One Organic Chemist One Day............Honouring Profiles of leading Organic Chemists brought to you by DR ANTHONY MELVIN CRASTO, worlddrugtracker, helping millions, firstname.lastname@example.org, +91 9323115463, India, skype amcrasto64
DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai) , INDIA 29Yrs Exp. in the feld of Organic Chemistry,Working for GLENMARK PHARMA at Navi Mumbai, INDIA. Serving chemists around the world. Helping them with websites on Chemistry.Million hits on google, world acclamation from industry, academia, drug authorities for websites, blogs and educational contribution
Postdoctoral Research Associate, University of Illinois, Urbana Champaign
Chemical and Life Sciences Laboratory, Department of Chemistry
Sandhya earned a Masters in Biomedical Sciences from University of Delhi and Bachelors in Biochemistry from Kurukshetra University, India. She completed her PhD from Dr. B.R Ambedkar center for Biomedical Research, University of Delhi and her research project was "Studying selective mechanism of inhibition of E. coli and Mammalian DNA Topoisomerases by benzimidazoles in developing new antibacterials". She worked as Postdoctoral Research Associate at Regional Centre for Biotechnology, Gurgaon, India, where her research focused on identification of bile acid amphiphiles as anticancer and antibacterial agents. Currently she works as Postdoctoral Research Associate at Chemical and Life Sciences Laboratory, Department of Chemistry, University of Illinois, Urbana Champaign. Her interests of study are resistance mechanisms in infectious diseases and advancement of alternative therapies to overcome resistance.
Post Doctoral Fellow
I come from Delhi/NCR. I like trying new things, my idea of life is everything happens in life in first time so try to learn as much as possible each day. My passion is to explore new destinations around the globe, reading books and paint my imagination.
Ph.D(Biomedical Sciences): University of Delhi, 2012.
M.Sc. (Biomedical Sciences): University of Delhi, 2005.
My research interest is to look into the molecular mechanisms underlying different disease in response to molecules administered externally. How improved molecules can be used in clinics to cure some common diseases and bacterial infections. I am much more interested in studying the patients with resistant drug profiles and how the existing combinations of drugs can be can be improved to be clinically effective in patients.
SreekanthVedaguporum*, SandhyaBansal*,Rajender K Motiani, SomanathKundu, ShravanKumar Muppu, TapodharaDattaMajumdar, K.Panjamurthy, SagarSengupta and Avinash Bajaj Design, Synthesis and Mechanistic Investigations of Bile Acid-Tamoxifen Conjugates for Breast Cancer Therapy. Bioconjugate Chem.(August,2013) (Just Accepted). (*Equal contribution)
Manish Singh, Ashima Singh, SomanathKundu,SandhyaBansal, and Avinash Bajaj. Interactions of Bile Acid based Facial Amphiphiles with Membranes Influences their Anticancer Activities for Colon Cancer. Biophys. Biochim. ActaBiomembranes, April 2013.
SandhyaBansal, DevapriyaSinha,Manish Singh,Bokun Cheng, Yuk ChingTse-Dinh and VibhaTandon. 3, 4 dimethoxyphenylbisbenzimidazole, a novel DNA Topoisomerase Inhibitor that Preferentially Targets Type IA Topoisomerase.Journal of Antimicrobial Chemotherapy, (2012) 67(12): 2882-2891.
SandhyaBansaland VibhaTandon. Contribution of mutations in DNA gyrase and topoisomerase IV genes to ciprofloxacin resistance in Escherichia coli clinical isolates.International Journal of Antimicrobial Agents 37 (2011) 253-255.
SandhyaBansal, UrmilaTawar, Manish Singh,AbbasNikravesh, Liam Good, VibhaTandon. Old class but new dimethoxy analogue ofbenzimidazole: a bacterial topoisomerase I Inhibitor. International Journal of Antimicrobial Agents 35 (2010) 186-190.
UrmilaTawar, SandhyaBansal,ShiteshuShrimal,Manish Singh, VibhaTandon. Nuclear condensation and Free radical Scavenging: A Dual Mechanism of Bisbenzimidazoles to Modulate Radiation Damage to DNA. Mol. Cell. Biochem.(2007) 305: 221-233.
SandhyaBansal, Jaspal Singh, Rakesh KumarTiwari, Kasi Shankar, VibhaTandon and RameshChandra.Synthesis and in vitro cytotoxicity ofhaloderivatives of noscapine; Akhilesh KumarVerma, Bioorganic & Medicinal Chemistry, 2006,Oct 1; 14(19): 6733-6.
Prof. Major completed his undergraduate studies in chemistry and computer sciences at Bar-Ilan University in 1997. He received his Ph.D. from Bar-Ilan University in 2003 under Prof. Bilha Fischer. During his Ph.D. he worked on molecular properties of nucleotide derivatives, theoretical modeling of G-protein coupled receptors, as well as molecular recognition.
He did a post-doctorate at the University of Minnesota under Prof. Jiali Gao during the years 2003-2006. During his post-doctorate he was involved in development and application of theoretical methods for enzyme catalysis.
Since 2007 he is a Faculty member in the Chemistry Department at Bar-Ilan University. His main research interests are in the field of computational chemistry, computational biochemistry, and computational nanotechnology.
ACADEMIC AWARDS AND DISTINCTIONS
Krill Prize (Wolf Foundation), 2009.
Alon Fellowship, 2008-2010.
Fulbright Scholarship, 2003-2004.
Excellence in teaching, Rector’s Office, Bar-Ilan University, 2001.
Eshkol Scholarship, 2000-2003.
Excellent young scientist from the Israeli Chemical Society, 2001.
Moris Benin Prize, 1999.
Bar-Ilan University Chemistry Department Prize, 1998.
Wolf Foundation Prize, young scientist, 1998.
Rachel and Reuven Jacobs Prize, 1997.
Theoretical study of enzymatic and solution-phase reactions using state-of-the-art combined quantum mechanics/molecular mechanics Hamiltonians
Molecular Dynamics and Monte Carlo simulations of proteins
Development of novel path-integral simulation methodology for the investigation of quantum nuclear effects in solution phase and enzymatic reactions
Development of hybrid quantum mechanics/molecular mechanics Hamiltonians
High-level quantum mechanical calculations of small biomolecules