SHALIGRAM,  THOOVARA SASI KUMAR MOHAN,   SAWANT KAMLESH DIGAMBAR,  ..........http://www.google.im/patents/WO2008035364A2?cl=en



WO 2008093360
A PROCESS FOR PREPARATION OF (S)-(+)-N-METHYL-3(1-NAPHTHYLOXY)-3(2-THIENYL)PROPYLAMINE HYDROCHLORIDEThe present invention provides an improved process for preparation of intermediate of Duloxetine base and hydrochloride salt thereof.IPC: A61K31/381 A61P25/24 C07D333/20 Applicants: SATHE DHANANJAY GOVIND,   BHISE NANDU BABAN,   TARUR VENKATASUBRAMANIAN RADHAKRISHNAN,   USV LTD,   CHOUDHARI CHHAYENDRA JANARDAN,   SRIVASTAVA NEERAJ,   http://www.google.im/patents/WO2008093360A2?cl=en

Duloxetine hydrochloride of formula I.
Figure imgf000002_0001


Polymorphic forms of dolasetron mesylate and processes thereof
WO 2007072506 A2..........https://www.google.im/patents/WO2007072506A2

A process for the preparation of 1-(9h-carbazol-4-yloxy)-3-2-(-methoxyphenoxy)-ethyl amino-propan-2-ol
Figure imgf000002_0001


Novel polymorphs of atovaquone and process of preparation thereof
WO 2006008752 A1
https://www.google.im/patents/WO2006008752A1


A process for the preparation of substantially pure 4-amino-1-isobutyl-1h-imidazo[4,5-c]-quinoline (imiquimod)
WO 2006070408 A2.......https://www.google.im/patents/WO2006070408A2


Process for preparation of rasagiline and salts thereof
EP 2364967 A2.........https://www.google.im/patents/EP2364967A2



Conferences

sciupnew logo-master


The 3rd International Conference and Exhibition

Developing Chemical Processes for APIs

10 & 11 January 2011

The Residence Hotel and Convention Centre, Mumbai, India

by

Dr Dhananjay Sathe, USV Ltd, INDIA

Challenges in API Process Development for the Generic Markets: Ropinirole Experience




Tofacitinib Citrate

An Improved and Efficient Process for the Preparation of Tofacitinib Citrate

Publication Date (Web): November 17, 2014 (Article)
DOI: 10.1021/op500274j
 
MS m/z 313 (M+ + 1); 
mp 201–202 °C;  
1H NMR (CDCl3) δ 8.34 (s, 1H), δ 7.38 (d, 1H, J = 2.4 Hz), δ 6.93 (d, 1H, J = 2.4 Hz), δ 4.97 (m, 1H), δ 3.93–4.03 (m, 4H), δ 3.66 (m, 1H), δ 3.50 (m, 4H), δ 2.91 (d, 2H, J = 15.6 Hz), δ 2.80 (t, 2H, J = 12.8 Hz), δ 2.55 (m, 1H), δ 1.99 (m, 1H), δ 1.77 (m, 1H), δ 1.13–1.18 (m, 3H).
Abstract Image




Dhananjay Sathe

Alto Porvorim, India
Current city, goa   india










UNICHEM 

Research Centre - Goa

Unichem Laboratories Ltd.
Plot No. 17 & 18,
Pilerne Industrial Estate,
Pilerne Bardez, Goa - 403 511
Tel: + 91 832 2407202-6




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