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Friday 23 January 2015

Neil K. Garg


Neil K. Garg
UCLA – Department of Chemistry and Biochemistry 607 Charles Young Drive East Los Angeles, CA 90095
office: (310) 825–1536, mobile: (626) 399–4274
neilgarg@chem.ucla.edu













From left to right: Neil Garg, Michelle Riener, Kyle Quasdorf





Neil Garg with his Chemistry 14D Students (Credit: Penny Jennings)



UCLA Department of 
Chemistry and Biochemistry

Natural Product Synthesis 
& Reaction Discovery

 

Website
Division
Organic
Title
Faculty
Professor
Vice Chair
Specialties
organic
Synthesis

Contact Information

Email
Office
Molecular Sciences Building 5505C
(310)- 825-1536
Lab
Molecular Sciences Building 5234, 5235
(310) 794-9264

Short Biography

Professor Garg received his B.S. degree in 2000 from New York University, and his PhD in 2005 from the California Institute of Technology. After training as an NIH postdoctoral scholar at the University of California, Irvine, he joined the faculty at UCLA in 2007. In 2012, he was appointed as Vice Chair for Education. In 2013, Professor Garg was promoted to full Professor.


Biography

Professor Garg received a B.S. in Chemistry from New York University where he did undergraduate research with Professor Marc Walters. During his undergraduate years, he spent several months in Strasbourg, France while conducting research with Professor Mir Wais Hosseini at Université Louis Pasteur as an NSF REU Fellow. Garg obtained his PhD in 2005 from the California Institute of Technology under the direction of Professor Brian Stoltz. He then joined Professor Larry Overman's research laboratory at the University of California, Irvine as an NIH Postdoctoral Scholar. In 2007, Garg joined the faculty at UCLA.
In 2013, Professor Garg was promoted to full Professor.

Research Interest

Professor Neil Garg and his coworkers develop new reaction methodologies and synthetic strategies to prepare complex organic molecules. Specific areas of interest include cross-coupling reactions, green chemistry, heterocycle synthesis, and natural product total synthesis.

Honors & Awards

  • Arthur C. Cope Scholar Award, 2015
  • UCLA Distinguished Teaching Award & Eby Award for the Art of Teaching, 2014
  • Bristol-Myers Squibb Unrestricted Grant in Synthetic Organic Chemistry, 2013
  • Camille Dreyfus Teacher-Scholar Award, 2013
  • S. T. Li Prize for Achievements in Science and Technology, 2012
  • ACS Green Chemistry Institute Pharmaceutical Roundtable Grantee Award, 2012
  • A. P. Sloan Research Fellowship, 2012
  • Glenn T. Seaborg Award, 2012
  • Roche Excellence in Chemistry Award, 2012
  • UCLA Hanson–Dow Award for Excellence in Teaching, 2011
  • UCLA Herbert Newby McCoy Award, 2011
  • AstraZeneca Excellence in Chemistry Award, 2011
  • Amgen Young Investigator Award, 2011
  • Eli Lilly Grantee Award, 2010
  • DuPont Young Professor Award, 2010
  • NSF CAREER Award, 2010
  • Thieme Chemistry Journal Award, 2010
  • Boehringer Ingelheim New Investigator Award, 2009
  • UCLA Faculty Career Development Award, 2008
  • UCLA Faculty Research Grant, 2008
  • National Institutes of Health Pathway to Independence Award, 2006–2010
  • National Institutes of Health Postdoctoral Fellowship, 2005–2006
  • Herbert Newby McCoy Thesis Award at the California Institute of Technology, 2005
  • Dow Chemical Company Travel Fellowship, 2002
  • National Defense Science & Engineering Graduate Fellowship, 2001–2004

Publications

[ Selected Publications ]

