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Thursday, 16 June 2016

Murugan Kaliyappan

Murugan Kaliyappan.

Murugan Kaliyappan

Research scientist at Yung Shin pharamaceutical group


Dr. K. Murugan, M.Sc., Ph.D  
Research Scientist                                                                                                                                  
Generics R&D, Yung Zip Chemical                                                                                                        
Dajia, Taichung, Taiwan-43767                                                                           
( +886-919575034;  
EMAIL * muruganjk5@gmail.com


Founded in 1978, Yung Zip Chemical is located in Youth Industrial Park, Tachia, Taichung. Yung Zip Chemical specializes in the production and sales of API ...




Research Scientist

yung shin pharmaceuticals group
– Present (1 year 9 months)Taichung City, Taiwan

Postdoctoral fellow

National Taiwan University
(3 years)Taiwan

Senior Research Scientist

Sanmar Group
(11 months)Chennai Area, India
Process development
medicinal chemistry research

Junior Research Scientist

Malladi Drugs and Pharmaceuticals Limited
(2 years 3 months)


National Dong Hwa University

Doctor of Philosophy (Ph.D.), Organic Chemistry

Dr. K. Murugan, M.Sc., Ph.D  
Research Scientist                                                                                                                                                  
Generics R&D, Yung Zip Chemical                                                                                                        
Dajia, Taichung, Taiwan-43767                                                                           
( +886-0919575034;  * muruganjk5@gmail.com

Current position

Research Scientist at Yung Zip Chemical (Yung Shin Pharma Group), Taiwan. (Oct. 2014 – present):

Academic and Industrial experience

National Taiwan University,
Dept. of Chemistry and School of Pharmacy, Taiwan
(Aug. 2011 – Jul. 2014)
Postdoc. Research Fellow
(Prof. Ya-Ching Shen Lab)
Sanmar Speciality Chemicals Ltd, Chennai
(Oct. 2006 – Aug. 2007)
Senior Research Officer
Malladi Drugs & Pharmaceuticals Ltd, Chennai
(Jul. 2004 – Sep. 2006)
Junior Scientist
IIT Madras, Chennai
(Jan. 2004 – Jul. 2004)
Research Fellow,
   Industrial Project
(Prof. B.Viswantahn)

Academic Profile

§  Ph.D Organic Chemistry, (Advisor: Prof. Chinpiao Chen), National Dong Hwa University, Taiwan (Sep.2007-Aug-2011)
§  MSc Chemistry (first class), St. Joseph College, Bharathidasan University, Tamilnadu, India (2001− 2003).
§  BSc Chemistry (first class),  Govt. Arts College, Dharmapuri, Madras University, Tamilnadu, India (1996−1999).

Key achievements

Yung Zip Chemical:
§  Activities includes synthetic route selection, process optimization, costing, in-process controls and complete specification generation, lab validation.
§  Non-infringing selection of process, and polymorph identification (innovator).
§  Impurities identification (process-related, KSM carry-over) for the related substances of final API and their synthetic route selection.
§  Cross functional team interactions with analytical R&D, IP, engineering, etc. at different stages of project.
§  Non-infringing routes, impurity synthesis, and process optimization of the following API molecules:
§  Non-infringing routes, impurity synthesis, process optimization and lab validation of the following API molecules:

Sanmar Specialities Chemicals Ltd.:
§  CRO work and custom synthesis for Pfizer, Merck, BMS and Asinex Moscow.
§  Preparation of library molecules and API intermediates and delivery of 1 g to   100 g samples.

Malladi Drugs & Pharmaceuticals Ltd.:
§  Process optimization, impurity synthesis, validation and scale-up to plant level for the following API molecules and Intermediates:

Postdoctoral Research:
§  Development of organocatalytic reactions for synthesis of a key precursor to DMP 777, a leukocyte elastase inhibitor.
§  Organocatalytic-mediated synthesis of model core of Atorvastatin from enamide starting material.
§  Synthesis of carbozolyl-3,4-dihydro-β-carboline analogues as potential antitumor agents.
§  Semisynthesis of Ambrox (terpenoid) from naturally occurring starting material.

Academic output

Research Papers:
1.      Sankareswaran, Srimurugan, Kaliyappan Murugan, Chinpiao Chen* A facile method for preparation of 2 [ H3]-Sufentanil and its metabolites, Chem. Pharm. Bull. 57(12) 1421-1424 (2009).

