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Saturday, 9 July 2016

Malika Makhlouf , Process Research Chemist at Synphabase

Malika Makhlouf.

Malika Makhlouf

Process Research Chemist at Synphabase





My Professional Experience:

I completed my Ph.D thesis in organic chemistry at the University of Pierre & Marie Curie in Paris then, I pursued postdoctoral research in medicinal chemistry. Currently, I am working as a process research chemist for Synphabase company.

My Expertise:

I have extensive experience in multi-step organic synthesis with a thorough knowledge of modern synthetic methods, new product development, and product improvement.
I enjoy taking up new intellectual challenges, find innovative solutions and share my experience in a team. I am always interested to learn new concepts through literature research and apply them in a unique way.

My Personal Qualities:

I have learned to work and communicate with people from various backgrounds. I am flexible and highly motivated to work in a team.

Malika Makhlouf


Process Research Chemist

SynphaBase AG
 – Present (3 years 4 months)Basel Area, Switzerland
- Development and improvement of known and new synthetic routes to meet specifications
- Working with complex molecules including Active Pharmaceutical Ingredients (APIs)
- Developing scalable process using in-house and state-of-the-art technology, including statistical design of experiments (DOE)
- Support of process scale-up in Kilo-Lab
- Managing projects

Marketing and PR committee

Healthcare Businesswomen’s Association
 – Present (1 year 9 months)Basel Area, Switzerland
Healthcare Businesswomen's Association 2015
Healthcare Businesswomen's Association 2015

Postdoctoral Research Scientist

University of Basel
 –  (2 years 3 months)Basel Area, Switzerland
• Multi-step synthesis and biological evaluation of organic molecules derived from natural products

• Isolation of natural products

Prof. Dr. Karl Gademann
Cyanobacteria Culture
Cyanobacteria Culture

PhD Student in Organic Chemistry

University P.Curie UPMC-Paris6
 –  (3 years 4 months)
Investigation of the Reactivity of NHC-Boranes Complexes

N-heterocyclic carbenes boranes (NHC-Boranes) complexes are novel structures whose reactivity —especially organic— has not been explored. Our goal was to investigate the influence of the NHC complexation on the reactivity at the boron atom.

Director: Prof. Dr. Max Malacria

Supervisor: Prof. Dr. Louis Fensterbank, Dr. Emmanuel Lacôte, Prof. Dr. Dennis P. Curran

Research Internship

 –  (5 months)Chilly-Mazarin, southern suburbs of Paris
Synthesis of biologically active compound


Substituent Effects in NHC-Boranes: Reactivity Switch in the Nucleophilic Fluorination of NHC- Boranes.(Link)

Substituents on the boron atom of NHC–boranes direct the reactivity of the ligated boreniums obtained through hydride abstraction. Depending on the electronics of the substituent, the reaction is selectively steered toward either B-substitution or Lewis base exchange.

Chem. Eur. J.
January 31, 2013
By using the Telospot assay, 27 different extracts of cyanobacteria were evaluated for telomerase inhibition. All extracts showed varying, but significant activity. We selected Microcystis aeruguinosa PCC 7806 to identify the active compound and a bioassay guided fractionation led us to isolate mixtures of sulfoquinovosyl diacylglycerols (SQDGs), which were identified by 2D NMR and MS/MS...more

Synthesis and Reactions of N-Heterocyclic Carbene Boranes.(Link)

Angew. Chem. Int. Ed.
September 7, 2011
Boranes are widely used Lewis acids and N-heterocyclic carbenes (NHCs) are popular Lewis bases, so it is remarkable how little was known about their derived complexes until recently. NHC-boranes are typically readily accessible and many are so stable that they can be treated like organic compounds rather than complexes. They do not exhibit “borane chemistry”, but instead are proving to have a rich...more

Electron Paramagnetic Resonance and Computational Studies of Radicals derived from Boron-Substituted N-Heterocyclic Carbene Boranes.(Link)

J. Am. Chem. Soc.
May 28, 2011
Fifteen second-generation NHC-ligated boranes with aryl and alkyl substituents on boron were prepared, and their radical chemistry was explored by electron paramagnetic resonance (EPR) spectroscopy and calculations. Hydrogen atom abstraction from NHC–BH2Ar groups produced boryl radicals akin to diphenylmethyl with spin extensively delocalized across the NHC, BH, and aryl units. All of the NHC–B·...more Curie

Preparation of NHC Borane Complexes by Lewis Base Exchange with Amine− and Phosphine−Boranes.(Link)