  • Total Synthesis of the Akuammiline Alkaloid Picrinine. Joel M. Smith, Jesus Moreno, Ben W. Boal, and Neil K. Garg. J.Am. Chem. Soc. 2014, 136,4504.
  • Concise Enantiospecific Total Synthesis of Tubingensin A. Adam E. Goetz, Amanda L. Silberstein,  Michael A. Corsello, and Neil K. Garg. J. Am. Chem. Soc. 2014,136, 3036.
  • Total Syntheses of Indolactam Alkaloids (–)-Indolactam V,(–)-Pendolmycin, (–)-Lyngbyatoxin A, and (–)-Teleocidin A-2. Noah F. Fine Nathel, Tejas K. Shah,  Sarah M. Bronner, and Neil K. Garg. Chem.Sci. 2014,5, 2184.
  • Enantiospecific Total Synthesis of N-Methylwelwitindolinone D Isonitrile. Evan D. Styduhar, Alexander D. Huters, Nicholas A. Weires, and Neil K. Garg. Angew.Chem. Int. Ed. 2013, 52, 12422.
  • Regioselective Reactions of 3,4-Pyridynes Enabled by the Aryne Distortion Model. Adam E. Goetz and Neil K. Garg. Nature Chemistry 2013, 5, 54.
  • Steric Effects Compete with Aryne Distortion to Control Regioselectivities of Nucleophilic Additions to 3-Silylarynes. Sarah M. Bronner, Joel L. Mackey, K. N. Houk, and Neil K. Garg. J. Am. Chem. Soc. 2012, 134, 13966.
  • Total Synthesis of Oxidized Welwitindolinones and (–)-N-Methylwelwitindolinone C Isonitrile. Kyle W. Quasdorf, Alexander D. Huters, Michael W. Lodewyk, Dean J. Tantillo, and Neil K. Garg. J. Am. Chem. Soc. 2012, 134, 1396.
  • Total Synthesis of (–)-N-Methylwelwitindolinone C Isothiocyanate. Alexander D. Huters, Kyle W. Quasdorf, Evan D. Styduhar, and Neil K. Garg. J. Am. Chem. Soc. 2011, 133, 15797.
  • Total Synthesis of (±)-Aspidophylline A. Liansuo Zu, Ben W. Boal, and Neil K. Garg. J. Am. Chem. Soc. 2011,133, 8877.
  • Overturning Indolyne Regioselectivities and Synthesis of Indolactam V. Sarah M. Bronner, Adam E. Goetz, and Neil K. Garg. J.Am. Chem. Soc. 2011, 133, 3832.
  • Nickel-Catalyzed Amination of Aryl Sulfamates. Stephen D. Ramgren, Amanda L. Silberstein, Yang Yang, and Neil K. Garg. Angew. Chem. Int. Ed. 2011, 50, 2171.
  • Indolyne and Aryne Distortions and Nucleophilic Regioselectivities. Paul H.-Y. Cheong, Robert S. Paton, Sarah M. Bronner, G-Yoon J. Im, Neil K. Garg, and K. N. Houk. J. Am. Chem. Soc. 2010, 132,1267.
  • Suzuki–Miyaura Coupling of Aryl Carbamates, Carbonates, and Sulfamates. Kyle W. Quasdorf, Michelle Riener, Krastina V. Petrova, and Neil K. Garg. J. Am. Chem. Soc. 2009, 131, 17748.
  • Cross-Coupling Reactions of Aryl Pivalates with Boronic Acids. Kyle W. Quasdorf, Xia Tian, and Neil K. Garg. J. Am. Chem. Soc. 2008, 130, 14422.
 Home
  
Professor Neil Garg has been awarded the 2013 Bristol-Myers Squibb Unrestricted Grant in Synthetic Organic Chemistry.
The award for synthetic organic chemistry is bestowed annually by researchers at BMS, in consultation with leading organic chemists in academia. The award recognizes faculty in the early stages of their careers who have made a fundamental contribution to organic synthesis. The award carries $150K over its two-year span. As part of the award, Professor Garg will visit Bristol-Myers Squibb in 2014 to deliver the award lecture.

