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Thursday 8 October 2015

Amiram Goldblum

Amiram Goldblum

Amiram Goldblum

Professor at The Hebrew University of Jerusalem, Inst. for Drug Research
Current
  1. The Hebrew University of Jerusalem
Previous
  1. Hebrew UNiversity of Jerusalem,
  2. Stanford Research Institute
Education
  1. The Hebrew University
https://il.linkedin.com/pub/amiram-goldblum/0/b02/b8a
https://www.researchgate.net/profile/Amiram_Goldblum














Prof. Amiram Goldblum's laboratory of molecular modeling and drug design develops algorithms and computer techniques and employs them, as well as other computational methods, for solving problems in structural biology of proteins and associated problems in ligand binding and drug design.
A central activity in the laboratory is the development of novel optimization methods for solving complex combinatorial problems that are part of most research subjects in structural biology and in drug design. A large scope may be addressed by our novel core technology, called Iterative Stochastic Elimination (ISE) which is used to find optimal solutions to diverse issues such as molecular conformational ensembles, multiple loops in proteins, protein-ligand docking, protein design, focused libraries, cheminformatics and others.
ISE was recently devised in our lab, and is now extended by PhD and MSc students to:
  • Constructing conformational ensembles of large (>8 amino acids) loops
  • Predicting the preexisting ensembles multiple protein loops
  • Building populations and computing properties of large ligands
  • Structure based design from molecular scaffolds and fragments
  • Predicting molecular properties from database comparisons
  • Assigning Drug likeness and molecular bioactivity to molecules
  • Docking molecules to their targets
  • Design of new functions in proteins
  • Designing protein sequence for inhibiting protein – protein interactions
  • Differentiating between folding and non-folding sequences
  • Assigning Mollecular Bioactivity Indexes and Drug Like Indexes
  • Chemoinformatics and QSAR applications

Recent Experimental Success with ISE:

  • Acetylcholinesterase inhibition: An ISE model for distinguishing between active inhibitors and non-inhibitors was constructed and applied to the ZINC database with more than 2 million molecules. Top 800 molecules were docked (ISE-dock) and 9 best ones by MBI and docking results were purchased for in vitro studies at the lab of Prof. Marta Weinstock-Rosin (Excellon (rivastigmine) inventor). Only 5 could be dissolved, and 3 displayed IC50 values of 3.25, 3.5 and 3.75 micromolars.
  • Computational Protein Design: we designed 10 peptides (12 positions in each) to block the dimerization/tetramerization of the N-terminal of Bcr-Abl, that triggers the proliferation of Chronic Myeloid Leukemia (CML) cells. The peptide sequences were sent to Prof. Martin Rutahrdt at Goethe University, Frankfurt, and 6 of them inhibited the proliferation of CML cells in vitro more than a reference peptide that was used for the design.
  • Differential Toxicity:  We applied ISE to distinguish between molecules that displayed toxicity to cancer cells (HCT116 Colon Cancer cell line) more than to normal cell culture (human), and used the results to discover other toxic molecules (about 150 molecuels were picked out of 30,000, with 10% of them showing differential toxiciy, measured both at Targetex company in Budapest, our partners in the CancerGrid consortium (www.cancergrid.eu). Further molecules (~250) were picked and purchased from the enamine catalog of about 1 million molecules, and some 25 of them showed differential cytotoxicity, with about 12 showing it in concentrations < 2 micromolar
Hebrew University of Jerusalem

Prof. Amiram Goldblum's

School of Pharmacy

 

Contacts

AddressProf. Amiram Goldblum,
Molecular Modeling and Drug Design,The Institute for Drug Research,
School of Pharmacy, Hebrew University of Jerusalem,
Jerusalem 91120, Israel
Emailamiram@vms.huji.ac.il
PhoneOffice +972-2-6758701
Cellular +972-544-653292
Fax+972-2-6796584
LocationThe Hebrew University, Ein Kerem Campus,
Pharmacy School Building,
4th Floor,
Room 403 (Office),
Room 424 (MSc students lab)
The group of Amiram Goldblum currently consists of 1 research associate, 6 PhD students and 6 MSc students:

 

Summary

Professor of Chemistry
Chairman of Medicinal Chemistry Department
Spokesperson of the "Peace Now" movement
Announcer, Israeli Public Radio ("Kol Israel")
Specialties:Molecular Modeling, Drug Design, Optimization algorithms, Computational Chemistry, Semiempirical Quantum Chemistry


Experience


Professor of Medicinal Chemistry

The Hebrew University of Jerusalem
September 2009 – Present (6 years 2 months)
Head of Molecular Modeling and Drug Design and Discovery at the Institute for Drug Research

Professor

Hebrew UNiversity of Jerusalem
1979 – 2009 (30 years)
Algorithm development for Drug Discovery and Structural Biology and applications to Drug Discovery in many fields, primarily Alzheimer and Cancers