J. Org. Chem.
September 14, 2010
A versatile new method for the preparation of NHC boranes starting from two stable, readily available reactants―an heterocyclic salt and an amine or phosphine−borane―is reported. It uses a Lewis base exchange at boron and provides easy access to new NHC boranes, in particular B-substituted borane ones.Curie

N-Heterocyclic Carbenes−Borane Complexes: A New Class of Initiators for Radical Photopolymerization.(Link)

February 8, 2010
Newly discovered N-heterocyclic carbene-boryl radicals (NHC-BH2•) derived from readily available N-heterocyclic carbene−boranes are found to be efficient initiators for acrylate photopolymerization. Laser flash photolysis (LFP) experiments were used to generate three carbene-boryl radicals, which were characterized by their transient absorption spectra with the aid of DFT calculations. Rate...more

EPR Studies of the Generation, Structure, and Reactivity of N-Heterocyclic Carbene Borane Radicals.(Link)

J. Am. Chem. Soc
January 27, 2010
N-Heterocyclic carbene boranes (NHC−boranes) are a new “clean” class of reagents suitable for reductive radical chain transformations. Their structures are well suited for their reactivity to be tuned by inclusion of different NHC ring units and by appropriate placement of diverse substituents. EPR spectra were obtained for the boron-centered radicals generated on removal of one of the BH3...more

Ionic and Organometallic Reductions with N-Heterocyclic Carbene Boranes.(Link)

Chem. Eur. J.
November 4, 2009
N-Heterocyclic carbene–borane complexes such as depicted are neutral, organic soluble analogues of borohydride anions with a weak hydridic character, compatible with organometallic catalysis. They are applicable for surgical reductions in complex, multifunctional molecules.

Suzuki-Miyaura Coupling of NHC-Boranes: A New Addition to the C-C bond Toolbox(Link)

Org. Lett.
October 2, 2009
Complexes of triaryl- and trialkylboranes with N-heterocyclic carbenes (NHCs) participate in Suzuki−Miyaura cross-coupling reactions and provide coupled products in good yields under base-free conditions. The reaction can be applied to Csp2−Csp2 and Csp2−Csp3 carbon−carbon bond formation with triflates, iodides, bromides, and chlorides. These results enrich the utility of NHC−borane complexes,...more

Complexes of Borane and N-Heterocyclic Carbenes: A New Class of Radical Hydrogen Atom Donor(Link)

J. Am. Chem. Soc.
July 9, 2008
Calculations suggest that complexes of borane with N-heterocyclic carbenes (NHC) have B−H bond dissocation energies more then 20 kcal/mol less than free borane, diborane, borane−THF, and related complexes. Values are in the range of popular radical hydrogen atom donors like tin hydrides (70−80 kcal/mol). The resulting prediction that NHC borane complexes could be used as radical hydrogen atom...more


Université Pierre et Marie Curie (Paris VI)

Bachelor of Science (BS), Chemistry

Synphabase Welcome to SynphaBase 
SynphaBase AG has been founded in December 2000. We are located in Pratteln, Switzerland.
We offer MULTI-STEP SYNTHESIS on a mg-scale up to multi metric tons.
Our catalogue comprises more than 500 compounds:
  • CARBOHYDRATES, GLYCANS, SUGARS, MONOSACCARIDES, DISACCHARIDES (blood group antigen H), OLIGOSACCHARIDES (blood group antigen A, blood group antigen B)
  • natural amino acids, unnatural amino acids
  • nucleosides
  • various SMALL MOLECULES: aromatics and heterocyclics
Our services are LAB SCALE SYNTHESIS, ROUTE FINDING & PROCESS DEVELOPMENT and PRODUCTION of small molecules and human glycans.

SynphaBase AG | Gueterstrasse 82 CH-4133 Pratteln | Switzerland 
T +41 61 827 7900 | F +41 61 827 7999 | office@synphabase.ch

Synphabase Contact 
SynphaBase AG
Gueterstrasse 82, Bau 3
CH-4133 Pratteln

T +41 61 827 7900
F +41 61 827 7999

How to find us
From (Basel, Bern or Zurich) take A2 exit Pratteln,
direction Pratteln, at the 1st roundabout take the first right direction
Industriegebiet West straight on through 2 roundabouts.
After ca. 500m turn right direction Pratteln West
on top of the ramp turn left, after 200m turn left again,
into Magnet Areal.

For satnav use N 47°31'20'', E 7°40'16'' or  Pratteln, Güterstrasse 105

Pratteln, Güterstrasse