Neil Garg (Photo: Penny Jennings)
BIOGRAPHY
Professor Garg received a B.S. in Chemistry from New York University where he did undergraduate research with Professor Marc Walters. During his undergraduate years, he spent several months in Strasbourg, France while conducting research with Professor Mir Wais Hosseini at Université Louis Pasteur as an NSF REU Fellow. Garg obtained his Ph.D. in 2005 from the California Institute of Technology under the direction of Professor Brian Stoltz. He then joined Professor Larry Overman’s research laboratory at the University of California, Irvine as an NIH Postdoctoral Scholar. Garg joined the faculty at UCLA in 2007. In 2012, he was promoted to Associate Professor and began serving as Vice Chair for the Department of Chemistry and Biochemistry. In 2013, he was promoted to Full Professor.
SELECTED AWARDS & HONORS
•2013 Bristol-Myers Squibb Unrestricted Grant in Synthetic Organic Chemistry
•Camille Dreyfus Teacher-Scholar Award, 2013
•S. T. Li Prize for Achievements in Science and Technology, 2012
•ACS Green Chemistry Institute Pharmaceutical Roundtable Grantee Award, 2012
•A. P. Sloan Research Fellowship, 2012
•Roche Excellence in Chemistry Award, 2012
•UCLA Hanson-Dow Award for Excellence in Teaching, 2011
•UCLA Herbert Newby McCoy Award, 2011
•AstraZeneca Excellence in Chemistry Award, 2011–2012 
•Amgen Young Investigator Award, 2011–2012
•Eli Lilly Grantee Award, 2010–2012
•DuPont Young Professor Award, 2010–2013
•NSF CAREER Award, 2010–2015
•Thieme Chemistry Journal Award, 2010
•Boehringer Ingelheim New Investigator Award, 2009 
•National Institutes of Health Postdoctoral Fellowship, 2005–2006
•National Science Foundation Research Experience for Undergraduates Fellowship, 1999

Neil Garg with his research group students
RESEARCH
Research in the Garg Laboratory is directed toward the development of synthetic strategies and methods that enable the synthesis of complex bioactive molecules.  Our methodological interests lie primarily in the areas of transition-metal catalyzed cross-coupling reactions of unconventional phenol-based electrophiles and tactics for the preparation of functionalized heterocycles.  These efforts have facilitated syntheses of the drugs flurbiprofen and zyvox, in addition to the natural products aspidophylline A, physovenine, debromoflustramine B, indolactam V, and N-methylwelwitindolinone C isothiocyanate.

Professor Garg received a B.S. in Chemistry from New York University where he did undergraduate research with Professor Marc Walters. During his undergraduate years, he spent several months in Strasbourg, France while conducting research with Professor Mir Wais Hosseini at Université Louis Pasteur as an NSF REU Fellow. Garg obtained his Ph.D. in 2005 from the California Institute of Technology under the direction of Professor Brian Stoltz. He then joined Professor Larry Overman’s research laboratory at the University of California, Irvine as an NIH Postdoctoral Scholar. Garg joined the faculty at UCLA in 2007. In 2012, he was promoted to Associate Professor and began serving as Vice Chair for the Department of Chemistry and Biochemistry. In 2013, he was promoted to Full Professor.




UCLA











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Wilma Lukas


Wilma Lukas.jpg

Wilma Lukas, PhD, MBA

Founder & Managing Director at W Life Sciences - Expert Board at Skolkovo Foundation

Dr Lukas has over 20 years of experience in drug discovery, R&D, licensing and business development. Ph.D. in Biology from the Universtity of Geneva, completed by an MBA, she gained pharmaceutical expertise at the Glaxo Institute (GSK) and Serono (now Merck Serono) before joining a start-up that was later on successfully acquired byMolecular Devices Corp (USA).
Dr Lukas joined Debiopharm in 2007. She was in charge of the search and evaluation process and identified pre-clinical and clinical opportunities to in-license in line with Debiopharm’s strategy, business model and portfolio. 
Dr Lukas has created her own consultancy (W Life Sciences) to provide strategic advices and expert scientific opinion to biotech companies, start-ups, universities, investors or pharmaceutical companies. She is supported by expert advisors with more than twenty years of experience in business development and clinical development.

