One Organic Chemist One Day: Neil K. Garg

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Friday 23 January 2015

Neil K. Garg

UCLA – Department of Chemistry and Biochemistry 607 Charles Young Drive East Los Angeles, CA 90095

office: (310) 825–1536, mobile: (626) 399–4274

neilgarg@chem.ucla.edu

From left to right: Neil Garg, Michelle Riener, Kyle Quasdorf

Neil Garg with his Chemistry 14D Students (Credit: Penny Jennings)

UCLA Department of

Chemistry and Biochemistry

Natural Product Synthesis

& Reaction Discovery

Website	Home URL
Division	Organic
Title	Faculty Professor Vice Chair
Specialties	organic Synthesis

Contact Information

Email	neilgarg@chem.ucla.edu
Office	Molecular Sciences Building 5505C (310)- 825-1536
Lab	Molecular Sciences Building 5234, 5235 (310) 794-9264

Short Biography

Professor Garg received his B.S. degree in 2000 from New York University, and his PhD in 2005 from the California Institute of Technology. After training as an NIH postdoctoral scholar at the University of California, Irvine, he joined the faculty at UCLA in 2007. In 2012, he was appointed as Vice Chair for Education. In 2013, Professor Garg was promoted to full Professor.

Biography

Professor Garg received a B.S. in Chemistry from New York University where he did undergraduate research with Professor Marc Walters. During his undergraduate years, he spent several months in Strasbourg, France while conducting research with Professor Mir Wais Hosseini at Université Louis Pasteur as an NSF REU Fellow. Garg obtained his PhD in 2005 from the California Institute of Technology under the direction of Professor Brian Stoltz. He then joined Professor Larry Overman's research laboratory at the University of California, Irvine as an NIH Postdoctoral Scholar. In 2007, Garg joined the faculty at UCLA.

In 2013, Professor Garg was promoted to full Professor.

Research Interest

Professor Neil Garg and his coworkers develop new reaction methodologies and synthetic strategies to prepare complex organic molecules. Specific areas of interest include cross-coupling reactions, green chemistry, heterocycle synthesis, and natural product total synthesis.

Honors & Awards

Arthur C. Cope Scholar Award, 2015
UCLA Distinguished Teaching Award & Eby Award for the Art of Teaching, 2014
Bristol-Myers Squibb Unrestricted Grant in Synthetic Organic Chemistry, 2013
Camille Dreyfus Teacher-Scholar Award, 2013
S. T. Li Prize for Achievements in Science and Technology, 2012
ACS Green Chemistry Institute Pharmaceutical Roundtable Grantee Award, 2012
A. P. Sloan Research Fellowship, 2012
Glenn T. Seaborg Award, 2012
Roche Excellence in Chemistry Award, 2012
UCLA Hanson–Dow Award for Excellence in Teaching, 2011
UCLA Herbert Newby McCoy Award, 2011
AstraZeneca Excellence in Chemistry Award, 2011
Amgen Young Investigator Award, 2011
Eli Lilly Grantee Award, 2010
DuPont Young Professor Award, 2010
NSF CAREER Award, 2010
Thieme Chemistry Journal Award, 2010
Boehringer Ingelheim New Investigator Award, 2009
UCLA Faculty Career Development Award, 2008
UCLA Faculty Research Grant, 2008
National Institutes of Health Pathway to Independence Award, 2006–2010
National Institutes of Health Postdoctoral Fellowship, 2005–2006
Herbert Newby McCoy Thesis Award at the California Institute of Technology, 2005
Dow Chemical Company Travel Fellowship, 2002
National Defense Science & Engineering Graduate Fellowship, 2001–2004

Publications

[ Selected Publications ]

Total Synthesis of the Akuammiline Alkaloid Picrinine. Joel M. Smith, Jesus Moreno, Ben W. Boal, and Neil K. Garg. J.Am. Chem. Soc. 2014, 136,4504.
Concise Enantiospecific Total Synthesis of Tubingensin A. Adam E. Goetz, Amanda L. Silberstein, Michael A. Corsello, and Neil K. Garg. J. Am. Chem. Soc. 2014,136, 3036.
Total Syntheses of Indolactam Alkaloids (–)-Indolactam V,(–)-Pendolmycin, (–)-Lyngbyatoxin A, and (–)-Teleocidin A-2. Noah F. Fine Nathel, Tejas K. Shah, Sarah M. Bronner, and Neil K. Garg. Chem.Sci. 2014,5, 2184.
Enantiospecific Total Synthesis of N-Methylwelwitindolinone D Isonitrile. Evan D. Styduhar, Alexander D. Huters, Nicholas A. Weires, and Neil K. Garg. Angew.Chem. Int. Ed. 2013, 52, 12422.
Regioselective Reactions of 3,4-Pyridynes Enabled by the Aryne Distortion Model. Adam E. Goetz and Neil K. Garg. Nature Chemistry 2013, 5, 54.
Steric Effects Compete with Aryne Distortion to Control Regioselectivities of Nucleophilic Additions to 3-Silylarynes. Sarah M. Bronner, Joel L. Mackey, K. N. Houk, and Neil K. Garg. J. Am. Chem. Soc. 2012, 134, 13966.
Total Synthesis of Oxidized Welwitindolinones and (–)-N-Methylwelwitindolinone C Isonitrile. Kyle W. Quasdorf, Alexander D. Huters, Michael W. Lodewyk, Dean J. Tantillo, and Neil K. Garg. J. Am. Chem. Soc. 2012, 134, 1396.
Total Synthesis of (–)-N-Methylwelwitindolinone C Isothiocyanate. Alexander D. Huters, Kyle W. Quasdorf, Evan D. Styduhar, and Neil K. Garg. J. Am. Chem. Soc. 2011, 133, 15797.
Total Synthesis of (±)-Aspidophylline A. Liansuo Zu, Ben W. Boal, and Neil K. Garg. J. Am. Chem. Soc. 2011,133, 8877.
Overturning Indolyne Regioselectivities and Synthesis of Indolactam V. Sarah M. Bronner, Adam E. Goetz, and Neil K. Garg. J.Am. Chem. Soc. 2011, 133, 3832.
Nickel-Catalyzed Amination of Aryl Sulfamates. Stephen D. Ramgren, Amanda L. Silberstein, Yang Yang, and Neil K. Garg. Angew. Chem. Int. Ed. 2011, 50, 2171.
Indolyne and Aryne Distortions and Nucleophilic Regioselectivities. Paul H.-Y. Cheong, Robert S. Paton, Sarah M. Bronner, G-Yoon J. Im, Neil K. Garg, and K. N. Houk. J. Am. Chem. Soc. 2010, 132,1267.
Suzuki–Miyaura Coupling of Aryl Carbamates, Carbonates, and Sulfamates. Kyle W. Quasdorf, Michelle Riener, Krastina V. Petrova, and Neil K. Garg. J. Am. Chem. Soc. 2009, 131, 17748.
Cross-Coupling Reactions of Aryl Pivalates with Boronic Acids. Kyle W. Quasdorf, Xia Tian, and Neil K. Garg. J. Am. Chem. Soc. 2008, 130, 14422.

