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Monday, 15 August 2016

Dr.Gowravaram Sabitha

  • Prof. Gowravaram Sabitha (CSIR-Indian Institute of Chemical Technology, Hyderabad, India)

Sabitha Gowravaram

Sabitha Gowravaram

Senior Principal Scientist at Indian Institute of Chemical Technology

Dr. Gowravaram Sabitha
AddressScientist, Organic Division I, Indian Institute of Chemical Technology, Hyderabad-500 007, India
Phone number+91-40-27160512
Fax number+91-40-27160512
  • Custom synthesis
  • New chemical entities
  • New methodologies
  • Synthetic organic chemistry
  • Total synthesis of natutral products


Total Stereoselective Synthesis and Structural Revision of a γ-Lactone Polyketide of Fungal Origin

Gowravaram Sabitha reports the stereoselective synthesis and structural revision of a γ-lactone polyketide of fungal origin.
Stereoselective Synthesis of the Revised Structure of γ-Lactone Polyketide from Diaporthe sp. SXZ-19 and Its C-8 Epimer: K. S. N. Reddy, A. Y. Reddy, G. Sabitha
Synthesis 201648, DOI: 10.1055/s-0035-1561463
A recently described γ-lactone polyketide originally isolated from the fungal strain Diaporthe sp. SXZ-19 of Camptotheca acuminata and its C-8 epimer were synthesized in stereoselective manner and their structure revised by Professor Gowravaram Sabitha and her colleagues from the CSIR-Indian Institute of Chemical Technology (Hyderabad, India).
  • Revised structures of polyketide γ-lactone and its C-8 epimer
Professor Reddy – one of the article’s co-authors – said: “Synthesis of a γ-lactone polyketide has been achieved by utilizing Carreira, Ohira–Bestmann and alkyne–aldehyde coupling reactions.” 

LIST OF PUBLICATIONS 1. Synthesis of the C1-C25 Southern Domain of Spirastrellolides B and F. Gowravaram Sabitha,* Allu Senkara Rao and J. S. Yadav. Org & Biomol. Chem. 2013, 11, 7218-7231. 
2. Stereoselective formal synthesis of aspergillide A. Gowravaram Sabitha,* D. Vasudeva Reddy, Allu Senkara Rao and J. S. Yadav. Tetrahedron Lett. 2010, 51, 4195–4198. 
3. The First Stereoselective Total Synthesis of (−)-Synrotolide. Gowravaram Sabitha,* Allu Senkara Rao, AnkiReddy Sandeep and Jhillu S. Yadav. Eur. J. Org. Chem. 2013, accepted. 
4. Stereoselective synthesis of (−)-synparvolide B. Gowravaram Sabitha,* Allu Senkara Rao and J. S. Yadav. Tetrahedron: Asymmetry 2011, 22, 866-871. 
5. The First Total Synthesis of (−)-Synparvolide C. Gowravaram Sabitha,* AnkiReddy Sandeep, Allu Senkara Rao and J. S. Yadav. Eur. J. Org. Chem. 2013, accepted. 
6. Synthesis of the C1-C13 Subunit of Spirastrellolide A and B by Prins Cyclization. Gowravaram Sabitha,* Allu Senkara Rao and J. S. Yadav. Synthesis, 2010, 505-509. 
7. International Application published Under The Patent Cooperation Treaty (PCT). Process For The Preparation Of ASENAPINE Intermediate. Inventors: SHARMA, Ramnic; H. No. 1012, 2nd Floor, Sector 17B, Gurgaon, Haryana 122015 (IN). ALLU, Senkara, Rao; s/o Bheemu Naidu, Narasimha Puram, Gedda Kancharam, Metta Palli, Srikakulam, Andhra Pradesh 535125 (IN). ARYAN, Ram, Chander; 1066, Sector-A, Pocket-A, Vasant Kunj, New Delhi 110070 (IN). International Publication Number: WO 2013/080069 A1