Wilma Lukas, PhD, MBA

Summary

* PhD, MBA, over twenty years experience in the pharmaceutical industry (GSK, Merck Serono, Debiopharm, Molecular Devices)

* Business development, Licensing, Drug Discovery, R&D and Drug Development expertise

Experience





Founder & Managing Director

W Life Sciences
 – Present Geneva Area, Switzerland
- In Licensing: search and identify innovative opportunities
- Out Licensing: search and identify potential partners
- Fund raising
- Mentoring early-stage biotech / start-up companies
- Interim / Part-time business development
- Strategy and positionning
- Market and competition analysis
- Due diligence
- Valuation

- Evaluation of > 1000s opportunities
- All major therapeutic areas, small molecules, biologics, diagnostics

www.wlifesciences.com




Expert Board

Skolkovo Foundation
 – Present (less than a year)Geneva Area, Switzerland




Senior S&E Officer, in Licensing - PhD, MBA

Debiopharm
 –  (3 years)
Drive search and evaluation process of new product opportunities
Identify preclinical and clinical licensing opportunities and companion diagnostics in alignment with company portfolio strategy
Participate and present at international partnering and investor conferences
Discover new areas of innovation and growth opportunities
Perform competitive intelligence and monitor the business environment
Strong network within biotechs, pharmaceutical companies, start-ups, technology transfer centers, bioclusters, science parks, venture capital companies, brokers or governmental organizations




Senior Prospector, PhD, MBA

Debiopharm
 –  (3 years)Switzerland
Drive search and evaluation process of new product opportunities
Identify preclinical and clinical licensing opportunities and companion diagnostics in alignment with company portfolio strategy




Biotech & Pharma Consultant

-
 –  (3 years)
Expertise in Life Sciences, Pharma, New Technologies, Biomedical Devices
Provide scientific support in project evaluation and strategy




Group Leader Biology

Molecular Devices (Cytion)
 –  (2 years)
Development of a new drug screening technology (HTS) for the pharmaceutical industry and academia
Managerial experience in a multicultural environment




Scientist

Merck Serono
 –  (3 years)
Drug discovery and development
Managed cross-functional team in multinational environment




Ass. Scientist

GlaxoSmithKline
 –  (8 years)
R&D in Neurobiology, Physiology, Immunology, Molecular Biology, Biochemistry, Ion channel-related diseases.
Projects management
Scientific publications

Organizations





Swiss HLG (Pharma Licensing Group)

Member
 – Present




HBA (Healthcare Businesswomen's Association)

Member
 – Present




Geneva Pharma Network

Member
 – Present




G.E.I. (Gruppo Esponenti Italiani)

Member
 – Present
Lausanne, Switzerland




Trevisani nel Mondo

President, Lausanne, Switzerland
 – Present

Education




University of Geneva

Ph.D., Biological Sciences

Ph.D. thesis with honors
Two pores potassium channel: structure and function study




IFCAM

Master of Business Administration (MBA)

• Finance
• Accounting
• Law
• Marketing
• Production
• Human Resources
• General Business Administration



Université de Lausanne

MSc Biology

W Life Sciences facilitates strategic relationships, provides advisory services in business development, licensing activities and evaluation of opportunities
Identifying innovation and boosting promissing drug candidates is a must
W Life sciences is an independent consulting firm based in Switzerland
W Life Sciences
Wilma Lukas, PhD, MBA
Managing Director
W Life Sciences
1260 Nyon - Switzerland
Mobile: +41 (0) 79 362 51 91
www.wlifesciences.com
fibers.jpg

Lake_Geneva,_Nyon.JPG

lusanne....below








Skolkovo Foundation

Skolkovo Foundation FIRST ACHIEVEMENTS. 2010—2011Creatingin Skolkovo The foundation expert network: Berkley, Russian and International Skolkovo Innovation ...





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