Visiting Scientist

Stanford Research Institute
July 1982 – September 1982 (3 months)Ravenswood Ave. Menlo Park California
Quantuim Chemistry computations of Molecular Reactions

Education


The Hebrew University

Doctor of Philosophy (PhD), Medicinal and Pharmaceutical Chemistry
1967 – 1977

The Hebrew University

PhD, Chemistry
1967 – 1977
 
 
 
 
 
 The Hebrew University of Jerusalem
 
 
 Map of hebrew university of jerusalem
 
 
 
 
 
 
 
 
 
 
 
 
 
 

















//////Amiram Goldblum

Jabbar Khalafy, Urmia University

Jabbar Khalafy

Jabbar Khalafy

Full Professor at Faculty of Chemistry, Urmia University
Department of Chemistry, Faculty of Science, Urmia University
Urmia - IRAN
Phone (Office):(+98) 441 2972038
Fax (Office):(+98) 441 2776707
E-Mail:j.khalafi@mail.urmia.ac.ir,
jkhalafi@yahoo.com
Born.29 / July / 1952
Place of Birth:Marand - Iran




Experience


Professor of Organic Chemistry

Urmia University
January 1980 – Present (35 yearsplus)Iran
1. Head of Chemistry and Biochemistry Department (1980-1981).
2. Member of Supervising Committee of Science Faculty (1980-1982).
3. Director of Central Library (1984-1986).
4. Head of Chemistry Department (1988-1992).
5. General Director for Research and Publication of Urmia University (1994-1998).
6. Head of Chemistry Department (1998-1999).
7. Deputy for Research of Science Faculty (1999-present).

Full Professor

Faculty of Chemistry, Urmia University
January 1980 – Present (35 years 10 months)Iran
1. Head of Chemistry and Biochemistry Department (1980-1981).
2. Member of Supervising Committee of Science Faculty (1980-1982).
3. Director of Central Library (1984-1986).
4. Head of Chemistry Department (1988-1992).
5. General Director for Research and Publication of Urmia University (1994-1998).
6. Head of Chemistry Department (1998-1999).
7. Deputy for Research of Science Faculty (1999-present).
Academic Degrees:
1.Ph. D.,
Organic Chemistry, Manchester University, Manchester,
England, 1979.
Regiospecific Synthesis of 1, 4-Naphthoquinones and 9, 10-Anthraquinones
2.M. Sc.,
Organic Chemistry, Manchester University, Manchester,
Engeland, 1977.
The Synthesis and Diels-Alder Reactions of 1’-Hydroxyalky-1, 4-benzoquinones and Related Compounds
3.B. Sc.,
Chemistry, Tabriz University, Tabriz. Iran, 1975.

Publications


F. B. H. Ahmad, J. M. Bruce, J. Khalafy, K. Sabetian and I. Watt, Acyl Migration in Diels-Alder Adduct of Acyl-1,4-ben-zoquinone, J. Chem. Soc. Chem. Comm, 1981, 166-169. 2. F. B. H. Ahmad, J. M. Bruce, J. Khalafy and K. Sabetian, [1,5] and [

Map of Iran with West Azerbaijan highlightedWest Azerbaijan Province
استان آذربایجان ØºØ±Ø¨ÛŒ
Kakh Muzeh Maku, near Maku, built by one of the commanders of Mozzafar-al-Din Shah, is a popular attraction.
Urmia is located in Iran
Iran-Photo of beautiful flowers in the city of Urmia.jpg
An aerial view of Urmia
Map of urmia

//////Jabbar Khalafy , Urmia University

Yael Schuster

Yael Schuster, a PhD in organic chemistry
Networking was an important part of the summit for Yael Schuster, a Virginia native who made aliyah to Israel 10 years ago. Schuster has a PhD in organic chemistry and manages a laboratory for the Weizmann Institute in Rehovot.
‘The goal is to give girls the tools they need to dream of being scientists’
Her start-up, the Know-It-Alls, makes science toys for girls ages eight to 12. In both the United States and Israel, science is mostly geared to boys, says Schuster. Her company’s toy sets include a story book, a chemistry kit and a miniature jet car. Girls will build the car through the story in the book and power it with materials from the chemistry set. They will also be able to share the results through an online community set up by the company. It launches next month on Kickstarter.
“The goal is to give girls the tools they need to dream of being scientists,” says Schuster. “Science should be fun and the girls should see role models.”
She says the summit was much different from science conferences she has been to, which are more hierarchical and less interactive than the ROI activities. She hopes the connections she made at the conference will help the start-up succeed.
Her two children, both boys, love the toy already, she says.
Current
  1. Weizmann Institute of Science
Previous
  1. Weizmann Institute of Science,
  2. Technion - Israel Institute of Technology,
  3. Ehrlich & Fenster
Education
  1. Technion-Machon Technologi Le' Israel

Summary

Extremely successful researcher in organic chemistry with multiple publications, patents, and awards.
Highly proficient in grant writing, scientific writing, and editing.