2.      Kaliyappan Murugan,Sankareswaran Srimurugan and Chinpiao Chen* A mild, catalytic and efficient Nazarov cyclization mediated by phosphomolybdicacid, Chem. Commun., 2010, 46, 1127–1129.
3.      Kaliyappan Murugan, Sankareswaran Srimurugan, Chinpiao Chen* Silicomolybdicacid supported on silica-gel: An efficient catalyst for Hosomi-Sakurai allylation reactions. Tetrahedron 2011, 67, 5621.
4.      Kaliyappan Murugan,Chinpiao Chen* HClO4-supported on silica gel: a mild and efficient catalyst for Hosomi-Sakurai reaction, Tetrahedron Lett. 2011, 52, 5827-5830.
5.      Sankareswaran Srimurugan, Chi-Ju Su, Hun-Chi Shu, Kaliyappan Murugan, Chinpiao Chen* A facile and improved synthesis of desomorphine and its deuterium labeled analogue, MonatshChem. 2012, 143, 171-174.
6.      Kaliyappan Murugan, Da-wei Huang, Yu-Ting Chien, Shiuh-Tzung Liu* An efficient preparation of Nacetylenamides catalyzed by Ru(II) complexes, Tetrahedron 2013, 69, 268-273.
7.      Kaliyappan Murugan, Shiuh-Tzung Liu* Preparation of substituted pyrroles via Ru(II)-catalyzed coupling of alkynes with enamides, Tetrahedron Lett. 2013, 54, 2608-2611.
8.      Chun-RuYang, Wei-Siang Liaob, Ya-Hui Wu, Kaliyappan Murugan, Chinpiao Chen*, Jui-I Chao* CR108, a novel vitamin K3 derivative induces apoptosis and breast tumor inhibition by reactive oxygen species and mitochondrial dysfunction, Toxicology and Applied Pharmacology, 2013, 273, 611–622.
9.      Atul Chaskar* Kaliyappan Murugan* Direct Allylation of Alcohols using allyltrimethyl-silane: A Move Towards Economical and Ecological Protocol for C-C Bond Formation, (Review) Catalysis Science & Technology, 2014, 4, 1852-1868.
10.  Hanuman P. Kalmode,  Kamlesh S. Vadagaonkar  Kaliyappan Murugan* and   Atul C. Chaskar* A multicomponent pathway-inspired regioselective synthesis of 2,3,4-trisubstit -uted 1H-pyrroles via [3+2] cycloaddition reaction, New J. Chem, 2015, 39, 4631-4639.

Academic Scholarships/Fellowships Received:
§  NSC post-doctoral fellowship, Taiwan, 2011-2014.
§  Taiwan scholarship for PhD from National Science Council (NSC)  Taiwan, 2007- 2010.
§  TITAN Merit Scholarship for MSc from Titan India Ltd. from 2001-2003.

Personal Information

         Name               :           K. Murugan
         Gender             :           Male
         Gender             :           May, 5, 1978
         Marital status   :           Married
         Nationality       :           Indian
         Languages        :           English, Tamil, Chinese (elementary level)
            Professor Chinpiao Chen
            Department of Chemistry
             National Dong Hwa University, Hualien-974, Taiwan
            Email: chinpiao@mail.ndhu.edu.tw Ph: +886-3-8633597      
            Professor Ya-Ching Chen
            School of pharmacy, National Taiwan University Medical college
            No.1, Sec.1, Jen-Ai Road, Taipei, Taiwan.
            Email: ycshen@ntu.edu.tw Ph: +886-2-33668774      
            Professor B.Viswanathan
            Department of Chemistry,
            Indian Institute of Technology Madras, Chennai, India-600036.
            Email: bvnathan@iitm.ac.in Ph: +9144- 22574241.

In 1978, initially Yung Zip Chemical was founded for manufacturing and supplying the active pharmaceutical ingredients (APIs) to Yung Shin Pharma. (one of the leading pharmaceutical industries in Taiwan). Through years' researching and improving, Yung Zip Chemical had laid the groundwork for the technology and quality, also started expanding its business scope, Yung Zip started serving and supplying the APIs
to other domestic pharmaceutical industries, and earned a foremost position in bulk pharmaceutical chemical industry in Taiwan. It was an important foundation for Yung Zip to step into international market and become an international company.