Professor Neil Garg has been awarded the 2013 Bristol-Myers Squibb Unrestricted Grant in Synthetic Organic Chemistry.

The award for synthetic organic chemistry is bestowed annually by researchers at BMS, in consultation with leading organic chemists in academia. The award recognizes faculty in the early stages of their careers who have made a fundamental contribution to organic synthesis. The award carries $150K over its two-year span. As part of the award, Professor Garg will visit Bristol-Myers Squibb in 2014 to deliver the award lecture.

Neil Garg (Photo: Penny Jennings)

BIOGRAPHY

Professor Garg received a B.S. in Chemistry from New York University where he did undergraduate research with Professor Marc Walters. During his undergraduate years, he spent several months in Strasbourg, France while conducting research with Professor Mir Wais Hosseini at Université Louis Pasteur as an NSF REU Fellow. Garg obtained his Ph.D. in 2005 from the California Institute of Technology under the direction of Professor Brian Stoltz. He then joined Professor Larry Overman’s research laboratory at the University of California, Irvine as an NIH Postdoctoral Scholar. Garg joined the faculty at UCLA in 2007. In 2012, he was promoted to Associate Professor and began serving as Vice Chair for the Department of Chemistry and Biochemistry. In 2013, he was promoted to Full Professor.

SELECTED AWARDS & HONORS

•2013 Bristol-Myers Squibb Unrestricted Grant in Synthetic Organic Chemistry

•Camille Dreyfus Teacher-Scholar Award, 2013

•S. T. Li Prize for Achievements in Science and Technology, 2012

•ACS Green Chemistry Institute Pharmaceutical Roundtable Grantee Award, 2012

•A. P. Sloan Research Fellowship, 2012

•Roche Excellence in Chemistry Award, 2012

•UCLA Hanson-Dow Award for Excellence in Teaching, 2011

•UCLA Herbert Newby McCoy Award, 2011

•AstraZeneca Excellence in Chemistry Award, 2011–2012

•Amgen Young Investigator Award, 2011–2012

•Eli Lilly Grantee Award, 2010–2012

•DuPont Young Professor Award, 2010–2013

•NSF CAREER Award, 2010–2015

•Thieme Chemistry Journal Award, 2010

•Boehringer Ingelheim New Investigator Award, 2009

•National Institutes of Health Postdoctoral Fellowship, 2005–2006

•National Science Foundation Research Experience for Undergraduates Fellowship, 1999

Neil Garg with his research group students

RESEARCH

Research in the Garg Laboratory is directed toward the development of synthetic strategies and methods that enable the synthesis of complex bioactive molecules. Our methodological interests lie primarily in the areas of transition-metal catalyzed cross-coupling reactions of unconventional phenol-based electrophiles and tactics for the preparation of functionalized heterocycles. These efforts have facilitated syntheses of the drugs flurbiprofen and zyvox, in addition to the natural products aspidophylline A, physovenine, debromoflustramine B, indolactam V, and N-methylwelwitindolinone C isothiocyanate.

Professor Garg received a B.S. in Chemistry from New York University where he did undergraduate research with Professor Marc Walters. During his undergraduate years, he spent several months in Strasbourg, France while conducting research with Professor Mir Wais Hosseini at Université Louis Pasteur as an NSF REU Fellow. Garg obtained his Ph.D. in 2005 from the California Institute of Technology under the direction of Professor Brian Stoltz. He then joined Professor Larry Overman’s research laboratory at the University of California, Irvine as an NIH Postdoctoral Scholar. Garg joined the faculty at UCLA in 2007. In 2012, he was promoted to Associate Professor and began serving as Vice Chair for the Department of Chemistry and Biochemistry. In 2013, he was promoted to Full Professor.