 

 

Experience


Laboratory Manager

Weizmann Institute of Science
August 2013 – Present (2 years 3 months)
Laboratory manager working with Dr. Itay Halevy in the field of geochemistry

Laboratory Manager

Weizmann Institute of Science
August 2012 – August 2013 (1 year 1 month)
Working with Dr. Rafal Klajn- nanoparticles, organic chemistry, chemistry in confined spaces

Lecturer

Technion - Israel Institute of Technology
March 2012 – August 2012 (6 months)Haifa
Lecturer in Organic Chemistry

Technical Advisor

Ehrlich & Fenster
June 2011 – May 2012 (1 year)Ramat Gan, Israel
Patent Attorney Trainee

Assistant Editor

Bulletin of the Israel Chemical Society
December 2010 – May 2011 (6 months)
Responsible for receiving and editing articles for publication

Assistant Editor

Israel Journal of Chemistry
August 2010 – May 2011 (10 months)
Responsible for writing and editing journal articles, press releases, and related material

Associate Chemist

The Valspar Corporation
June 2004 – June 2005 (1 year 1 month)
Emerging Technologies Team: formulation of a new polyester coating platform.
Short-term formulation to custom-tailor polymer coatings and/or correct defects.
Acted as technical liaison to customers

Research Assistant

Combinatorial Chemistry Center
December 2002 – December 2003 (1 year 1 month)

 

 Yael Schuster is a PhD chemist, a single mom to two hilariously crazy kids, a baker of incredibly adorable fondant-decorated cakes, a player of bluegrass fiddle, and an occasional unicycler. Yael is a veritable southern belle, from middle-of-nowhere Virginia, who came to Israel 9 years ago on aliyah. After a short stint of learning-hebrew-on-a-kibbutz, Yael moved to Haifa to complete her PhD in Organic Chemistry at the Technion. She now lives in Rehovot, where she manages a laboratory at Weizmann Institute of Science, and spends her free time biking through the nearby fields. Yael is trying to learn the language of non-scientists, and apologizes in advance if she sounds like she is talking in gibberish.

Education


Technion-Machon Technologi Le' Israel

Ph.D, Chemistry
2006 – 2011
2011 ICS Prize Recipient
Schulich Graduate Student Fellowship 2008-2010
AdvisorProfessor Gandelman Mark
Advisor's Emailchmark@tx.technion.ac.il
Advisor's Home-Site
No of theses10
DepartmentChemistry
Department Web Siteschulich.technion.ac.il
Technion Israel Institute of Technology - Graduate School


University of Pittsburgh

B.Sc., ChemistryEducation
2001 – 2004
Activities and Societies: Graduated Magna Cum Laude

 

 

Publications


Organometallics

Azidomethyl Phenyl Sulfide(Link)

Encyclopedia of Reagents for Organic Synthesis
2011
Triazolylidene-based Complexes via Post-modification of Pincer Click Ligands

Dalton Transactions
2011
DOI:10.1039/C1DT10264H

Photochemical Flow Reactions(Link)

Israel Journal of Chemistry
April 8, 2014

 

 

Volunteer Experience & Causes


EMT

Ashcake Volunteer Rescue Squad
1997 – 2004 (7 years)Health

Founder

University of Pittsburgh Chemistry Outreach Program
2001 – 2004 (3 years)Children
Founded program that brought chemistry after school activities to at-risk youth in citywide programs
The Weizmann Institute of Science in Rehovot, Israel,
Weizmann Institute, RehovotWeizmann Institute of Science 3
Yekev, First President St.
rehovot
Weizmann Institute of Science 1
Weizmann Institute of Science 1
Faculty of Chemistry Schulich
Technion Israel Institute of Technology
Technion City, 3200008, Haifa
Phone: (972-4) 8293727/3664
Fax: (972-4) 8295860

The campus on Mount Carmel, Haifa

Churchill Auditorium

Aerospace Faculty (Technion)

Civil and Environmental Engineering Faculty Technion

View towards the Electrical and Electronics Engineering Building from Obelisk

Computer Science Faculty Building

Faculty of Industrial Engineering & Management

Faculty of Mathematics

Technion Faculty of Medicine

The Obelisk, the stainless-steel structure 28 meters tall, is a kinetic sculpture
Albert Einstein at Technion; 11 February 1923


Dan Shechtman, who has taught at Technion since 1975, was awarded the 2011 Nobel Laureates in Chemistry for the discovery of quasicrystals.
/////Yael Schuster, The Weizmann Institute of Science, Rehovot, Israel, Technion-Machon Technologi Le' Israel