In 2001, Yung Zip Chemical had been inspected, approved by US FDA and ensured our excellent quality, allowing our products to market in US, Europe and other industrialization countries. In order to offer our qualified products worldwide and serving our international customers, extensive marketing-networks were set up and the Drug Master Files for most Active Pharmaceutical Ingredients are prepared and offered to satisfy our customer's information requirement. With the foundation in Taiwan, Yung Zip Chemical has a brilliant achievement in world market and aims to be the top APIs manufacturer in the world.
For the past few years, the opto-electrical industries are rising and flourishing in Taiwan, the material supplying is unable to meet the demand. Base on our technology in fine chemicals, Yung Zip started researching and developing the special chemicals for opto-electrical industries in order to satisfy the market demand and solve the situation. We are successful in R&D the OPC drums materials and become the main supplier in Taiwan,
products also market in Korea, China and etc. Yung Zip chemical is enthusiastic in this domain, also R&D the liquid crystal materials, we not only want to satisfy Taiwan market, but also the world market. It is our ambition to become the world-class manufacturer of APIs and opto-electrical chemical materials.

Technical Collaboration
R&D Department
Sung, Che-Ming Manager

Yung Zip Chemical manufactures and markets qualify quality Active Pharmaceutical Ingredients products, such as anti-viral, anti-inflammatory, analgesic, anti-fungal, anti-cancer and etc. We always R&D new APIs without end to satisfy our customer's requirement and more choice.

Product DOH Taiwan US FDA Other Countries
Acyclovir                           *FDA 036596 19948 95111 Canada
20050831-33-A-74-02 Korea
217MF10872 Japan
Cefaclor 044799      
Cephalexin 034027      
Clonidine Hydrochloride 22873      
Clopidogrel Bisulfate   22280    
Diclofenac Acid        
Diclofenac Diethylamine        
Diclofenac Epolamine        
Diclofenac Potassium         *FDA 38298 10831    
Diclofenac Sodium             *FDA 22090 6981 97/31308 Australia
225 Belgium
94131 Canada
95-012 France
770 Greece
IS-74 Iceland
11140002 Ireland
819812741 Italy
0035 Netherlands
95/03204-001 Norway
015:166 Singapore
DS/195/98 Spain
5154401 Switzerland
11263-A4745 UK
20071228-80-D-16-03 Korea
218MF10677 Japan
Econazole Nitrate 23124 11140    
Famotidine 047598      
Lovastatin                          *FDA 042724 14049    
Meclofenamate Sodium 038157      
Meclofenamic Acid        
Mefenamic Acid 22087 5677 9154 Canada
98-041 France
246 Greece
11140001 Ireland
11263-A0854 UK
2003-DMF-43 Cyprus
TT60-664-18-1 New Zealand
217-MF10873 Japan
Meloxicam 049938      
Metaxalone 047595      
Metoprolol Succinate        
Miconazole Base        
Miconazole Nitrate             *FDA 22089 6982 9363 Canada
217-MF10874 Japan
Modafinil 048090      
Paclitaxel (Extraction) 044779 15319    
Paclitaxel  42226      
Quetiapine Fumarate        
Sodium Starch Glycolate   7247    
Valacyclovir Hydrochloride        
*FDA Accepted

 Photo of Taichung Xingwu Shou Yanwuchang
 ung Zip Chemical would like to further strengthen their R&D abilities, integrate the laboratory's achievement with actually mass-produce in produce line and hope our new products could successful enter the market as soon as possible, so Yung Zip invests such amount to make replacements of facilities and upgrade the equipments, enable us to appear our R&D's achievements, that's the reasons why we strengthen our pilot plant.

Science and technology is changing with each passing day, cease making progress is equal to

do less well than before, due to the R&D news products influences the life and death ofa company, we are enthusiastic to enhance our R&D and employ many professional persons to enter our R&D teams.

The increasing of new facilities and upgrading equipments of pilot plant is the foundation for Yung Zip to expand its business scope in photoelectron domain, also combines with modernized management, Yung Zip has a strong background forward to its brightness future.


 Dajia, Taichung