Room Number: 517
Post doc: University of Louvain-la-Neuve, Belgium, 1989 in the field of organic chemistry with Prof. Leon Ghosez
Ph.D: University Pierre-et-Marie Curie, Paris, France, 1988
Prof. Ilan Marek
Schulich Faculty of Chemistry
Technion - Israel Institute of Technology
|2005 - present||Holder of the Sir Michael and Lady Sobell Academic Chair|
|2004 - present||Full Professor, Department of Chemistry, Technion-Israel Institute of Technology|
|2000 - 2004||Associate Professor, Department of Chemistry, Technion-Israel Institute of Technology|
|1997 - 2000||Senior Lecturer, Department of Chemistry, Technion-Israel Institute of Technology|
|1990 - 1997||Research Position as Charge de Recherche at the CNRS (National Center for Scientific Research), Université Pierre et Marie Curie, Paris, France|
|1989 - 1990||Post-Doc at Louvain-la-Neuve, Belgium|
|1986 - 1988||Ph. D. from Université Pierre et Marie Curie, Paris, France|
|1986||M. Sc., Université Pierre et Marie Curie, Paris, France|
Professor Mareks research is focussed on organometallic chemistry applied to organic synthesis, homogeneous catalysis, and asymmetric synthesis.
Professor Marek edited the Thematic Series in the Beilstein Journal of Organic Chemistry
Zen and the Art of Organic Chemistry
Innovative Chemistry : Technion Scientists Developed A New Method, The “Zipper Approach,” For Selective Synthesis Of Complex Molecules-
Professor Ilan Marek Photo: Technion’s Spokesperson’s Office
This is a new approach to complex molecular framework for which Professor Ilan Marek from the Schulich Faculty of Chemistry received a grant in the amount of 2.4 million Euros from the European Union – it is for “thinking differently about chemical synthesis and going against mainstream wisdom.”
Technion scientists developed a new method, the “zipper approach”, for selective synthesis of complex molecules. This has been reported by the prestigious scientific journal, Nature.
The synthesis of new molecules is central to the development of many areas of science frommedicine to materials science. Since the 19th century, the conventional approach to syntheses of organic materials was through the building of new bonds, mainly carbon-carbon (C-C), while controlling their spatial structure (stereochemistry). But is this the only way to create complex organic molecules, asked Prof. Marek
According to an article published by the prestigious scientific journal, Nature, Professor Ilan Marek and his research team from the Schulich Faculty of Chemistry, have demonstrated for the first time, a novel approach through selective bond activation that combines the simultaneous activation and fragmentation of otherwise difficult transformations: allylic C-H (H=Hydrogen) and selective C-C bond activations.
To reach this goal, they used a molecule that has on one of its sides some strain, because of a presence of a three-membered ring, and on its other side a double bond. By adding zirconium complexes, they were able to initiate a double bond migration, similar to -the zipping action of a zipper, up towards the three-membered ring, causing a selective cleavage of one carbon-carbon bond of the strained ring.
“It’s much like zipping up your jacket, joining both sides of the zipper from the bottom end and zipping it upwards,” explains Professor Marek. “Sometimes the link between the two sides disconnect when you move the zipper up. We were able to conceive this detachment and fragment it in a premeditative manner to achieve our target.”
This breakthrough is linked to a publication made a year ago, also in Nature, in which Professor Marek’s team reported an innovative approach for creating molecules possessing a specific chiral center in a single-pot operation using only primary material. Up till then, only few scientists reached this point through tedious synthetic approaches.
Both of these groundbreaking studies by Professor Marek have far-reaching implications for the synthesis and development of new drugs and have aroused great interest in the scientific and industrial community. For his “innovative and alternative way of thinking about synthetic chemistry which went against the mainstream” Professor Marek has now received a grant in the amount of 2.4 million Euros from the European Union. He is getting ready to recruit additional researchers to assist in this promising research.
For developing unconventional methods of synthesis, Professor Ilan Marek received in 2012 the Israel Chemical Society (ICS) Award for Excellence and the Janssen Pharmaceutical Prize for Creativity in Organic Synthesis and the Moore Distinguished Scholar Appointment from the California Institute of Technology.Read more about: against, Chemistry, Complex Molecules, Professor Ilan Marek, Professor Marek, research,Selective Synthesis, Technion, The “Zipper Approach”
Technion President Prof. Peretz Lavie with 2015 Yanai Prize for Excellence in Academic Education award winners (from right to left): Prof. Danny Raz, Assoc. Prof. Ran El-Yaniv, Assoc. Prof. Shlomo Bekhor, Assoc. Prof. Mark Talesnick, Asst. Prof. Ayelet Baram-Tsabari, Prof. Daniel Lewin, Prof. Joseph Avron, Technion President Prof. Peretz Lavie, Prof. Joseph Ben-Asher, Prof. Ross Pinsky, Prof. Ilan Marek, Asst. Prof. Moran Bercovici, with Omar Amit, the Chairman of the Technion’s Student Union